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1. 发明公开

EP0517484A2 Fermentation analogs of virginiamycin M1 失效
标题翻译：维吉尼亚州M1的Gärungsanalagen。
公开(公告)号：EP0517484A2
公开(公告)日：1992-12-09
申请号：EP92305044.7
申请日：1992-06-02
申请人： MERCK & CO. INC.
发明人： Freidinger, Roger M. , Bock, Mark G. , Lam, Yiu-kuen T. , Chang, Raymond S. , Hensens, Otto D. , Schwartz, Cheryl D. , Zink, Deborah L.
IPC分类号： C07K5/06 , A61K37/02
CPC分类号： C07K5/06182 , A61K38/00
摘要： Pharmaceutical compositions containing Virginiamycin M 1 having the Formula :

and virginiamycin M 1 analogs having the Formulae I-IV:

are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
摘要翻译：公开了含有具有式：的弗吉尼亚霉素M1和具有式I-IV的维吉尼亚霉素M1类似物的药物组合物： CHEM> CHEM>可用于治疗恐慌症或焦虑症。

2. 发明公开

EP0517484A3 Fermentation analogs of virginiamycin M1 失效
标题翻译： VIRGINIAMYCIN M1的发酵模拟
公开(公告)号：EP0517484A3
公开(公告)日：1993-08-04
申请号：EP92305044.7
申请日：1992-06-02
申请人： MERCK & CO. INC.
发明人： Freidinger, Roger M. , Bock, Mark G. , Lam, Yiu-kuen T. , Chang, Raymond S. , Hensens, Otto D. , Schwartz, Cheryl D. , Zink, Deborah L.
IPC分类号： C07K5/06 , A61K37/02
CPC分类号： C07K5/06182 , A61K38/00
摘要： Pharmaceutical compositions containing Virginiamycin M 1 having the Formula :

and virginiamycin M 1 analogs having the Formulae I-IV:

are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
摘要翻译：公开了含有具有式：的弗吉尼亚霉素M1和具有式I-IV的维吉尼亚霉素M1类似物的药物组合物： CHEM> CHEM>可用于治疗恐慌症或焦虑症。

3. 发明公开

EP0269322A1 Virginiamycin analogs 失效
标题翻译： Fermentationsanaloge von弗吉尼亚霉素M1。
公开(公告)号：EP0269322A1
公开(公告)日：1988-06-01
申请号：EP87310022.6
申请日：1987-11-12
申请人： Merck & Co., Inc.
发明人： Lam, Yiu-Kuen T. , Chang, Raymond S. , Hensens, Otto D. , Schwartz, Cheryl D. , Zink, Deborah L. , Woodruff, H. Boyd
IPC分类号： C12P17/18 , C12P17/16 , C12P1/06 , C07D498/18 , A61K31/395 , A61K31/41 , A23K1/17
CPC分类号： C12R1/58 , A61K38/00
摘要： Virginiamycin M₁ having the Formula:
and virginiamycin M₁ analogs having the Formulae I-IV:

Virginiamycin M₁ and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M₁ and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus , ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
摘要翻译：具有式：的弗吉尼亚霉素M1和具有式I-IV的维吉尼亚霉素M1类似物：维生素M1和类似物I-IV是缩胆囊素（CCK）和胃泌素的拮抗剂。缩胆囊素拮抗剂可用作止痛剂，以及用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。胃泌素拮抗剂可用于阻断人胃泌素的受体，并且可用作治疗溃疡，肿瘤或其他胃肠道疾病的药剂。式I-IV的化合物也是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。维生素霉素M1和式I，III和IV的类似物通过对链霉菌链霉菌ATCC No.55327的受控好氧发酵产生，而式II的类似物通过化学合成制备。

4. 发明公开

EP0256847A3 Oxytocin and vasopressin antagonists 失效
标题翻译：氧化应激和血管紧张素转化酶
公开(公告)号：EP0256847A3
公开(公告)日：1989-01-04
申请号：EP87307132.8
申请日：1987-08-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
IPC分类号： C12P21/04 , A61K37/02 , C12N1/20
CPC分类号： C12R1/465 , A61K38/00 , C07K7/16
摘要： Cyclic peptides having the formula: are produced by the controlled aerobic fermentation of Streptomyces silvensis , ATCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.

5. 发明公开

EP0256847A2 Oxytocin and vasopressin antagonists 失效
标题翻译：催产素和加压素拮抗剂。
公开(公告)号：EP0256847A2
公开(公告)日：1988-02-24
申请号：EP87307132.8
申请日：1987-08-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
IPC分类号： C12P21/04 , A61K37/02 , C12N1/20
CPC分类号： C12R1/465 , A61K38/00 , C07K7/16
摘要： Cyclic peptides having the formula:

are produced by the controlled aerobic fermentation of Streptomyces silvensis , ATCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.
摘要翻译：具有下式的环状肽：是通过对链霉菌（Streptomyces silvensis），ATCC No.55325或ATCC No.55326的受控好氧发酵产生的。这些化合物是催产素的拮抗剂，可用于治疗早产和血管加压素可用于治疗和预防其中可能涉及血管加压素的疾病状态，例如充血性心力衰竭，高血压，水肿和低钠血症。

6. 发明授权

EP0269322B1 Virginiamycin analogs 失效
标题翻译：维吉尼亚霉素类似物
公开(公告)号：EP0269322B1
公开(公告)日：1992-12-23
申请号：EP87310022.6
申请日：1987-11-12
申请人： Merck & Co., Inc.
发明人： Lam, Yiu-Kuen T. , Chang, Raymond S. , Hensens, Otto D. , Schwartz, Cheryl D. , Zink, Deborah L. , Woodruff, H. Boyd
IPC分类号： C12P17/18 , C12P17/16 , C12P1/06 , C07D498/18 , A61K31/395 , A61K31/41 , A23K1/17
CPC分类号： C12R1/58 , A61K38/00

7. 发明授权

EP0256847B1 Oxytocin and vasopressin antagonists 失效
标题翻译：氧化应激和血管紧张素转化酶
公开(公告)号：EP0256847B1
公开(公告)日：1991-11-21
申请号：EP87307132.8
申请日：1987-08-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
IPC分类号： C12P21/04 , A61K37/02 , C12N1/20
CPC分类号： C12R1/465 , A61K38/00 , C07K7/16

8. 发明公开

EP0327744A1 Oxytocin and vasopressin antagonists 失效
标题翻译：催产素和加压素拮抗剂。
公开(公告)号：EP0327744A1
公开(公告)日：1989-08-16
申请号：EP88301199.1
申请日：1988-02-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
IPC分类号： C12P21/04 , C07K7/64 , C12N1/20 , A61K37/02
CPC分类号： C07K7/16 , A61K38/00
摘要： Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis , ATCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.
摘要翻译：循环肽是通过对链霉菌（Streptomyces silvensis），ATCC No.55325或ATCC No.55326的受控好氧发酵产生的。这些化合物是催产素的拮抗剂，可用于治疗早产和加压素，因此可用于治疗和预防可能涉及血管加压素的疾病状态，例如充血性心力衰竭，高血压，水肿和低钠血症。

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