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1. 发明申请

WO2010135164A1 IMPLANTABLE MEDICAL DEVICE FOR CARDIAC ELECTRICAL STIMULATION 审中-公开
标题翻译：用于心脏电刺激的可植入医疗装置
公开(公告)号：WO2010135164A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/034825
申请日：2010-05-14
申请人： MEDTRONIC, INC. , SOMMER, John, L. , BRABEC, Scott, J. , URBAN, Jon, F. , YONG-FU, Xiao , ZHOU, Xiaohong
发明人： SOMMER, John, L. , BRABEC, Scott, J. , URBAN, Jon, F. , YONG-FU, Xiao , ZHOU, Xiaohong
IPC分类号： A61N1/362 , A61B5/0452 , A61B5/0456 , A61N1/37
CPC分类号： A61N1/3621 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/0452 , A61B5/0456 , A61N1/3627 , A61N1/3702
摘要： An apparatus for reducing a patient's heart rate or blood pressure. The apparatus provides stimulation to the patient's atrial and/or nodal tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial an/or nodal tissue, responsive to detecting an occurrence of a ventricular depolarization following a preceding atrial depolarization. The apparatus may define a time window following the ventricular depolarization, following the atrial depolarization or determined based upon the timing of both the atrial and ventricular depolarizations. The stimulus may be delivered during or on expiration of the defined time window. The duration of the time window may be pre-set or determined based upon measurements of the patient's refractory periods.
摘要翻译：一种减轻患者心率或血压的装置。该装置响应于检测在前面的心室去极化的发生之后，在心室的相关不应期内但在受刺激的心房和/或淋巴结组织的相关不应期之外对患者的心房和/或淋巴结组织提供刺激。心房去极化。该装置可以在心室去极化之后定义心室去极化之后的时间窗口，或者基于心房和心室去极化的时间确定。刺激可以在定义的时间窗口期间或期满时传送。时间窗口的持续时间可以基于患者的不应期的测量来预先确定或确定。

2. 发明申请

WO2012057857A1 SUPRAVENTRICULAR STIMULATION TO CONTROL VENTRICULAR RATE 审中-公开
标题翻译：用于控制心室速率的紧急刺激
公开(公告)号：WO2012057857A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/033981
申请日：2011-04-26
申请人： MEDTRONIC, INC. , XIAO, Yong-fu , SOMMER, John, L. , BRABEC, Scott, J. , ZENG, Lepeng , URBAN, Jon, F.
发明人： XIAO, Yong-fu , SOMMER, John, L. , BRABEC, Scott, J. , ZENG, Lepeng , URBAN, Jon, F.
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3622 , A61N1/36564 , A61N1/368
摘要： Various techniques for delivering atrial pacing and supraventricular stimulation to achieve a desired ventricular rate and/or cardiac output are described. One example method described includes delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during the cardiac cycle, and delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle.
摘要翻译：描述用于递送心房起搏和室上性刺激以实现期望的心室率和/或心输出量的各种技术。所描述的一个示例性方法包括递送起搏信号，所述起搏信号被配置成对患者的心脏进行心房去极化，其中所述心房去极化在心脏周期期间导致相关联的不应期，并将信号传递到心脏的心脏的室上部分患者在心房不良期后和心动周期心室不应期。

3. 发明申请

WO2006078700A1 MEDICAL DEVICES INCORPORATING CARBON NANOTUBE MATERIAL AND METHODS OF FABRICATING SAME 审中-公开
标题翻译：纳入碳纳米管材料的医疗器械及其制造方法
公开(公告)号：WO2006078700A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/001714
申请日：2006-01-18
申请人： MEDTRONIC, INC. , BRABEC, Scott, J. , GARDESKI, Kenneth, C.
发明人： BRABEC, Scott, J. , GARDESKI, Kenneth, C.
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0565 , Y10S977/905 , Y10S977/925 , Y10S977/931
摘要： The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.
摘要翻译：本发明一般涉及医疗器械; 特别是但不限于用于刺激心脏组织，肌肉组织，神经组织，脑组织和/或器官组织的独特电极和/或电引线组件; 用于电生理测绘和消融导管，用于监测和选择性地改变生理传导途径; 并且其中所述电极，引线组件和导管可选地包括用于向相邻生物组织提供治疗和/或性能增强材料的流体冲洗导管，并且其中每个所述装置与其中的纳米结构或材料耦合或结合。本发明还提供了制造，部署和操作这种医疗装置的方法。

4. 发明申请

WO2004073790A1 BIOMEDICAL ELECTRODE OF ENHANCED SURFACE AREA 审中-公开
标题翻译：增强表面区域的生物医学电极
公开(公告)号：WO2004073790A1
公开(公告)日：2004-09-02
申请号：PCT/US2004/004631
申请日：2004-02-17
申请人： MEDTRONIC, INC. , BRENNEN, Kenneth, R. , BRABEC, Scott, J. , SCHINDELDECKER, William, J.
发明人： BRENNEN, Kenneth, R. , BRABEC, Scott, J. , SCHINDELDECKER, William, J.
IPC分类号： A61N1/04
CPC分类号： A61N1/0565 , A61N1/056
摘要： An implantable biomedical electrode includes platinum particles electrochemically deposited upon, and sintered to a surface.
摘要翻译：植入式生物医学电极包括电化学沉积在表面上并烧结到表面上的铂颗粒。

5. 发明申请

WO2006081344A1 METHOD FOR FABRICATION OF LOW-POLARIZATION IMPLANTABLE STIMULATION ELECTRODE 审中-公开
标题翻译：低极化可植入刺激电极的制备方法
公开(公告)号：WO2006081344A1
公开(公告)日：2006-08-03
申请号：PCT/US2006/002737
申请日：2006-01-25
申请人： MEDTRONIC, INC. , BRABEC, Scott, J. , ROSE, Randy, G. , NYGREN, Lea, A. , COLES, James, A. Jr.
发明人： BRABEC, Scott, J. , ROSE, Randy, G. , NYGREN, Lea, A. , COLES, James, A. Jr.
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , C23C28/32 , Y10T29/49204
摘要： A method for fabricating an implantable medical electrode includes roughening the electrode substrate, applying an adhesion layer, and depositing a valve metal oxide coating over the adhesion layer under conditions optimized to minimize electrode impedance and post-pulse polarization. The electrode substrate may be a variety of electrode metals or alloys including titanium, platinum, platinum-iridium, or niobium. The adhesion layer may be formed of titanium or zirconium. The valve metal oxide coating is a ruthenium oxide coating sputtered onto the adhesion layer under controlled target power, sputtering pressure, and sputter gas ratio setting optimized to minimize electrode impedance and post-pulse polarization.
摘要翻译：一种用于制造可植入医疗电极的方法包括使电极基板粗糙化，施加粘合层，以及在优化以最小化电极阻抗和脉冲后极化的条件下，在粘附层上沉积阀金属氧化物涂层。电极基板可以是各种电极金属或包括钛，铂，铂 - 铱或铌的合金。粘合层可以由钛或锆形成。阀金属氧化物涂层是在受控目标功率，溅射压力和溅射气体比设置下溅射到粘附层上的氧化钌涂层，其被优化以最小化电极阻抗和后脉冲极化。

6. 发明申请

WO2006012159A1 MULTIPOLAR MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：多功能医用电线
公开(公告)号：WO2006012159A1
公开(公告)日：2006-02-02
申请号：PCT/US2005/022131
申请日：2005-06-22
申请人： MEDTRONIC, INC. , HINE, Douglas, S. , BRABEC, Scott, J.
发明人： HINE, Douglas, S. , BRABEC, Scott, J.
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A pacing lead includes a first pacing cathode coupled to a first conductor, a second pacing cathode coupled to a second conductor, and a flexible anode coupled to a third conductor. The flexible anode has a length less than approximately 10 millimeters and is spaced apart from and proximal to the first pacing cathode and spaced apart from and distal to the second pacing cathode. The spacing between the anode and the first pacing cathode is approximately equal to the spacing between the anode and the second pacing cathode.
摘要翻译：起搏引线包括耦合到第一导体的第一起搏阴极，耦合到第二导体的第二起搏阴极和耦合到第三导体的柔性阳极。柔性阳极具有小于约10毫米的长度，并且与第一起搏阴极间隔开并靠近第一起搏阴极并与第二起搏阴极间隔开并远离第二起搏阴极。阳极和第一起搏阴极之间的间隔大致等于阳极和第二起搏阴极之间的间隔。

7. 发明申请

WO2003035164A3 IMPLANTABLE NEUROLOGICAL LEAD WITH LOW POLORIZATION ELECTRODE 审中-公开
公开(公告)号：WO2003035164A3
公开(公告)日：2003-05-01
申请号：PCT/US2002/032023
申请日：2002-10-07
申请人： MEDTRONIC,INC.
发明人： BAUDINO, Michael, D. , BRABEC, Scott, J. , STYPULKOWSKI, Paul, H.
IPC分类号： A61N1/05
摘要： An implantable neurological lead (40) having at least one low polarization electrode (42) carried on the distal end (41) of the lead (40). The implantable neurological lead (40) is coupleable to an implantable neurological stimulator or implantable neurological monitor. In exemplary embodiments, the low polarization electrode (42) provides (a) delivery of a constant current pulse (85) having a current leading edge (86) and a current trailing edge (87) that are substantially the same, or (b) sensing of a physiological signal substantially immediately after delivering a stimulation pulse through electrode (42) without substantial distortion. Systems and methods of using or making the lead (40) are also disclosed.

8. 发明授权

EP2432551B1 IMPLANTABLE MEDICAL DEVICE FOR CARDIAC ELECTRICAL STIMULATION 有权
标题翻译：用于心脏电刺激的可植入医疗装置
公开(公告)号：EP2432551B1
公开(公告)日：2017-11-01
申请号：EP10720230.1
申请日：2010-05-14
申请人： Medtronic, Inc.
发明人： SOMMER, John, L. , BRABEC, Scott, J. , URBAN, Jon, F. , YONG-FU, Xiao , ZHOU, Xiaohong
IPC分类号： A61N1/362 , A61B5/0452 , A61B5/0456 , A61N1/37 , A61B5/0215 , A61B5/024
CPC分类号： A61N1/3621 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/0452 , A61B5/0456 , A61N1/3627 , A61N1/3702

9. 发明申请

WO2004052447A1 MEDICAL DEVICES INCORPORATING CARBON NANOTUBE MATERIAL AND METHODS OF FABRICATING SAME 审中-公开
标题翻译：纳入碳纳米管材料的医疗器械及其制造方法
公开(公告)号：WO2004052447A1
公开(公告)日：2004-06-24
申请号：PCT/US2003/038955
申请日：2003-12-08
申请人： MEDTRONIC, INC.
发明人： GARDESKI, Kenneth, C. , BRABEC, Scott, J.
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/056 , A61N1/0565
摘要： The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanotube structures or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.
摘要翻译：本发明一般涉及医疗器械; 特别是但不限于用于刺激心脏组织，肌肉组织，神经组织，脑组织和/或器官组织的独特电极和/或电引线组件; 用于电生理测绘和消融导管，用于监测和选择性地改变生理传导途径; 并且其中所述电极，引线组件和导管可选地包括用于向相邻生物组织提供治疗和/或增强性能的材料的流体冲洗导管，并且其中每个所述装置在其中耦合或纳入其中的纳米管结构或材料。本发明还提供了制造，部署和操作这种医疗装置的方法。

10. 发明授权

EP1848495B1 METHOD FOR FABRICATION OF LOW-POLARIZATION IMPLANTABLE STIMULATION ELECTRODE 失效
标题翻译：方法用于制造具有低偏振可植入刺激LEAD
公开(公告)号：EP1848495B1
公开(公告)日：2009-11-25
申请号：EP06719552.9
申请日：2006-01-25
申请人： Medtronic, Inc.
发明人： BRABEC, Scott, J. , ROSE, Randy, G. , NYGREN, Lea, A. , COLES, James, A. Jr.
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , C23C28/32 , Y10T29/49204

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