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1. 发明申请

WO2010085526A1 CO-LOCATION OF EMITTERS AND DETECTORS AND METHOD OF OPERATION 审中-公开
标题翻译：发射器和探测器的合作位置及其操作方法
公开(公告)号：WO2010085526A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021584
申请日：2010-01-21
申请人： MEDTRONIC, INC. , KUHN, Jonathan, L. , ROBERTS, Jonathan, P. , RIES, Andrew, J. , REINKE, James D. , JELEN, Jeffrey, M. , ECKER, Robert, M. , DAVIS, Timothy, J. , CINBIS, Can , ANDERSON, Thomas A.
发明人： KUHN, Jonathan, L. , ROBERTS, Jonathan, P. , RIES, Andrew, J. , REINKE, James D. , JELEN, Jeffrey, M. , ECKER, Robert, M. , DAVIS, Timothy, J. , CINBIS, Can , ANDERSON, Thomas A.
IPC分类号： G06F19/00
CPC分类号： A61B5/1459 , A61B5/14542 , A61B5/1495 , A61B2562/0233 , A61B2562/046 , A61N1/36557 , G06F19/00 , G16H40/63
摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test.
摘要翻译：具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。每个组件设置有至少一个发光装置和至少一个光检测装置。耦合到光学传感器的设备控制器控制每个组件的功能。控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。响应于性能测试的结果，控制器选择多个光学传感器组件中的至少一个以作为光检测组件进行操作。

2. 发明申请

WO2009132060A1 OPTICAL DEVICE 审中-公开
标题翻译：光学装置
公开(公告)号：WO2009132060A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041345
申请日：2009-04-22
申请人： MEDTRONIC, INC. , ECKER, Robert, M. , KUHN, Jonathan, L. , REINKE, James, D. , CINBIS, Can , DAVIS, Timothy, J. , ROBERTS, Jonathan, P. , GERRRISH, Paul, F.
发明人： ECKER, Robert, M. , KUHN, Jonathan, L. , REINKE, James, D. , CINBIS, Can , DAVIS, Timothy, J. , ROBERTS, Jonathan, P. , GERRRISH, Paul, F.
IPC分类号： A61B5/00
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译：反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大致垂直于衬底的顶表面的方向上重定向。光学传感器可以使用微机电系统（MEMS）制造技术来制造。

3. 发明申请

WO2011093916A1 CLOCK SYNCHRONIZATION IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：可插入医疗设备系统中的时钟同步
公开(公告)号：WO2011093916A1
公开(公告)日：2011-08-04
申请号：PCT/US2010/033408
申请日：2010-05-03
申请人： MEDTRONIC, INC. , REINKE, James, D. , ECKER, Robert, M. , PATIL, Kaustubh, R. , TERRY, Michael, B. , ROBERTS, Jonathan, P. , COREY, Robert, A.
发明人： REINKE, James, D. , ECKER, Robert, M. , PATIL, Kaustubh, R. , TERRY, Michael, B. , ROBERTS, Jonathan, P. , COREY, Robert, A.
IPC分类号： A61N1/372
CPC分类号： G06F1/12 , A61N1/37288 , G06F1/06
摘要： This disclosure is directed to the synchronization of clocks of a secondary implantable medical device (IMD) to a clock of a primary IMD. The secondary IMD includes a communications clock. The communications clock may be synchronized based on at least one received communications pulse. The secondary IMD further includes a general purpose clock different than the communications clock. The general purpose clock may be synchronized based on at least one received power pulse. The communications clock may also be synchronized based on the at least one received power pulse.
摘要翻译：本公开涉及二次可植入医疗装置（IMD）的时钟与主IMD的时钟的同步。辅助IMD包括通信时钟。通信时钟可以基于至少一个接收到的通信脉冲来同步。次级IMD还包括与通信时钟不同的通用时钟。可以基于至少一个接收的功率脉冲同步通用时钟。通信时钟也可以基于至少一个接收的功率脉冲来同步。

4. 发明申请

WO2005061044A2 IMPLANTABLE MEDICAL DEVICE COMMUNICATION SYSTEM WITH PULSED POWER BIASING 审中-公开
标题翻译：具有脉冲功率偏置的可植入医疗设备通信系统
公开(公告)号：WO2005061044A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/041872
申请日：2004-12-09
申请人： MEDTRONIC, INC. , REINKE, James, D. , ECKER, Robert, M.
发明人： REINKE, James, D. , ECKER, Robert, M.
IPC分类号： A61N
CPC分类号： A61N1/37252 , A61N1/025 , A61N1/372
摘要： An implantable medical device communication system communicates information between an implantable medical device and at least one slave device by way of a two-wire bus. Slave devices may include remote sensors, actuators and other implantable medical devices. The implantable medical device includes a communication unit to output commands and power pulses, and receive information from the slave devices over the two-wire bus. The implantable medical device and slaves communicate over the bus by selectively changing one of the lines of the bus between a first and second voltage, the second voltage substantially equal to a reference voltage of the second line, e.g., zero volts. In some embodiments, the power pulses take the form of bipolar pulse pairs. The slave device includes a recovery unit to recover power from the power pulses.
摘要翻译：可植入医疗装置通信系统通过两线总线在可植入医疗装置与至少一个从属装置之间传送信息。从设备可以包括远程传感器，致动器和其它可植入医疗设备。可植入医疗装置包括通信单元，用于输出命令和功率脉冲，并通过双线总线从从设备接收信息。可植入医疗装置和从动装置通过在第一和第二电压之间选择性地改变总线线路之一来通过总线通信，第二电压基本上等于第二线路的基准电压，例如零伏特。在一些实施例中，功率脉冲采取双极性脉冲对的形式。从设备包括从功率脉冲恢复功率的恢复单元。

5. 发明申请

WO2004073795A1 IMPEDANCE MEASUREMENT IN IMPLANTED DEVICE 审中-公开
标题翻译：嵌入式设备中的阻抗测量
公开(公告)号：WO2004073795A1
公开(公告)日：2004-09-02
申请号：PCT/US2004/004524
申请日：2004-02-13
申请人： MEDTRONIC INC. , JORGENSON, David, J. , MANRODT, Christopher, M. , ECKER, Robert, M. , MCCLURE, Lawrence, C. , MALMSKOG, Charles, H.
发明人： JORGENSON, David, J. , MANRODT, Christopher, M. , ECKER, Robert, M. , MCCLURE, Lawrence, C. , MALMSKOG, Charles, H.
IPC分类号： A61N1/36
CPC分类号： A61N1/3706 , A61N1/3718 , A61N2001/083
摘要： In an implantable medical device having an electrical lead coupled to tissue of a user and a circuit for measuring the impedance of the lead, a method and apparatus for responding to impedance variations in the lead which includes measuring the impedance of the lead while monitoring physiologic parameters of the user, detecting the presence or absence of electromagnetic interference, and if the impedance of the lead is out-of-range, determining whether the electromagnetic interference exceeds a predetermined value, and if the electromagnetic interference exceeds a predetermined value, administering a therapy to the tissue of the user.
摘要翻译：在具有耦合到用户的组织的电引线和用于测量引线的阻抗的电路的可植入医疗设备中，一种用于响应引线中的阻抗变化的方法和装置，其包括在监测生理参数的同时测量引线的阻抗检测电磁干扰的存在或不存在，并且如果引线的阻抗超出范围，则确定电磁干扰是否超过预定值，并且如果电磁干扰超过预定值，则施用治疗到使用者的纸巾。

6. 发明申请

WO1997035638A1 VERIFICATION OF CAPTURE USING PRESSURE WAVES TRANSMITTED THROUGH A PACING LEAD 审中-公开
标题翻译：使用通过一个PACL引擎传输的压力波检测的验证
公开(公告)号：WO1997035638A1
公开(公告)日：1997-10-02
申请号：PCT/US1997004302
申请日：1997-03-18
申请人： MEDTRONIC INC.
发明人： MEDTRONIC INC. , ECKER, Robert, M. , McCLURE, Lawrence, C. , WAHSTRAND, John, D.
IPC分类号： A61N01/37
CPC分类号： A61N1/3702 , A61N1/36542 , A61N1/36578 , A61N1/3712
摘要： A capture verification system for a cardiac pacemaker comprising an implantable pulse generator (IPG) and one or more pacing leads having a proximal end coupled to the IPG and a distal end in contact with a patient's heart. The capture verification system employs a pressure wave sensor mounted in the IPG in relation to the proximal end of the pacing lead for sensing pressure waves transmitted from the distal end of the pacing lead to the proximal end thereof. The pressure waves include characteristic sounds of heart contraction and/or distal end lead motion caused by the contraction motion of the patient's heart that are transmitted along the lead body to the active sensor. A further isolated, reference sensor is also incorporated into the IPG in a similar fashion. Signal processors are coupled to the pressure wave and reference sensors for nulling out common mode noise.
摘要翻译：一种用于心脏起搏器的捕获验证系统，包括可植入脉冲发生器（IPG）和一个或多个起搏引线，其具有耦合到IPG的近端和与患者心脏接触的远端。捕获验证系统使用安装在IPG中的压力波传感器相对于起搏引线的近端，用于感测从起搏引线的远端传递到其近端的压力波。压力波包括由沿着引导体传递到有源传感器的患者心脏的收缩运动引起的心脏收缩和/或远端引导运动的特征性声音。另一个隔离的参考传感器也以类似的方式并入到IPG中。信号处理器耦合到压力波和参考传感器，以消除共模噪声。

7. 发明申请

WO2013134092A1 VOLTAGE SUPPLY AND METHOD WITH TWO REFERENCES HAVING DIFFERING ACCURACY AND POWER CONSUMPTION 审中-公开
标题翻译：具有两种参考的电压供应和方法具有不同的精度和功耗
公开(公告)号：WO2013134092A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/028810
申请日：2013-03-04
申请人： MEDTRONIC, INC.
发明人： LIANG, Weizheng , GORDON, Charles, R. , TERRY, Michael, B. , TYLER, Larry, E. , REINKE, James, D. , BOND, Matthew, C. , HOSSAIN, Shohan, T. , ECKER, Robert, M.
IPC分类号： G05F3/24 , G05F3/30
CPC分类号： G05F3/02 , G05F3/242 , G05F3/30
摘要： Voltage supply and method having a first reference and a second reference. The first reference has an operation mode configured to supply a first reference voltage at a first accuracy and consume an operation power and a standby mode configured to consume standby power less than the operation power. The second reference is configured to supply a second reference having a second accuracy less than the first accuracy of the first reference and which consumes a second reference power less than the operation power of the first reference, the second reference voltage being trimmable based, at least in part, on a comparison of the first reference voltage to the second reference voltage.
摘要翻译：电压供应和方法具有第一参考和第二参考。第一参考具有被配置为以第一精度提供第一参考电压并且消耗操作功率的操作模式和被配置为消耗小于操作功率的待机功率的待机模式。第二参考被配置为提供具有小于第一参考的第一精度的第二精度并且消耗小于第一参考的操作功率的第二参考功率的第二参考，第二参考电压至少基于可修整部分地，在第一参考电压与第二参考电压的比较中。

8. 发明申请

WO1997035637A1 METHOD AND APPARATUS FOR RATE-RESPONSIVE CARDIAC PACING 审中-公开
标题翻译：方法和装置用于速率反应性心脏病
公开(公告)号：WO1997035637A1
公开(公告)日：1997-10-02
申请号：PCT/US1997004172
申请日：1997-03-14
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , ECKER, Robert, M. , McCLURE, Lawrence, C. , WAHLSTRAND, John, D.
IPC分类号： A61N01/37
CPC分类号： A61N1/36542 , A61N1/3702
摘要： In a pacemaker, a method and apparatus for providing rate in response to the patient's breathing rate or respiratory minute ventilation or contraction strength, optionally augmented by the patient's activity level. An implantable pulse generator (IPG) has one or more pacing leads (18) having a proximal end (40) coupled to the IPG and a distal end in contact with a patient's heart. A pressure wave transducer (32) mounted in the IPG in relation to the proximal end (40) of the pacing lead (18) senses pressure waves transmitted from the distal end of the pacing lead (18) to the proximal end (40) thereof. The pressure waves originate from disturbances imparted to the lead by heart contractions and breathing. A further isolated, reference sensor (34) is also incorporated into the IPG in a similar fashion. An activity signal processor is coupled to the pressure wave or reference sensor (32, 34) for providing a patient activity physiologic signal. A respiration signal processor and a contraction strength signal processor are coupled to said pressure wave and reference transducer providing physiologic respiration rate and/or respiratory minute ventilation signals. A contraction strength signal processor is coupled to said pressure wave and reference transducers (32, 34) for nulling out common mode noise and providing physiologic contraction strength signals. Pacing rate control circuitry is responsive to one or more of the physiologic signals for setting the pacing rate to meet the metabolic demand.
摘要翻译：在起搏器中，用于响应于患者的呼吸频率或呼吸分钟通气或收缩强度提供速率的方法和装置，可选地由患者的活动水平增加。植入式脉冲发生器（IPG）具有一个或多个起搏引线（18），其具有耦合到IPG的近端（40）和与患者心脏接触的远端。相对于起搏引线（18）的近端（40）安装在IPG中的压力波传感器（32）感测从起搏引线（18）的远端传递到其起始端（40）的压力波。压力波起源于通过心脏收缩和呼吸引起的引起的干扰。另一个隔离的参考传感器（34）也以类似的方式结合到IPG中。活动信号处理器耦合到压力波或参考传感器（32,34），用于提供患者活动生理信号。呼吸信号处理器和收缩强度信号处理器耦合到所述压力波和参考换能器，其提供生理呼吸速率和/或呼吸分钟通气信号。收缩强度信号处理器耦合到所述压力波和参考换能器（32,34），用于消除共模噪声并提供生理收缩强度信号。起搏速率控制电路响应一个或多个生理信号以设定起搏速率以满足代谢需求。

9. 发明公开

EP1551501A1 IMPLANTABLE MEDICAL DEVICE COMMUNICATION SYSTEM 有权
标题翻译：数据通信系统的医疗植入设备
公开(公告)号：EP1551501A1
公开(公告)日：2005-07-13
申请号：EP03759432.2
申请日：2003-09-19
申请人： Medtronic, Inc.
发明人： REINKE, James, D. , ECKER, Robert, M.
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/025
摘要： An implantable medical device communication system communicates information between an implantable medical device and at least one slave device by way of a two-wire bus. Slave devices may include remote sensors and other implantable medical devices. The implantable medical device includes a communication unit to combine data and power for transmission over the two-wire bus. The transmitted signal is selectively changeable between a first and second voltage. The slave device includes a recovery unit to recover data and power from the received signal. An extendable command set includes long commands to set up the system and shorter commands to conserve power. Selectively addressable multicast commands, and shortened quick trigger commands conserve power by lowering system current and increasing data throughput.

10. 发明申请

WO2004028627A1 IMPLANTABLE MEDICAL DEVICE COMMUNICATION SYSTEM 审中-公开
标题翻译：可植入医疗设备通信系统
公开(公告)号：WO2004028627A1
公开(公告)日：2004-04-08
申请号：PCT/US2003/029936
申请日：2003-09-19
申请人： MEDTRONIC, INC.
发明人： REINKE, James, D. , ECKER, Robert, M.
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/025
摘要： An implantable medical device communication system communicates information between an implantable medical device and at least one slave device by way of a two-wire bus. Slave devices may include remote sensors and other implantable medical devices. The implantable medical device includes a communication unit to combine data and power for transmission over the two-wire bus. The transmitted signal is selectively changeable between a first and second voltage. The slave device includes a recovery unit to recover data and power from the received signal. An extendable command set includes long commands to set up the system and shorter commands to conserve power. Selectively addressable multicast commands, and shortened quick trigger commands conserve power by lowering system current and increasing data throughput.
摘要翻译：可植入医疗设备通信系统通过双线总线在可植入医疗设备和至少一个从设备之间传递信息。从属设备可能包括远程传感器和其他植入式医疗设备。可植入医疗设备包括通信单元以组合数据和电力以通过双线总线进行传输。传输的信号在第一和第二电压之间可选择性地改变。从设备包括恢复单元，以从接收到的信号中恢复数据和功率。可扩展的命令集包括用于设置系统的长命令和用于节省电源的较短命令。有选择地寻址的多播命令和缩短的快速触发命令通过降低系统电流和提高数据吞吐量来节省功耗。

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