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1. 发明申请

WO2004112658A1 TENSIONING DEVICE AND SYSTEM FOR TREATING MITRAL VALVE REGURGITATION 审中-公开
标题翻译：张力装置和用于处理麻药注射器的系统
公开(公告)号：WO2004112658A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/019745
申请日：2004-06-21
申请人： MEDTRONIC VASCULAR INC.
发明人： BLOOM, Eliot , DOUK, Nareak , HORRIGAN, John , HUYNH, Rany , RAFIEE, Nasser
IPC分类号： A61F2/24
CPC分类号： A61F2/2487 , A61B2017/00243 , A61B2017/00783 , A61B2017/0409 , A61B2017/0437 , A61B2017/0445 , A61B2017/0462 , A61B2017/0464
摘要： A system for treating mitral valve regurgitation comprises tensioning device 110 slidably received within delivery catheter 120. The tensioning device includes tether 112 linking proximal anchoring member 111 and distal anchoring member 113. At least one of the anchoring members 111 includes an elastic portion that flexes in response to a heartpulsebeat when tensioning device 110 is positioned across a chamber of a heart. Tether 112 includes at least one locking member 116, 514 initially positioned between the anchoring members 111.
摘要翻译：用于治疗二尖瓣回流的系统包括可滑动地容纳在输送导管120内的张紧装置110.张紧装置包括连接近端锚固构件111和远侧锚固构件113的系绳112.锚固构件111中的至少一个包括弹性部分，当张紧装置110定位在心脏的腔室时对心脏脉搏的响应。系带112包括起初定位在锚定构件111之间的至少一个锁定构件116,514。

2. 发明申请

WO2004093730A2 METHOD AND REPAIR DEVICE FOR TREATING MITRAL VALVE INSUFFICIENCY 审中-公开
标题翻译：用于治疗麻醉药物的方法和修复装置
公开(公告)号：WO2004093730A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012229
申请日：2004-04-21
申请人： MEDTRONIC VASCULAR, INC. , SAINT, Sean, T. , DOUK, Nareak , RAFIEE, Nasser
发明人： SAINT, Sean, T. , DOUK, Nareak , RAFIEE, Nasser
IPC分类号： A61F
CPC分类号： A61F2/2451 , A61B17/00234 , A61B17/12013 , A61B2017/00243 , A61B2017/00783 , A61B2017/22038 , A61F2/2466 , A61M2025/009
摘要： A system, device and method for repairing mitral valve regurgitation is provided. A device is placed external to the mitral valve in the atrioventricular sulcus or groove of the heart and is cinched to reduce the mitral valve annulus or the radius of curvature of the heart around the atrioventricular groove thus reducing the circumference of the mitral annulus.
摘要翻译：提供了一种用于修复二尖瓣回流的系统，装置和方法。将一个装置放置在心脏的房室沟或沟槽中的二尖瓣外部，并且被夹带以减少二尖瓣环或围绕房室沟的心脏的曲率半径，从而减小二尖瓣环的周长。

3. 发明申请

WO2007115152A2 TELESCOPING CATHETER WITH ELECTROMAGNETIC COILS FOR IMAGING AND NAVIGATION DURING CARDIAC PROCEDURES 审中-公开
标题翻译：电磁线圈用于在心脏手术过程中成像和导航的电缆导管
公开(公告)号：WO2007115152A2
公开(公告)日：2007-10-11
申请号：PCT/US2007/065612
申请日：2007-03-30
申请人： MEDTRONIC VASCULAR, INC. , HUYNH, Rany , RAFIEE, Nasser , DOUK, Nareak , HOUSE, Morgan , HILL, Alex
发明人： HUYNH, Rany , RAFIEE, Nasser , DOUK, Nareak , HOUSE, Morgan , HILL, Alex
CPC分类号： A61B5/1076 , A61B90/36 , A61B2017/00039 , A61B2090/397
摘要： An image guided navigation system for mapping at least one of the shape, size and location of a structure within a heart of a patient, including a catheter system having a first catheter with a longitudinally extending lumen, a second catheter having a longitudinally extending lumen and positioned at least partially within and moveable relative to the lumen of the first catheter, an elongated member positioned at least partially within and moveable relative to a lumen of the second catheter, a first detectable marker located at a generally distal end of the first catheter, a second detectable marker located at a generally distal end of the second catheter, and a third detectable marker located at a generally distal end of the elongated member, wherein at least one of the three detectable markers is axially moveable relative to at least one of the other detectable markers.
摘要翻译：一种用于映射患者心脏内的结构的形状，尺寸和位置中的至少一个的图像引导导航系统，包括具有具有纵向延伸的内腔的第一导管的导管系统，具有纵向延伸腔的第二导管和相对于第一导管的内腔至少部分地位于内部并且可移动;细长构件，其至少部分地位于第二导管的内腔内并且可相对于第二导管的内腔移动，第一可检测标记位于第一导管的大致远端，位于第二导管的通常远端的第二可检测标记和位于细长构件的大体远端的第三可检测标记，其中三个可检测标记中的至少一个相对于至少一个其他可检测标记。

4. 发明申请

WO2005087303A1 GUIDEWIRE WITH HOLLOW DISTAL SECTION 审中-公开
标题翻译： GUIDEWIRE与中空部分
公开(公告)号：WO2005087303A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/007257
申请日：2005-03-03
申请人： MEDTRONIC VASCULAR INC.
发明人： DOUK, Nareak
IPC分类号： A61M25/01
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A medical guidewire includes a proximal section (102), a hollow distal section (104) and a joint (118) there between. The hollow distal section has decreasing wall thickness along a portion of its length.
摘要翻译：医疗导丝包括近端部分（102），中空远端部分（104）和其间的关节（118）。中空的远端部分沿其长度的一部分具有减小的壁厚。

5. 发明申请

WO2005046488A3 CARDIAC VALVE ANNULUS REDUCTION SYSTEM 审中-公开
公开(公告)号：WO2005046488A3
公开(公告)日：2005-05-26
申请号：PCT/US2004/037867
申请日：2004-11-12
申请人： MEDTRONIC VASCULAR, INC. , DOUK, Nareak , RAFIEE, Nasser , BLOOM, Eliot , FOGG, Douglas, A. , HUYNH, Rany , BARONE, David, D.
发明人： DOUK, Nareak , RAFIEE, Nasser , BLOOM, Eliot , FOGG, Douglas, A. , HUYNH, Rany , BARONE, David, D.
IPC分类号： A61F2/24
摘要： A catheter-based, annulus reduction device and system (100, 200) for cardiac valve repair and method of using the same. The system is usable for treating mitral valve regurgitation and comprises a catheter (252), a reduction ring (220) carried within the catheter, the reduction ring including a plurality of exit ports (224) formed in a side wall of the reduction ring and filament (214) received in the reduction ring. The filament includes a plurality of radially extendible barbs (212) corresponding to the sidewall openings. The reduction ring carrying the filament is deployed adjacent a mitral valve annulus and the filament is translated relative to the reduction ring to deploy the barbs through the exit ports and into the annulus and to further translate the reduction ring with deployed barbs to reshape the annulus.

6. 发明申请

WO2005011786A1 ASPIRATION CATHETER HAVING A VARIABLE OVER-THE-WIRE LENGTH AND METHODS OF USE 审中-公开
标题翻译：具有可变长度的吸入管和使用方法
公开(公告)号：WO2005011786A1
公开(公告)日：2005-02-10
申请号：PCT/US2004/023622
申请日：2004-07-22
申请人： MEDTRONIC VASCULAR INC.
发明人： DOUK, Nareak
IPC分类号： A61M25/00
CPC分类号： A61M1/008 , A61M2025/0004 , A61M2025/0175 , A61M2025/1068
摘要： An aspiration catheter (100) includes an aspiration shaft (105) and a telescoping outer sheath which can be passed over a guidewire. The sheath includes "nesting" proximal and distal tubes (102 and 104). The distal tube slides within a proximal tube lumen, and the aspiration shaft slides within a distal tube lumen. The catheter can be placed in an expanded position by pushing the aspiration shaft, thereby causing the distal tube to be moved distally. The catheter can be retracted by pulling the aspiration shaft proximally so that a distal segment of the aspiration shaft is drawn into the distal tube lumen and the distal tube is drawn into the proximal tube lumen. Alternatively, a middle tube is slidingly disposed over the aspiration shaft between the proximal and distal tubes. In this embodiment, the middle tube nests within the proximal tube lumen and the distal tube nests within a middle tube lumen.
摘要翻译：抽吸导管（100）包括抽吸轴（105）和可以穿过导丝的伸缩外护套。护套包括“嵌套”近端和远端管（102和104）。远侧管在近端管腔内滑动，并且抽吸轴在远端管腔内滑动。导管可以通过推动抽吸轴而放置在扩张位置，从而使远端管能够向远侧移动。可以通过向近侧拉动吸引轴来缩回导管，使得吸引轴的远侧部分被牵引到远端管腔中，并且远端管被拉入近端管腔。或者，中间管滑动地设置在近端管和远端管之间的抽吸轴之上。在该实施例中，中管嵌套在近端管腔内，远端管嵌套在中管腔内。

7. 发明申请

WO2004112657A1 CARDIAC VALVE ANNULUS COMPRESSOR SYSTEM 审中-公开
标题翻译： CARDIAC阀门ANNULUS压缩机系统
公开(公告)号：WO2004112657A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/019744
申请日：2004-06-21
申请人： MEDTRONIC VASCULAR INC.
发明人： DOUK, Nareak , RAFIEE, Nasser , BLOOM, Eliot
IPC分类号： A61F2/24
CPC分类号： A61F2/2433 , A61F2/2418 , A61F2002/8483 , A61F2002/9583 , A61F2220/0016 , A61F2230/0017
摘要： A cardiac valve annulus compressor comprises a generally cylindrical main body having plain and barbed ends and an actuator portion. Barbs disposed on the barbed end are engageable with the valve annulus. The length of the circumference of the barbed end is responsive to movement of the actuator portion. The annulus compressor can be delivered percutaneously or surgically. A cardiac valve annulus compressor system and methods of use are also taught.
摘要翻译：心脏瓣膜环压缩机包括具有平坦和有倒钩的端部的大致圆柱形的主体和致动器部分。设在倒钩端的倒钩可与阀环接合。倒钩端的圆周长度对致动器部分的运动是有反应的。环形压缩机可经皮或手术输送。还教导了心脏瓣膜环空压缩机系统和使用方法。

8. 发明申请

WO2004112652A2 DEVICE, SYSTEM, AND METHOD FOR CONTRACTING TISSUE IN A MAMMALIAN BODY 审中-公开
标题翻译：用于在哺乳动物体内组织组织的装置，系统和方法
公开(公告)号：WO2004112652A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/019829
申请日：2004-06-21
申请人： MEDTRONIC VASCULAR, INC. , BLOOM, Eliot , DOUK, Nareak , RAFIEE, Nasser
发明人： BLOOM, Eliot , DOUK, Nareak , RAFIEE, Nasser
IPC分类号： A61F
CPC分类号： A61B17/068 , A61B17/0644 , A61B17/10 , A61B2017/00243 , A61B2017/0641 , A61B2017/081 , A61F2/2445
摘要： A device, a system and a method for contracting tissue in a mammalian body. The contracting device comprises a body and a plurality of legs radially splayed there from. Each leg includes a snap-acting spring tip. When a force is applied to the device, the tips operate to transform the device from a deployment state into a treatment state. Each leg may also be bent at one or more deformation elements in response to the application of force. The system comprises a contracting device slidably received within a delivery catheter. The method of contracting tissue in a mammalian body comprises delivering a contracting device in a lumen of a catheter proximate a treatment area, releasing the contracting device from the catheter, positioning legs of the contracting device on tissue to be contracted, exerting a force on the contracting device, transforming the device into a treatment state, and reducing a compass of the tissue in response to the attainment of the treatment state.
摘要翻译：用于在哺乳动物体内收缩组织的装置，系统和方法。收缩装置包括主体和在其上径向张开的多个腿。每个腿包括弹性弹簧尖端。当力施加到设备时，提示操作以将设备从部署状态转换成处理状态。响应于施加力，每个腿也可以在一个或多个变形元件处弯曲。该系统包括可滑动地容纳在输送导管内的收缩装置。在哺乳动物身体中收缩组织的方法包括将收缩装置输送到靠近治疗区域的导管的内腔中，将收缩装置从导管释放，将收缩装置的腿定位在要收缩的组织上，在其上施加力收缩装置，将装置转化为治疗状态，以及响应于治疗状态的实现而减少组织的罗盘。

9. 发明申请

WO2007015876A1 CARDIAC VALVE ANNULUS RESTRAINING DEVICE 审中-公开
标题翻译：心脏瓣膜神经限制装置
公开(公告)号：WO2007015876A1
公开(公告)日：2007-02-08
申请号：PCT/US2006/027893
申请日：2006-07-19
申请人： MEDTRONIC VASCULAR, INC. , DOUK, Nareak
发明人： DOUK, Nareak
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2433 , A61F2/2466 , A61F2250/001
摘要： A catheter based system for treating mitral valve regurgitation includes a restraining device (100) having a flexible member (102) , a plurality of movable anchor members (112) attached to the outer surface of the flexible member, and an adjustment filament (110) attached to the ends of the flexible member. One embodiment of the invention includes a method for attaching a flexible restraining device to the annulus of a mitral valve, and adjusting the length of the adjustment filament attached to the flexible member of the restraining device, thereby reshaping the mitral valve annulus so that the anterior and posterior leaflets of the mitral valve close during ventricular contraction.
摘要翻译：一种用于治疗二尖瓣反流的基于导管的系统包括具有柔性构件（102）的限制装置（100），附接到柔性构件的外表面的多个可移动锚固构件（112）和调节细丝（110）连接到柔性构件的端部。本发明的一个实施例包括一种用于将柔性约束装置附接到二尖瓣环的方法，以及调节附着在约束装置的柔性构件上的调节细丝的长度，从而重新形成二尖瓣环，使前并且在心室收缩期间二尖瓣的后小叶关闭。

10. 发明申请

WO2005032421A2 APPARATUS AND METHOD FOR ELONGATION OF A PAPILLARY MUSCLE 审中-公开
标题翻译：延长乳头肌的装置和方法
公开(公告)号：WO2005032421A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/030083
申请日：2004-09-15
申请人： MEDTRONIC VASCULAR, INC. , BLOOM, Eliot , RAFIEE, Nasser , DOUK, Nareak
发明人： BLOOM, Eliot , RAFIEE, Nasser , DOUK, Nareak
IPC分类号： A61F2/00
CPC分类号： A61F2/2466 , A61B90/02 , A61B2017/00243 , A61B2017/088 , A61F2/2457
摘要： A system and method for treating a dilated heart valve by elongating a papillary muscle. The system comprises a delivery catheter (110) and a holding catheter (130). The system further comprises a muscle elongation device (200) including at least two clamping rings (210), (215) slidably connected by at least one connecting rod (220). The muscle elongation device (200) is delivered to a papillary muscle (560) associated with the dilated heart valve, where it is released from the delivery catheter (110) and the clamping rings (210), (215) wrap about and engage the papillary muscle. The muscle tissue is cut between the clamping rings (210), (215), which then move away from each other to a predetermined position, thus permitting the papillary muscle to elongate.
摘要翻译：通过拉长乳头肌来治疗扩张型心脏瓣膜的系统和方法。该系统包括输送导管（110）和保持导管（130）。该系统还包括肌肉延长装置（200），其包括至少两个由至少一个连杆（220）可滑动地连接的夹紧环（210），（215）。将肌肉伸长装置（200）递送到与扩张的心脏瓣膜相关联的乳头状肌肉（560），其中它从输送导管（110）释放并且夹紧环（210），（215）围绕并围绕乳头肌。在夹紧环（210），（215）之间切割肌肉组织，然后它们彼此远离移动到预定位置，从而允许乳头肌拉长。

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