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1. 发明专利

DE59510001D1 未知
公开(公告)号：DE59510001D1
公开(公告)日：2002-02-21
申请号：DE59510001
申请日：1995-02-18
申请人： MERCK PATENT GMBH
发明人： ECKSTEIN JUERGEN , KOPPE THOMAS , SCHWARZ MICHAEL , CASUTT MICHAEL
IPC分类号： A61K31/415 , C07D495/04 , C07F3/02
摘要： PCT No. PCT/EP95/00593 Sec. 371 Date Sep. 26, 1996 Sec. 102(e) Date Sep. 26, 1996 PCT Filed Feb. 18, 1995 PCT Pub. No. WO95/26965 PCT Pub. Date Oct. 12, 1995The present invention relates to an improved process for making heterocyclic compounds suitable for intermediate products for making D-(+)-biotin and a process for making D-(+)-biotin itself.

2. 发明专利

DE19850029A1 未知
公开(公告)号：DE19850029A1
公开(公告)日：2000-05-04
申请号：DE19850029
申请日：1998-10-30
申请人： MERCK PATENT GMBH
发明人： BUCHHOLZ HERWIG , KOPPE THOMAS , SCHLEEHAHN MICHAEL
IPC分类号： A23L1/30 , A23L1/00 , C12N9/14 , C12P19/02 , C12P19/04 , C12P19/44 , C12P19/60 , C07H3/02
摘要： Disclosed is a method for enzymatic splitting of rutinosides, whereby rhamnose and/or corresponding glucopyranosides is/are obtained . The inventive method is carried out in the presence of a solvent mixture made up of water and one or several organic solvents.

3. 发明专利

ES2225513T3 PROCEDIMIENTO PARA LA OBTENCION DE HETEROCICLOS BENZO-ANILLADOS. 未知
公开(公告)号：ES2225513T3
公开(公告)日：2005-03-16
申请号：ES01921324
申请日：2001-03-09
申请人： MERCK PATENT GMBH
发明人： WARTENBERG FRANK-HARDI , KOPPE THOMAS , WETZEL WALTER , WYDRA MARKUS , BENZ ACHIM
IPC分类号： C07D333/68
摘要： Procedimiento para la obtención de heterociclos benzo-anillados de la fórmula general I en la que X significa S, O o NH, R1 significa CN, NO2, Ac, COAr, COOAr, COOH, COOA o CONR4R5, R2 y R3 significan respectivamente, de manera independiente entre sí, H, A, NO2, CN, OH, OA o Ac, R4 y R5 significan respectivamente, de manera independiente entre sí, H, A, Ar o Ac, R4 y R5 significan conjuntamente, también -(CH2)- (CH2)n-(CH2)-, A significa alquilo con 1 a 6 átomos de carbono, Ac significa acilo con 1 a 6 átomos de carbono, Ar significa fenilo insubstituido o substituido por A, NO2, CN, OH, OA, n significa 2, 3 o 4, mediante reacción de heterociclos tetrahidrobenzo- anillados de la fórmula II en la que X significa S, O o NH, R1 significa CN, NO2, Ac, COAr, COOAr, COOH, COOA o CONR4R5, R2 y R3 significan respectivamente, de manera independiente entre sí, H, A, NO2, CN, OH, OA o Ac, R4 y R5 significan respectivamente, de manera independiente entre sí, H, A, Ar o Ac, R4 y R5 significan conjuntamente, también -(CH2)- (CH2)n-(CH2)-, A significa alquilo con 1 a 6 átomos de carbono, Ac significa acilo con 1 a 6 átomos de carbono, Ar significa fenilo insubstituido o substituido por A, NO2, CN, OH, OA, n significa 2, 3 o 4, con una cantidad catalítica de un catalizador de metal noble en presencia de aceptores de hidrógeno y, a continuación, desacilación del grupo amino acilado mediante adición de una amina.

4. 发明专利

SI1280792T1 METHOD FOR PRODUCING BENZO ANNELATED HETEROCYCLES 未知
公开(公告)号：SI1280792T1
公开(公告)日：2004-12-31
申请号：SI200130197
申请日：2001-03-09
申请人： MERCK PATENT GMBH
发明人： WARTENBERG FRANK-HARDI , KOPPE THOMAS , WETZEL WALTER , WYDRA MARKUS , BENZ ACHIM
IPC分类号： C07D333/68

5. 发明专利

DK1280792T3 未知
公开(公告)号：DK1280792T3
公开(公告)日：2004-11-15
申请号：DK01921324
申请日：2001-03-09
申请人： MERCK PATENT GMBH
发明人： WARTENBERG FRANK-HARDI , KOPPE THOMAS , WETZEL WALTER , WYDRA MARKUS , BENZ ACHIM
IPC分类号： C07D333/68

6. 发明专利

DK0789700T3 未知
公开(公告)号：DK0789700T3
公开(公告)日：2002-04-29
申请号：DK95909741
申请日：1995-02-18
申请人： MERCK PATENT GMBH
发明人： ECKSTEIN JUERGEN , KOPPE THOMAS , SCHWARZ MICHAEL , CASUTT MICHAEL
IPC分类号： A61K31/415 , C07D495/04 , C07F3/02
摘要： PCT No. PCT/EP95/00593 Sec. 371 Date Sep. 26, 1996 Sec. 102(e) Date Sep. 26, 1996 PCT Filed Feb. 18, 1995 PCT Pub. No. WO95/26965 PCT Pub. Date Oct. 12, 1995The present invention relates to an improved process for making heterocyclic compounds suitable for intermediate products for making D-(+)-biotin and a process for making D-(+)-biotin itself.

7. 发明专利

AU6338799A Method for enzymatic splitting of rutinosides 未知
公开(公告)号：AU6338799A
公开(公告)日：2000-05-22
申请号：AU6338799
申请日：1999-10-13
申请人： MERCK PATENT GMBH
发明人： BUCHHOLZ HERWIG , KOPPE THOMAS , SCHLEEHAHN MICHAEL
IPC分类号： A23L1/30 , A23L1/00 , C12N9/14 , C12P19/02 , C12P19/04 , C12P19/44 , C12P19/60 , A61K7/00
摘要： Disclosed is a method for enzymatic splitting of rutinosides, whereby rhamnose and/or corresponding glucopyranosides is/are obtained The inventive method is carried out in the presence of a solvent mixture made up of water and one or several organic solvents.

8. 发明专利

TR200402271T4 未知
公开(公告)号：TR200402271T4
公开(公告)日：2004-12-21
申请号：TR200402271
申请日：2001-03-09
申请人： MERCK PATENT GMBH
发明人： WARTENBERG FRANK-HARDI , KOPPE THOMAS , WETZEL WALTER , WYDRA MARKUS , BENZ ACHIM
IPC分类号： C07D333/68
摘要： Process for the preparation of benzo-fused heterocycles of general formula I: in which X, R1, R2, R3, R4, R5 and n are as defined in claim 1, by reacting tetrahydrobenzo-fused heterocycles of formula II: in which X, R1, R2, R3, R4, R5, n and Ac are as defined in claim 1, with a catalytic amount of a noble metal catalyst in the presence of a hydrogen acceptor and then deacylating the acylated amino group by the addition of an amine.

9. 发明专利

ZA200209067B Method for producing benzo annelated heterocycles. 未知
公开(公告)号：ZA200209067B
公开(公告)日：2004-01-21
申请号：ZA200209067
申请日：2002-11-07
申请人： MERCK PATENT GMBH
发明人： WARTENBERG FRANK-HARDI , WETZEL WALTER , BENZ ACHIM , KOPPE THOMAS , WYDRA MARKUS
IPC分类号： C07D333/68 , C07D
摘要： Process for the preparation of benzo-fused heterocycles of general formula I: in which X, R1, R2, R3, R4, R5 and n are as defined in claim 1, by reacting tetrahydrobenzo-fused heterocycles of formula II: in which X, R1, R2, R3, R4, R5, n and Ac are as defined in claim 1, with a catalytic amount of a noble metal catalyst in the presence of a hydrogen acceptor and then deacylating the acylated amino group by the addition of an amine.

10. 发明专利

AU1876802A Method for preparing (+)-biotine 未知
公开(公告)号：AU1876802A
公开(公告)日：2002-01-21
申请号：AU1876802
申请日：2001-06-20
申请人： MERCK PATENT GMBH
发明人： HEYWANG ULRICH , KOPPE THOMAS , SCHWARZ MICHAEL
IPC分类号： C07D491/048 , C07D495/04
摘要： The invention relates to a novel method for preparing biotine while using 5-hydroxy-2(5H)-furanone as a starting substance. The invention also relates to a method in which 1-chlorosulfonyl-1,2,2a,3,5,5a-hexa-hydro-3-((1R)-menthyloxy-)-furo[3,4-b]azet-2-one is formed as an intermediate product.

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