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1. 发明公开

EP2301427A1 Glucose sensing system with auxiliary display 审中-公开
标题翻译： Glukosemessungsystem mit Hilfsanzeige
公开(公告)号：EP2301427A1
公开(公告)日：2011-03-30
申请号：EP10183507.2
申请日：2005-07-19
申请人： Medtronic MiniMed, Inc.
发明人： Talbot, Cary D. , Mastrototaro, John J. , Shah, Rajiv , Chernoff, Edward , Mueller, John C. Jr. , Shahmirian, Varaz , Purvis, Richard E. , Morgan, Wayne A. , Gottlieb, Rebecca K.
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/145 , A61B5/14532 , A61B5/412 , A61B2560/0209 , A61B2560/0443 , A61B2560/0456
摘要： A system is provided for sensing blood glucose concentration of a user. The system comprises a sensor to sense blood glucose data, sensor electronics in electrical communication with the sensor, a user interface in wireless communication with the sensor electronics and a patient monitor in communication with the sensor electronics. The system for sensing blood glucose data of a person comprises a sensor power supply and a memory in the sensor electronics, including a user interface and an input device for inputting reference information into the memory of the sensor electronics.
摘要翻译：提供了一种用于感测使用者的血糖浓度的系统。该系统包括用于感测血糖数据的传感器，与传感器电通信的传感器电子设备，与传感器电子设备无线通信的用户接口以及与传感器电子设备通信的患者监护仪。用于感测人的血糖数据的系统包括传感器电子设备中的传感器电源和存储器，包括用户接口和用于将参考信息输入到传感器电子设备的存储器中的输入设备。

2. 发明公开

EP2442101A1 Real-time self-calibrating sensor system and method 审中-公开
标题翻译：在Echtzeit selbstkalibrierendes Sensorsystem und Verfahren
公开(公告)号：EP2442101A1
公开(公告)日：2012-04-18
申请号：EP11188435.9
申请日：2006-12-21
申请人： Medtronic MiniMed, Inc.
发明人： Wang, Lu , Shah, Rajiv , Morgan, Wayne A. , Keenan, Barry
IPC分类号： G01N27/416 , A61B5/00
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A sensor-calibration module for a sensor producing a signal indicative of a characteristic of a user, the sensor including a counter electrode, a reference electrode, and a working electrode in communication with the user's blood or interstitial fluids; the sensor-calibration module having a first control unit, wherein the first control unit comprises an operational amplifier (op amp) connected in an electrical circuit such that a first voltage V1 equal to the measured difference between the working electrode voltage and the reference electrode voltage provides a first input into the op amp, an applied voltage V2 provides a second input into the op amp, and the output of the op amp is electrically connected to the counter electrode, said sensor-calibration module being configured to calibrate the sensor based on the value of the measured voltage V1 and compensating for an IR drop due to a resistance between the reference and working electrodes. An alternative way of deriving the IR drop is by applying ACC signals at a frequency which is sufficiently high that the inherent capacitance across the Faradaic part of the resistance between the reference and working electrodes appears as a short circuit and obtaining a value for said unwanted resistance by dividing the applied AC voltage by the AC current flowing, and thereafter calculating the IR drop by multiplying the current passing between the reference and working electrodes by the value of said unwanted resistance.
摘要翻译：一种用于传感器的传感器校准模块，其产生指示用户的特征的信号，所述传感器包括与用户的血液或间质液体通信的对电极，参比电极和工作电极; 所述传感器校准模块具有第一控制单元，其中所述第一控制单元包括连接在电路中的运算放大器（运算放大器），使得等于所述工作电极电压和所述参考电极电压之间的测量差的第一电压V1 向运算放大器提供第一输入，施加的电压V2向运算放大器提供第二输入，并且运算放大器的输出电连接到对电极，所述传感器校准模块被配置为基于测量电压V1的值，并补偿由于参考电极和工作电极之间的电阻引起的IR下降。导出IR下降的另一种方法是通过以足够高的频率施加ACC信号，使得参考电极和工作电极之间的电阻的法拉第部分的固有电容出现为短路并获得所述不需要的电阻的值通过将所施加的AC电压除以流过的AC电流，然后通过将通过参考电极和工作电极的电流乘以所述不需要的电阻的值来计算IR降低。

3. 发明授权

EP2578142B1 METHOD OF AND SYSTEM FOR STABILIZATION OF SENSORS 有权
标题翻译：稳定传感器的方法和系统
公开(公告)号：EP2578142B1
公开(公告)日：2018-02-14
申请号：EP13150098.5
申请日：2006-12-21
申请人： Medtronic MiniMed, Inc.
发明人： Hoss, Udo , Shah, Rajiv , Reghabi, Bahar , Henke, James L. , Morgan, Wayne A. , Soundararajan, Gopikrishnan , Choy, David Y. , Schultz, Peter
IPC分类号： A61B5/00 , A61B5/145 , A61M5/172 , A61B5/1486 , G01N27/327
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B2560/0223 , A61M5/1723 , A61M2230/201 , G01N27/327 , G01N27/3274
摘要： A method of stabilizing a sensor in physiological parameter sensing applications during initialization of the sensor, comprises (a) applying a first voltage to an electrode in a sensor for a first timeframe; (b) applying a second voltage to an electrode in a sensor for a second timeframe; (c) making a measurement of an electrical characteristic of the sensor; and (d) based on the measurement, determining whether the sensor is stabilized. A corresponding blood glucose sensing system, comprises a sensor, the sensor including a plurality of electrodes; and a sensor electronics device, the sensor electronics device including circuitry configured (a) to provide a first voltage to one of the plurality of electrodes for a first timeframe, (b) to provide a second voltage to the one of the plurality of electrodes for a second timeframe, (c) to make a measurement of an electrical characteristic of the sensor and, (d) based on the measurement, to determine whether the sensor is stabilized. Also described is a program code storage device, comprising: computer-readable storage medium; and computer-readable program code, the computer-readable program code being stored on the computer-readable storage medium and having instructions, which when executed cause the glucose sensing system to (a) transmit a first signal to a digital-to-analogue converter (DAC), the DAC being coupled to an electrode of a sensor in physiological parameter sensing applications, the first signal representative of a first voltage that the DAC is to apply to the electrode for a first predetermined time; (b) transmit a second signal instructing the DAC to apply a second voltage to the electrode for a second predetermined time; (c) transmit a measurement signal to an analyzation module to cause the analyzation module to measure an electrical characteristic of the sensor; and (d) receive a third signal from the analyzation module indicating whether the sensor is stabilized based on the measurement.

4. 发明公开

EP3158935A1 APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS 审中-公开
标题翻译：电化学阻抗光谱学在传感器系统，器件和相关方法中的应用
公开(公告)号：EP3158935A1
公开(公告)日：2017-04-26
申请号：EP16199494.2
申请日：2013-05-24
申请人： MEDTRONIC MINIMED, INC.
发明人： Yang, Ning , Gautham, Raghavendhar , Liang, Bradley C. , Shah, Rajiv , Szyman, Catherine M. , Miller, Michael E. , Wang, Jenn-Hann Larry , LI, Yiwen , Morgan, Wayne A. , Chen, Paris , Mucic, Robert C. , De Barros, Genival D. , Callirgos, Carlos A. , Sirigiri, Manjunath , Brinson, Joseph Paul
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/1495 , A61B5/00
CPC分类号： G01N27/4163 , A61B5/0537 , A61B5/0538 , A61B5/14503 , A61B5/14532 , A61B5/1459 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/6852 , A61B5/7203 , A61B5/7221 , A61B5/7225 , A61B5/7242 , A61B5/746 , A61B2562/0214 , A61B2562/04 , A61M5/14244 , A61M5/14276 , A61M5/1582 , A61M5/1723 , A61M2005/1726 , G01N27/026 , G01N27/028 , G01N27/416 , G01N33/49 , G01N33/66 , G01N33/96 , G01R35/00 , G01R35/005
摘要： A sensor system, comprises a subcutaneous or implanted sensor, said sensor having a plurality of independent working electrodes (4310), a counter electrode (4320), and a reference electrode (4330); and sensor electronics operably coupled to said sensor and including: electronic circuitry (4255) configured to selectively perform an electrochemical impedance spectroscopy (EIS) procedure for one or more of said plurality of independent working electrodes (4310) to generate impedance-related data for said one or more working electrodes (4310); a programmable sequencer (4266) configured to provide a start stimulus and a stop stimulus for performing said EIS procedure; and a microcontroller interface configured to operably couple the sensor electronics to a microcontroller.
摘要翻译：传感器系统包括皮下或植入的传感器，所述传感器具有多个独立的工作电极（4310），反电极（4320）和参考电极（4330）; 以及传感器电子器件，所述传感器电子器件可操作地耦合到所述传感器并且包括：被配置为针对所述多个独立工作电极（4310）中的一个或多个选择性地执行电化学阻抗谱（EIS）过程的电子电路（4255），以产生所述阻抗相关数据一个或多个工作电极（4310）; 可编程序列发生器（4266），其被配置为提供用于执行所述EIS过程的启动激励和停止激励; 以及配置成将传感器电子器件可操作地耦合到微控制器的微控制器接口。

5. 发明公开

EP4349249A3 METHOD FOR APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS 审中-公开
公开(公告)号：EP4349249A3
公开(公告)日：2024-07-10
申请号：EP24159810.1
申请日：2013-05-24
申请人： Medtronic MiniMed, Inc.
发明人： Yang, Ning , Gautham, Raghavendhar , Liang, Bradley C. , Shah, Rajiv , Szyman, Catherine , Miller, Michael E. , Wang, Jenn-Hann Larry , Li, Yiwen , Morgan, Wayne A. , Chen, Paris , Mucic, Robert C. , De Barros, Genival D. , Callirgos, Carlos A. , Sirigiri, Manjunath , Brinson, Joseph Paul
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/1495 , A61B5/00
CPC分类号： A61B5/1459 , A61B5/7221 , A61M5/1582 , A61B5/14865 , A61M2005/172620130101 , A61M5/14276 , A61M5/14244 , A61B5/14532 , A61B5/1473 , A61B5/746 , A61B5/0537 , A61B5/1495 , G01N33/49
摘要： A method provides for calibrating a sensor, the method comprises performing an electrochemical impedance spectroscopy (EIS) procedure for a working electrode of a sensor to obtain values of at least one impedance-based parameter for said working electrode; performing a bound check on said values of the at least one impedance-based parameter to determine whether said at least one impedance-based parameter is in-bounds and, based on said bound check, calculating a reliability-index value for said working electrode; and determining, based on the value of said reliability index, whether calibration should be performed, or whether calibration should be delayed until a later time.

6. 发明公开

EP2578142A1 Method of and system for stabilization of sensors 有权
标题翻译：传感器稳定的方法和系统
公开(公告)号：EP2578142A1
公开(公告)日：2013-04-10
申请号：EP13150098.5
申请日：2006-12-21
申请人： Medtronic MiniMed, Inc.
发明人： Hoss, Udo , Shah, Rajiv , Reghabi, Bahar , Henke, James L. , Morgan, Wayne A. , Soundararajan, Gopikrishnan , Choy, David Y. , Schultz, Peter
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B2560/0223 , A61M5/1723 , A61M2230/201 , G01N27/327 , G01N27/3274
摘要： A method of stabilizing a sensor in physiological parameter sensing applications during initialization of the sensor, comprises (a) applying a first voltage to an electrode in a sensor for a first timeframe; (b) applying a second voltage to an electrode in a sensor for a second timeframe; (c) making a measurement of an electrical characteristic of the sensor; and (d) based on the measurement, determining whether the sensor is stabilized. A corresponding blood glucose sensing system, comprises a sensor, the sensor including a plurality of electrodes; and a sensor electronics device, the sensor electronics device including circuitry configured (a) to provide a first voltage to one of the plurality of electrodes for a first timeframe, (b) to provide a second voltage to the one of the plurality of electrodes for a second timeframe, (c) to make a measurement of an electrical characteristic of the sensor and, (d) based on the measurement, to determine whether the sensor is stabilized. Also described is a program code storage device, comprising: computer-readable storage medium; and computer-readable program code, the computer-readable program code being stored on the computer-readable storage medium and having instructions, which when executed cause the glucose sensing system to (a) transmit a first signal to a digital-to-analogue converter (DAC), the DAC being coupled to an electrode of a sensor in physiological parameter sensing applications, the first signal representative of a first voltage that the DAC is to apply to the electrode for a first predetermined time; (b) transmit a second signal instructing the DAC to apply a second voltage to the electrode for a second predetermined time; (c) transmit a measurement signal to an analyzation module to cause the analyzation module to measure an electrical characteristic of the sensor; and (d) receive a third signal from the analyzation module indicating whether the sensor is stabilized based on the measurement.
摘要翻译：一种在传感器初始化期间稳定生理参数感测应用中的传感器的方法，包括：（a）在第一时间帧内向传感器中的电极施加第一电压; （b）将第二电压施加到传感器中的电极达第二时间范围; （c）测量传感器的电特性; 和（d）基于测量，确定传感器是否稳定。相应的血糖传感系统包括传感器，传感器包括多个电极; 和传感器电子设备，所述传感器电子设备包括电路，所述电路被配置为（a）在第一时间帧内向所述多个电极中的一个提供第一电压，（b）向所述多个电极中的所述一个提供第二电压，第二时间范围，（c）测量传感器的电特性，以及（d）基于测量，确定传感器是否稳定。还描述了一种程序代码存储设备，包括：计算机可读存储介质; 以及计算机可读程序代码，所述计算机可读程序代码被存储在所述计算机可读存储介质上并具有指令，所述指令在被执行时使得所述葡萄糖感测系统（a）将第一信号发送到数模转换器（DAC），所述DAC耦合到生理参数感测应用中的传感器的电极，所述第一信号表示所述DAC要在所述电极施加第一预定时间的第一电压; （b）发送指示DAC将第二电压施加到电极第二预定时间的第二信号; （c）将测量信号发送到分析模块以使分析模块测量传感器的电特性; 以及（d）基于该测量从分析模块接收指示传感器是否稳定的第三信号。

7. 发明公开

EP4349249A2 METHOD FOR APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS 审中-实审
公开(公告)号：EP4349249A2
公开(公告)日：2024-04-10
申请号：EP24159810.1
申请日：2013-05-24
申请人： Medtronic MiniMed, Inc.
发明人： Yang, Ning , Gautham, Raghavendhar , Liang, Bradley C. , Shah, Rajiv , Szyman, Catherine , Miller, Michael E. , Wang, Jenn-Hann Larry , Li, Yiwen , Morgan, Wayne A. , Chen, Paris , Mucic, Robert C. , De Barros, Genival D. , Callirgos, Carlos A. , Sirigiri, Manjunath , Brinson, Joseph Paul
IPC分类号： A61B5/00
摘要： A method provides for calibrating a sensor, the method comprises performing an electrochemical impedance spectroscopy (EIS) procedure for a working electrode of a sensor to obtain values of at least one impedance-based parameter for said working electrode; performing a bound check on said values of the at least one impedance-based parameter to determine whether said at least one impedance-based parameter is in-bounds and, based on said bound check, calculating a reliability-index value for said working electrode; and determining, based on the value of said reliability index, whether calibration should be performed, or whether calibration should be delayed until a later time.

8. 发明公开

EP3167803A1 APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS 审中-公开
标题翻译：采用电化学阻抗谱传感器系统及相关设备和方法
公开(公告)号：EP3167803A1
公开(公告)日：2017-05-17
申请号：EP16199487.6
申请日：2013-05-24
申请人： MEDTRONIC MINIMED, INC.
发明人： Yang, Ning , Gautham, Raghavendhar , Liang, Bradley C. , Shah, Rajiv , Szyman, Catherine M. , Miller, Michael E. , Wang, Jenn-Hann Larry , LI, Yiwen , Morgan, Wayne A. , Chen, Paris , Mucic, Robert C. , De Barros, Genival D. , Callirgos, Carlos A. , Sirigiri, Manjunath , Brinson, Joseph Paul
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/1495 , A61B5/00
CPC分类号： G01N27/4163 , A61B5/0537 , A61B5/0538 , A61B5/14503 , A61B5/14532 , A61B5/1459 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/6852 , A61B5/7203 , A61B5/7221 , A61B5/7225 , A61B5/7242 , A61B5/746 , A61B2562/0214 , A61B2562/04 , A61M5/14244 , A61M5/14276 , A61M5/1582 , A61M5/1723 , A61M2005/1726 , G01N27/026 , G01N27/028 , G01N27/416 , G01N33/49 , G01N33/66 , G01N33/96 , G01R35/00 , G01R35/005
摘要： A method of calibrating a blood glucose sensor is disclosed comprising: defining an electrochemical impedance spectroscopy (ElS)-based sensor status vector (V) for each one of a plurality of sensor current (Isig)-blood glucose (BG) pairs; monitoring the status vectors for the plurality of Isig-BG pairs over time; detecting when there is a difference between a first status vector for a first Isig-BG pair and a subsequent status vector for a subsequent Isig-BG pair, said first Isig-BG pair having assigned thereto a first offset value; and if a magnitude of said difference is larger than a predetermined threshold, assigning a dynamic offset value for said subsequent Isig-BG pair that is different from said first offset value so as to maintain a substantially linear relationship between said subsequent Isig and said subsequent BG. Optionally, for each Isig-BG pair, the elements of the sensor status vector can include 1kHz real impedance, 1kHz imaginary impedance, Nyquist slope, and Nyquist R square. Alternatively, for each Isig-BG pair, the sensor status vector can include impedance and Nyquist slope as elements of the vector, or 1kHz real impedance, 1kHz imaginary impedance, or Nyquist slope as an element of the vector.
摘要翻译：校准血糖传感器的一种方法，游离缺失盘包括：在定义为传感器的电流（的Isig） - 血液葡萄糖（BG）对多个每一个电化学阻抗谱（EIS）为基础的传感器状态向量（V）; 监控超时的Isig-BG对所述多个状态矢量; 检测当存在用于第一的Isig-BG对和用于随后的Isig-BG对随后的状态向量的第一状态矢量之间的差，所说的分配给它的第一偏移值的第一的Isig-BG对; 和如果所述差的幅度大于预定阈值时，分配用于所述后续的Isig-BG对的动态偏移值所做的是从所述第一偏移值不同，以便保持所述随后的Isig之间基本上线性的关系，并且所述随后的BG ，可选地，对于每个的Isig-BG对，传感器状态向量的元素可以包括1kHz的实数阻抗，1kHz的虚部阻抗，奈奎斯特斜率，和奈奎斯特R平方。可替代地，对于每个的Isig-BG对，传感器状态向量可包括阻抗和奈奎斯特斜率作为向量的元素，或者为1kHz实数阻抗，1kHz的虚部阻抗，或奈奎斯特斜率作为与载体的元素。

9. 发明公开

EP3158934A1 APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS 有权
标题翻译：电化学阻抗光谱学在传感器系统，器件和相关方法中的应用
公开(公告)号：EP3158934A1
公开(公告)日：2017-04-26
申请号：EP16199481.9
申请日：2013-05-24
申请人： MEDTRONIC MINIMED, INC.
发明人： Yang, Ning , Gautham, Raghavendhar , Liang, Bradley C. , Shah, Rajiv , Szyman, Catherine M. , Miller, Michael E. , Wang, Jenn-Hann Larry , LI, Yiwen , Morgan, Wayne A. , Chen, Paris , Mucic, Robert C. , De Barros, Genival D. , Callirgos, Carlos A. , Sirigiri, Manjunath , Brinson, Joseph Paul
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/1495 , A61B5/00
CPC分类号： G01N27/4163 , A61B5/0537 , A61B5/0538 , A61B5/14503 , A61B5/14532 , A61B5/1459 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/6852 , A61B5/7203 , A61B5/7221 , A61B5/7225 , A61B5/7242 , A61B5/746 , A61B2562/0214 , A61B2562/04 , A61M5/14244 , A61M5/14276 , A61M5/1582 , A61M5/1723 , A61M2005/1726 , G01N27/026 , G01N27/028 , G01N27/416 , G01N33/49 , G01N33/66 , G01N33/96 , G01R35/00 , G01R35/005
摘要： A method of performing real-time sensor diagnostics on a subcutaneous or implanted sensor having at least one working electrode, comprises (a) performing a first electrochemical impedance spectroscopy (EIS) procedure to generate a first set of impedance-related data for the at least one working electrode; (b) after a predetermined time interval, performing a second EIS procedure to generate a second set of impedance-related data for the at least one electrode; and (c) based on the first and second sets of impedance-related data, determining whether the sensor is functioning normally. The first and second sets of impedance-related data can include data for at least one impedance-related parameter that is substantially glucose- independent, for example imaginary impedance measured at a frequency of at least 1kHz.
摘要翻译：一种在具有至少一个工作电极的皮下或植入传感器上执行实时传感器诊断的方法，包括：（a）执行第一电化学阻抗谱（EIS）程序以生成第一组阻抗相关数据，用于至少一个工作电极; （b）在预定时间间隔之后，执行第二EIS程序以产生用于所述至少一个电极的第二组阻抗相关数据; 和（c）基于第一和第二组阻抗相关数据，确定传感器是否正常工作。第一和第二组阻抗相关数据可以包括用于至少一个基本上与葡萄糖无关的阻抗相关参数的数据，例如在至少1kHz的频率下测量的虚阻抗。

10. 发明公开

EP2754391A1 Sensing system with auxiliary display 审中-公开
标题翻译： Abtastsystem mit Hilfsanzeige
公开(公告)号：EP2754391A1
公开(公告)日：2014-07-16
申请号：EP13187695.5
申请日：2005-07-19
申请人： Medtronic MiniMed, Inc.
发明人： Talbot, Cary D. , Mastrototaro, John J. , Shah, Rajiv , Chernoff, Edward , Mueller, John C. Jr. , Shahmirian, Varaz , Purvis, Richard E. , Morgan, Wayne A. , Gottlieb, Rebecca K.
IPC分类号： A61B5/145
CPC分类号： A61B5/0002 , A61B5/145 , A61B5/14532 , A61B5/412 , A61B2560/0209 , A61B2560/0443 , A61B2560/0456
摘要： A system for sensing blood glucose concentration of a user comprises a sensor (100) to sense blood glucose data; sensor electronics (120) in electrical communication with the sensor (100); a user interface (200) in wireless communication with the sensor electronics (120); and a patient monitor (300) in communication with the sensor electronics (120).
摘要翻译：用于感测使用者的血糖浓度的系统包括感测血糖数据的传感器（100）; 与传感器（100）电连通的传感器电子器件（120）; 与所述传感器电子设备（120）无线通信的用户接口（200）; 和与传感器电子装置（120）连通的患者监视器（300）。

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