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1. 发明申请

WO2008002621A2 BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS 审中-公开
标题翻译：苄基取代的喹诺酮M1受体阳性变体调节剂
公开(公告)号：WO2008002621A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/014943
申请日：2007-06-27
申请人： MERCK & CO., INC. , LINDSLEY, Craig , SHIPE, William, D. , YANG, Feng , BUNDA, Jaime, Lynn
发明人： LINDSLEY, Craig , SHIPE, William, D. , YANG, Feng , BUNDA, Jaime, Lynn
IPC分类号： A61K31/4709
CPC分类号： C07D401/10 , C07D215/56 , C07D405/10 , C07D417/10
摘要： The present invention is directed to benzyl-substituted quinolone compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of diseases in which the M1 receptor is involved.
摘要翻译：本发明涉及通式（I）的苄基取代的喹诺酮化合物，其是M1受体正变构调节剂并且可用于治疗其中涉及M1受体的疾病，例如如阿尔茨海默病，疼痛或睡眠障碍。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及M1受体的疾病中的用途。

2. 发明申请

WO2006086255A2 INHIBITORS OF CHECKPOINT KINASES 审中-公开
标题翻译：检查点动物的抑制剂
公开(公告)号：WO2006086255A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/003981
申请日：2006-02-03
申请人： MERCK & CO., INC. , ARRINGTON, Kenneth, L. , FRALEY, Mark, E. , GARBACCIO, Robert, M. , HUANG, Shaei, Y. , LINDSLEY, Craig, W. , STEEN, Justin, T. , YANG, Feng
发明人： ARRINGTON, Kenneth, L. , FRALEY, Mark, E. , GARBACCIO, Robert, M. , HUANG, Shaei, Y. , LINDSLEY, Craig, W. , STEEN, Justin, T. , YANG, Feng
IPC分类号： A61K31/416
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10
摘要： The instant invention provides for compounds which comprise substituted indolyl indazoles that inhibit CHK1 activity. The instant compounds provide a novel mechanism of action with unexpected advantageous properties; such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译：本发明提供了包含抑制CHK1活性的取代的吲哚吲嗪的化合物。本发明化合物提供具有意想不到的有利性质的新颖作用机理; 这种意想不到的有利性质可以包括增加的细胞效能/溶解度，更大的选择性，增强的药代动力学性质，缺乏目标活性等。本发明还提供了包含这种抑制性化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制CHK1活性的方法。

3. 发明申请

WO2021247038A1 SYSTEMS AND METHODS FOR MESSAGE EMBEDDING IN THREE-DIMENSIONAL IMAGE DATA 审中-公开
公开(公告)号：WO2021247038A1
公开(公告)日：2021-12-09
申请号：PCT/US2020/036249
申请日：2020-06-05
申请人： GOOGLE LLC , YOO, Innfarn , LUO, Xiyang , YANG, Feng , STAVA, Ondrej
发明人： YOO, Innfarn , LUO, Xiyang , YANG, Feng , STAVA, Ondrej
IPC分类号： G09C5/00 , G06T1/0028 , G06T1/005 , G06T2201/0065 , G06T2201/0202
摘要： Systems and methods are directed to a computing system. The computing system can include one or more processors, a message embedding model, a message extraction model, and a first set of instructions that cause the computing system to perform operations including obtaining the three-dimensional image data and the message vector. The operations can include inputting three-dimensional image data and a message vector into the message embedding model to obtain encoded three-dimensional image data. The operations can include using the message extraction model to extract an embedded message from the encoded three-dimensional image data to obtain a reconstructed message vector. The operations can include evaluating a loss function for a difference between the reconstructed message vector and the message vector and modifying values for parameters of at least the message embedding model based on the loss function.

4. 发明申请

WO2012040935A1 CHANNEL QUALITY INFORMATION PREDICTION METHOD, DEVICE AND SYSTEM 审中-公开
标题翻译：信道质量信息预测方法，装置和系统
公开(公告)号：WO2012040935A1
公开(公告)日：2012-04-05
申请号：PCT/CN2010/077533
申请日：2010-09-30
申请人： FRANCE TELECOM RESEARCH & DEVELOPMENT BEIJING COMPANY LIMITED , YANG, Feng , GU, Daqing
发明人： YANG, Feng , GU, Daqing
IPC分类号： H04W24/10 , H04W72/00
CPC分类号： H04L1/0026 , H04B7/0452 , H04B7/0632 , H04B7/0654 , H04B17/373 , H04L1/0019 , H04L1/20 , H04L25/0204 , H04L25/0222 , H04L25/0242 , H04L25/03898 , H04L25/03949 , H04W24/00 , H04W72/00 , H04W72/12 , H04W88/08
摘要： A method of computing a channel quality indicator of a channel in a telecommunication network, said channel quality indicator characterizing the quality of the signal received on a channel by a device in said telecommunication network, said method comprising, for a device, the acts of monitoring the state of the channel; computing a prediction of the channel based on a past and the current state of the monitored channel; obtaining a channel variation indicator, said channel variation indicator characterizing the variation of the channel between a past and the current state of the channel; computing a channel quality indicator based on the channel prediction and the channel variation indicator.
摘要翻译：一种计算电信网络中的信道的信道质量指示符的方法，所述信道质量指示符表征所述电信网络中的设备在信道上接收的信号的质量，所述方法包括：对于设备来说，监视频道状态的行为; 基于过去和所监视的信道的当前状态来计算信道的预测; 获得信道变化指示符，所述信道变化指示符表征信道在过去和当前状态之间的变化; 基于信道预测和信道变化指示符来计算信道质量指示符。

5. 发明申请

WO2011028887A3 METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS 审中-公开
公开(公告)号：WO2011028887A3
公开(公告)日：2011-03-10
申请号：PCT/US2010/047653
申请日：2010-09-02
申请人： BECTON, DICKINSON AND COMPANY , YANG, Feng , WANG, Sha-sha , VAUGHAN, Laurence, Michael , PORTER, Michael , ROSE, Elaine
发明人： YANG, Feng , WANG, Sha-sha , VAUGHAN, Laurence, Michael , PORTER, Michael , ROSE, Elaine
IPC分类号： C12N1/06 , C12Q1/68 , G01N33/48 , G01N1/28
摘要： A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

6. 发明申请

WO2018058290A1 RADIO ACCESS NETWORK AS A SERVICE FOR A WIRELESS NETWORK 审中-公开
标题翻译：无线接入网络作为无线网络的服务
公开(公告)号：WO2018058290A1
公开(公告)日：2018-04-05
申请号：PCT/CN2016/100305
申请日：2016-09-27
申请人： INTEL CORPORATION , HUANG, Min , YANG, Feng , ZHANG, Xu
发明人： HUANG, Min , YANG, Feng , ZHANG, Xu
IPC分类号： H04W4/00
CPC分类号： H04W24/02 , H04W84/042
摘要： Particular embodiments described herein provide for an electronic device that can be configured to identify a resource package, where the resource package includes standardized functions for use in communication on a radio access network. The identified resource package with one or more APIs to create a customized resource package, where the customized resource package includes customized functions for use in communication on a radio access network for a customized service, where the customized resource package is communicated on the network as a standardized package. In an example, the customized resource package includes a standard API and an overwriting API and the standard API follows standardized procedures to implement RAN services while the overwriting API causes non-standardized handling to implement RAN services
摘要翻译：这里描述的特定实施例提供了可以被配置为识别资源包的电子设备，其中资源包包括用于在无线电接入网络上通信的标准化功能。所标识的资源包具有一个或多个API以创建定制资源包，其中定制资源包包括用于在无线电接入网络上进行通信以用于定制服务的定制功能，其中定制资源包在网络上作为标准化套餐。在一个示例中，定制资源包包括标准API和覆盖API，并且标准API遵循用于实现RAN服务的标准化过程，而覆盖API导致非标准化处理来实现RAN服务

7. 发明申请

WO2002096982A1 ORGANIC/INORGANIC NANOCOMPOSITES OBTAINED BY EXTRUSION 审中-公开
标题翻译：有机/无机纳米复合材料
公开(公告)号：WO2002096982A1
公开(公告)日：2002-12-05
申请号：PCT/US2002/017250
申请日：2002-05-31
申请人： NELSON, Gordon, L. , YANG, Feng
发明人： NELSON, Gordon, L. , YANG, Feng
IPC分类号： C08J3/20
CPC分类号： C08K9/04 , B82Y30/00 , C08J3/212 , C08J3/226 , C08J5/005 , C08J2325/06 , C08J2333/12 , C08J2425/00 , C08J2433/00
摘要： Organic/inorganic nanocomposites and methods for their preparation are disclosed. In one embodiment, the method comprises the steps of providing an organic/inorganic concentrate and processing the concentrate with a polymer resin. In a preferred embodiment the organic/inorganic concentrate and polymer resin are processed by extrusion using a single-screw extruder. In another embodiment, the method further comprises surface modifying an inorganic additive, mixing the modified additive with a polymer solution to produce an organic/inorganic solution, and removing solvent from the organic/inorganic solution to produce the organic/inorganic concentrate. Processing of the organic/inorganic concentrate with a polymer resin produces a homogeneous nanocomposite with superior mechanical and thermal properties.
摘要翻译：公开了有机/无机纳米复合材料及其制备方法。在一个实施方案中，该方法包括提供有机/无机浓缩物并用聚合物树脂处理浓缩物的步骤。在优选的实施方案中，使用单螺杆挤出机挤出加工有机/无机浓缩物和聚合物树脂。在另一个实施方案中，该方法还包括对无机添加剂进行表面改性，将改性添加剂与聚合物溶液混合以产生有机/无机溶液，以及从有机/无机溶液中除去溶剂以产生有机/无机浓缩物。用聚合物树脂处理有机/无机浓缩物产生具有优异机械和热性能的均匀的纳米复合材料。

8. 发明申请

WO2022019913A1 SYSTEMS AND METHODS FOR GENERATION OF MACHINE-LEARNED MULTITASK MODELS 审中-公开
公开(公告)号：WO2022019913A1
公开(公告)日：2022-01-27
申请号：PCT/US2020/043285
申请日：2020-07-23
申请人： GOOGLE LLC , WANG, Qifei , KE, Junjie , CHU, Grace , BENDER, Gabriel Mintzer , SBAIZ, Luciano , YANG, Feng , HOWARD, Andrew Gerald , GO, Alec Michael , GILBERT, Jeffrey M. , MILANFAR, Peyman , GREAVES, Joshua William Charles
发明人： WANG, Qifei , KE, Junjie , CHU, Grace , BENDER, Gabriel Mintzer , SBAIZ, Luciano , YANG, Feng , HOWARD, Andrew Gerald , GO, Alec Michael , GILBERT, Jeffrey M. , MILANFAR, Peyman , GREAVES, Joshua William Charles
IPC分类号： G06N3/00 , G06N3/04 , G06N3/08
摘要： Systems and methods of the present disclosure are directed to a method for generating a machine-learned multitask model configured to perform tasks. The method can include obtaining a machine-learned multitask search model comprising candidate nodes. The method can include obtaining tasks and machine-learned task controller models associated with the tasks. As an example, for a task, the method can include using the task controller model to route a subset of the candidate nodes in a machine-learned task submodel for the corresponding task. The method can include inputting task input data to the task submodel to obtain a task output. The method can include generating, using the task output, a feedback value based on an objective function. The method can include adjusting parameters of the task controller model based on the feedback value.

9. 发明申请

WO2021112852A1 WATERMARK-BASED IMAGE RECONSTRUCTION 审中-公开
公开(公告)号：WO2021112852A1
公开(公告)日：2021-06-10
申请号：PCT/US2019/064661
申请日：2019-12-05
申请人： GOOGLE LLC , YOO, Innfarn , YANG, Feng , LUO, Xiyang
发明人： YOO, Innfarn , YANG, Feng , LUO, Xiyang
IPC分类号： G06T1/00 , G06T9/00 , H04N19/00
摘要： A computer-implemented method that provides watermark-based image reconstruction to compensate for lossy encoding schemes. The method can generate a difference image describing the data loss associated with encoding an image using a lossy encoding scheme. The difference image can be encoded as a message and embedded in the encoded image using a watermark and later extracted from the encoded image. The difference image can be added to the encoded image to reconstruct the original image. As an example, an input image encoded using a lossy JPEG compression scheme can be embedded with the lost data and later reconstructed, using the embedded data, to a fidelity level that is identical or substantially similar to the original.

10. 发明申请

WO2017096531A1 SOFTWARE DEFINED NETWORK SWITCH AND EVOLVED NODE-B (ENB) FOR MULTIPLE BEARER CONNECTIVITY 审中-公开
标题翻译：用于多承载连接的软件定义网络交换和演进节点B（ENB）
公开(公告)号：WO2017096531A1
公开(公告)日：2017-06-15
申请号：PCT/CN2015/096691
申请日：2015-12-08
申请人： INTEL CORPORATION , YANG, Feng , ZHANG, Xu , LI, Guangjie , YU, Yifan , SIROTKIN, Alexander
发明人： YANG, Feng , ZHANG, Xu , LI, Guangjie , YU, Yifan , SIROTKIN, Alexander
IPC分类号： H04W88/08
CPC分类号： H04W76/15 , H04W88/14
摘要： Embodiments of a Master Evolved Node-B (MeNB), a software-defined network (SDN) switch, and methods for multiple bearer connectivity are generally described herein. The MeNB may receive, from a software-defined network (SDN) switch, a data packet to be forwarded to a User Equipment (UE) as part of a first Evolved Packet System (EPS) bearer between a Serving Gateway (S-GW) and the UE. The MeNB may transmit the data packet to the UE on a first radio bearer included in the first EPS bearer. The MeNB may further transmit, to the SDN switch, a configuration message to identify a second EPS bearer between the S-GW and the UE. The second EPS bearer may include a second radio bearer between the UE and a secondary Evolved Node-B (SeNB), and may exclude radio bearers between the UE and the MeNB.
摘要翻译：本文总体上描述了主演进节点B（MeNB），软件定义网络（SDN）交换机和用于多承载连接的方法的实施例。 MeNB可以从软件定义网络（SDN）交换机接收要作为服务网关（S-GW）之间的第一演进分组系统（EPS）承载的一部分而被转发到用户设备（UE）的数据分组，和UE。 MeNB可以在包括在第一EPS承载中的第一无线电承载上向UE发送数据分组。 MeNB还可以向SDN交换机发送配置消息以标识S-GW与UE之间的第二EPS承载。第二EPS承载可以包括UE与辅助演进型节点B（SeNB）之间的第二无线电承载，并且可以排除UE与MeNB之间的无线电承载。

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