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1. 发明申请

WO2006001894A1 INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF 审中-公开
标题翻译：吲哚，1H-INDAZOLES，1,2-苄基氧杂环己烷，1,2-苯并唑烷，及其制备及用途
公开(公告)号：WO2006001894A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/013938
申请日：2005-04-22
申请人： MEMORY PHARMACEUTICAL CORPORATION , HERBERT, Brian , GAUSS, Carla, Maria , XIE, Wenge , NGUYEN, Truc, Minh , MA, Jianguo , SCHUMACHER, Richard , TEHIM, Ashok
发明人： HERBERT, Brian , GAUSS, Carla, Maria , XIE, Wenge , NGUYEN, Truc, Minh , MA, Jianguo , SCHUMACHER, Richard , TEHIM, Ashok
IPC分类号： C07D451/04
CPC分类号： C07D451/04 , C07D451/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译：本发明一般涉及烟碱乙酰胆碱受体（nACh受体）的配体领域，nACh受体的活化以及与缺陷或功能异常的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状态的治疗。此外，本发明涉及作为a7 nACh受体亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。

2. 发明申请

WO2005092890A3 INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF 审中-公开
公开(公告)号：WO2005092890A3
公开(公告)日：2005-10-06
申请号：PCT/US2005/010120
申请日：2005-03-25
申请人： MEMORY PHARMACEUTICALS CORPORATION , XIE, Wenge , HERBERT, Brian , SCHUMACHER, Richard , NGUYEN, Truc, Minh , MA, Jianguo , GAUSS, Carla, Maria , TEHIM, Ashok
发明人： XIE, Wenge , HERBERT, Brian , SCHUMACHER, Richard , NGUYEN, Truc, Minh , MA, Jianguo , GAUSS, Carla, Maria , TEHIM, Ashok
IPC分类号： C07D453/02
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the a7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

3. 发明申请

WO2007038367A1 INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF 审中-公开
标题翻译：辛唑，苯并噻唑，苯并三唑，苯并咪唑，吡唑并吡啶，异亮氨酸，其制备及用途
公开(公告)号：WO2007038367A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/037142
申请日：2006-09-22
申请人： MEMORY PHARMACEUTICALS CORPORATION , SCHUMACHER, Richard , DANCA, Mihaela Diana , MA, Jianguo , HERBERT, Brian , NGUYEN, Truc Minh , XIE, Wenge , TEHIM, Ashok
发明人： SCHUMACHER, Richard , DANCA, Mihaela Diana , MA, Jianguo , HERBERT, Brian , NGUYEN, Truc Minh , XIE, Wenge , TEHIM, Ashok
IPC分类号： C07D453/02 , A61K31/435 , A61P25/00
CPC分类号： C07D453/02
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译：本发明一般涉及烟碱乙酰胆碱受体（nACh受体）的配体领域，nACh受体的活化以及与缺陷或功能异常的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状态的治疗。此外，本发明涉及作为a7 nACh受体亚型的配体的新化合物（例如吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。

4. 发明申请

WO2006069097A2 NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF 审中-公开
标题翻译：烟碱α-7受体配体及其制备和用途
公开(公告)号：WO2006069097A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/046256
申请日：2005-12-21
申请人： MEMORY PHARMACEUTICALS CORPORATION , NGUYEN, Truc, Minh , XIE, Wenge , SCHUMACHER, Richard , HERBERT, Brian , TEHIM, Ashok
发明人： NGUYEN, Truc, Minh , XIE, Wenge , SCHUMACHER, Richard , HERBERT, Brian , TEHIM, Ashok
IPC分类号： C07D453/02 , A61K31/439 , A61P25/00
CPC分类号： C07D453/02
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译：本发明一般涉及烟碱乙酰胆碱受体（nAChR）配体领域，nAChRs的激活以及治疗与烟碱乙酰胆碱受体缺陷或功能障碍相关的疾病状态，尤其是脑部。此外，本发明涉及用作α7nAChR亚型的配体的新化合物，制备这些化合物的方法，含有这些化合物的组合物，以及它们的使用方法。

5. 发明申请

WO2009055437A3 (1,4-DIAZA-BICYCLO[3.2.2]NON-6-EN-4-YL)-HETEROCYCLYL-METHANONE LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, USEFUL FOR THE TREATMENT OF DISEASE 审中-公开
公开(公告)号：WO2009055437A3
公开(公告)日：2009-04-30
申请号：PCT/US2008/080743
申请日：2008-10-22
申请人： MEMORY PHARMACEUTICALS CORPORATION , HERBERT, Brian , SCHUMACHER, Richard , DAI, Guangxiu , XIE, Wenge
发明人： HERBERT, Brian , SCHUMACHER, Richard , DAI, Guangxiu , XIE, Wenge
IPC分类号： C07D453/00 , C07D307/78 , A61K31/4045 , A61K31/439
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds, which act as ligands for the a7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof. The novel compounds include compounds of formula I: (I) wherein X, R1, and R2 are as herein defined.

6. 发明申请

WO2006135828A2 PHOSPHODIESTERASE 4 INHIBITORS 审中-公开
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：WO2006135828A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022655
申请日：2006-06-09
申请人： MEMORY PHARMACEUTICALS CORPORATION , F. HOFFMANN-LA ROCHE AG , TALAMAS, Francisco, Xavier , CAROON, Joan, Marie , DUNN, Robert , HOPPER, Allen , KUESTER, Eric , SCHUMACHER, Richard , TEHIM, Ashok
发明人： TALAMAS, Francisco, Xavier , CAROON, Joan, Marie , DUNN, Robert , HOPPER, Allen , KUESTER, Eric , SCHUMACHER, Richard , TEHIM, Ashok
IPC分类号： C07D211/58 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/4427 , A61K31/4468 , A61P29/00
CPC分类号： C07D211/58 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： PDE4 inhibition is achieved by novel compounds,' e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I-III; (I), (II) and (III) wherein A, B, D, E, G, J, K, R 1 , R 2 , R 3 , R 4 , R 11 , R 12 , R 13 , R 14 , R 21 , R 22 , R 23 and R 24 are as defined herein.
摘要翻译：新的化合物，例如N-取代的二芳基胺类似物可以实现PDE4抑制。本发明的化合物是式I-III的化合物; （I），（II）和（III）其中A，B，D，E，G，J，K，R 1，R 2， R 4，R 4，R 11，R 12，R 13，R 12， 14，R 21，R 22，R 23和R 24如本文所定义。

7. 发明申请

WO2005061458A2 PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS 审中-公开
标题翻译：磷酸二酯酶4抑制剂，包括N-取代的二胺类似物
公开(公告)号：WO2005061458A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/041068
申请日：2004-12-10
申请人： MEMORY PHARMACEUTICALS CORPORATION , SCHUMACHER, Richard , HOPPER, Allen , DUNN, Robert , KUESTER, Erik , TEHIM, Ashok , RENAU, Thomas, E. , CAROON, Joan , TALAMAS, Francisco , LABADIE, Sharada
发明人： SCHUMACHER, Richard , HOPPER, Allen , DUNN, Robert , KUESTER, Erik , TEHIM, Ashok , RENAU, Thomas, E. , CAROON, Joan , TALAMAS, Francisco , LABADIE, Sharada
IPC分类号： C07D213/74
CPC分类号： C07D213/74 , A61K31/444 , A61K31/4545 , C07C229/60 , C07D213/36 , C07D213/75 , C07D277/28 , C07D401/12 , C07D405/12 , C07D405/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formula (I), wherein A, B, D, R 1 , R 2 , R 3 and R 4 are as defined herein.
摘要翻译： PDE4抑制通过新化合物例如N-取代的二芳基胺类似物来实现。本发明的化合物具有式（I），其中A，B，D，R 1，R 2，R 3和R 4如本文所定义。

8. 发明公开

EP1828179A2 NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF 有权
标题翻译：烟碱α-7 CNS的受体配体对疾病的
公开(公告)号：EP1828179A2
公开(公告)日：2007-09-05
申请号：EP05854897.5
申请日：2005-12-21
申请人： Memory Pharmaceutical Corporation
发明人： NGUYEN, Truc, Minh , XIE, Wenge , SCHUMACHER, Richard , HERBERT, Brian , TEHIM, Ashok
IPC分类号： C07D453/02 , A61K31/439 , A61P25/00
CPC分类号： C07D453/02
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

9. 发明申请

WO2007117594A2 ELECTRICAL ENCODING OF CABLE TYPES AND CONFIGURATIONS 审中-公开
标题翻译：电缆类型和配置的电编码
公开(公告)号：WO2007117594A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/008569
申请日：2007-04-05
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , BARNETTE, Christopher M. , SCHUMACHER, Richard
发明人： BARNETTE, Christopher M. , SCHUMACHER, Richard
CPC分类号： G06F13/4072
摘要： In one embodiment, a system comprises a first circuit assembly (210) having a plurality of circuit traces (212, 214, 216, 218), a second circuit assembly (270) having a plurality of circuit traces (272, 274, 276, 278), a cable assembly (260) connecting the plurality of circuit traces (212, 214, 216, 218) on the first circuit assembly (210) to the plurality of circuit traces (272, 274, 276, 278) on the second circuit assembly (270), signal generating circuitry (240, 242, 246, 248) to generate signal values on one or more of the plurality of circuit traces (212, 214, 216, 218) in the first circuit assembly (210), and an operational logic module (166) to compare signal values on one or more of the plurality of circuit traces (272, 274, 276, 278) in the second circuit assembly (270) to an expected signal value.
摘要翻译：在一个实施例中，系统包括具有多个电路迹线（212,214,216,218）的第一电路组件（210），具有多个电路（212,214,216,218）的第二电路组件（270）（272,274,276,278）;将所述第一电路组件（210）上的所述多个电路迹线（212,214,216,218）连接到所述多个电路迹线（272,274）的电缆组件（260），所述信号生成电路（240,242,246,248）在所述第二电路组件（270）上的所述多个电路迹线（212,214,216,218）中的一个或多个上生成信号值，所述第一电路组件（210）和操作逻辑模块（166），用于将所述第二电路组件（270）中的所述多个电路迹线（272,274,276,278）中的一个或多个电路迹线上的信号值与预期的信号值。

10. 发明申请

WO2011025740A3 TARGET ASSEMBLY WITH ELECTRON AND PHOTON WINDOWS 审中-公开
公开(公告)号：WO2011025740A3
公开(公告)日：2011-03-03
申请号：PCT/US2010/046361
申请日：2010-08-23
申请人： VARIAN MEDICAL SYSTEMS, INC. , SCHUMACHER, Richard , JENSEN, David, K. , HARDING, Maynard, C. , ROBINSON, Randall, D.
发明人： SCHUMACHER, Richard , JENSEN, David, K. , HARDING, Maynard, C. , ROBINSON, Randall, D.
IPC分类号： H01J35/08
摘要： An X-ray target assembly includes a substrate, a target supported by the substrate adapted to generate X-rays when impinged by an electron beam, and an enclosure over the target providing a volume for the target. The enclosure is made of a material substantially transparent to electrons. The volume is substantially vacuum or filled with an inert gas.

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