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1. 发明申请

WO2008036865A3 RADIOFREQUENCY (RF)-SHUNTED SLEEVE HEAD AND USE IN ELECTRICAL STIMULATION LEADS 审中-公开
标题翻译：无线射频（RF）-SHUNTED SLEEVE HEAD AND USE IN ELECTRICAL STIMULATION LEADS
公开(公告)号：WO2008036865A3
公开(公告)日：2008-12-11
申请号：PCT/US2007079112
申请日：2007-09-21
申请人： MEDTRONIC INC , REINKE JAMES D , YANG ZHONGPING , SOMMER JOHN L
发明人： REINKE JAMES D , YANG ZHONGPING , SOMMER JOHN L
IPC分类号： A61N1/37 , A61N1/05 , A61N1/08 , A61N1/16 , A61N1/362
CPC分类号： A61N1/056 , A61N1/086 , A61N1/3718
摘要： A medical device lead is presented. The medical device lead includes a lead body and a tip electrode. A radio frequency shunted sleeve head is coupled to the lead body and to the tip electrode. The sleeve head includes a proximal end and a distal end. A biostable dielectric coating is introduced over the sleeve head.
摘要翻译：提供医疗器械引线。医疗装置引线包括引线体和尖端电极。射频分流套管头与引线主体和尖端电极耦合。套筒头包括近端和远端。在套筒头上引入生物稳定的电介质涂层。

2. 发明申请

WO2008002831A2 IMPLANTABLE MEDICAL DEVICE HAVING A CONFORMAL COATING AND METHOD FOR MANUFACTURE 审中-公开
标题翻译：具有合适涂层的可植入医疗装置及其制造方法
公开(公告)号：WO2008002831A2
公开(公告)日：2008-01-03
申请号：PCT/US2007071856
申请日：2007-06-22
申请人： MEDTRONIC INC , MCVENES RICK D , YANG ZHONGPING
发明人： MCVENES RICK D , YANG ZHONGPING
IPC分类号： C23C16/455 , A61L15/00 , A61N1/00
CPC分类号： C23C16/45525 , A61N1/0551 , A61N1/0558 , A61N1/056 , C23C16/45555
摘要： An implantable electrical medical device and method for manufacturing the same are provided. The method includes forming a conductive substrate, placing the conductive substrate in a deposition chamber; and forming a conformal coating over the conductive substrate using atomic layer deposition. In various embodiments, the conformal coating is a conductive coating and in other embodiments the conformal coating is a dielectric coating.
摘要翻译：提供了一种可植入式电气医疗装置及其制造方法。该方法包括：形成导电基板，将导电基板放置在沉积室中; 以及使用原子层沉积在所述导电基底上形成保形涂层。在各种实施例中，保形涂层是导电涂层，在其它实施例中，保形涂层是电介质涂层。

3. 发明申请

WO2010088698A3 ANTIMICROBIAL ACCESSORY FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗装置的抗微生物附件
公开(公告)号：WO2010088698A3
公开(公告)日：2011-01-27
申请号：PCT/US2010022944
申请日：2010-02-02
申请人： MEDTRONIC INC , COBIAN KENNETH E , EICHENBERG GALLAGHER GENEVIEVE LOUISE , SEILER PETER M , DANG KIEM H , HEMENWAY MICHAEL S , YANG ZHONGPING , SCHULD JAMES L , BLUMENTHAL TICO
发明人： COBIAN KENNETH E , EICHENBERG GALLAGHER GENEVIEVE LOUISE , SEILER PETER M , DANG KIEM H , HEMENWAY MICHAEL S , YANG ZHONGPING , SCHULD JAMES L , BLUMENTHAL TICO
IPC分类号： A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61L2/0082 , A61K31/496 , A61K31/65 , A61L2/24 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/208 , A61L2300/404 , A61L2300/406 , A61L2300/604 , A61L2300/608 , Y10T428/249953 , C08L89/06
摘要： An antimicrobial accessory may include a pressure sensitive adhesive and an antimicrobial mixed in the pressure sensitive adhesive. In some examples, an antimicrobial accessory may include at least one first domain comprising a pressure sensitive adhesive and a first antimicrobial and at least one second domain including a second polymer and a second antimicrobial. The antimicrobial accessory may be configured to be attached to a housing of an implantable medical device (IMD).
摘要翻译：抗微生物附件可以包括压敏粘合剂和混合在压敏粘合剂中的抗微生物剂。在一些实例中，抗微生物附件可包括至少一个包含压敏粘合剂和第一抗微生物剂的第一区域和至少一个包含第二聚合物和第二抗微生物剂的第二区域。抗微生物附件可以被配置为附着到可植入医疗设备（IMD）的外壳。

4. 发明申请

WO2010088697A3 ANTIMICROBIAL ACCESSORY FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械的抗微生物附件
公开(公告)号：WO2010088697A3
公开(公告)日：2011-01-27
申请号：PCT/US2010022943
申请日：2010-02-02
申请人： MEDTRONIC INC , COBIAN KENNETH E , EICHENBERG GALLAGER GENEVIEVE LOUISE , SEILER PETER M , DANG KIEM H , HEMENWAY MICHAEL S , YANG ZHONGPING , SCHULD JAMES L , BLUMENTHAL TICO
发明人： COBIAN KENNETH E , EICHENBERG GALLAGER GENEVIEVE LOUISE , SEILER PETER M , DANG KIEM H , HEMENWAY MICHAEL S , YANG ZHONGPING , SCHULD JAMES L , BLUMENTHAL TICO
IPC分类号： A61L27/34 , A61L27/54
CPC分类号： A61L2/0082 , A61K31/496 , A61K31/65 , A61L2/24 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/208 , A61L2300/404 , A61L2300/406 , A61L2300/604 , A61L2300/608 , Y10T428/249953 , C08L89/06
摘要： An antimicrobial accessory may include a pressure sensitive adhesive and an antimicrobial mixed in the pressure sensitive adhesive. In some examples, an antimicrobial accessory may include at least one first domain comprising a pressure sensitive adhesive and a first antimicrobial and at least one second domain including a second polymer and a second antimicrobial. The antimicrobial accessory may be configured to be attached to a housing of an implantable medical device (IMD).
摘要翻译：抗微生物附件可以包括压敏粘合剂和在压敏粘合剂中混合的抗微生物剂。在一些实例中，抗微生物附件可以包括至少一个包含压敏粘合剂的第一结构域和包含第二聚合物和第二抗微生物剂的第一抗微生物剂和至少一个第二结构域。抗微生物附件可以被配置为附接到可植入医疗装置（IMD）的壳体。

5. 发明申请

WO2004071291A3 IMPLANTABLE CHEMICAL SENSOR 审中-公开
标题翻译：可植入化学传感器
公开(公告)号：WO2004071291A3
公开(公告)日：2005-03-17
申请号：PCT/US2004004210
申请日：2004-02-12
申请人： MEDTRONIC INC , YANG ZHONGPING , MARTIN ROY C , CARNEY JAMES K
发明人： YANG ZHONGPING , MARTIN ROY C , CARNEY JAMES K
IPC分类号： A61B5/00 , G01N21/64 , G01N21/77
CPC分类号： A61B5/0031 , G01N21/6428 , G01N21/77 , G01N2021/6419 , G01N2021/6421 , G01N2021/7759 , G01N2021/7786 , G01N2201/022 , G01N2201/0227
摘要： A method and apparatus is provided for determining a property of an analyte using a sensing layer whose optical response changes with the analyte. The apparatus includes a housing (12) with an optically transparent window (13) for receiving the sensing layer (36). The window passes optical stimulation (41) to the sensing layer and the optical response (43, 45) from the sensing layer. A stimulating light emitter (40) is coupled to a first face of an optical body (38) monolithically coupled to the window and a light detector (42, 44) is coupled to a second face of the optical body for receiving the response. The optical response changes as the concentration of the analyte changes. Reference molecules (62) included in the sensing layer can provide a calibration signal to a second light detector mounted on a third face of the optical body. The first, second and third faces of the optical body are different and not coplanar.
摘要翻译：提供了一种使用其光响应随分析物变化的感测层来确定分析物的性质的方法和装置。该装置包括具有用于接收感测层（36）的光学透明窗口（13）的壳体（12）。窗口将光学刺激（41）传递到感测层和从感测层的光学响应（43,45）。刺激光发射器（40）耦合到单体耦合到窗口的光学主体（38）的第一面，并且光检测器（42,44）耦合到光学主体的第二面以接收响应。光学响应随分析物浓度的变化而变化。包括在感测层中的参考分子（62）可以向安装在光学体的第三面上的第二光检测器提供校准信号。光学体的第一面，第二面和第三面不同，不共面。

6. 发明申请

WO2012058586A3 TELESCOPING CATHETER DELIVERY SYSTEM FOR LEFT HEART ENDOCARDIAL DEVICE PLACEMENT 审中-公开
标题翻译：用于左心内膜器械放置的远视导管输送系统
公开(公告)号：WO2012058586A3
公开(公告)日：2012-07-19
申请号：PCT/US2011058375
申请日：2011-10-28
申请人： MEDTRONIC INC , ASLESON ANDREA J , YANG ZHONGPING , KIMMEL MICHAEL , MARQUARD KYLE R , FOERSTER LAURIE
发明人： ASLESON ANDREA J , YANG ZHONGPING , KIMMEL MICHAEL , MARQUARD KYLE R , FOERSTER LAURIE
IPC分类号： A61F2/24 , A61M25/06
CPC分类号： A61N1/056 , A61B17/00234 , A61B17/3468 , A61B18/1492 , A61B2017/00247 , A61B2017/00331 , A61B2018/00351 , A61B2018/00601 , A61B2018/144 , A61F2/2427 , A61M25/0041 , A61M25/0133 , A61M25/0662 , A61M25/09 , A61M29/00 , A61M2025/0175 , A61M2025/0681 , A61M2210/125
摘要： A transseptal catheter delivery system includes an elongate first tubular member and an elongate second tubular member receivable within the first tubular member. The first tubular member includes an adjustable portion adjacent a distal end. The second tubular member is adapted to receive an instrument to be placed in the left ventricle, and includes a curved portion adjacent its distal end in a relaxed state. The adjustable portion is deflectable toward the atrial septum to guide a puncturing tool and/or guide insertion of the second tubular member through a septal puncture into the left atrium. Within the left atrium, the curved portion is oriented toward the left ventricle to guide insertion of a guide wire, and subsequently the second tubular member, into the left ventricle. Methods of transvenously accessing a left ventricle are also provided.
摘要翻译：经中隔导管递送系统包括细长的第一管状构件和可容纳在第一管状构件内的细长的第二管状构件。第一管状构件包括邻近远端的可调节部分。第二管状构件适于接收放置在左心室中的器械，并且包括在松弛状态下靠近其远端的弯曲部分。可调节部分朝向心房隔膜偏转以引导穿刺工具和/或引导第二管状部件穿过隔膜穿刺插入左心房。在左心房内，弯曲部分朝向左心室定向以引导导丝的插入，并且随后引导第二管状构件进入左心室。还提供了经静脉进入左心室的方法。

7. 发明申请

WO2007117899A2 IMPLANTABLE MEDICAL ELECTRODE 审中-公开
标题翻译：可植入的医用电极
公开(公告)号：WO2007117899A2
公开(公告)日：2007-10-18
申请号：PCT/US2007064469
申请日：2007-03-21
申请人： MEDTRONIC INC , YANG ZHONGPING , MCVENES RICK D
发明人： YANG ZHONGPING , MCVENES RICK D
IPC分类号： A61N1/05
CPC分类号： A61N1/0565 , A61N1/056
摘要： An implantable medical electrode for use with implantable medical device systems having a base formed of a tungsten alloy. The tungsten alloy electrode may be a lead-based or leadless electrode and may be provided with or without a coating. The tungsten alloy electrode is utilized in an implantable medical device that includes an electrode having a base formed of a tungsten alloy, an electrical contact, and an electronics module adapted to be electrically coupled to the electrode via the electrical contact.
摘要翻译：一种与具有由钨合金形成的基部的可植入医疗装置系统一起使用的可植入医用电极。钨合金电极可以是铅基或无铅电极，并且可以提供有或没有涂层。钨合金电极用于可植入的医疗装置中，该装置包括具有由钨合金形成的基部的电极，电触头以及适于经由电触头电连接至电极的电子模块。

8. 发明申请

WO2005020797A3 IMPLANTABLE BIOSENSOR DEVICES FOR MONITORING CARDIAC MARKER MOLECULES 审中-公开
标题翻译：用于监测心脏标记分子的可植入生物传感器装置
公开(公告)号：WO2005020797A3
公开(公告)日：2005-05-12
申请号：PCT/US2004027958
申请日：2004-08-26
申请人： MEDTRONIC INC , MANDA VEN , BENNETT TOMMY D , YANG ZHONGPING
发明人： MANDA VEN , BENNETT TOMMY D , YANG ZHONGPING
IPC分类号： A61B5/00 , A61N1/365 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61N1/36514
摘要： An implantable biosensor System is disclosed for determining Ievels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and mana ment of cardiovascular diseases. The sensor (10) includes nanowire sensor elements (20) having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a Iiving body.
摘要翻译：公开了一种可植入式生物传感器系统，用于确定患者心脏标志物的水平，以帮助诊断，确定心血管疾病的严重性和疗效。传感器（10）包括纳米线传感器元件（20），其具有连接到纳米线转换器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。在选定的时间，保护构件可以被禁用，从而允许传感器元件开始感测Iive身体内的信号。

9. 发明申请

WO0167104A2 MICROSTAMPING ACTIVATED POLYMER SURFACES 审中-公开
标题翻译：微量激活聚合物表面
公开(公告)号：WO0167104A2
公开(公告)日：2001-09-13
申请号：PCT/US0106547
申请日：2001-03-01
申请人： UNIV DUKE , CHILKOTI ASHUTOSH , YANG ZHONGPING
发明人： CHILKOTI ASHUTOSH , YANG ZHONGPING
IPC分类号： B01J19/00 , B05D1/18 , B05D1/28 , C07B61/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/545 , G01N33/543 , C12Q1/68
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B05D1/185 , B05D1/283 , B82Y40/00 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/545
摘要： Functionalized polymer surfaces having reactive moieties thereon are contacted with stamps having ligands adsorbed thereto, the ligands also comprising reactive moieties. The reactive moieties of the functionalized surfaces and the ligands form covalent bonds, thus providing a method of microstamping polymer surfaces directly with ligands such as biological ligands. Using this method, devices such as tissue culture plates with polymer surfaces that are microstamped directly with ligands can be made.
摘要翻译：其上具有反应性部分的官能化聚合物表面与吸附有配体的标记物接触，所述配体还包含反应性部分。功能化表面和配体的反应性部分形成共价键，从而提供了直接与诸如生物配体的配体微聚合聚合物表面的方法。使用该方法，可以制造诸如具有直接与配体微阻挡的聚合物表面的组织培养板的装置。

10. 发明申请

WO2009064879A2 ANTIMICROBIAL COATINGS FOR MEDICAL DEVICES AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：医疗设备的抗微生物涂料及其制备和使用方法
公开(公告)号：WO2009064879A2
公开(公告)日：2009-05-22
申请号：PCT/US2008083395
申请日：2008-11-13
申请人： MEDTRONIC MINIMED INC , YANG ZHONGPING , JIN EUNJOO , CHRISTOFERSON LAURA , SHAH RAJIV
发明人： YANG ZHONGPING , JIN EUNJOO , CHRISTOFERSON LAURA , SHAH RAJIV
IPC分类号： A61L27/34 , A61L27/50
CPC分类号： A61L27/34 , A61L27/54 , A61L2300/11 , A61L2300/208
摘要： Embodiments of the invention provide methods for using compositions to inhibit microbial growth on a surface of a medical device having the composition applied thereto, to medical devices having the composition applied to a surface thereof and to methods for using the compositions to coat medical devices.
摘要翻译：本发明的实施方案提供了使用组合物抑制其施用组合物的医疗装置的表面上的微生物生长的方法，以及将组合物施用于其表面的医疗装置以及使用该组合物涂覆医疗装置的方法。

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