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1. 发明申请

WO2004098698A3 METHODS AND APPARATUS FOR THE REGULATION OF HORMONE RELEASE 审中-公开
标题翻译：用于调节激素释放的方法和装置
公开(公告)号：WO2004098698A3
公开(公告)日：2005-01-27
申请号：PCT/US2004011736
申请日：2004-04-16
申请人： MEDTRONIC INC , ZHOU XIAOHONG , KING GARY W , MULLEN THOMAS J , HILL MICHAEL R S
发明人： ZHOU XIAOHONG , KING GARY W , MULLEN THOMAS J , HILL MICHAEL R S
IPC分类号： A61N1/05 , A61N1/34 , A61N1/32
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes.
摘要翻译：提供了一种通过激素调节进行矫正治疗的方法和装置。通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。电刺激部位包括但不限于在T7-L2皮层区域内的T7-L2级和相关神经纤维的脊髓。

2. 发明专利

DE60134878D1 未知
公开(公告)号：DE60134878D1
公开(公告)日：2008-08-28
申请号：DE60134878
申请日：2001-10-26
申请人： MEDTRONIC INC
发明人： HILL MICHAEL R S , KING GARY W , MULLEN THOMAS J , ZHOU XIAOHONG
IPC分类号： A61N1/00 , A61N1/05 , A61N1/36 , A61N1/362 , A61N1/365 , A61N1/39

3. 发明专利

CA2340911A1 METHOD AND APPARATUS FOR PREVENTION OF ATRIAL TACHYARRHYTHMIAS 未知
公开(公告)号：CA2340911A1
公开(公告)日：2000-02-24
申请号：CA2340911
申请日：1999-08-13
申请人： MEDTRONIC INC
发明人： MEHRA RAHUL , MONGEON LUC R , FITTS STEPHANIE M , HILL MICHAEL R S
IPC分类号： A61N1/362 , A61N1/37
摘要： A tachyarrhythmia prevention pacemaker. The pacemaker paces a patient's hear t in a tachyarrhythmia prevention pacing mode for an extended time period, defines a metric of success of the tachyarrhythmia prevention pacing mode, monitors the metric over the extended time period and, responsive to the monitored metric, adjusts the tachyarrhythmia prevention pacing mode. Adjustment of the tachyarrhythmia prevention pacing mode may take the form o f pacing the patient's heart with a different set of electrodes, pacing the patient's heart with a different tachyarrhythmia prevention pacing mode and/ or terminating operation of the tachyarrhythmia prevention pacing mode.

4. 发明专利

AU5604298A Method and apparatus for diagnosis and treatment of arrhythmias 未知
公开(公告)号：AU5604298A
公开(公告)日：1998-07-03
申请号：AU5604298
申请日：1997-12-10
申请人： MEDTRONIC INC
发明人： PETERSON DAVID K , HILL MICHAEL R S , ZHOU REN , PRIEVE KATHLEEN A
IPC分类号： A61N1/362 , A61N1/39 , A61N1/368
摘要： An implantable pacemaker employing an arrhythmia prevention pacing modality particularly optimized for inclusion in dual chamber pacemakers and anti-arrhythmia devices which include dual chamber pacemakers. When the pacing mode is in effect, the device alters timing of scheduled atrial and/or ventricular pacing pulses in response to depolarizations sensed during the refractory periods and to ventricular depolarizations sensed outside of the pacemaker's A-V escape intervals. The arrhythmia prevention pacing mode is activated and deactivated in conjunction with the operation of arrhythmia detection features which may also be employed by the device to trigger delivery of anti-arrhythmia therapies.

5. 发明专利

AU2996497A Arrhythmia and fibrillation prevention pacemaker using consistent pacing 未知
公开(公告)号：AU2996497A
公开(公告)日：1997-11-26
申请号：AU2996497
申请日：1997-05-05
申请人： MEDTRONIC INC
发明人： MEADOR JOHN T , HESS MICHAEL F , HILL MICHAEL R S , MEAD R HARDWIN
IPC分类号： A61N1/368 , A61N1/362

6. 发明专利

CA2519269A1 METHOD AND APPARATUS FOR GAUGING CARDIAC STATUS USING POST PREMATURE HEART RATE TURBULENCE 未知
公开(公告)号：CA2519269A1
公开(公告)日：2004-10-07
申请号：CA2519269
申请日：2004-03-18
申请人： MEDTRONIC INC
发明人： HILL MICHAEL R S , BURNES JOHN E , MULLIGAN LAWRENCE J
IPC分类号： A61B5/0245 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/39
摘要： A hemodynamic status of a patient is determined in an implanted medical devi ce (IMD) by observing a perturbation of the patient's heart, measuring heart ra te turbulence resulting from the perturbation, and quantifying the heart rate turbulence to determine the hemodynamic status. The perturbation may be naturally-occurring, or may be generated by the implantable medical device. The patient's response to heart rate turbulence may also be used to provide a response to the patient, such as providing an alarm and/or administering a therapy. Heart rate turbulence may also be used to tune and/or optimize a device parameter such as A-V or V-V pacing intervals.

7. 发明专利

ES2197380T3 未知
公开(公告)号：ES2197380T3
公开(公告)日：2004-01-01
申请号：ES97951739
申请日：1997-12-16
申请人： MEDTRONIC INC
发明人： PETERSON DAVID K , JIRAK THOMAS L , ZHOU REN , HILL MICHAEL R S
IPC分类号： A61N1/362 , A61N1/368

8. 发明专利

CA2433049A1 IMPLANTABLE MEDICAL DEVICE FOR MONITORING CONGESTIVE HEART FAILURE 未知
公开(公告)号：CA2433049A1
公开(公告)日：2002-07-11
申请号：CA2433049
申请日：2001-12-27
申请人： MEDTRONIC INC
发明人： HILL MICHAEL R S , IGEL DAVID , BENNETT TOM D , DENO D CURTIS
IPC分类号： A61B5/0215 , A61B5/05 , A61N1/05 , A61N1/08 , A61N1/365 , A61N1/37
摘要： An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P - diastolic P), and/or dP/dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau ($(mc)$(mc)); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (EES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level. However, certain of the parameters are only measured or certain of the data are only stored when the patient heart rate is regular and within a normal sinus rang e between programmed lower and upper heart rates. The parameter data is associated with a date and time stamp and with other patient data, e.g., patient activity level, and the associated parameter data is stored in IMD memory for retrieval at a later date employing conventional telemetry system s. Incremental changes in the parameter data over time, taking any associated time of day and patient data into account, provide a measure of the degree o f change in the heart failure state of the heart.

9. 发明专利

CA2426810A1 METHOD AND APPARATUS FOR ELECTRICALLY STIMULATING THE NERVOUS SYSTEM TO IMPROVE VENTRICULAR DYSFUNCTION, HEART FAILURE, AND OTHER CARDIAC COMDITIONS 未知
公开(公告)号：CA2426810A1
公开(公告)日：2002-06-13
申请号：CA2426810
申请日：2001-10-26
申请人： MEDTRONIC INC
发明人： HILL MICHAEL R S , ZHOU XIAOHONG , MULLEN THOMAS J , KING GARY W
IPC分类号： A61N1/05 , A61N1/36 , A61N1/362 , A61N1/365 , A61N1/39 , A61N1/04 , A61M37/00 , A61N1/08 , A61N1/18
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermine d physiologic parameters.

10. 发明专利

AU720675B2 Arrhythmia and fibrillation prevention pacemaker using consistent pacing 未知
公开(公告)号：AU720675B2
公开(公告)日：2000-06-08
申请号：AU2996497
申请日：1997-05-05
申请人： MEDTRONIC INC
发明人： MEADOR JOHN T , HESS MICHAEL F , HILL MICHAEL R S , MEAD R HARDWIN
IPC分类号： A61N1/368 , A61N1/362

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