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1. 发明申请

WO2008039242A1 IMPLANTABLE MEDICAL DEVICE WITH SENSOR SELF-TEST FEATURE 审中-公开
标题翻译：具有传感器自检功能的可植入医疗器械
公开(公告)号：WO2008039242A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/009852
申请日：2007-04-24
申请人： MEDTRONIC, INC. , PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
发明人： PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/3706 , A61B2560/0276 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.
摘要翻译：当感测装置产生指示事件的传感器信号时，或者当传感器用于验证另一个设备检测到的事件时，可植入医疗设备（IMD）应用传感器自检。事件可以基于触发操作调整的感测条件，例如IMD内的治疗或诊断调整。传感器自检可以验证可植入的感测装置是否起作用，并且可以在启动或不启动传感器的情况下执行。激活传感器可能涉及施加导致传感器产生输出信号的电输入信号。或者，可以通过分析传感器和传感器接口电路之间的信号路径的连续性而不激活传感器来执行传感器自检。在任一种情况下，传感器自检将验证正确的操作，以便可以更有信心地进行操作调整。

2. 发明申请

WO2008054992A1 METHOD AND APPARATUS FOR ATRIAL FIBRILLATION DETECTION BASED ON VENTRICULAR CYCLE LENGTHS 审中-公开
标题翻译：基于静脉循环长度的ATRIAL FIBRILLATION检测方法与装置
公开(公告)号：WO2008054992A1
公开(公告)日：2008-05-08
申请号：PCT/US2007/081600
申请日：2007-10-17
申请人： MEDTRONIC, INC. , LEE, Brian, B. , PANKEN, Eric, J.
发明人： LEE, Brian, B. , PANKEN, Eric, J.
IPC分类号： A61B5/04
CPC分类号： A61B5/046 , A61B5/02405 , A61N1/3621 , A61N1/3925 , A61N1/395
摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.
摘要翻译：用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。响应于所计算的差异，在第一时间间隔之后检测心房心律失常。响应于心房心律失常检测触发心脏信号的存储。

3. 发明申请

WO2012057866A1 POSTURE-INDUCED CHANGES TO PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：对生理参数的诱导变化
公开(公告)号：WO2012057866A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/034479
申请日：2011-04-29
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio , LEE, Brian, B.
发明人： CORBUCCI, Giorgio , LEE, Brian, B.
IPC分类号： A61B5/024 , A61B5/029
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/024 , A61B5/02438 , A61B5/029 , A61B5/1116 , A61B5/686 , A61B5/7246 , A61B5/7282 , A61N1/3627 , A61N1/36535 , A61N1/36585 , A61N1/3702 , A61N1/37247 , G06F19/00
摘要： Methods and devices for analyzing posture-induced changes to physiological parameters of a patient (e.g., ejection time, heart rate, etc.) to provide an assessment of one or more conditions of the patient.
摘要翻译：用于分析姿势引起的对患者的生理参数的变化的方法和装置（例如，射血时间，心率等）以提供对患者的一个或多个状况的评估。

4. 发明申请

WO2010011632A1 VIRTUAL PHYSICIAN ACUTE MYOCARDIAL INFARCTION DETECTION SYSTEM AND METHOD 审中-公开
标题翻译：虚拟医学急性心肌梗死检测系统及方法
公开(公告)号：WO2010011632A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051220
申请日：2009-07-21
申请人： MEDTRONIC, INC. , WENGREEN, Eric, J. , SONG, Zhendong , LEE, Brian, B.
发明人： WENGREEN, Eric, J. , SONG, Zhendong , LEE, Brian, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/0006 , A61B5/0031 , A61B5/02405 , A61B5/0404 , A61B5/0452 , A61B5/04525 , A61B5/076 , A61N1/365
摘要： A system and method for virtually detecting a medical condition, such as acute myocardial infarction (AMI), in a patient using holistic diagnostic procedures implemented in medical devices. Physiological parameters in a patient are monitored in an implantable medical device (IMD) to detect deviations from desired characteristics. When severe physiological parameter deviations exist indicating with a desired certainty that the patient is experiencing a medical condition (e.g., AMI), an alert is generated. If only minor deviations from the desired characteristics exist, additional holistic diagnostic procedures are performed virtually for diagnosing whether the patient is likely to be experiencing the medical condition, such as querying the patient through an external device regarding symptoms the patient is experiencing and analyzing the patient's responses to the questions to determine whether the patient is experiencing the medical condition. When diagnosis is still unclear, additional holistic diagnostic procedures can be performed virtually until diagnosis is certain.
摘要翻译：用于使用在医疗装置中实施的整体诊断程序来虚拟检测医疗状况的系统和方法，例如急性心肌梗塞（AMI）。在可植入医疗器械（IMD）中监测患者的生理参数，以检测与所需特征的偏差。当存在严重的生理参数偏差，指示患者正在经历医疗状况（例如，AMI）的期望确定性时，产生警报。如果仅存在与期望特征的微小偏差，则虚拟地执行附加的整体诊断程序，用于诊断患者是否可能经历医疗状况，例如通过外部设备查询患者所遇到的症状并分析患者的回答问题以确定患者是否正在经历医疗状况。当诊断仍不清楚时，可以进行额外的整体诊断程序，直到诊断确定为止。

5. 发明申请

WO2007065050A1 MEDICAL DEVICE PACKAGING SYSTEM 审中-公开
标题翻译：医疗器械包装系统
公开(公告)号：WO2007065050A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/060655
申请日：2006-11-08
申请人： MEDTRONIC, INC. , PLOMBON, William, J. , LEE, Brian, B. , WENGER, Willaim, K. , KRAUSE, Paul, G. , LU, Steven, N. , MCADAMS, Sean, B. , STYLOS, Lee , SALZER, Judy, B. , MONTGOMERY, Gerald, J.
发明人： PLOMBON, William, J. , LEE, Brian, B. , WENGER, Willaim, K. , KRAUSE, Paul, G. , LU, Steven, N. , MCADAMS, Sean, B. , STYLOS, Lee , SALZER, Judy, B. , MONTGOMERY, Gerald, J.
IPC分类号： A61N1/375 , A61N1/372
CPC分类号： A61N1/372 , A61N2001/37294
摘要： A system, comprising a sterilizable package; an implantable medical device placed inside the sterilizable package; and an electrical interface electrically coupled to the implantable medical device and extending from inside the sterilizable package to outside the sterilizable package. In various embodiments, the interface may include package contacts electrically coupled to electrode terminals on the implantable medical device, patient terminals and conductors extending between the package contacts and the patient terminals.
摘要翻译：一种包括可灭菌包装的系统; 可植入医疗器械放置在可灭菌包装内; 以及电接口，其电耦合到所述可植入医疗装置并且从所述可灭菌包装内部延伸到所述可灭菌包装之外。在各种实施例中，接口可以包括电耦合到可植入医疗装置上的电极端子的封装接点，在封装触点和患者端子之间延伸的患者端子和导体。

6. 发明申请

WO2005053791A1 MULTI-LEVEL AVERAGING SCHEME FOR ACQUIRING HEMODYNAMIC DATA 审中-公开
标题翻译：用于获取血液动力学数据的多级平均方案
公开(公告)号：WO2005053791A1
公开(公告)日：2005-06-16
申请号：PCT/US2004/039412
申请日：2004-11-23
申请人： MEDTRONIC, INC. , LEE, Brian, B. , BENNETT, Tommy, D.
发明人： LEE, Brian, B. , BENNETT, Tommy, D.
IPC分类号： A61N1/37
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/04325 , A61B5/145 , A61B5/14532 , G06F19/00
摘要： A system and method for storing and processing physiological data in a medical recording device that allows continuous data collection and storage of such data in multiple time-resolved levels are provided. The method includes: sampling one or more physiological signals at a selected sampling rate; deriving physiological parameter values from the sampled signal; storing the parameter values as they are determined in a temporary memory buffer for a predetermined storage interval; determining a statistical aspect of the stored parameter values upon expiration of the storage interval; and writing the statistical aspect to a long-term memory buffer. A number of long-term memory buffers may be designated for storing a statistical aspect of a physiological parameter at uniquely different time resolutions. The resolution of each long-term memory buffer is determined by the storage interval defined for an associated temporary memory buffer, which stores parameter values from which statistical aspects are computed.
摘要翻译：提供一种在医疗记录装置中存储和处理生理数据的系统和方法，其允许以多个时间分辨级别连续数据收集和存储这些数据。该方法包括：以选定的采样速率对一个或多个生理信号进行采样; 从采样信号中得到生理参数值; 将其在临时存储器缓冲器中确定的参数值存储在预定的存储间隔中; 在所述存储间隔期满时确定所存储的参数值的统计方面; 并将统计方面写入长期内存缓冲区。可以指定多个长期记忆缓冲器用于以独特的不同时间分辨率存储生理参数的统计方面。每个长期存储器缓冲器的分辨率由为关联的临时存储器缓冲器定义的存储间隔确定，其存储从其计算统计方面的参数值。

7. 发明申请

WO2007065049A1 MEDICAL DEVICE PACKAGING SYSTEM 审中-公开
标题翻译：医疗器械包装系统
公开(公告)号：WO2007065049A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/060640
申请日：2006-11-08
申请人： MEDTRONIC, INC. , PLOMBON, William, J. , LEE, Brian, B. , WENGER, Willaim, K. , KRAUSE, Paul, G. , LU, Steven, N. , MCADAMS, Sean, B. , STYLOS, Lee , SALZER, Judy, B. , MONTGOMERY, Gerald, J.
发明人： PLOMBON, William, J. , LEE, Brian, B. , WENGER, Willaim, K. , KRAUSE, Paul, G. , LU, Steven, N. , MCADAMS, Sean, B. , STYLOS, Lee , SALZER, Judy, B. , MONTGOMERY, Gerald, J.
IPC分类号： A61B19/02 , A61N1/372 , A61N1/375
CPC分类号： A61N1/08 , A61B50/30 , A61B2050/0065 , A61N1/372 , A61N1/375 , A61N2001/37294
摘要： A system, comprising a sterilizable package (60) ; an implantable medical device (IMD) (10) placed inside the sterilizable package; and an electrical interface (50) electrically coupled to the implantable medical device and extending from inside the sterilizable package to outside the sterilizable package. In various embodiments, the interface in the form of a flexible circuit, may include package contacts (52) electrically coupled to electrode terminals on the implantable medical device, patient terminals (54) and conductors extending between the package contacts and the patient terminals. The packaging system allows to obtain pre-implant test data without compromising the sterility of the IMD within the package.
摘要翻译：一种系统，包括可灭菌包装（60）; 将可植入医疗装置（IMD）（10）放置在可灭菌包装内; 以及电接口（50），其电连接到所述可植入医疗装置并且从所述可灭菌包装内部延伸到所述可灭菌包装之外。在各种实施例中，柔性电路形式的接口可以包括电耦合到可植入医疗装置上的电极端子的包装触点（52），患者端子（54）和在包装触头和患者端子之间延伸的导体。包装系统允许获得植入前测试数据，而不会影响包装内IMD的无菌性。

8. 发明申请

WO2004075737A2 METHOD AND APPARATUS FOR MONITORING HEART FUNCTION IN A SUBCUTANEOUSLY IMPLANTED DEVICE 审中-公开
标题翻译：一种用于监测手术中的心脏功能的方法和装置
公开(公告)号：WO2004075737A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005854
申请日：2004-02-26
申请人： MEDTRONIC INC. , LEE, Brian, B.
发明人： LEE, Brian, B.
IPC分类号： A61B
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/7232 , A61N1/05 , A61N1/3702
摘要： A minimally invasive, implantable monitor and associated method for chronically monitoring a patient's hemodynamic function based on signals sensed by one or more acoustical sensors. The monitor may be implanted subcutaneously or submuscularly in relation to the heart to allow acoustic signals generated by heart or blood motion to be received by a passive or active acoustical sensor. Circuitry for filtering and amplifying and digitizing acoustical data is included, and sampled data may be continuously or intermittently written to a looping memory buffer. ECG electrodes and associated circuitry may be included to simultaneously record ECG data. Upon a manual or automatic trigger event acoustical and ECG data may be stored in long-term memory for future uploading to an external device. The external device may present acoustical data visually and acoustically with associated ECG data to allow interpretation of both electrical and mechanical heart function.
摘要翻译：基于由一个或多个声学传感器感测到的信号的用于长期监测患者血液动力学功能的微创可植入监测器和相关方法。监测器可以相对于心脏皮下或肌肉下植入，以允许由心脏或血液运动产生的声信号由被动或主动声学传感器接收。包括用于滤波和放大和数字化声学数据的电路，并且采样数据可以被连续地或间歇地写入循环存储器缓冲器。可以包括ECG电极和相关联的电路以同时记录ECG数据。在手动或自动触发事件中，声学和ECG数据可以存储在长期存储器中，以便将来上传到外部设备。外部设备可以使用相关联的ECG数据在视觉和声学上呈现声学数据，以允许解释电和机械心脏功能。

9. 发明申请

WO2021061689A1 DETERMINING HEART CONDITION STATUSES USING SUBCUTANEOUS IMPEDANCE MEASUREMENTS 审中-公开
公开(公告)号：WO2021061689A1
公开(公告)日：2021-04-01
申请号：PCT/US2020/052080
申请日：2020-09-23
申请人： MEDTRONIC, INC.
发明人： SARKAR, Shantanu , ZIELINSKI, Todd, M. , LEE, Brian, B. , EISELE III, Val, D. , WARMAN, Eduardo, N.
IPC分类号： A61B5/0537 , A61B5/0538 , A61B5/00
摘要： Techniques for obtaining impedance data to provide an early warning for heart failure decompensation are described. An example device may be configured to measure subcutaneous impedance values, and increment an impedance score. In some examples, the device may use an adaptive threshold and fluid index in incrementing the impedance score. In some examples, the impedance score is compared to a threshold to determine a heart failure status of a patient.

10. 发明申请

WO2004023995A1 METHODS AND APPARATUS FOR CARDIAC R-WAVE SENSING IN A SUBCUTANEOUS ECG WAVEFORM 审中-公开
标题翻译：心外膜心电图波形检测方法与装置
公开(公告)号：WO2004023995A1
公开(公告)日：2004-03-25
申请号：PCT/US2003/027427
申请日：2003-09-02
申请人： MEDTRONIC, INC.
发明人： CAO, Jian , LEE, Brian, B. , KANE, Michael, R. , HURD, Spencer, R.
IPC分类号： A61B5/0456
CPC分类号： A61B5/0468 , A61B5/04325 , A61B5/0456 , A61B5/7203 , A61B5/7221
摘要： The present invention uses a R-wave sensing algorithm that uniquely combines an automatic threshold adjustment method with a new noise rejection technique. This algorithm has significant advantages in avoiding the sensing of T-waves, P-waves, and noise/artifacts. Detecting the presence of noise bursts uses features that determine if an R-R interval adjacent to or within the noise signal is valid. Circuitry that discriminates noise signals from R-waves can use any one of several features including, but not limited to, the following: detection events occurring so close together that they are outside normal physiologic heart rates; frequency content that is wider than that of QRS complexes; amplitudes that are different than the adjacent or encompassing R-waves; and amplitudes that display greater than normal variability. The present invention employs multiple discrete thresholds optionally with different decay constants, alone or in combination with one or more substantially constant magnitude sensing threshold.
摘要翻译：本发明使用独特地组合自动阈值调整方法和新的噪声抑制技术的R波感测算法。该算法在避免T波，P波和噪声/伪影的检测方面具有显着的优势。检测噪声突发的存在使用确定与噪声信号相邻或在噪声信号内的R-R间隔是否有效的特征。鉴别来自R波的噪声信号的电路可以使用几个特征中的任何一个，包括但不限于以下：检测事件如此紧密地发生，使得它们在正常生理心率之外; 频率含量比QRS复合物宽; 与相邻或包围的R波不同的振幅; 和显示大于正常变异性的幅度。本发明单独或与一个或多个基本上恒定的幅度感测阈值组合使用多个离散阈值，其可选地具有不同的衰减常数。

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