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1. 发明申请

WO2010083363A1 IMPLANTABLE MEDICAL DEVICE WITH ADAPTIVE SIGNAL PROCESSING AND ARTIFACT CANCELLATION 审中-公开
标题翻译：具有自适应信号处理和人工取消的可植入医疗器械
公开(公告)号：WO2010083363A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/021120
申请日：2010-01-15
申请人： MEDTRONIC, INC. , O'BRIEN, Richard, J. , DENO, D. Curtis , ANDERSON, David, A. , BLOEM, David R.
发明人： O'BRIEN, Richard, J. , DENO, D. Curtis , ANDERSON, David, A. , BLOEM, David R.
IPC分类号： A61B5/0205 , A61B5/04 , A61B5/024 , A61B5/0245
CPC分类号： A61B5/0002 , A61B5/0006 , A61B5/0031 , A61B5/076 , A61B5/7207
摘要： A medical device includes one or more sensors used to acquire a multi-dimensional signal. In one embodiment, principal component analysis is performed on the multi-dimensional signal to produce signal data. The principal component analysis results are used to cancel signal artifact in one embodiment. A medical device controller produces one of a therapy control and a diagnostic output in response to the signal data.
摘要翻译：医疗装置包括用于获取多维信号的一个或多个传感器。在一个实施例中，对多维信号执行主成分分析以产生信号数据。在一个实施例中，主成分分析结果用于消除信号伪像。医疗设备控制器响应于信号数据产生治疗控制和诊断输出之一。

2. 发明申请

WO2011031727A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031727A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048088
申请日：2010-09-08
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David, A. , HAVEL, William, J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David, A. , HAVEL, William, J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件;发射光的传感器，检测由与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;耦合到所述传感器的控制模块，以响应于递送所述治疗而控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。

3. 发明申请

WO2004091681A1 SHAPE MEMORY ALLOY ACTUATORS 审中-公开
标题翻译：形状记忆合金执行器
公开(公告)号：WO2004091681A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/009777
申请日：2004-03-31
申请人： MEDTRONIC, INC. , ANDERSON, David, A. , KELLEY, James, F. , ISTEPHANOUS, Naim , WALDHAUSER, Steven, L.
发明人： ANDERSON, David, A. , KELLEY, James, F. , ISTEPHANOUS, Naim , WALDHAUSER, Steven, L.
IPC分类号： A61L29/02
CPC分类号： F16K31/025 , A61L29/02 , A61L29/085 , A61L2400/16 , A61M25/00 , A61M25/09 , A61M2025/0064 , A61M2025/09141 , A61M2205/0266 , F03G7/065 , Y10T83/0304
摘要： A shape memory alloy (SMA) actuator includes a groove formed in a surface of a shape memory alloy (SMA) substrate establishing a trace pattern for a layer of conductive material formed over an electrically insulative layer. The trace pattern includes a first end, a second end, and a heating element disposed between the first and second ends. The SMA substrate is trained to deform at a transition temperature achieved when electricity is conducted through the conductive material via first and second interconnect pads terminating the first and second ends of the trace pattern.
摘要翻译：形状记忆合金（SMA）致动器包括形成在形状记忆合金（SMA）基板的表面中的凹槽，其形成在电绝缘层上形成的导电材料层的迹线图案。迹线图案包括设置在第一和第二端之间的第一端，第二端和加热元件。训练SMA基底，以在通过导电材料通过终止迹线图案的第一和第二端的第一和第二互连焊盘传导电导时实现的转变温度下变形。

4. 发明申请

WO2009121049A1 REVERSIBLE IMPLANTABLE ACOUSTIC SENSOR 审中-公开
标题翻译：可反射式无声传感器
公开(公告)号：WO2009121049A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038730
申请日：2009-03-30
申请人： MEDTRONIC, INC. , GANION, Vincent, P. , WERNER, Lewis, J. , ANDERSON, David, A.
发明人： GANION, Vincent, P. , WERNER, Lewis, J. , ANDERSON, David, A.
IPC分类号： A61B5/00 , A61B7/00
CPC分类号： A61B7/00 , A61B5/0031 , A61B7/023
摘要： An implantable medical device having an acoustic element includes a control module coupled to the acoustic element, an acoustic sensing module coupled to the control module, and a patient alert driver module coupled to the control circuit. The patient alert driver module generates a patient alert drive signal for activating the acoustic element to emit a patient alert signal. The control module includes an isolation circuit for isolating the acoustic sensing module from the acoustic element in response to the patient alert drive signal.
摘要翻译：具有声学元件的可植入医疗设备包括耦合到声学元件的控制模块，耦合到控制模块的声学感测模块以及耦合到控制电路的患者警报驱动器模块。患者警报驱动器模块产生用于激活声学元件以发出患者警报信号的患者警报驱动信号。控制模块包括用于响应于患者警报驱动信号将声学感测模块与声学元件隔离的隔离电路。

5. 发明申请

WO2011002535A1 HEART SOUND SENSING TO REDUCE INAPPROPRIATE TACHYARRHYTHMIA THERAPY 审中-公开
标题翻译：心脏感觉减少不明显的TACHYARRHYTHMIA治疗
公开(公告)号：WO2011002535A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/030268
申请日：2010-04-07
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , ANDERSON, David, A. , HUSTON, Jeffrey, M. , GILLBERG, Jeffrey, M.
发明人： ZHANG, Xusheng , ANDERSON, David, A. , HUSTON, Jeffrey, M. , GILLBERG, Jeffrey, M.
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/36528 , A61N1/36535
摘要： Techniques for detecting heart sounds to reduce inappropriate tachyarrhythmia therapy are described. In some examples, a medical device determines that a cardiac rhythm of the patient is treatable with a therapy, such as a defibrillation pulse, based on a cardiac electrogram (EGM). The medical device analyzes detected heart sounds, and withholds or allows the therapy based on the analysis of the heart sounds.
摘要翻译：描述了用于检测心音以减少不适当的快速性心律失常治疗的技术。在一些示例中，医疗装置通过基于心电图（EGM）的治疗，例如除颤脉冲来确定患者的心律是可治疗的。医疗器械分析检测到的心脏声音，并根据对心脏声音的分析，保留或允许进行治疗。

6. 发明申请

WO2010144652A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144652A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038087
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James, K. , KUHN, Jonathan, L. , ANDERSON, David, A.
发明人： CINBIS, Can , CARNEY, James, K. , KUHN, Jonathan, L. , ANDERSON, David, A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译：医疗器械系统和相关方法用于监测心力衰竭患者。用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块，以及被配置为计算第一组织氧合在开始递送治疗之前从光学传感器信号测量，在开始递送治疗之后，从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为成功地响应于第一次组织氧合测量和第二次组织氧合测量。

7. 发明申请

WO2010144648A1 SHOCK REDUCTION USING ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：使用绝对标准组织氧气饱和和总HEMOGLOBIN体积分数减少减少
公开(公告)号：WO2010144648A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038082
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan, L. , CINBIS, Can , ANDERSON, David, A. , CARNEY, James, K.
发明人： KUHN, Jonathan, L. , CINBIS, Can , ANDERSON, David, A. , CARNEY, James, K.
IPC分类号： A61B5/1455 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.
摘要翻译：用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。

8. 发明申请

WO2005075477A1 ANTIBACTERIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2005075477A1
公开(公告)日：2005-08-18
申请号：PCT/US2004/040993
申请日：2004-12-08
申请人： ABBOTT LABORATORIES , ANDERSON, David, A. , BEUTEL, Bruce, A. , COOPER, Curt, S. , GU, Yu-Gui , HINMAN, Mira, M. , KALVIN, Douglas, M. , KEYES, Robert, F. , SEARLE, Xenia, B. , WAGNER, Rolf
发明人： ANDERSON, David, A. , BEUTEL, Bruce, A. , COOPER, Curt, S. , GU, Yu-Gui , HINMAN, Mira, M. , KALVIN, Douglas, M. , KEYES, Robert, F. , SEARLE, Xenia, B. , WAGNER, Rolf
IPC分类号： C07D471/04
CPC分类号： C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译：公开了具有式（I）的具有式（I）的细菌蛋白质合成抑制化合物及其前体药物的前体药物，其制备方法，含该化合物的组合物，使用该化合物的方法。

9. 发明申请

WO2005030440A1 BASIN WRENCH 审中-公开
标题翻译：盆地扳手
公开(公告)号：WO2005030440A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031500
申请日：2004-09-23
申请人： W.J. TECHNOLOGIES, LLC , JOHNSON, Steven, X. , WERNER, Gary, D. , ANDERSON, David, A.
发明人： JOHNSON, Steven, X. , WERNER, Gary, D. , ANDERSON, David, A.
IPC分类号： B25B13/28
CPC分类号： B25B13/28 , B25G1/063
摘要： A basin wrench (10) with a jaw assembly (20) pivotally mounted about an axis (A) at a first end (14) of a handle (12). The jaw assembly including a lower jazz (22) and a upper jaw (24). The wrench including an actuator assembly (80) at a second end (16) of a handle (12) mechanically linked to the jaw assembly (20) to pivot the jaws to an open position against a spring element (28) biaised to keep the jaws in the closed position.
摘要翻译：具有钳口组件（20）的水槽扳手（10）在手柄（12）的第一端（14）处围绕轴线（A）枢转地安装。钳口组件包括下爵士（22）和上钳口（24）。所述扳手包括在手柄（12）的第二端（16）处的机构连接到所述钳口组件（20）上的致动器组件（80），以将所述钳口枢转到打开位置以抵抗弹簧元件（28），所述弹簧元件颚关闭位置。

10. 发明申请

WO2008070924A1 A METHOD OF DRUG DESIGN 审中-公开
标题翻译：药物设计方法
公开(公告)号：WO2008070924A1
公开(公告)日：2008-06-19
申请号：PCT/AU2007/001930
申请日：2007-12-13
申请人： PICORAL PTY LTD , GAZINA, Elena, V. , PETROU, Steven , HARRISON, David, N. , ANDERSON, David, A.
发明人： GAZINA, Elena, V. , PETROU, Steven , HARRISON, David, N. , ANDERSON, David, A.
IPC分类号： C12Q1/25 , C12N9/00 , C12N9/99
CPC分类号： G01N33/56983 , C12N9/127 , G01N2333/085 , G01N2333/9125
摘要： The description discloses that amiloride-like compounds inhibit enterovirus RNA replication by interaction with RNA dependent RNA polymerase (RdRP). The description discloses in silico and in vitro methods of screening for inhibitors of RdRP activity, amiloride-resistant enterovirus variants and amiloride-like compounds.
摘要翻译：该描述公开了阿米洛利类化合物通过与RNA依赖性RNA聚合酶（RdRP）的相互作用来抑制肠道病毒RNA复制。该描述公开了用于筛选RdRP活性抑制剂，阿米洛利抗性肠病毒变体和阿米洛利样化合物的硅和体外方法。

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