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    • 5. 发明专利
    • FR2366279A1
    • 1978-04-28
    • FR7729459
    • 1977-09-30
    • MEIJI SEIKA KAISHA
    • KOEDA TAKEMITSURUOKA TAKASHISHIBATA UICHIASAOKA HIROYASUHACHISU MITSUGUITOH OSAMUSEKIZAWA YASUHARUINOUYE SHIGEHARUNIIDA TARO
    • A61K31/44A61P9/12C07D213/65C07D213/79
    • 5-Alkoxy-picolinic acids and the salts and the esters thereof represented by the formula (I): (I) wherein R represents an alkyl group having 1 to 6 carbon atoms and M represents a hydrogen atom; a calcium atom; a sodium atom; a potassium atom; an aluminum atom; an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom); a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; or an acyloxyalkyl group having the formula wherein R2 represents a hydrogen atom or a methyl group and R3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic acids and the salts and the esters thereof, and anti-hypertensive compositions containing the 5-alkoxy-picolinic acids and the salts and the esters thereof.
    • 9. 发明专利
    • 5-SUBSTITUTED-HYDROXY PICOLINIC ACID DERIVATIVES
    • CA1115709A
    • 1982-01-05
    • CA323912
    • 1979-03-21
    • MEIJI SEIKA KAISHA
    • SEKIZAWA YASUHARUTSURUOKA TAKASHIHACHISU MITSUGUSEZAKI MASAJIMIYAMOTO MASASHISHIBATA UICHIMIZUTANI KAZUKOINOUYE SHIGEHARUKOEDA TAKEMISHIMOMURA KEIZONIIDA TARO
    • C07D213/65C07D213/79C07D213/81C07D213/78
    • 5-Substituted picolinic acid derivatives represented by the formula (I): (I) wherein Rl represents a straight or branched chain halogensubstituted alkyl group having 2 to 6 carbon atoms or a substituted phenyl group having the formula - wherein R3 and R4, which may be the same or different, each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, an N-alkyl-substituted amino group, an acylamino group, an acetyl group, an acyloxy group, a hydroxy group or a halogen-substituted alkyl group or R3 and R4, when taken together, represent a polymethylene chain; and R2 represents an -OM group wherein M represents a hydrogen, sodium, potassium, calcium, aluminium or magnesium atom, a straight or branched chain or cyclic alkoxy group having 1 to 6 carbon atoms, an aminoalkoxy group, a phenoxy group, a.substituted phenoxy group, a 5-indanyloxy? group, an acyloxyalkyloxy group having the formula wherein R5 represents a hydrogen atom or a methyl group and R6 represents a lower alkyl group having 1 to 6 carbon atoms, a phenyl group or a substituted phenyl group, or an amino group represented by the formula wherein R7 and R8, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, or a phenyl group which are useful as anti-hypertensive agents, a process for preparing the above 5-substituted picolinic acid derivatives, and anti-hyper-tensive compositions containing the same. 5-Indanyl ester of 5-alkoxy-picolinic acid represented by the formula (A): . (A) wherein Ra represents an alkyl group having 1 to 6 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-indanyl ester of 5-alkoxy-picolinic acid, and anti-hypertensive compositions containing the 5-indanyl ester of 5-alkoxy-picolinic acid.