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1. 发明公开

EP0784987A3 Method of making in situ filler material for mammary, penile and testicular prosthesis and tissue expanders 失效
标题翻译：一种用于在原位的填充材料制备用于乳房，阴茎和睾丸假体，和组织扩张器过程
公开(公告)号：EP0784987A3
公开(公告)日：1999-04-07
申请号：EP97300087.0
申请日：1997-01-08
申请人： MENTOR CORPORATION
发明人： Purkait, Bobby
IPC分类号： A61L27/00
CPC分类号： A61L27/18 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/20 , A61L27/52 , C08L5/08 , C08L5/04 , C08L1/26 , C08L39/06 , C08L33/26 , C08L29/04 , C08L75/04 , C08L67/04 , C08L71/02
摘要： An inflatable prosthesis which contains a dehydrated substance that forms a gel when mixed with an aqueous solution. The dehydrated substance is a biocompatible material such as an hydrophilic polymer which includes but is not limited to polyacrylamide, polyvinylprolidone, hydroxypropyl methylcellulose, polyvinyl alcohol, polyethylene oxides, polypropylene oxides, polyethylene glycol, polylactic, polyglycoloic acids, hydrogel polyurethane, chrondotoin sulfate, hyaluronic acid and alginate. The prosthesis includes a flexible inflatable outer shell that has an inner cavity. The inner cavity may contain the sterile dehydrated substance. The prosthesis is provided to the surgical site while the substance is in the dehydrated state. An initial volume of aqueous solution can be added to the inner cavity of the outer shell. The dehydrated substance combines with the aqueous solution to form a gel within the implant. The semi-inflated prosthesis can be implanted into a breast and inflated to a desired size with an additional volume of aqueous solution. The dehydrated substance may be coated along the inner surface of the prosthesis to form a lubricant which reduces crease-fold rupture. As an alternate embodiment, the dehydrated substance may be supplied in a package separate from the outer shell. An aqueous solution can be added to the package in situ to form a gel which can be subsequently added to the inner cavity of the outer shell.

2. 发明公开

EP0895785A3 Filling material for soft tissue implant prostheses and implants made therewith 失效
标题翻译：对于由软组织和植入它的植入假体填充材料
公开(公告)号：EP0895785A3
公开(公告)日：1999-09-15
申请号：EP98306040.1
申请日：1998-07-29
申请人： MENTOR CORPORATION
发明人： Purkait, Bobby
IPC分类号： A61L27/00 , A61F2/12
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/18 , A61L27/20 , C08L33/26 , C08L5/08 , C08L5/04 , C08L3/04 , C08L1/28 , C08L39/06 , C08L33/14 , C08L29/04 , C08L75/04 , C08L71/02 , C08L67/04
摘要： A new soft tissue implant filling material is disclosed. The surgically implantable soft tissue implant filling material has good aesthetic properties, as measured by viscosity and elasticity, and good elimination properties. One embodiment of such a new filling material is a gel which comprises three components. The first component is a water soluble polymer or hydrogel that has a high molecular weight. Alternatively, the first component is both crosslinked and has a high molecular weight. The second component of the filling material is a water-soluble polymer that has a molecular weight and a molecular weight distribution that is essentially under the renal threshold molecular weight of the polymer. The third component of this filling material is saline, which is used to dissolve the polymer and to adjust the osmolality of the polymer. In addition, a buffer may be added to the filling material to adjust the pH of the gel. One gel formulation of the present invention, in its preferred embodiment, consists of polyacrylamide and derivatives thereof.

3. 发明公开

EP0895785A2 Filling material for soft tissue implant prostheses and implants made therewith 失效
标题翻译：用于软组织植入假体的填充材料和由其制成的植入物
公开(公告)号：EP0895785A2
公开(公告)日：1999-02-10
申请号：EP98306040.1
申请日：1998-07-29
申请人： MENTOR CORPORATION
发明人： Purkait, Bobby
IPC分类号： A61L27/00 , A61F2/12
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/18 , A61L27/20 , C08L33/26 , C08L5/08 , C08L5/04 , C08L3/04 , C08L1/28 , C08L39/06 , C08L33/14 , C08L29/04 , C08L75/04 , C08L71/02 , C08L67/04
摘要： A new soft tissue implant filling material is disclosed. The surgically implantable soft tissue implant filling material has good aesthetic properties, as measured by viscosity and elasticity, and good elimination properties. One embodiment of such a new filling material is a gel which comprises three components. The first component is a water soluble polymer or hydrogel that has a high molecular weight. Alternatively, the first component is both crosslinked and has a high molecular weight. The second component of the filling material is a water-soluble polymer that has a molecular weight and a molecular weight distribution that is essentially under the renal threshold molecular weight of the polymer. The third component of this filling material is saline, which is used to dissolve the polymer and to adjust the osmolality of the polymer. In addition, a buffer may be added to the filling material to adjust the pH of the gel. One gel formulation of the present invention, in its preferred embodiment, consists of polyacrylamide and derivatives thereof.
摘要翻译：公开了一种新的软组织植入物填充材料。手术植入式软组织植入物填充材料具有良好的美学特性，如通过粘度和弹性测量的，以及良好的消除特性。这种新型填充材料的一个实施方案是包含三种组分的凝胶。第一种组分是具有高分子量的水溶性聚合物或水凝胶。或者，第一组分是交联的并且具有高分子量。填充材料的第二组分是水溶性聚合物，其分子量和分子量分布基本上低于聚合物的肾阈值分子量。这种填充材料的第三种成分是盐水，用于溶解聚合物并调节聚合物的渗透压。另外，可以向填充材料添加缓冲剂以调节凝胶的pH。在其优选实施方案中，本发明的一种凝胶制剂由聚丙烯酰胺及其衍生物组成。

4. 发明公开

EP1382356A1 Filling material for soft tissue implant prostheses and implants made therewith 失效
标题翻译：用于软组织植入假体的填充材料和由其制成的植入物
公开(公告)号：EP1382356A1
公开(公告)日：2004-01-21
申请号：EP03077954.0
申请日：1996-02-05
申请人： MENTOR CORPORATION
发明人： Brunstedt, Michael , Woo, Yi-Ren , Purkait, Bobby , Bhate, Anand
IPC分类号： A61L27/20 , A61F2/12
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/18 , A61L27/20 , C08L5/08 , C08L5/04 , C08L3/04 , C08L1/28 , C08L39/06 , C08L33/26 , C08L33/14 , C08L29/04 , C08L75/04 , C08L71/02 , C08L67/04
摘要： The invention provides an implantable soft-tissue prosthesis, comprising:

a hollow shell formed of a flexible elastomeric polymer, the prosthesis being adapted to be surgically implanted and to retain a desired shape when filled with a filing material; and
a filling material comprising a gel or viscous liquid comprising hyaluronic acid, wherein the filling material has an osmolarity between 200 and 400 mOsm/kg and a radiation penetration equal to or better than 0.9% saline.
摘要翻译：本发明提供了一种可植入的软组织假体，其包括：由柔性弹性体聚合物形成的中空壳体，所述假体适于手术植入并在填充填充材料时保持期望的形状; 以及包含凝胶或包含透明质酸的粘性液体的填充材料，其中所述填充材料具有200至400mOsm / kg的同渗容摩和等于或优于0.9％盐水的辐射渗透性。

5. 发明公开

EP0784987A2 Method of making in situ filler material for mammary, penile and testicular prosthesis and tissue expanders 失效
标题翻译：一种用于在原位的填充材料制备用于乳房，阴茎和睾丸假体，和组织扩张器过程
公开(公告)号：EP0784987A2
公开(公告)日：1997-07-23
申请号：EP97300087.0
申请日：1997-01-08
申请人： MENTOR CORPORATION
发明人： Purkait, Bobby
IPC分类号： A61L27/00
CPC分类号： A61L27/18 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/20 , A61L27/52 , C08L5/08 , C08L5/04 , C08L1/26 , C08L39/06 , C08L33/26 , C08L29/04 , C08L75/04 , C08L67/04 , C08L71/02
摘要： An inflatable prosthesis which contains a dehydrated substance that forms a gel when mixed with an aqueous solution. The dehydrated substance is a biocompatible material such as an hydrophilic polymer which includes but is not limited to polyacrylamide, polyvinylprolidone, hydroxypropyl methylcellulose, polyvinyl alcohol, polyethylene oxides, polypropylene oxides, polyethylene glycol, polylactic, polyglycoloic acids, hydrogel polyurethane, chrondotoin sulfate, hyaluronic acid and alginate. The prosthesis includes a flexible inflatable outer shell that has an inner cavity. The inner cavity may contain the sterile dehydrated substance. The prosthesis is provided to the surgical site while the substance is in the dehydrated state. An initial volume of aqueous solution can be added to the inner cavity of the outer shell. The dehydrated substance combines with the aqueous solution to form a gel within the implant. The semi-inflated prosthesis can be implanted into a breast and inflated to a desired size with an additional volume of aqueous solution. The dehydrated substance may be coated along the inner surface of the prosthesis to form a lubricant which reduces crease-fold rupture. As an alternate embodiment, the dehydrated substance may be supplied in a package separate from the outer shell. An aqueous solution can be added to the package in situ to form a gel which can be subsequently added to the inner cavity of the outer shell.
摘要翻译：可充气的假体里面包含了脱水物质形式的凝胶做当与在wässrige溶液混合。脱水物质是一种生物相容的材料：例如，以亲水性聚合物，其包括但不限于聚丙烯酰胺，polyvinylprolidone，羟丙基甲基纤维素，聚乙烯醇，聚环氧乙烷，聚环氧丙烷，聚乙二醇，聚乳酸，polyglycoloic酸，水凝胶的聚氨酯，chrondotoin硫酸盐，透明质酸酸和藻酸盐。该假体包括一个柔性可膨胀外壳那样具有内腔。内腔可以含有无菌脱水物质。而该物质是在脱水状态的假体被提供给手术部位。 wässrige溶液的初始体积可以被添加到所述外壳的内空腔中。与wässrige溶液脱水物质结合形成在植入物内的凝胶。半膨胀假体可以在wässrige溶液的额外体积被植入到乳房上并充气到所需的尺寸与。脱水物质可以沿着假体的内表面被涂覆以形成润滑剂这减少折痕倍破裂。至于替代实施例中，脱水的物质可以在一个包从外壳体分开提供。在wässrige溶液可以添加到包中原位形成可随后添加到外壳的内腔凝胶。

6. 发明公开

EP0727232A3 Filling material for soft tissue implant prostheses and implants made therewith 失效
标题翻译：用于软组织植入假体的填充材料和由其制成的植入物
公开(公告)号：EP0727232A3
公开(公告)日：1996-11-06
申请号：EP96300768.7
申请日：1996-02-05
申请人： MENTOR CORPORATION
发明人： Brunstedt, Michael , Purkait, Bobby , Bhate, Anand , Woo, Yi-Ren
IPC分类号： A61L27/00 , A61F2/12
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/18 , A61L27/20 , C08L5/08 , C08L5/04 , C08L3/04 , C08L1/28 , C08L39/06 , C08L33/26 , C08L33/14 , C08L29/04 , C08L75/04 , C08L71/02 , C08L67/04
摘要： A new soft tissue implant filling material is disclosed. The material may be polyvinylpyrollidone, polyvinyl alcohol, hydroxypropylmethyl cellulose, polyethylene oxide, hyaluronic acid, sodium or calcium alginate, hydrogel polyurethane, hydroxyethyl starch, polyglycolic acid, polyacrylamide, hydroxyethylmethacrylate (HEMA), and several naturally derived biopolymers including sodium kinate, seaweed, and agar.
摘要翻译：公开了一种新的软组织植入物填充材料。材料可以是聚乙烯吡咯烷酮，聚乙烯醇，羟丙基甲基纤维素，聚环氧乙烷，透明质酸，藻酸钠或藻酸钙，水凝胶聚氨酯，羟乙基淀粉，聚乙醇酸，聚丙烯酰胺，甲基丙烯酸羟乙酯（HEMA）和几种天然来源的生物聚合物，包括海藻酸钠，和琼脂。

7. 发明公开

EP1382313A1 Filling material for soft tissue implant prostheses and implants made therewith 失效
标题翻译： Füllmaterialfürimplantierbare Prothesen aus Weichgewebe und Implantate daraus
公开(公告)号：EP1382313A1
公开(公告)日：2004-01-21
申请号：EP03077947.4
申请日：1996-02-05
申请人： MENTOR CORPORATION
发明人： Brunstedt, Michael , Purkait, Bobby , Bhate, Anand , Woo, Yi-Ren
IPC分类号： A61F2/12 , A61L27/16
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/18 , A61L27/20 , C08L5/08 , C08L5/04 , C08L3/04 , C08L1/28 , C08L39/06 , C08L33/26 , C08L33/14 , C08L29/04 , C08L75/04 , C08L71/02 , C08L67/04
摘要： The invention provides an implantable soft-tissue prosthesis, comprising:

a hollow shell formed of a flexible elastomeric polymer, the prosthesis being adapted to be surgically implanted and to retain a desired shape when filled with a filling material; and
a filling material comprising a gel or viscous liquid comprising polyvinylpyrrolidone, wherein the filling material has an osmolarity between 200 and 400 mOsm/kg and a radiation penetration equal to or better than 0.9% saline.
摘要翻译：本发明提供了一种植入式软组织假体，包括：由柔性弹性体聚合物形成的中空壳体，所述假体适于手术植入，并且在填充填充材料时保持所需形状; 以及包含包含聚乙烯吡咯烷酮的凝胶或粘稠液体的填充材料，其中所述填充材料具有200至400mOsm / kg的渗透压和等于或优于0.9％盐水的辐射穿透。

8. 发明公开

EP1378214A1 Filling material for soft tissue implant prostheses and implants made therewith 失效
标题翻译：用于软组织植入假体的填充材料和由其制成的植入物
公开(公告)号：EP1378214A1
公开(公告)日：2004-01-07
申请号：EP03077948.2
申请日：1996-02-05
申请人： MENTOR CORPORATION
发明人： Brunstedt, Michael , Purkait, Bobby , Bhate, Anand , Woo, Yi-Ren
IPC分类号： A61F2/12 , A61L27/16
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/18 , A61L27/20 , C08L5/08 , C08L5/04 , C08L3/04 , C08L1/28 , C08L39/06 , C08L33/26 , C08L33/14 , C08L29/04 , C08L75/04 , C08L71/02 , C08L67/04
摘要： The invention provides an implantable soft-tissue prosthesis, comprising:

a hollow shell formed of a flexible elastomeric polymer, the prosthesis being adapted to be surgically implanted and to retain a desired shape when filled with a filling material; and
a filling material comprising a gel or viscous liquid comprising polyvinyl alcohol, wherein the filling material has an osmolarity between 200 and 400 mOsm/kg and a radiation penetration equal to or better than 0.9% saline.
摘要翻译：本发明提供了一种可植入的软组织假体，其包括：由柔性弹性体聚合物形成的中空壳体，所述假体适于手术植入并在填充填充材料时保持期望的形状; 以及包含凝胶或包含聚乙烯醇的粘性液体的填充材料，其中所述填充材料具有200至400mOsm / kg的渗透压和等于或优于0.9％盐水的辐射渗透性。

9. 发明授权

EP0727232B1 Filling material for soft tissue implant prostheses and implants made therewith 失效
标题翻译：对于由软组织和植入它的植入假体填充材料
公开(公告)号：EP0727232B1
公开(公告)日：2003-10-08
申请号：EP96300768.7
申请日：1996-02-05
申请人： MENTOR CORPORATION
发明人： Brunstedt, Michael , Purkait, Bobby , Bhate, Anand , Woo, Yi-Ren
IPC分类号： A61L27/00 , A61F2/12
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/18 , A61L27/20 , C08L5/08 , C08L5/04 , C08L3/04 , C08L1/28 , C08L39/06 , C08L33/26 , C08L33/14 , C08L29/04 , C08L75/04 , C08L71/02 , C08L67/04

10. 发明授权

EP0784987B1 Method of making in situ filler material for mammary, penile and testicular prosthesis and tissue expanders 失效
标题翻译：一种用于在原位的填充材料制备用于乳房，阴茎和睾丸假体，和组织扩张器过程
公开(公告)号：EP0784987B1
公开(公告)日：2003-10-01
申请号：EP97300087.0
申请日：1997-01-08
申请人： MENTOR CORPORATION
发明人： Purkait, Bobby
IPC分类号： A61L27/16 , A61L27/18 , A61L27/20 , A61L27/52 , A61F2/12 , A61F2/26
CPC分类号： A61L27/18 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/20 , A61L27/52 , C08L5/08 , C08L5/04 , C08L1/26 , C08L39/06 , C08L33/26 , C08L29/04 , C08L75/04 , C08L67/04 , C08L71/02

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