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1. 发明申请

WO2007123764A2 SYSTEMS AND METHODS OF IDENTIFYING CATHETER MALFUNCTIONS USING PRESSURE SENSING 审中-公开
标题翻译：使用压力感测识别导管畸变的系统和方法
公开(公告)号：WO2007123764A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/008020
申请日：2007-03-30
申请人： MEDTRONIC, INC. , MIESEL, Keith, A. , PANKEN, Eric, J.
发明人： MIESEL, Keith, A. , PANKEN, Eric, J.
IPC分类号： A61M5/168 , A61M5/142
CPC分类号： A61M5/16859 , A61M5/14276 , A61M2205/14 , A61M2205/15
摘要： Methods and systems for determining whether a catheter malfunction is present in a catheter by analyzing changes in the pressure of fluids being pumped through the delivery lumen of the catheter. The pressure changes that may be monitored may include, e.g., the peak pressure within the catheter and/or the pressure decay profile. The catheter malfunctions that may be determined using the methods and systems of the invention may include, e.g., leaks, blockages, the presence of gas bubbles, etc.
摘要翻译：通过分析通过导管的输送腔泵送的流体的压力变化来确定导管故障是否存在于导管中的方法和系统。可以监测的压力变化可以包括例如导管内的峰值压力和/或压力衰减曲线。可以使用本发明的方法和系统确定的导管故障可以包括例如泄漏，堵塞，气泡的存在等

2. 发明申请

WO2010056402A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
标题翻译：基于颅内压和患者运动的癫痫病评估
公开(公告)号：WO2010056402A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/051343
申请日：2009-07-22
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M. , WERDER, Jonathan, C. , PANKEN, Eric, J. , DENISON, Timothy, J. , MIESEL, Keith, A. , HERZOG, Michele, H.
发明人： GIFTAKIS, Jonathon, E. , GRAVES, Nina, M. , WERDER, Jonathan, C. , PANKEN, Eric, J. , DENISON, Timothy, J. , MIESEL, Keith, A. , HERZOG, Michele, H.
IPC分类号： A61B5/03 , A61B5/11 , A61B5/0482 , A61N1/36 , A61B5/053 , A61B5/04
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
摘要翻译：可以监测患者的颅内压力以评估癫痫症。在一些示例中，可监测颅内压随时间的趋势，例如以检测患者状况的变化。另外，在一些示例中，基于感测到的颅内压可以针对检测到的癫痫发作产生癫痫发作度量。癫痫发作度量可以指示例如在癫痫发作期间观察到的平均，中值或最高相对颅内压值，在癫痫发作期间从基线值的百分比变化，或者颅内压力在癫痫发作之后恢复到基线状态的时间发作的发生。除了颅内压之外或代替颅内压，可以监测患者的运动或姿势以评估患者的癫痫症。例如，癫痫发作类型或严重程度可以基于在癫痫发作期间感测到的患者运动来确定。

3. 发明申请

WO2010056401A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
标题翻译：基于内分泌压力和患者运动的癫痫病症评估
公开(公告)号：WO2010056401A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/051140
申请日：2009-07-20
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M. , WERDER, Jonathan, C. , PANKEN, Eric, J. , DENISON, Timothy, J. , MIESEL, Keith, A. , HERZOG, Michele, H.
发明人： GIFTAKIS, Jonathon, E. , GRAVES, Nina, M. , WERDER, Jonathan, C. , PANKEN, Eric, J. , DENISON, Timothy, J. , MIESEL, Keith, A. , HERZOG, Michele, H.
IPC分类号： A61B5/03 , A61B5/11 , A61B5/0482 , A61N1/36 , A61B5/053 , A61B5/04
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
摘要翻译：可以监测患者的颅内压，以评估癫痫发作障碍。在一些示例中，可以监测颅内压力随时间的趋势，例如以检测患者状况的变化。此外，在一些示例中，可以基于感测的颅内压力产生针对检测到的发作的发作量度。癫痫发作度数可以表示例如在癫痫发作期间观察到的平均值，中值或最高相对颅内压值，在癫痫发作期间从基线值变化的百分比，或颅内压力回到基线状态的时间发生癫痫发作。除了或代替颅内压之外，可以监测患者的运动或姿势以评估患者的癫痫发作障碍。例如，可以基于在癫痫发作期间感测到的患者运动来确定癫痫发作类型或严重程度。

4. 发明申请

WO2008039242A1 IMPLANTABLE MEDICAL DEVICE WITH SENSOR SELF-TEST FEATURE 审中-公开
标题翻译：具有传感器自检功能的可植入医疗器械
公开(公告)号：WO2008039242A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/009852
申请日：2007-04-24
申请人： MEDTRONIC, INC. , PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
发明人： PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/3706 , A61B2560/0276 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.
摘要翻译：当感测装置产生指示事件的传感器信号时，或者当传感器用于验证另一个设备检测到的事件时，可植入医疗设备（IMD）应用传感器自检。事件可以基于触发操作调整的感测条件，例如IMD内的治疗或诊断调整。传感器自检可以验证可植入的感测装置是否起作用，并且可以在启动或不启动传感器的情况下执行。激活传感器可能涉及施加导致传感器产生输出信号的电输入信号。或者，可以通过分析传感器和传感器接口电路之间的信号路径的连续性而不激活传感器来执行传感器自检。在任一种情况下，传感器自检将验证正确的操作，以便可以更有信心地进行操作调整。

5. 发明申请

WO2009051638A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 审中-公开
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：WO2009051638A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/011109
申请日：2008-09-25
申请人： MEDTRONIC, INC. , MOLNAR, Gregory, F. , GILL, Steven, S. , MIESEL, Keith, A. , LENT, Mark, S. , DENISON, Timothy, J. , PANKEN, Eric, J. , WAHLSTRAND, Carl, D. , WERDER, Jonathan, C.
发明人： MOLNAR, Gregory, F. , GILL, Steven, S. , MIESEL, Keith, A. , LENT, Mark, S. , DENISON, Timothy, J. , PANKEN, Eric, J. , WAHLSTRAND, Carl, D. , WERDER, Jonathan, C.
IPC分类号： A61N1/36 , A61B5/04 , G06F3/01
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

6. 发明申请

WO2010005832A2 ASSOCIATING THERAPY ADJUSTMENTS WITH PATIENT POSTURE STATES 审中-公开
标题翻译：将治疗调整与患者的姿势状态联系起来
公开(公告)号：WO2010005832A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/049219
申请日：2009-06-30
申请人： MEDTRONIC, INC. , SKELTON, Dennis, M. , DAVIS, Jon, P. , GOKALDAS, Shyam , PANKEN, Eric, J.
发明人： SKELTON, Dennis, M. , DAVIS, Jon, P. , GOKALDAS, Shyam , PANKEN, Eric, J.
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61B5/1116 , A61B5/103 , A61B5/686 , A61B2560/0219 , A61B2562/0219 , A61N1/36071 , A61N1/36139 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： The disclosure provides a method for associating a detected therapy adjustment to a posture state and storing the association with a plurality of associations for the posture state. In a record mode, an implantable medical device is configured to store therapy adjustments for each posture state and allow a user to find efficacious therapy based upon review of the associations made during therapy. The system may determine the associations through implementation of a posture search timer and a posture stability timer. These timers allow the system to correctly associate therapy adjustments to posture states when the patient anticipates the posture change by adjusting therapy before engaging in the desired posture state. An external programmer may present a range of the therapy adjustments for each posture state to allow a user to review the therapy adjustments that have been made during the therapy.
摘要翻译：本公开提供了一种用于将检测到的治疗调节与姿势状态相关联并将该关联与用于姿势状态的多个关联进行存储的方法。在记录模式中，可植入医疗装置被配置为存储针对每个姿势状态的治疗调整，并且允许用户基于对治疗期间所产生的关联的评论来找到有效的治疗。系统可以通过实施姿势搜索定时器和姿势稳定性定时器来确定关联。这些定时器允许系统在患者在参与所需姿势状态之前通过调整治疗来预测姿势变化时将治疗调整正确地与姿势状态相关联。外部程序员可以为每个姿势状态呈现一系列治疗调整，以允许用户查看在治疗期间已经进行的治疗调整。

7. 发明申请

WO2008133683A1 IMPLANTABLE MEDICAL DEVICE FOR TREATING NEUROLOGICAL CONDITIONS WITH AN INITIALLY DISABLED CARDIAC THEREPY PORT AND LEADLESS ECG SENSING 审中-公开
标题翻译：用于通过端口和无铅ECG感测治疗神经病变的可移植医疗设备与初始禁用的心脏
公开(公告)号：WO2008133683A1
公开(公告)日：2008-11-06
申请号：PCT/US2007/067625
申请日：2007-04-27
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M. , WERDER, Jonathan, C. , PANKEN, Eric, J.
发明人： GIFTAKIS, Jonathon, E. , GRAVES, Nina, M. , WERDER, Jonathan, C. , PANKEN, Eric, J.
IPC分类号： A61N1/375 , A61N1/36
CPC分类号： A61N1/375 , A61N1/36082 , A61N1/36114 , A61N1/37 , A61N1/3756
摘要： An implantable medical device such as an implantable pulse generator that includes EEG sensing for monitoring and treating neurological conditions, and leadless ECG sensing for monitoring cardiac signals. The device includes a connector block with provisions for cardiac leads which may be used/enabled when needed. If significant co-morbid cardiac events are observed in patients via the leadless ECG monitoring, then cardiac leads may be subsequently connected for therapeutic use.
摘要翻译：可植入的医疗装置，例如植入式脉冲发生器，其包括用于监测和治疗神经病症的脑电图感测，以及用于监测心脏信号的无引导心电图感测。该装置包括具有用于心脏引线的装置的连接器块，其可以在需要时使用/启用。如果通过无引导心电图监测在患者中观察到显着的并发心脏事件，则心脏引线可以随后连接用于治疗用途。

8. 发明申请

WO2010005822A2 BLENDED POSTURE STATE CLASSIFICATION AND THERAPY DELIVERY 审中-公开
标题翻译：混合状态分类和治疗交付
公开(公告)号：WO2010005822A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/049071
申请日：2009-06-29
申请人： MEDTRONIC, INC. , PANKEN, Eric, J.
发明人： PANKEN, Eric, J.
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques for classification of a posture state of a patient using multiple posture state definitions, and for delivering therapy according to the patient's classified posture state. Detected parameter values describing a patient's posture state are compared to posture state definitions. This comparison is used to determine similarity values describing how similar the patient's posture state is to each of the posture states described by the posture state definitions. Weighting factors may be determined from the similarity values and used to weight therapy parameter values that are associated with each of the posture state definitions. The resulting weighted therapy parameter values may be used to derive a blended therapy parameter value for use in delivering therapy to the patient. The patient's posture state may be expressed in terms of a blending of the multiple posture state definitions.
摘要翻译：用于使用多个姿势状态定义对患者的姿势状态进行分类的技术，以及根据患者分类的姿势状态进行治疗的技术。将描述患者姿势状态的检测参数值与姿势状态定义进行比较。该比较用于确定描述患者姿势状态与由姿势状态定义描述的每个姿势状态相似的相似性值。加权因子可以根据相似度值确定并用于与每个姿势状态定义相关联的加权治疗参数值。所得到的加权治疗参数值可用于导出用于向患者递送疗法的混合治疗参数值。患者的姿势状态可以用多姿势状态定义的混合来表示。

9. 发明申请

WO2010005809A2 POSTURE STATE RESPONSIVE THERAPY DELIVERY USING DWELL TIMES 审中-公开
标题翻译：姿势状态反应性治疗的用药时间
公开(公告)号：WO2010005809A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/048852
申请日：2009-06-26
申请人： MEDTRONIC, INC. , SKELTON, Dennis, M. , DAVIS, Jon, P. , PANKEN, Eric, J.
发明人： SKELTON, Dennis, M. , DAVIS, Jon, P. , PANKEN, Eric, J.
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques related to classifying a posture state of a living body are disclosed. One aspect relates to sensing at least one signal indicative of a posture state of a living body. Posture state detection logic classifies the living body as being in a posture state based on the at least one signal, wherein this classification may take into account at least one of posture and activity state of the living body. The posture state detection logic further determines whether the living body is classified in the posture state for at least a predetermined period of time. Response logic is described that initiates a response as a result of the body being classified in the posture state only after the living body has maintained the classified posture state for at least the predetermined period of time. This response may involve a change in therapy delivered to the living body.
摘要翻译：公开了与分类活体姿势状态有关的技术。一个方面涉及感测指示活体的姿势状态的至少一个信号。姿势状态检测逻辑基于至少一个信号将生物体分类为处于姿势状态，其中该分类可以考虑活体的姿势和活动状态中的至少一个。姿势状态检测逻辑进一步确定活体是否在姿势状态中被分类了至少预定的时间段。描述响应逻辑，其仅在生物体已经保持分类姿势状态达至少预定时间段之后才开始响应，作为身体被分类到姿势状态的结果。这种反应可能涉及到对生物体进行治疗的改变。

10. 发明申请

WO2010005802A2 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的状态分类
公开(公告)号：WO2010005802A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/048686
申请日：2009-06-25
申请人： MEDTRONIC, INC. , PANKEN, Eric, J. , SKELTON, Dennis, M.
发明人： PANKEN, Eric, J. , SKELTON, Dennis, M.
IPC分类号： A61B5/103 , A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： One embodiment relates to a medical device including a sensor to provide signals indicative of a detected posture state of a patient. A memory stores one or more defined vectors, each defined vector being associated with a tolerance describing a relationship with the defined vector. A processor determines a respective similarity between the detected vector and each of one or more of the defined vectors and classifies a posture state of the patient based on whether any similarity has a relationship to the respective defined vector that is described by the associated tolerance. In one embodiment, the similarity is determined without regard to a coordinate system of the patient. Another embodiment relates to determining the similarity based on at least one of an inner product, a length of the defined posture vector and a length of the detected vector.
摘要翻译：一个实施例涉及一种医疗设备，其包括用于提供指示患者的检测到的姿势状态的信号的传感器。存储器存储一个或多个定义的向量，每个定义的向量与描述与所定义的向量的关系的公差相关联。处理器确定检测到的矢量与一个或多个定义矢量中的每一个之间的各自的相似度，并且基于任何相似性是否与由相关联的容限描述的相应定义的矢量具有关系来对患者的姿势状态进行分类。在一个实施例中，不考虑患者的坐标系确定相似度。另一实施例涉及基于内积，所定义的姿态向量的长度和所检测的向量的长度中的至少一个来确定相似性。

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