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1. 发明申请

WO2007124270A3 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：WO2007124270A3
公开(公告)日：2008-05-08
申请号：PCT/US2007066334
申请日：2007-04-10
申请人： MEDTRONIC INC , DREW TOUBY A , PANKEN ERIC J , WERDER JONATHAN C , CARLSON DAVID L
发明人： DREW TOUBY A , PANKEN ERIC J , WERDER JONATHAN C , CARLSON DAVID L
IPC分类号： A61B5/0456 , A61B5/0482 , A61N1/36 , A61N1/372 , G06K9/00
CPC分类号： A61B5/02405 , A61B5/0456 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , A61N2/006 , G06K9/00543
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Further embodiments of the invention include preparing for the delivery of therapy by warming up therapy delviery components prior to the expected delivery of therapy.
摘要翻译：公开了用于检测和/或治疗诸如癫痫发作的神经系统疾病的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。本发明的其它实施方案包括通过在预期的治疗递送之前预热治疗偏爱成分来准备递送治疗。

2. 发明申请

WO2007124190A3 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 审中-公开
公开(公告)号：WO2007124190A3
公开(公告)日：2008-05-08
申请号：PCT/US2007061141
申请日：2007-01-26
申请人： MEDTRONIC INC , CARLSON DAVID L , PANKEN ERIC J , DREW TOUBY A , WERDER JONATHAN C
发明人： CARLSON DAVID L , PANKEN ERIC J , DREW TOUBY A , WERDER JONATHAN C
IPC分类号： A61B5/0476 , A61B5/0482 , A61N1/372 , G06K9/00
CPC分类号： A61B5/02405 , A61B5/0456 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , A61N2/006 , G06K9/00543
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.

3. 发明申请

WO2007143234A3 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：用于检测神经系统病症的方法和装置
公开(公告)号：WO2007143234A3
公开(公告)日：2008-04-24
申请号：PCT/US2007061145
申请日：2007-01-26
申请人： MEDTRONIC INC , CARLSON DAVID L , PANKEN ERIC J , GIFTAKIS JONATHON E
发明人： CARLSON DAVID L , PANKEN ERIC J , GIFTAKIS JONATHON E
IPC分类号： A61B5/00
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/048 , A61B5/4094 , A61B5/7275 , A61N1/36082
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：公开了用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施例总体上涉及适用于检测和治疗IMD患者的神经系统病症的可植入医疗装置（IMD）。本发明的某些实施例包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施例包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测癫痫发作活动。

4. 发明申请

WO2010005832A3 ASSOCIATING THERAPY ADJUSTMENTS WITH PATIENT POSTURE STATES 审中-公开
标题翻译：与患者心理状态相关的治疗调整
公开(公告)号：WO2010005832A3
公开(公告)日：2010-12-02
申请号：PCT/US2009049219
申请日：2009-06-30
申请人： MEDTRONIC INC , SKELTON DENNIS M , DAVIS JON P , GOKALDAS SHYAM , PANKEN ERIC J
发明人： SKELTON DENNIS M , DAVIS JON P , GOKALDAS SHYAM , PANKEN ERIC J
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61B5/1116 , A61B5/103 , A61B5/686 , A61B2560/0219 , A61B2562/0219 , A61N1/36071 , A61N1/36139 , A61N1/36535 , A61N1/37247 , G06F19/3481 , G16H40/63
摘要： The disclosure provides a method for associating a detected therapy adjustment to a posture state and storing the association with a plurality of associations for the posture state. In a record mode, an implantable medical device is configured to store therapy adjustments for each posture state and allow a user to find efficacious therapy based upon review of the associations made during therapy. The system may determine the associations through implementation of a posture search timer and a posture stability timer. These timers allow the system to correctly associate therapy adjustments to posture states when the patient anticipates the posture change by adjusting therapy before engaging in the desired posture state. An external programmer may present a range of the therapy adjustments for each posture state to allow a user to review the therapy adjustments that have been made during the therapy.
摘要翻译：本公开提供了一种用于将检测到的治疗调节与姿势状态相关联并且存储与用于姿势状态的多个关联的关联的方法。在记录模式中，可植入医疗装置被配置为存储针对每个姿势状态的治疗调整，并且允许用户基于对治疗期间所进行的关联的检查而找到有效的治疗。系统可以通过实施姿态搜索定时器和姿势稳定性定时器来确定关联。当患者在参与所需姿势状态之前通过调整治疗来预测姿势变化时，这些计时器允许系统将治疗调整正确地与姿势状态相关联。外部程序员可以呈现针对每个姿势状态的治疗调整范围，以允许用户复查治疗过程中进行的治疗调整。

5. 发明申请

WO2007123764A3 SYSTEMS AND METHODS OF IDENTIFYING CATHETER MALFUNCTIONS USING PRESSURE SENSING 审中-公开
标题翻译：使用压力感测识别导管畸变的系统和方法
公开(公告)号：WO2007123764A3
公开(公告)日：2008-01-31
申请号：PCT/US2007008020
申请日：2007-03-30
申请人： MEDTRONIC INC , MIESEL KEITH A , PANKEN ERIC J
发明人： MIESEL KEITH A , PANKEN ERIC J
IPC分类号： A61M5/168 , A61M5/142
CPC分类号： A61M5/16859 , A61M5/14276 , A61M2205/14 , A61M2205/15
摘要： Methods and systems for determining whether a catheter malfunction is present in a catheter by analyzing changes in the pressure of fluids being pumped through the delivery lumen of the catheter. The pressure changes that may be monitored may include, e.g., the peak pressure within the catheter and/or the pressure decay profile. The catheter malfunctions that may be determined using the methods and systems of the invention may include, e.g., leaks, blockages, the presence of gas bubbles, etc.
摘要翻译：通过分析通过导管的输送腔泵送的流体的压力变化来确定导管故障是否存在于导管中的方法和系统。可以监测的压力变化可以包括例如导管内的峰值压力和/或压力衰减曲线。可以使用本发明的方法和系统确定的导管故障可以包括例如泄漏，堵塞，气泡的存在等

6. 发明申请

WO2010005809A3 POSTURE STATE RESPONSIVE THERAPY DELIVERY USING DWELL TIMES 审中-公开
标题翻译：使用DWELL时间的心理状态的治疗方法
公开(公告)号：WO2010005809A3
公开(公告)日：2010-05-27
申请号：PCT/US2009048852
申请日：2009-06-26
申请人： MEDTRONIC INC , SKELTON DENNIS M , DAVIS JON P , PANKEN ERIC J
发明人： SKELTON DENNIS M , DAVIS JON P , PANKEN ERIC J
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： Techniques related to classifying a posture state of a living body are disclosed. One aspect relates to sensing at least one signal indicative of a posture state of a living body. Posture state detection logic classifies the living body as being in a posture state based on the at least one signal, wherein this classification may take into account at least one of posture and activity state of the living body. The posture state detection logic further determines whether the living body is classified in the posture state for at least a predetermined period of time. Response logic is described that initiates a response as a result of the body being classified in the posture state only after the living body has maintained the classified posture state for at least the predetermined period of time. This response may involve a change in therapy delivered to the living body.
摘要翻译：公开了对活体姿势状态进行分类的技术。一个方面涉及感测指示生物体的姿势状态的至少一个信号。姿势状态检测逻辑基于至少一个信号将生物体分为处于姿势状态，其中该分类可以考虑活体的姿势和活动状态中的至少一个。姿势状态检测逻辑进一步确定生物体是否至少在预定时间段内分类为姿势状态。描述了响应逻辑，其仅在生物体至少在预定时间段内保持分类姿势状态之后，作为身体被分类为姿势状态的结果而发起响应。这种反应可能涉及向生物体递送的治疗方法的改变。

7. 发明申请

WO2010005802A3 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的姿态分类
公开(公告)号：WO2010005802A3
公开(公告)日：2010-05-27
申请号：PCT/US2009048686
申请日：2009-06-25
申请人： MEDTRONIC INC , PANKEN ERIC J , SKELTON DENNIS M
发明人： PANKEN ERIC J , SKELTON DENNIS M
IPC分类号： A61B5/11
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： One embodiment relates to a medical device including a sensor to provide signals indicative of a detected posture state of a patient. A memory stores one or more defined vectors, each defined vector being associated with a tolerance describing a relationship with the defined vector. A processor determines a respective similarity between the detected vector and each of one or more of the defined vectors and classifies a posture state of the patient based on whether any similarity has a relationship to the respective defined vector that is described by the associated tolerance. In one embodiment, the similarity is determined without regard to a coordinate system of the patient. Another embodiment relates to determining the similarity based on at least one of an inner product, a length of the defined posture vector and a length of the detected vector.
摘要翻译：一个实施例涉及一种医疗装置，其包括用于提供指示患者的检测到的姿势状态的信号的传感器。存储器存储一个或多个定义的矢量，每个定义的矢量与描述与定义的矢量的关系的容差相关联。处理器确定检测到的矢量与一个或多个定义的矢量中的每一个之间的相应相似性，并且基于任何相似性是否与由相关容差描述的相应定义矢量有关系来对患者的姿势状态进行分类。在一个实施例中，不考虑患者的坐标系来确定相似性。另一个实施例涉及基于内积，所定义的姿势向量的长度和检测到的向量的长度中的至少一个来确定相似性。

8. 发明申请

WO2010005816A3 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的姿态分类
公开(公告)号：WO2010005816A3
公开(公告)日：2010-05-27
申请号：PCT/US2009048995
申请日：2009-06-29
申请人： MEDTRONIC INC , PANKEN ERIC J , SKELTON DENNIS M
发明人： PANKEN ERIC J , SKELTON DENNIS M
IPC分类号： A61B5/11
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： Techniques for posture classification of a patient in a coordinate system of a sensor. According to one aspect, a defined vector is obtained from a sensor disposed in a substantially fixed manner relative to the patient. The defined vector is described in a coordinate system of the sensor and without regard to an orientation in which the sensor is disposed in relation to the patient. A detected vector is obtained from the sensor that is described using the coordinate system of the sensor. The detected vector and the defined vector to are used to classify the posture state of the patient without regard to the orientation in which the sensor is disposed in relation to the patient. A response may be initiated by a medical device, which may include adjusting therapy delivery.
摘要翻译：在传感器的坐标系中对患者进行姿态分类的技术。根据一个方面，从相对于患者以基本上固定的方式布置的传感器获得定义的矢量。所定义的矢量在传感器的坐标系中进行描述，并且不考虑传感器相对于患者布置的方向。检测到的矢量是从使用传感器的坐标系描述的传感器获得的。检测到的矢量和定义的矢量用于分类患者的姿势状态，而不考虑传感器相对于患者布置的方向。响应可以由医疗设备发起，该医疗设备可以包括调整治疗递送。

9. 发明申请

WO2010005800A3 POSTURE STATE DETECTION USING SELECTABLE SYSTEM CONTROL PARAMETERS 审中-公开
标题翻译：姿态检测采用可选系统控制参数
公开(公告)号：WO2010005800A3
公开(公告)日：2010-05-27
申请号：PCT/US2009048676
申请日：2009-06-25
申请人： MEDTRONIC INC , PANKEN ERIC J , SKELTON DENNIS M
发明人： PANKEN ERIC J , SKELTON DENNIS M
IPC分类号： A61B5/11
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： Techniques for detecting and classifying a posture state of a patient are disclosed, wherein a posture state includes at least one of a posture and/or an activity state related to motion. In one embodiment, one or more signals indicative of at least one of posture and activity state of the patient may be sensed by a sensor. Control logic may be provided to process the one or more sensed signals in a selectable manner. This selectable manner may be based on current posture state data describing a posture state in which the patient has previously been classified. Alternatively or additionally, this current posture state data may describe a posture state transition previously undergone by the patient. The one or more signals that are so processed may then be used to classify a posture state of the patient.
摘要翻译：公开了用于检测和分类患者的姿势状态的技术，其中姿势状态包括与运动有关的姿势和/或活动状态中的至少一个。在一个实施例中，可以由传感器感测指示患者的姿势和活动状态中的至少一个的一个或多个信号。可以提供控制逻辑以便以可选方式处理一个或多个感测信号。该可选择的方式可以基于描述患者先前已被分类的姿势状态的当前姿势状态数据。可选地或另外地，该当前姿势状态数据可以描述患者先前经历的姿势状态转变。然后可以使用如此处理的一个或多个信号来分类患者的姿势状态。

10. 发明申请

WO2010005822A3 BLENDED POSTURE STATE CLASSIFICATION AND THERAPY DELIVERY 审中-公开
标题翻译：混合的姿势状态分类和治疗递送
公开(公告)号：WO2010005822A3
公开(公告)日：2010-05-20
申请号：PCT/US2009049071
申请日：2009-06-29
申请人： MEDTRONIC INC , PANKEN ERIC J
发明人： PANKEN ERIC J
IPC分类号： A61B5/11 , A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： Techniques for classification of a posture state of a patient using multiple posture state definitions, and for delivering therapy according to the patient's classified posture state. Detected parameter values describing a patient's posture state are compared to posture state definitions. This comparison is used to determine similarity values describing how similar the patient's posture state is to each of the posture states described by the posture state definitions. Weighting factors may be determined from the similarity values and used to weight therapy parameter values that are associated with each of the posture state definitions. The resulting weighted therapy parameter values may be used to derive a blended therapy parameter value for use in delivering therapy to the patient. The patient's posture state may be expressed in terms of a blending of the multiple posture state definitions.
摘要翻译：用于使用多姿势状态定义对患者的姿势状态进行分类以及用于根据患者的分类姿势状态递送治疗的技术。将描述患者姿势状态的检测参数值与姿势状态定义进行比较。该比较用于确定描述病人姿势状态与姿势状态定义所描述的每个姿势状态有多相似的相似性值。可以根据相似性值来确定加权因子并且用于加权与每个姿势状态定义相关联的治疗参数值。得到的加权治疗参数值可以用于导出用于向患者递送治疗的混合治疗参数值。患者的姿势状态可以用多姿势状态定义的混合来表示。

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