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1. 发明专利

CA2888644A1 MICROARRAY ELECTRODES USEFUL WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM 未知
公开(公告)号：CA2888644A1
公开(公告)日：2014-06-12
申请号：CA2888644
申请日：2013-12-05
申请人： MEDTRONIC MINIMED INC
发明人： PESANTEZ DANIEL E , LI XIAOLONG , LIANG BRADLEY CHI
IPC分类号： A61B5/1486 , G01N27/327
摘要： The invention provides analyte sensors having optimized electrodes and/ or configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

2. 发明专利

CA2888644C MICROARRAY ELECTRODES USEFUL WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM 未知
公开(公告)号：CA2888644C
公开(公告)日：2021-08-31
申请号：CA2888644
申请日：2013-12-05
申请人： MEDTRONIC MINIMED INC
发明人： PESANTEZ DANIEL E , LI XIAOLONG , LIANG BRADLEY CHI
IPC分类号： A61B5/1486 , G01N27/327
摘要： A single sensor electrode is provided. The single sensor electrode has a base layer and a plurality of electrically conductive members disposed on the base layer in an array. The array has at least electrically conductive members that form the single sensor electrode. The base layer has a plurality of indentations and the conductive members are individually positioned within the indentations. The electrically conductive members each have an electroactive surface shaped as a circular disc and adapted to sense fluctuations in electrical current. The array of electrically conductive members is coupled to a common electrical conduit. The array of electrically conductive members is arranged to be coupled to the common electrical conduit so as to be electrically linked as a group. The single sensor electrode may be included as part of an analyte sensor apparatus. A method for making the single sensor electrode is also provided.

3. 发明专利

DK2369977T3 Fremgangsmåder og systemer til observering af sensorparametre 未知
公开(公告)号：DK2369977T3
公开(公告)日：2015-11-23
申请号：DK09799839
申请日：2009-12-28
申请人： MEDTRONIC MINIMED INC
发明人： LIANG BRADLEY CHI , TYLER LARRY E , ASKARINYA MOHSEN , GORDON CHARLES R , SCHULHAUSER RANDAL C , COOPER KENNETH W , HOLTZCLAW KRIS R , KANNARD BRIAN T , SHAH RAJIV
IPC分类号： A61B5/00

4. 发明专利

CA2870481C FOLDOVER SENSORS AND METHODS FOR MAKING AND USING THEM 未知
公开(公告)号：CA2870481C
公开(公告)日：2021-03-09
申请号：CA2870481
申请日：2013-05-24
申请人： MEDTRONIC MINIMED INC
发明人： LITTLE MEGAN E , WOLFE KATHERINE T , RAGHAVENDHAR GAUTHAM , LIANG BRADLEY CHI , SHAH RAJIV
IPC分类号： A61B5/1486
摘要： The application disclosed herein includes implantable blood glucose sensors having three dimensional configurations that allow expansive "360°" sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Disclsed is an analyte sensor apparatus comprising: a base substrate comprising a planar sheet of a flexible material adapted to transition from a first configuration to a second configuration when the base substrate is folded to form a fixed bend; a working electrode, a counter electrode and a reference electrode disposed upon a first surface of the base substrate; a plurality of contact pads disposed upon the first surface of the base substrate; a plurality of electrical conduits disposed upon the first surface of the base substrate, wherein the plurality of electrical conduits are adapted to transmit electrical signals between electrodes and contact pads separated by the fixed bend; and an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; wherein: the base substrate comprises the fixed bend so as to form a configuration in which: at least one electrode is disposed on a first side of the fixed bend; and at least one electrode is disposed on a second side of the fixed bend.

5. 发明专利

CA2747830C METHODS AND SYSTEMS FOR OBSERVING SENSOR PARAMETERS 未知
公开(公告)号：CA2747830C
公开(公告)日：2017-03-21
申请号：CA2747830
申请日：2009-12-28
申请人： MEDTRONIC MINIMED INC
发明人： LIANG BRADLEY CHI , TYLER LARRY E , ASKARINYA MOHSEN , GORDON CHARLES R , SCHULHAUSER RANDAL C , COOPER KENNETH W , HOLTZCLAW KRIS R , KANNARD BRIAN T , SHAH RAJIV
IPC分类号： A61B5/00
摘要： The invention disclosed herein provides methods and materials for observing the state of a sensor, for example those used by diabetic patients to monitor blood glucose levels. Typically a voltage such as a voltage pulse is applied to the sensor in order to solicit a current response from which for example, factors such as impedance values can be derived. Such values can then be used as indicators of a sensor's state, for example the state of sensor hydration, sensor noise, sensor offset, sensor drift or the like.

6. 发明专利

CA2870481A1 FOLDOVER SENSORS AND METHODS FOR MAKING AND USING THEM 未知
公开(公告)号：CA2870481A1
公开(公告)日：2013-11-28
申请号：CA2870481
申请日：2013-05-24
申请人： MEDTRONIC MINIMED INC
发明人： LITTLE MEGAN E , WOLFE KATHERINE T , RAGHAVENDHAR GAUTHAM , LIANG BRADLEY CHI , SHAH RAJIV
IPC分类号： A61B5/1486
摘要： The invention disclosed herein includes sensors having three dimensional configurations that allow expansive "360°" sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

7. 发明专利

CA2747830A1 METHODS AND SYSTEMS FOR OBSERVING SENSOR PARAMETERS 未知
公开(公告)号：CA2747830A1
公开(公告)日：2010-07-08
申请号：CA2747830
申请日：2009-12-28
申请人： MEDTRONIC MINIMED INC
发明人： LIANG BRADLEY CHI , TYLER LARRY E , ASKARINYA MOHSEN , GORDON CHARLES R , SCHULHAUSER RANDAL C , COOPER KENNETH W , HOLTZCLAW KRIS R , KANNARD BRIAN T , SHAH RAJIV
IPC分类号： A61B5/00
摘要： The invention disclosed herein provides methods and materials for observing the state of a sensor, for example those used by diabetic patients to monitor blood glucose levels. Typically a voltage such as a voltage pulse is applied to the sensor in order to solicit a current response from which for example, factors such as impedance values can be derived. Such values can then be used as indicators of a sensor's state, for example the state of sensor hydration, sensor noise, sensor offset, sensor drift or the like.

8. 发明申请

WO2013177573A3 FOLDOVER SENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： FOLDOVER传感器及其制造和使用方法
公开(公告)号：WO2013177573A3
公开(公告)日：2014-07-10
申请号：PCT/US2013042763
申请日：2013-05-24
申请人： MEDTRONIC MINIMED INC , LITTLE MEGAN E , WOLFE KATHERINE T , RAGHAVENDHAR GAUTHAM , LIANG BRADLEY CHI , SHAH RAJIV
发明人： LITTLE MEGAN E , WOLFE KATHERINE T , RAGHAVENDHAR GAUTHAM , LIANG BRADLEY CHI , SHAH RAJIV
IPC分类号： A61B5/1486
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/125 , A61B2562/166 , A61B2562/222 , C12Q1/001 , C12Q1/006 , G01N27/3272 , Y10T29/49204
摘要： The application disclosed herein includes implantable blood glucose sensors having three dimensional configurations that allow expansive "360°" sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Disclsed is an analyte sensor apparatus comprising: a base substrate comprising a planar sheet of a flexible material adapted to transition from a first configuration to a second configuration when the base substrate is folded to form a fixed bend; a working electrode, a counter electrode and a reference electrode disposed upon a first surface of the base substrate; a plurality of contact pads disposed upon the first surface of the base substrate; a plurality of electrical conduits disposed upon the first surface of the base substrate, wherein the plurality of electrical conduits are adapted to transmit electrical signals between electrodes and contact pads separated by the fixed bend; and an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; wherein: the base substrate comprises the fixed bend so as to form a configuration in which: at least one electrode is disposed on a first side of the fixed bend; and at least one electrode is disposed on a second side of the fixed bend.
摘要翻译：本文公开的应用包括具有三维结构的可植入血糖传感器，其允许在布置这些传感器的环境中进行膨胀的“360°”感测（即感测来自多个方向的分析物）。分解物是分析物传感器装置，包括：基底基底，其包括柔性材料的平面片，所述平面片适于在所述基底基底被折叠以形成固定弯曲时从第一构型转变到第二构型; 工作电极，对置电极和设置在所述基底基板的第一表面上的参考电极; 设置在所述基底基板的第一表面上的多个接触焊盘; 多个电导管，其设置在所述基底基板的所述第一表面上，其中所述多个电导管适于在电极与由所述固定弯曲部分开的接触垫之间传输电信号; 以及分析物感测层，其设置在所述工作电极之上，其中所述分析物感测层在分析物的存在下可检测地改变所述工作电极处的电流; 其中：所述基底基板包括所述固定弯曲部，以便形成其中：至少一个电极设置在所述固定弯曲部的第一侧上; 并且至少一个电极设置在固定弯管的第二侧上。

9. 发明申请

WO2010078263A3 METHODS AND SYSTEMS FOR OBSERVING SENSOR PARAMETERS 审中-公开
标题翻译：用于观察传感器参数的方法和系统
公开(公告)号：WO2010078263A3
公开(公告)日：2010-12-02
申请号：PCT/US2009069600
申请日：2009-12-28
申请人： MEDTRONIC MINIMED INC , LIANG BRADLEY CHI , TYLER LARRY E , ASKARINYA MOHSEN , GORDON CHARLES R , SCHULHAUSER RANDAL C , COOPER KENNETH W , HOLTZCLAW KRIS R , KANNARD BRIAN T , SHAH RAJIV
发明人： LIANG BRADLEY CHI , TYLER LARRY E , ASKARINYA MOHSEN , GORDON CHARLES R , SCHULHAUSER RANDAL C , COOPER KENNETH W , HOLTZCLAW KRIS R , KANNARD BRIAN T , SHAH RAJIV
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/14865
摘要： The invention disclosed herein provides methods and materials for observing the state of a sensor, for example those used by diabetic patients to monitor blood glucose levels. Typically a voltage such as a voltage pulse is applied to the sensor in order to solicit a current response from which for example, factors such as impedance values can be derived. Such values can then be used as indicators of a sensor's state, for example the state of sensor hydration, sensor noise, sensor offset, sensor drift or the like.
摘要翻译：本文公开的发明提供了用于观察传感器的状态的方法和材料，例如由糖尿病患者用来监测血糖水平的传感器的状态。典型地，诸如电压脉冲的电压被施加到传感器以便征求电流响应，例如可以导出诸如阻抗值之类的因素。然后可以将这些值用作传感器状态的指示，例如传感器水合状态，传感器噪声，传感器偏移，传感器漂移等。

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