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1. 发明申请

WO2008127888A2 DEGRADATION ASSOCIATED DRUG DELIVERY FOR DRUG ELUTING STENT AND MEDICAL DEVICE COATINGS 审中-公开
标题翻译：降解相关药物给药用药物和医疗器械涂料
公开(公告)号：WO2008127888A2
公开(公告)日：2008-10-23
申请号：PCT/US2008/059357
申请日：2008-04-04
申请人： MEDTRONIC VASCULAR INC. , COOK, Brian , BERGLUND, Joseph
发明人： COOK, Brian , BERGLUND, Joseph
CPC分类号： A61L31/10 , A61F2/95 , A61F2250/0067 , A61L31/16 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/44 , A61L2300/604
摘要： A system for treating a vascular condition includes a stent having a biodegradable coating on the stent framework. The coating releases a therapeutically effective amount of therapeutic agent as a function of degradation of the coating. Also provided is a method of treating a vascular condition by placing a stent having a biodegradable coating at a treatment site and delivering a therapeutically effective amount of therapeutic agent at the treatment site as a function of degradation of the coating. Also provided is a method of improving the performance of a medical device by including a biodegradable coating on the surface of the device and releasing a therapeutically effective amount of a therapeutic agent at the treatment site as a function of degradation of the coating.
摘要翻译：用于治疗血管病症的系统包括在支架框架上具有可生物降解的涂层的支架。涂层释放作为涂层降解的功能的治疗有效量的治疗剂。还提供了通过将具有可生物降解涂层的支架放置在治疗部位并在治疗部位输送治疗有效量的治疗剂作为涂层降解的功能来治疗血管病症的方法。还提供了通过在装置的表面上包括可生物降解的涂层并在治疗部位释放治疗有效量的治疗剂作为涂层降解的功能来改善医疗装置的性能的方法。

2. 发明申请

WO2010011464A1 LOW TEMPERATURE DEPOSITION OF A VAPORIZED DRUG 审中-公开
标题翻译：一种挥发性药物的低温沉积
公开(公告)号：WO2010011464A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/048913
申请日：2009-06-26
申请人： MEDTRONIC VASCULAR INC. , COATES, Paul , COOK, Brian
发明人： COATES, Paul , COOK, Brian
IPC分类号： C23C14/02 , C23C14/12 , A61L29/16 , A61F2/20
CPC分类号： C23C14/12 , A61F2/82 , A61F2250/0067 , A61L31/16 , A61L2300/606 , A61L2300/608 , A61L2420/02 , C23C14/024
摘要： A drug coating is formed by vaporizing a drug in a deposition chamber having an implantable medical device such as a stent loaded therein. A vacuum is utilized to lower the pressure within the deposition chamber, thereby reducing the temperature necessary to vaporize the drug. The drug is then deposited onto the implantable medical device while in a vapor phase to form the drug coating.
摘要翻译：通过在具有植入式医疗装置（诸如其中装载的支架）的沉积室中蒸发药物来形成药物涂层。利用真空来降低沉积室内的压力，从而降低蒸发药物所需的温度。然后将药物在气相中沉积到可植入医疗装置上以形成药物涂层。

3. 发明申请

WO2010096208A2 RETRACTABLE DRUG DELIVERY SYSTEM AND DEVICE 审中-公开
标题翻译：可回收药物递送系统和装置
公开(公告)号：WO2010096208A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/020261
申请日：2010-01-06
申请人： MEDTRONIC VASCULAR INC. , COOK, Brian , MITCHELL, James , VASQUEZ, Natividad , PELLIGRINI, Gianfranco
发明人： COOK, Brian , MITCHELL, James , VASQUEZ, Natividad , PELLIGRINI, Gianfranco
IPC分类号： A61M25/00 , A61M31/00 , A61L27/54 , A61L27/04
CPC分类号： A61M25/0082 , A61F2/91 , A61F2/95 , A61F2/966 , A61F2002/9665 , A61F2250/0068 , A61M25/0068 , A61M2025/0057 , A61M2025/0681
摘要： A system for treating a vascular condition includes a catheter having an inner member and an outer member, the outer member concentrically arranged about the inner member and a retractable drug delivery device disposed at a distal end of the inner member. A coating disposed on at least a portion of an outer surface of the retractable drug delivery device includes at least one therapeutic agent.
摘要翻译：用于治疗血管状态的系统包括具有内部构件和外部构件的导管，所述外部构件围绕内部构件同心地布置，以及设置在内部构件的远端处的可伸缩药物输送装置。设置在可伸缩药物输送装置的外表面的至少一部分上的涂层包括至少一种治疗剂。

4. 发明申请

WO2009064618A1 STENT MADE OF WIRE HAVING A SPIRAL CHANNEL FOR DRUG DELIVERY 审中-公开
标题翻译：具有用于药物递送的螺旋通道的线的制造
公开(公告)号：WO2009064618A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/081617
申请日：2008-10-29
申请人： MEDTRONIC VASCULAR INC. , COOK, Brian , DOLAN, Mark
发明人： COOK, Brian , DOLAN, Mark
IPC分类号： A61F2/86 , A61F2/88
CPC分类号： A61F2/88 , A61F2/86 , A61F2250/0035 , A61F2250/0068
摘要： A drug delivery stent (130) is formed by a metallic or polymeric tubular strut (138) which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen (348) for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel (136) extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion.
摘要翻译：药物递送支架（130）由金属或聚合物管状支柱（138）形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔（348）。管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道（136），该支柱围绕螺旋状螺旋地围绕管状支柱的圆周螺旋地设置，用于将治疗物质或药物输送至狭窄病变。

5. 发明授权

EP2318562B1 LOW TEMPERATURE DEPOSITION OF A VAPORIZED DRUG 失效
标题翻译：低温沉积气化原料药
公开(公告)号：EP2318562B1
公开(公告)日：2012-05-09
申请号：EP09789968.6
申请日：2009-06-26
申请人： Medtronic Vascular Inc.
发明人： COATES, Paul , COOK, Brian
IPC分类号： C23C14/02 , C23C14/12 , A61L31/16 , A61L29/16
CPC分类号： C23C14/12 , A61F2/82 , A61F2250/0067 , A61L31/16 , A61L2300/606 , A61L2300/608 , A61L2420/02 , C23C14/024
摘要： A drug coating is formed by vaporizing a drug in a deposition chamber having an implantable medical device such as a stent loaded therein. A vacuum is utilized to lower the pressure within the deposition chamber, thereby reducing the temperature necessary to vaporize the drug. The drug is then deposited onto the implantable medical device while in a vapor phase to form the drug coating.

6. 发明公开

EP2150287A2 DEGRADATION ASSOCIATED DRUG DELIVERY FOR DRUG ELUTING STENT AND MEDICAL DEVICE COATINGS 审中-公开
标题翻译：矿业与药物充电接口毒品和释放支架涂层的医疗器械
公开(公告)号：EP2150287A2
公开(公告)日：2010-02-10
申请号：EP08733118.7
申请日：2008-04-04
申请人： Medtronic Vascular Inc.
发明人： COOK, Brian , BERGLUND, Joseph
IPC分类号： A61L31/14 , A61L31/16 , A61L31/10
CPC分类号： A61L31/10 , A61F2/95 , A61F2250/0067 , A61L31/16 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/44 , A61L2300/604
摘要： A system for treating a vascular condition includes a stent having a biodegradable coating on the stent framework. The coating releases a therapeutically effective amount of therapeutic agent as a function of degradation of the coating. Also provided is a method of treating a vascular condition by placing a stent having a biodegradable coating at a treatment site and delivering a therapeutically effective amount of therapeutic agent at the treatment site as a function of degradation of the coating. Also provided is a method of improving the performance of a medical device by including a biodegradable coating on the surface of the device and releasing a therapeutically effective amount of a therapeutic agent at the treatment site as a function of degradation of the coating.

7. 发明授权

EP2211788B1 STENT MADE OF WIRE HAVING A SPIRAL CHANNEL FOR DRUG DELIVERY 有权
公开(公告)号：EP2211788B1
公开(公告)日：2018-12-05
申请号：EP08849320.0
申请日：2008-10-29
申请人： Medtronic Vascular Inc.
发明人： COOK, Brian , DOLAN, Mark
IPC分类号： A61F2/86 , A61F2/88
CPC分类号： A61F2/88 , A61F2/86 , A61F2250/0035 , A61F2250/0068
摘要： A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.

8. 发明公开

EP2318562A1 LOW TEMPERATURE DEPOSITION OF A VAPORIZED DRUG 失效
标题翻译：低温沉积气化原料药
公开(公告)号：EP2318562A1
公开(公告)日：2011-05-11
申请号：EP09789968.6
申请日：2009-06-26
申请人： Medtronic Vascular Inc.
发明人： COATES, Paul , COOK, Brian
IPC分类号： C23C14/02 , C23C14/12 , A61L29/16 , A61F2/20
CPC分类号： C23C14/12 , A61F2/82 , A61F2250/0067 , A61L31/16 , A61L2300/606 , A61L2300/608 , A61L2420/02 , C23C14/024
摘要： A drug coating is formed by vaporizing a drug in a deposition chamber having an implantable medical device such as a stent loaded therein. A vacuum is utilized to lower the pressure within the deposition chamber, thereby reducing the temperature necessary to vaporize the drug. The drug is then deposited onto the implantable medical device while in a vapor phase to form the drug coating.

9. 发明公开

EP2211788A1 STENT MADE OF WIRE HAVING A SPIRAL CHANNEL FOR DRUG DELIVERY 有权
标题翻译：覆膜支架从螺旋通道 - 释放进行WIRE
公开(公告)号：EP2211788A1
公开(公告)日：2010-08-04
申请号：EP08849320.0
申请日：2008-10-29
申请人： Medtronic Vascular Inc.
发明人： COOK, Brian , DOLAN, Mark
IPC分类号： A61F2/86 , A61F2/88
CPC分类号： A61F2/88 , A61F2/86 , A61F2250/0035 , A61F2250/0068
摘要： A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.

10. 发明申请

WO2011062687A1 CARRIER SHEET FOR A PHOTOSENSITIVE PRINTING ELEMENT 审中-公开
标题翻译：感光印刷元件的载体表
公开(公告)号：WO2011062687A1
公开(公告)日：2011-05-26
申请号：PCT/US2010/051100
申请日：2010-10-01
申请人： MACDERMID PRINTING SOLUTIONS, LLC , HENNESSY, Jim , ELWELL, David, X. , PINA, Nicholas, R. , COOK, Brian , VEST, Ryan
发明人： HENNESSY, Jim , ELWELL, David, X. , PINA, Nicholas, R. , COOK, Brian , VEST, Ryan
IPC分类号： B41M5/00 , G03F7/095
CPC分类号： G03F7/34 , B41F27/00 , B41N6/00 , B41N10/02
摘要： Apparatus for thermally developing a flexographic printing element to reveal a relief image on the surface and a method to develop a flexographic printing element. The method includes softening or melting a crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element. The apparatus includes a roll that contacts the imaged surface of the flexographic printing element and moves over the imaged surface of the flexographic printing element to remove the softened or melted non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element. The non-crosslinked photopolymer is softened or melted using a heater adjacent to the imaged surface of the flexographic printing element, or by heating the one roll that contacts the surface of the printing element. Optionally the apparatus a device to cure the imaged surface of the flexographic printing element prior to thermal development.
摘要翻译：用于热显影柔性版印刷元件以在表面上显示浮雕图像的装置和开发柔性版印刷元件的方法。该方法包括软化或熔化柔性版印刷元件的成像曝光表面上的交联光聚合物。该装置包括与柔性版印刷元件的成像表面接触并在柔性版印刷元件的成像表面上移动以去除柔性版印刷元件的成像和曝光表面上的软化或熔融的非交联光聚合物的卷。使用邻近柔性版印刷元件的成像表面的加热器或通过加热与印刷元件的表面接触的一个辊来使非交联的光聚合物软化或熔化。可选地，该装置是在热显影之前固化柔性版印刷元件的成像表面的装置。

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