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1. 发明申请

WO2004082738A3 OPTICALLY GUIDED PENETRATION CATHETERS AND THEIR METHODS OF USE 审中-公开
标题翻译：光导引导管及其使用方法
公开(公告)号：WO2004082738A3
公开(公告)日：2005-09-01
申请号：PCT/US2004007720
申请日：2004-03-12
申请人： MEDTRONIC TRANSVASCULAR INC , MCAULAY PATRICK E , CHANG JOHN Y , KIM ISAAC J , VRANY JULIA D
发明人： MCAULAY PATRICK E , CHANG JOHN Y , KIM ISAAC J , VRANY JULIA D
IPC分类号： A61B5/00 , A61B5/06 , A61B17/34 , A61B18/18 , A61F11/00 , A61M20060101 , A61M1/00 , A61M25/00
CPC分类号： A61M25/0045 , A61B5/0066 , A61B5/06 , A61B5/064 , A61B5/6852 , A61B17/3478 , A61B2017/00252 , A61M25/0084 , A61M2025/0037 , A61M2025/0046 , A61M2025/0047 , A61M2025/0096
摘要： Catheter devices, systems and methods for penetrating from one location within a patient's body to another location. An elongate catheter (12) is insertable into a natural or man-made lumen within the body of a patient. A penetrator (30) is advanceable from the catheter (12) to a target location outside of the lumen in which the catheter (12) is positioned. An optical imaging or tissue characterization apparatus (100) (e.g., an optical coherence tomography apparatus) is useable to image the anatomy and/or sense variables within tissue so as to locate the target location relative to indicia of the trajectory on which the penetrator (30) will advance from the catheter. The operator may then adjust the position and/or rotational orientation of the catheter (12) such that when the penetrator (30) is subsequently advanced, the penetrator (30) will enter the target location.
摘要翻译：用于从患者体内的一个位置穿透到另一位置的导管装置，系统和方法。细长导管（12）可插入患者体内的天然或人造腔内。穿透器（30）可以从导管（12）前进到位于导管（12）所在的内腔外部的目标位置。光学成像或组织表征装置（100）（例如，光学相干断层摄影装置）可用于对组织内的解剖和/或感测变量进行成像，以便相对于穿透器（ 30）将从导管前进。然后，操作员可以调整导管（12）的位置和/或旋转取向，使得当穿透器（30）随后前进时，穿透器（30）将进入目标位置。

2. 发明申请

WO2006135853A3 DEVICES, SYSTEMS AND METHODS USEABLE FOR TREATING SINUSITIS 审中-公开
标题翻译：用于处理SINUSITIS的设备，系统和方法
公开(公告)号：WO2006135853A3
公开(公告)日：2009-04-23
申请号：PCT/US2006022745
申请日：2006-06-08
申请人： ACCLARENT INC , CHANG JOHN Y , MAKOWER JOSHUA , VRANY JULIA D , MORRISS JOHN H , MUNI KETAN P , KIM ISAAC J , HA HUNG , FACTEAU WILLIAM M , WALKE AMRISH JAYPRAKASH
发明人： CHANG JOHN Y , MAKOWER JOSHUA , VRANY JULIA D , MORRISS JOHN H , MUNI KETAN P , KIM ISAAC J , HA HUNG , FACTEAU WILLIAM M , WALKE AMRISH JAYPRAKASH
IPC分类号： A61M37/00
CPC分类号： A61M29/00 , A61B1/233 , A61B17/12104 , A61B17/12136 , A61B17/1657 , A61B17/1688 , A61B17/24 , A61B17/320016 , A61B17/320725 , A61B34/20 , A61B2017/00292 , A61B2017/246 , A61B2034/2051 , A61B2090/3764 , A61B2503/40 , A61M25/0041 , A61M25/0054 , A61M25/0662 , A61M25/09 , A61M25/1002 , A61M29/02 , A61M2025/0008 , A61M2025/1079 , A61M2029/025 , A61M2210/0618 , A61M2210/1028
摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.
摘要翻译：使用具有柔性或刚性器械的微创方法诊断和/或治疗鼻窦炎和其他耳朵，鼻子和喉咙疾病。各种方法和装置用于重建或改变耳朵，鼻子或喉咙中的窦口或导管或其他解剖结构的形状，尺寸或构型; 植入装置，细胞或组织; 从耳朵，鼻子或喉咙去除物质; 提供诊断或治疗物质或执行其他诊断或治疗程序。可以使用引入装置（例如，引导导管，管，导线，细长探针，其它细长构件）来促进工作装置（例如，导管例如球囊导管，导线，组织切割或重塑装置，用于植入元件如支架的装置，电外科装置，能量发射装置，用于递送诊断或治疗剂，物质输送植入物，范围等的装置）到耳鼻窦或耳朵，鼻子或喉咙中的其他结构中。提供特定装置（例如，管状引导件，导丝，气囊导管，管状护套），制造和使用这种装置来治疗耳朵，鼻子或喉咙的障碍的方法。

3. 发明申请

WO2008134288A3 MECHANICAL DILATION OF THE OSTIA OF PARANASAL SINUSES AND OTHER PASSAGEWAYS OF THE EAR, NOSE AND THROAT 审中-公开
标题翻译：肛门手术的机械放大和其他耳蜗，鼻塞和喉咙的通气
公开(公告)号：WO2008134288A3
公开(公告)日：2008-12-24
申请号：PCT/US2008061048
申请日：2008-04-21
申请人： ACCLARENT INC , MORRISS JOHN H , JENKINS THOMAS R , GOLDFARB ERIC , BARON SCOTT J , MUNI KETAN P , CHANG JOHN Y , VRANY JULIA D , HARFE DANIEL T , SWEI SERENA , WOOD ROBERT N , CHAN RANDY S , HA HUNG V
发明人： MORRISS JOHN H , JENKINS THOMAS R , GOLDFARB ERIC , BARON SCOTT J , MUNI KETAN P , CHANG JOHN Y , VRANY JULIA D , HARFE DANIEL T , SWEI SERENA , WOOD ROBERT N , CHAN RANDY S , HA HUNG V
IPC分类号： A61M29/00 , A61B17/24 , A61M1/00
CPC分类号： A61B17/24 , A61B17/0218 , A61M29/02
摘要： Devices and methods for dilating the ostia of paranasal sinuses and other passageways within the ear, nose and throat. A mechanical dilator is inserted through a nostril and used to dilate an ostium or a paranasal sinus or other passageway within the ear, nose or throat (e.g., a Eustachian tube or nasolacrimal duct). The mechanical dilator may be an expandable dilators that comprises one or more non-balloon structures with or without an accompanying balloon or a members of varying diameter or cross dimension (e.g., a tapered member) that may be advanced into the ostium or other passageway to cause dilation of that passageway.
摘要翻译：用于扩张鼻窦口和耳，鼻和咽喉内其他通道的装置和方法。通过鼻孔插入机械扩张器，用于扩大耳朵，鼻子或咽喉（例如咽鼓管或鼻泪管）内的口或鼻旁窦或其他通道。机械扩张器可以是包括一个或多个非球囊结构的可膨胀扩张器，所述非球囊结构具有或不具有伴随的球囊或具有不同直径或横截面尺寸的部件（例如，锥形构件），其可被推进到口或其它通道中导致通道扩张。

4. 发明申请

WO2006020180A3 IMPLANTABLE DEVICES AND METHODS FOR DELIVERING DRUGS AND OTHER SUBSTANCES TO TREAT SINUSITIS AND OTHER DISORDERS 审中-公开
标题翻译：植入药物和其他物质以治疗鼻窦炎和其他疾病的可植入装置和方法
公开(公告)号：WO2006020180A3
公开(公告)日：2006-06-15
申请号：PCT/US2005025371
申请日：2005-07-18
申请人： EXPLORAMED NC1 INC , MAKOWER JOSHUA , CHANG JOHN Y , VRANY JULIA D , WALKE AMRISH JAYPRAKASH
发明人： MAKOWER JOSHUA , CHANG JOHN Y , VRANY JULIA D , WALKE AMRISH JAYPRAKASH
IPC分类号： A61K9/22 , A61B5/06 , A61B17/22 , A61B17/24 , A61B17/34 , A61B19/00 , A61F2/00 , A61F2/18 , A61F2/82 , A61F13/00 , A61M1/00 , A61M25/00 , A61M29/00
CPC分类号： A61M31/002 , A61B5/06 , A61B5/064 , A61B5/411 , A61B17/24 , A61B17/320725 , A61B17/320758 , A61B17/320783 , A61B17/3478 , A61B34/20 , A61B2017/22061 , A61F2/18 , A61F2/82 , A61F2002/825 , A61F2250/0039 , A61M25/0029 , A61M25/007 , A61M25/10 , A61M2025/0037 , A61M2025/105 , A61M2025/1052
摘要： Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.
摘要翻译：将药物和其他物质输送到人体或动物体内的位置以治疗或诊断鼻窦炎和各种其他疾病的可植入装置和方法。本发明包括可植入物质输送装置，其包括控制物质通过储存器的速率的储存器和屏障。输送装置可以使用导丝，导管，端口，引入器和其他进入装置推进到体内。在一些实施例中，递送装置可以在其被引入身体之前装载有一种或多种所需物质。在其他实施例中，在递送装置已经被引入身体之后，递送装置被加载和/或重新加载期望的物质。

5. 发明申请

WO2006116597A3 METHODS AND DEVICES FOR PERFORMING PROCEDURES WITHIN THE EAR, NOSE, THROAT AND PARANASAL SINUSES 审中-公开
标题翻译：用于在耳朵，鼻子，舌头和旁边牙齿中执行手术的方法和装置
公开(公告)号：WO2006116597A3
公开(公告)日：2007-06-28
申请号：PCT/US2006016026
申请日：2006-04-26
申请人： ACCLARENT INC , CHANG JOHN Y , MAKOWER JOSHUA , VRANY JULIA D , MORRISS JOHN H , MUNI KETAN P
发明人： CHANG JOHN Y , MAKOWER JOSHUA , VRANY JULIA D , MORRISS JOHN H , MUNI KETAN P
IPC分类号： A61B5/05 , A61B19/00 , A61F2/00 , A61F2/18 , A61F2/82 , A61F13/00 , A61K9/22 , A61M1/00 , A61M25/00 , A61M29/00
CPC分类号： A61B17/24 , A61B5/06 , A61B5/6851 , A61B17/320725 , A61B17/320758 , A61B17/320783 , A61B17/3478 , A61B34/20 , A61B90/16 , A61B90/361 , A61B90/39 , A61B2017/22061 , A61B2034/105 , A61B2034/107 , A61B2034/2048 , A61B2034/2051 , A61B2090/363 , A61B2090/365 , A61B2090/3958 , A61B2090/3983 , A61F2/18 , A61F2/82 , A61F2250/0039 , A61M25/007 , A61M25/10 , A61M2025/0037 , A61M2025/004 , A61M2025/1052
摘要： Devices, systems and methods for performing image guided interventional and surgical procedures, including various procedures to treat sinusitis and other disorders of the paranasal sinuses, ears, nose or throat.
摘要翻译：用于执行图像引导的介入和外科手术的装置，系统和方法，包括治疗鼻窦炎，鼻窦，鼻子或喉咙的鼻窦炎和其他疾病的各种程序。

6. 发明申请

WO2006078884A2 DEVICES, SYSTEMS AND METHODS FOR TREATING DISORDERS OF THE EAR, NOSE AND THROAT 审中-公开
标题翻译：用于治疗耳朵，鼻孔和咽喉疾病的装置，系统和方法
公开(公告)号：WO2006078884A2
公开(公告)日：2006-07-27
申请号：PCT/US2006002004
申请日：2006-01-18
申请人： ACCLARENT INC , CHANG JOHN Y , MAKOWER JOSHUA , VRANY JULIA D , LAMSON THEODORE C , WALKE AMRISH JAYPRAKASH
发明人： CHANG JOHN Y , MAKOWER JOSHUA , VRANY JULIA D , LAMSON THEODORE C , WALKE AMRISH JAYPRAKASH
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61F11/002 , A61B5/065 , A61B10/06 , A61B17/1204 , A61B17/12045 , A61B17/12104 , A61B17/12136 , A61B17/1604 , A61B17/1608 , A61B17/1679 , A61B17/1688 , A61B17/24 , A61B17/32002 , A61B17/32075 , A61B17/3478 , A61B34/20 , A61B50/13 , A61B50/15 , A61B50/20 , A61B90/16 , A61B90/361 , A61B2017/00247 , A61B2017/003 , A61B2017/320004 , A61B2017/3486 , A61B2017/3488 , A61B2018/00392 , A61B2034/2051 , A61F2/958 , A61F2250/0067 , A61M25/007 , A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.
摘要翻译：鼻窦炎，粘膜囊肿，肿瘤，感染，听力障碍，胆管闭锁，鼻旁窦的骨折和其他疾病，咽鼓管，泪道和其他耳，鼻，喉和嘴结构被诊断和/或使用微创方法治疗，在许多情况下，柔性导管与具有刚性轴的仪器相反。使用各种诊断程序和装置进行成像研究，粘液流动研究，空气/气体流动研究，解剖维度研究和内窥镜研究。可以使用进入和闭塞装置以便于诸如内窥镜，电线，探针，针，导管，球囊导管，扩张导管，扩张器，球囊，组织切割或重塑装置等工作装置的插入，抽吸或冲洗装置，成像装置，，活检装置，包含传感器或发射器的图像引导装置，电外科装置，能量发射装置，用于注射诊断或治疗剂的装置，用于植入诸如支架的装置，物质洗脱或递送装置和植入物等的装置。

7. 发明申请

WO2007035204A3 METHODS AND APPARATUS FOR TREATING DISORDERS OF THE EAR, NOSE AND THROAT 审中-公开
标题翻译：治疗耳鼻喉科疾病的方法和装置
公开(公告)号：WO2007035204A3
公开(公告)日：2009-04-30
申请号：PCT/US2006029695
申请日：2006-07-28
申请人： ACCLARENT INC , MAKOWER JOSHUA , CHANG JOHN Y , MUNI KETAN P , MORRISS JOHN H , HA HUNG V , KIM ISAAC HAN JOON , VRANY JULIA D
发明人： MAKOWER JOSHUA , CHANG JOHN Y , MUNI KETAN P , MORRISS JOHN H , HA HUNG V , KIM ISAAC HAN JOON , VRANY JULIA D
IPC分类号： A61B1/00
CPC分类号： A61B1/233 , A61B1/00135 , A61B1/0051 , A61B1/018 , A61B1/267 , A61B17/24 , A61B17/2804 , A61B17/282 , A61B17/3421 , A61B34/20 , A61B90/361 , A61B90/50 , A61B2017/3445 , A61B2017/3447 , A61B2034/2051 , A61B2034/2055 , A61B2034/2065 , A61B2090/063 , A61B2090/0811 , A61B2090/376 , A61B2090/3941 , A61B2090/3954 , A61M29/02 , A61M2029/025 , A61M2210/0681
摘要： Methods and apparatus for treating disorders of the ear, nose, throat or paranasal sinuses, including methods and apparatus for dilating ostia, passageways and other anatomical structures, endoscopic methods and apparatus for endoscopic visualization of structures within the ear, nose, throat or paranasal sinuses, navigation devices for use in conjunction with image guidance or navigation system and hand held devices having pistol type grips and other handpieces.
摘要翻译：用于治疗耳朵，鼻子，喉咙或鼻旁窦病变的方法和装置，包括用于扩张口腔，通道和其他解剖结构的方法和装置，用于耳鼻喉，鼻旁窦内结构内镜可视化的内窥镜方法和装置用于与图像引导或导航系统一起使用的导航装置以及具有手枪式手柄和其它手机的手持装置。

8. 发明申请

WO2006034008A3 APPARATUS AND METHODS FOR DILATING AND MODIFYING OSTIA OF PARANASAL SINUSES AND OTHER INTRANASAL OR PARANASAL STRUCTURES 审中-公开
标题翻译：抛物线和其他内部或外部结构的抛光和修饰的装置和方法
公开(公告)号：WO2006034008A3
公开(公告)日：2008-10-16
申请号：PCT/US2005033090
申请日：2005-09-14
申请人： ACCLARENT INC , CHANG JOHN Y , MAKOWER JOSHUA , VRANY JULIA D , WALKE AMRISH JAYPRAKASH
发明人： CHANG JOHN Y , MAKOWER JOSHUA , VRANY JULIA D , WALKE AMRISH JAYPRAKASH
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61M29/02 , A61B5/6852 , A61B17/24 , A61B17/32002 , A61B17/3403 , A61B17/3421 , A61B18/1492 , A61B2017/22039 , A61B2017/22051 , A61B2017/22061 , A61B2018/00327 , A61B2018/00595 , A61B2034/2051 , A61F2/186 , A61F2/82 , A61F2/90 , A61F2/95 , A61F2/958 , A61M25/0026 , A61M25/005 , A61M25/0082 , A61M25/0102 , A61M25/0138 , A61M25/0147 , A61M25/09 , A61M25/10 , A61M25/1006 , A61M25/1011 , A61M2025/0177 , A61M2025/1072 , A61M2025/1079 , A61M2025/109 , A61M2029/025 , A61M2210/0681 , A61M2210/1028
摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat.
摘要翻译：使用具有柔性或刚性器械的微创方法诊断和/或治疗鼻窦炎和其他耳朵，鼻子和喉咙疾病。各种方法和装置用于重建或改变耳朵，鼻子或喉咙中的窦口或导管或其他解剖结构的形状，尺寸或构型; 植入装置，细胞或组织; 从耳朵，鼻子或喉咙去除物质; 提供诊断或治疗物质或执行其他诊断或治疗程序。可以使用引入装置（例如，引导导管，管，导线，细长探针，其它细长构件）来促进工作装置（例如，导管例如球囊导管，导线，组织切割或重塑装置，用于植入元件如支架的装置，电外科装置，能量发射装置，用于递送诊断或治疗剂，物质输送植入物，范围等的装置）到耳鼻窦或耳朵，鼻子或喉咙中的其他结构中。

9. 发明申请

WO2008131195A2 SYSTEM AND METHOD FOR THE SIMULTANEOUS BILATERAL TREATMENT OF TARGET TISSUES WITHIN THE EARS 审中-公开
标题翻译：耳蜗内靶向组织同时双重治疗的系统与方法
公开(公告)号：WO2008131195A2
公开(公告)日：2008-10-30
申请号：PCT/US2008060779
申请日：2008-04-18
申请人： ACCLARENT INC , CLIFFORD ANTON , LIU GREG , MORRISS JOHN , MAKOWER JOSHUA , FACTEAU WILLIAM , GOLDFARB ERIC , CHANG JOHN Y , SHAHOIAN ERIK JAMES
发明人： CLIFFORD ANTON , LIU GREG , MORRISS JOHN , MAKOWER JOSHUA , FACTEAU WILLIAM , GOLDFARB ERIC , CHANG JOHN Y , SHAHOIAN ERIK JAMES
IPC分类号： A61F11/00
CPC分类号： A61M31/00 , A61B5/0077 , A61B2017/00787 , A61F11/002 , A61M2210/0662 , A61N1/30 , A61N1/306
摘要： A) Systems and methods for bilateral treatment of a patient having a head with a first ear and a second ear function by aligning a first device with a target tissue of the first ear; aligning a second device with a target tissue of the second ear; and therapeutically remodeling, with synchronization, the target tissues of the first and second ear with the first and second aligned devices, respectively. B) Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear; applying a therapeutic agent to the first ear by energizing an iontophoresis electrode supported by the support system; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. C) Systems and methods for treating a patient having an ear canal and a target tissue function by positioning a fluid or gel in the ear canal, the fluid or gel comprising a therapeutic agent; retaining the fluid or gel with a support structure, the support structure supporting an electrode and a battery; and applying the agent from the fluid or gel to the target tissue by energizing the electrode with an iontophoresis potential from the battery. D) Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. E) Systems and methods for treating a patient having a head with a first ear and a second ear, function by aligning a first device with a tympanic membrane of the first ear; inputting a command to an input device operatively coupled to the first device to generate a signal; and actuating the first device in response to the signal so as to drive a penetrator of the device through the tympanic membrane.
摘要翻译： A）通过将第一装置与第一耳朵的目标组织对准来双侧治疗具有第一耳朵和第二耳朵功能的患者的系统和方法; 将第二装置与第二耳朵的目标组织对准; 以及分别与第一和第二对准的装置分别对第一和第二耳朵的目标组织进行同步化的治疗重塑。 B）通过将支撑系统安装到患者的头部来治疗具有第一耳朵和第二耳朵功能的头部的患者的系统和方法，使得支撑系统与第一耳朵的目标组织对准; 通过对由所述支撑系统支撑的离子电渗电极通电来将治疗剂施加到所述第一耳朵; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。 C）通过将流体或凝胶定位在耳道中来治疗患有耳道和靶组织功能的患者的系统和方法，所述流体或凝胶包含治疗剂; 用支撑结构保持流体或凝胶，支撑结构支撑电极和电池; 以及通过从所述电池离子电渗电位激发所述电极，将所述药剂从所述流体或凝胶施加到所述靶组织。 D）用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法通过将支撑结构安装到患者的头部而起作用; 将支撑结构与第一耳的耳道中的目标组织对准; 通过将材料注入到管道中并使材料硬化来相对于目标组织稳定支撑结构; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。 E）用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法，其功能是使第一装置与第一耳朵的鼓膜对准; 向可操作地耦合到所述第一设备的输入设备输入命令以产生信号; 以及响应于所述信号致动所述第一装置，以便通过所述鼓膜驱动所述装置的穿透器。

10. 发明申请

WO2008124787A2 ETHMOIDOTOMY SYSTEM AND IMPLANTABLE SPACER DEVICES HAVING THERAPEUTIC SUBSTANCE DELIVERY CAPABILITY FOR TREATMENT OF PARANASAL SINUSITIS 审中-公开
标题翻译： ETHMOIDOTOMY系统和具有治疗物质传递能力的可植入间隔器装置治疗鼻旁窦炎
公开(公告)号：WO2008124787A2
公开(公告)日：2008-10-16
申请号：PCT/US2008059786
申请日：2008-04-09
申请人： ACCLARENT INC , MUNI KETAN P , HA HUNG V , CHANG JOHN Y , CHAN RANDY S , VAN NGA K , MAKOWER JOSHUA , FACTEAU WILLIAM M , LEVINE HOWARD L
发明人： MUNI KETAN P , HA HUNG V , CHANG JOHN Y , CHAN RANDY S , VAN NGA K , MAKOWER JOSHUA , FACTEAU WILLIAM M , LEVINE HOWARD L
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61B17/24 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B2090/062 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/04 , A61M29/02 , A61M31/00 , A61M2025/0681 , A61M2025/105
摘要： Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to provide sustained local delivery of a therapeutic or diagnostic substance. Also provided are sinus penetrator devices and systems for performing ethmoidotomy procedures or for creating other openings in the walls of paranasal sinuses or other anatomical structures.
摘要翻译：递送间隔物装置的物质可包括可植入副鼻窦和其他腔室，身体的开口和通道以维持开放并提供治疗或诊断物质的持续局部递送的可膨胀储存器。还提供了用于执行筛选手术或用于在副鼻窦或其他解剖结构的壁上创建其他开口的鼻窦穿刺器装置和系统。

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