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1. 发明申请

WO2020181283A1 CARBOXAMIDE-PYRIMIDINE DERIVATIVES AS SHP2 ANTAGONISTS 审中-公开
公开(公告)号：WO2020181283A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/021726
申请日：2020-03-09
申请人： MERCK PATENT GMBH , JORAND-LEBRUN, Catherine , BOIVIN, Roch , MOCHALKIN, Igor , JOHNSON, Theresa , LINDE, Nina , MUSCH, Doreen , KUMAR, Deepak
发明人： JORAND-LEBRUN, Catherine , BOIVIN, Roch , MOCHALKIN, Igor , JOHNSON, Theresa , LINDE, Nina , MUSCH, Doreen , KUMAR, Deepak
IPC分类号： C07D401/04 , C07D403/04 , C07D239/42 , C07D405/14 , C07D413/04 , C07D491/107 , A61P35/00 , A61K31/506 , C07D451/14
摘要： The invention relates to carboxamide-pyrimidine derivatives of the general formula (I), or a pharmaceutically acceptable salt thereof, and the use of the compounds of the present invention for the treatment of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.

2. 发明申请

WO2002081640A3 GENE SHINC-1 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：WO2002081640A3
公开(公告)日：2002-10-17
申请号：PCT/US2002/010849
申请日：2002-04-08
申请人： GEORGETOWN UNIVERSITY , KASID, Usha, N. , SAKABE, Isamu , SUY, Simeng , KUMAR, Deepak , AHMED, Imran
发明人： KASID, Usha, N. , SAKABE, Isamu , SUY, Simeng , KUMAR, Deepak , AHMED, Imran
IPC分类号： C07H21/04
摘要： The partial DNA sequence of new gene SHINC-1 is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SHINC-1 such as breast cancer, leukemia, lymphoma, melanoma, colorectal cancer, and lung cancer.

3. 发明申请

WO2011089564A1 BONE FRACTURE FIXATION MEANS 审中-公开
标题翻译：骨折固定手段
公开(公告)号：WO2011089564A1
公开(公告)日：2011-07-28
申请号：PCT/IB2011/050262
申请日：2011-01-20
申请人： KUMAR, Deepak
发明人： KUMAR, Deepak
IPC分类号： A61B17/17 , A61B17/80
CPC分类号： A61B17/8061 , A61B17/1728 , A61B17/1782 , A61B17/8085 , A61B17/809
摘要： A bone fracture fixation plate juxta-articular stabilisation means comprises a plate with integral pin and tail parts, a plate specific jig, a plate and jig specific drill sleeve, a slotted head top loading screw, a plate positioner and a pin bender. This system can be used for fixation of most types of fractures involving the juxta-articular radius. The plate has a most juxta-articular row of screw holes in individually bendable and detachable extensions especially designed for very juxta-articular or the volar lip fractures. The plate also has bendable and detachable pin part and tail parts on either ends that allows the plate to be used with a chuck as a wire or drill bit and also have longer purchase into the bone with minimal soft tissue exposure. The plate and targeting assembly have plate positioning slots for wires in its juxta-articular part to allow adjustment in position of plate in longitudinal, transverse and oblique directions after initial fixation with wires without committing to a screw hole. This allows a very precise placement of the plate in the most ideal position. The targeting assembly can be mounted onto the plate prior to surgery thus reducing surgical step and time. The specific orientation of the screw holes in the shaft part of the plate orientates the screws such that when tendons apply forces across the fracture, the plate is wedged between screw and the bone rather than pushed away from the bone. Therefore, more aggressive physical therapy can be commenced earlier or plates with fewer screws in the proximal part can be used without compromising the strength of the fixation.
摘要翻译：骨折固定板关节稳定装置包括具有整体销和尾部的板，板专用夹具，板和夹具专用钻套，开槽头顶装载螺钉，板定位器和销弯曲器。该系统可用于固定涉及关节半径的大多数类型的骨折。该板具有单个可弯曲和可拆卸的延伸部分中最为关键的一排螺钉孔，特别设计用于非常关节或手腕唇裂。该板还在两端都具有可弯曲和可拆卸的销部分和尾部部件，允许板材与卡盘一起用作线或钻头，并且在较少的软组织暴露下也可以更长时间地购入骨骼。板和瞄准组件在其关节部分中具有用于线的板定位槽，以允许在初始用线固定之后在纵向，横向和倾斜方向上调整板的位置而不致螺丝孔。这样可以非常精确地将板放置在最理想的位置。靶向组件可以在手术之前安装在板上，从而减少手术步骤和时间。板的轴部分中的螺孔的具体取向使得螺钉的方向使得当筋在穿过骨折时施加力时，板被楔入螺钉和骨之间，而不是被推离骨头。因此，可以更早地开始更积极的物理治疗，或者可以使用近端部分中具有较少螺钉的板，而不会影响固定的强度。

4. 发明申请

WO2002081641A2 GENE SCC-112 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：基因SCC-112及其诊断和治疗方法
公开(公告)号：WO2002081641A2
公开(公告)日：2002-10-17
申请号：PCT/US2002/010850
申请日：2002-04-08
申请人： GEORGETOWN UNIVERSITY , KASID, Usha, N. , KUMAR, Deepak , AHMAD, Imran
发明人： KASID, Usha, N. , KUMAR, Deepak , AHMAD, Imran
IPC分类号： C12N
CPC分类号： C07K14/82 , A61K38/00 , G01N33/574
摘要： A gene that is a modulator of tumor growth and metastasis in certain cancer type is provided. SCC-112 (about 150 kDa) and/or a mutant form of SCC-112 (about 65 kDa) is a tumor suppressor molecule. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-112 such as breast and kidney cancers.
摘要翻译：提供了某种癌症类型的肿瘤生长和转移调节剂的基因。 SCC-112（约150kDa）和/或突变形式的SCC-112（约65kDa）是肿瘤抑制分子。该基因和相应的多肽具有用于检测和治疗涉及表达SCC-112（例如乳腺和肾癌）的癌症的诊断和治疗应用。

5. 发明申请

WO2002081639A3 GENE BRCC2 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：WO2002081639A3
公开(公告)日：2002-10-17
申请号：PCT/US2002/010848
申请日：2002-04-08
申请人： GEORGETOWN UNIVERSITY , NEOPHARM, INC. , KASID, Usha , GOKHALE, Prafulla , KUMAR, Deepak , BROUSTAS, Constantinos , AHMAD, Imran , DRITSCHILO, Anatoly , RAHMAN, Aquilur
发明人： KASID, Usha , GOKHALE, Prafulla , KUMAR, Deepak , BROUSTAS, Constantinos , AHMAD, Imran , DRITSCHILO, Anatoly , RAHMAN, Aquilur
IPC分类号： C12Q1/68
摘要： A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC2 such as breast cancer and lung cancer.

6. 发明申请

WO2013148324A1 ANTI-CANCER POLYKETIDE COMPOUNDS 审中-公开
标题翻译：抗癌多肽化合物
公开(公告)号：WO2013148324A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/032179
申请日：2013-03-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BURKART, Michael, D. , LACLAIR, James, J. , JONES, Brian, D. , MANDEL, Alexander , VILLA, Reymundo , CASTRO, Januario, E. , KASHYAP, Manoj, Kumar , KUMAR, Deepak
发明人： BURKART, Michael, D. , LACLAIR, James, J. , JONES, Brian, D. , MANDEL, Alexander , VILLA, Reymundo , CASTRO, Januario, E. , KASHYAP, Manoj, Kumar , KUMAR, Deepak
IPC分类号： C07D313/00 , A61K31/335 , A61P35/00
CPC分类号： C07D407/06 , C07D313/00
摘要： Provided herein, inter alia , are anticancer polyketides. The uses of the polyketides described herein include treatment of cancer, for example, through regulation of the spliceosome and detection of spliceosome inhibition.
摘要翻译：其中尤其是抗癌聚酮化合物。本文所述的聚酮化合物的用途包括治疗癌症，例如通过调节剪接体和检测剪接体抑制。

7. 发明申请

WO2002081642A3 GENE BRCC-3 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：WO2002081642A3
公开(公告)日：2002-10-17
申请号：PCT/US2002/010855
申请日：2002-04-08
申请人： GEORGETOWN UNIVERSITY , NEOPHARM, INC. , KASID, Usha , GOKHALE, Prafulla , KUMAR, Deepak , BOUDREAU, Howard, E. , AHMAD, Imran , DRITSCHILO, Anatoly , RAHMAN, Aquilur
发明人： KASID, Usha , GOKHALE, Prafulla , KUMAR, Deepak , BOUDREAU, Howard, E. , AHMAD, Imran , DRITSCHILO, Anatoly , RAHMAN, Aquilur
IPC分类号： C12Q1/68
摘要： A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC-3 such as breast cancer and lung cancer.

8. 发明申请

WO2002081641A3 GENE SCC-112 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：WO2002081641A3
公开(公告)日：2002-10-17
申请号：PCT/US2002/010850
申请日：2002-04-08
申请人： GEORGETOWN UNIVERSITY , NEOPHARM, INC. , KASID, Usha, N. , KUMAR, Deepak , AHMAD, Imran
发明人： KASID, Usha, N. , KUMAR, Deepak , AHMAD, Imran
IPC分类号： C07H21/02
摘要： A gene that is a modulator of tumor growth and metastasis in certain cancer type is provided. SCC-112 (about 150 kDa) and/or a mutant form of SCC-112 (about 65 kDa) is a tumor suppressor molecule. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-112 such as breast and kidney cancers.

9. 发明申请

WO2002081639A2 GENE BRCC2 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：基因BRCC2及其诊断和治疗方法
公开(公告)号：WO2002081639A2
公开(公告)日：2002-10-17
申请号：PCT/US2002/010848
申请日：2002-04-08
申请人： GEORGETOWN UNIVERSITY , KASID, Usha , GOKHALE, Prafulla , KUMAR, Deepak , BROUSTAS, Constantinos , AHMAD, Imran , DRITSCHILO, Anatoly , RAHMAN, Aquilur
发明人： KASID, Usha , GOKHALE, Prafulla , KUMAR, Deepak , BROUSTAS, Constantinos , AHMAD, Imran , DRITSCHILO, Anatoly , RAHMAN, Aquilur
IPC分类号： C12N
CPC分类号： C07K14/82 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , G01N2333/82
摘要： A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC2 such as breast cancer and lung cancer.
摘要翻译：提供了一种在某些癌症类型中是肿瘤生长和转移的调节剂的基因。该基因和相应的多肽具有检测和治疗涉及乳腺癌和肺癌等BRCC2表达的癌症的诊断和治疗应用。

10. 发明申请

WO2002059337A1 ANTI-APOPTOPIC GENE SCC-S2 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：抗APPT基因SCC-S2及其诊断和治疗方法
公开(公告)号：WO2002059337A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/002212
申请日：2002-01-28
申请人： GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE , KASID, Usha, N. , KUMAR, Deepak , GOKHALE, Prafulla , AHMAD, Imran
发明人： KASID, Usha, N. , KUMAR, Deepak , GOKHALE, Prafulla , AHMAD, Imran
IPC分类号： C12N15/86
CPC分类号： C07K14/4747 , A61K38/1709 , A61K2039/505
摘要： A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous leukemia, lung, lymphoblastic leukemia, and colorectal adenocarcinoma cells.
摘要翻译：提供了一种在某些癌症类型中是肿瘤生长和转移的阳性介质的基因。该基因和相应的多肽具有检测和治疗涉及SCC-S2表达的癌症的诊断和治疗应用，例如肾，卵巢，头颈部，乳腺，前列腺，脑，慢性骨髓性白血病，肺，淋巴细胞白血病和结肠直肠腺癌细胞。

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