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1. 发明申请

WO2006002275A3 CATHETERS INCORPORATING VALVES AND PERMEABLE MEMBRANES 审中-公开
公开(公告)号：WO2006002275A3
公开(公告)日：2006-01-05
申请号：PCT/US2005/022136
申请日：2005-06-22
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , LENT, Mark, S. , BLANCO, Justin, A.
发明人： HERUTH, Kenneth, T. , LENT, Mark, S. , BLANCO, Justin, A.
IPC分类号： A61M25/00 , A61M5/142
摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes and one or more valves that control flow to the infusion sections.

2. 发明申请

WO2006135766A2 REGIONAL THERAPIES FOR TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的区域治疗
公开(公告)号：WO2006135766A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022519
申请日：2006-06-09
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , LENT, Mark, S. , SINGHAL, Ruchika , SCHENDEL, Michael, J.
发明人： HERUTH, Kenneth, T. , LENT, Mark, S. , SINGHAL, Ruchika , SCHENDEL, Michael, J.
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Systems and methods for coordinated delivery of a therapeutic agent and low (less than about 20 Hz) and high (greater than about 50 Hz)frequency stimulation therapy are described. The systems include a control unit for coordinating therapy delivery between an infusion device and a pulse generator, such that a therapeutic agent is administered at a predetermined time relative to application of either low frequency or high frequency stimulation. For example, the control unit may instruct the infusion device to deliver therapeutic agent at a predetermined time prior to delivery of low frequency stimulation. Systems that include more than one infusion device or an infusion pump capable of delivering more than one therapeutic agent are also described.
摘要翻译：描述了用于协调递送治疗剂和低（小于约20Hz）和高（大于约50Hz）频率刺激疗法的系统和方法。该系统包括用于协调输注装置和脉冲发生器之间的治疗递送的控制单元，使得治疗剂在相对于低频或高频刺激的施加的预定时间被施用。例如，控制单元可以在输送低频刺激之前的预定时间指示输注装置递送治疗剂。还描述了包括多于一个输注装置或能够递送多于一种治疗剂的输液泵的系统。

3. 发明申请

WO2006133443A2 REGIONAL THERAPIES FOR TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的区域治疗
公开(公告)号：WO2006133443A2
公开(公告)日：2006-12-14
申请号：PCT/US2006/022717
申请日：2006-06-09
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , LENT, Mark, S. , SINGHAL, Ruchika , SCHENDEL, Michael, J.
发明人： HERUTH, Kenneth, T. , LENT, Mark, S. , SINGHAL, Ruchika , SCHENDEL, Michael, J.
IPC分类号： A61N1/05 , A61M5/142 , A61K31/485
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.
摘要翻译：描述了治疗疼痛的增强疗法。这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。所述疗法还包括相对于施用高频或低频刺激而在预定时间施用疼痛治疗剂。描述了通过植入式输注系统递送疼痛治疗剂。还讨论了输液装置和脉冲发生器的输出协调以提供协调治疗。

4. 发明申请

WO2005058414A1 ANTIMICROBIAL PROTECTION FOR IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械的抗微生物保护
公开(公告)号：WO2005058414A1
公开(公告)日：2005-06-30
申请号：PCT/US2004/041212
申请日：2004-12-09
申请人： MEDTRONIC, INC. , COBIAN, Kenneth, E. , RIES, Richard, D. , DONOVAN, Maura, G. , SPARER, Randall, V. , SKIME, Robert, M. , SINGHAL, Ruchika , LENT, Mark, S. , HOOPER, William, J. , HOBOT, Christopher, M. , HERUTH, Kenneth, T.
发明人： COBIAN, Kenneth, E. , RIES, Richard, D. , DONOVAN, Maura, G. , SPARER, Randall, V. , SKIME, Robert, M. , SINGHAL, Ruchika , LENT, Mark, S. , HOOPER, William, J. , HOBOT, Christopher, M. , HERUTH, Kenneth, T.
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/406 , A61N1/3605
摘要： An anti-infective covering for an implantable medical device is described. The covering may be a polymeric boot that comprises an anti-infective agent in an amount effective to prevent an infection when implanted in a pocket of a patient. The boot is configured to snuggly engage at least a portion of the implantable medical device. The boot may contain a side hole that allows a housing of the implantable medical device to serve as a return electrode. The boot may be placed about the implantable medical device to render the device anti-infective.
摘要翻译：描述了用于可植入医疗装置的抗感染覆盖物。覆盖物可以是聚合物护套，其包含有效防止植入患者口袋时感染的抗感染剂。靴子被配置成紧密接合可植入医疗装置的至少一部分。靴子可以包含允许可植入医疗装置的壳体用作返回电极的侧孔。引导可以围绕可植入医疗装置放置以使装置抗感染。

5. 发明申请

WO2006135792A1 REGIONAL THERAPIES FOR TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的区域治疗
公开(公告)号：WO2006135792A1
公开(公告)日：2006-12-21
申请号：PCT/US2006/022566
申请日：2006-06-09
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , LENT, Mark, S. , SCHENDEL, Michael, J. , KING, Gary, W. , SINGHAL, Ruchika
发明人： HERUTH, Kenneth, T. , LENT, Mark, S. , SCHENDEL, Michael, J. , KING, Gary, W. , SINGHAL, Ruchika
IPC分类号： A61N1/34
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.
摘要翻译：描述了治疗疼痛的增强疗法。这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。皮下刺激可以应用在背部的结构附近，例如盘，小关节，神经根或神经节，交感神经链，韧带，肌肉等。还描述了与硬膜外刺激组合施加的高频和低频下的皮下刺激。

6. 发明申请

WO2006029301A3 METHOD OF MANUFACTURING DRUG-ELUTING MEDICAL DEVICE 审中-公开
公开(公告)号：WO2006029301A3
公开(公告)日：2006-03-16
申请号：PCT/US2005/032127
申请日：2005-09-08
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , KOULLICK, Edouard , LENT, Mark, S.
发明人： HERUTH, Kenneth, T. , KOULLICK, Edouard , LENT, Mark, S.
IPC分类号： A61L31/00
摘要： Methods for manufacturing medical devices comprising a polymeric material capable of releasing a therapeutic agent upon contact with bodily tissue or fluid are described. The method includes generating polymeric material having a matrix into or onto which a therapeutic agent is disposed and having pores. The method further includes disposing additional therapeutic agent into the pores of the polymeric material.

7. 发明申请

WO2006023859A1 MEDICAL DEVICE WITH TISSUE-DEPENDENT DRUG ELUTION 审中-公开
标题翻译：具有组织依赖性药物溶液的医疗装置
公开(公告)号：WO2006023859A1
公开(公告)日：2006-03-02
申请号：PCT/US2005/029805
申请日：2005-08-22
申请人： MEDTRONIC, INC. , LENT, Mark, S. , HERUTH, Kenneth, T.
发明人： LENT, Mark, S. , HERUTH, Kenneth, T.
IPC分类号： A61M5/142 , A61N1/36 , A61L29/16 , A61L31/16 , A61L27/54
CPC分类号： A61L31/10 , A61K9/0024 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61L2300/61 , A61M37/00 , A61M2025/0057 , A61N1/0534 , A61N1/0536 , A61N1/0551 , A61N1/36071
摘要： Medical devices configured to be implanted in two or more tissues simultaneously are discussed. A therapeutic agent is disposed on, in, or about at least a portion of an external surface of a medical device configured to be placed in one tissue, but not on, in or about a surface configured to be placed in another tissue. The therapeutic agent may be disposed on or in a polymeric material, which is disposed on or about at least a portion of an external surface of first portion the medical device. Such targeted placement of polymeric material may allow for the therapeutic agent to be eluted in an appropriate tissue and may allow for decreased undesired effects.
摘要翻译：讨论了被配置为同时植入在两个或更多个组织中的医疗装置。治疗剂设置在医疗器械的外表面的至少一部分上，或者围绕配置成放置在一个组织中但不在其上或周围的构造成放置在另一组织中的表面。治疗剂可以设置在聚合物材料上或聚合物材料中，聚合物材料设置在医疗装置的第一部分的外表面的至少一部分上或周围。聚合材料的这种靶向放置可允许治疗剂在合适的组织中洗脱并且可以减少不期望的效果。

8. 发明申请

WO2005061003A1 ANTI-INFECTIVE MEDICAL DEVICE 审中-公开
标题翻译：抗感染医疗器械
公开(公告)号：WO2005061003A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/041049
申请日：2004-12-09
申请人： MEDTRONIC, INC. , COBIAN, Kenneth, E. , RIES, Richard, D. , DONOVAN, Maura, G. , SPARER, Randall, V. , SKIME, Robert, M. , SINGHAL, Ruchika , LENT, Mark, S. , HOOPER, William, J. , HOBOT, Christopher, M. , HERUTH, Kenneth, T. , BERTRAND, William, J.
发明人： COBIAN, Kenneth, E. , RIES, Richard, D. , DONOVAN, Maura, G. , SPARER, Randall, V. , SKIME, Robert, M. , SINGHAL, Ruchika , LENT, Mark, S. , HOOPER, William, J. , HOBOT, Christopher, M. , HERUTH, Kenneth, T. , BERTRAND, William, J.
IPC分类号： A61K47/30
CPC分类号： A61K31/65 , A61L29/16 , A61L31/16 , A61L2300/21 , A61L2300/406 , A61L2300/604 , A61L2300/802
摘要： Implantable medical devices (IMDs) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
摘要翻译：描述具有抗感染性的植入式医疗装置（IMD）。抗感染剂设置在医疗装置的表面的至少一部分上，或者其周围。抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性抗感染剂会发展。

9. 发明申请

WO2009137119A1 PERIPHERAL NERVE FIELD STIMULATION CONTROL 审中-公开
标题翻译：外周神经网络刺激控制
公开(公告)号：WO2009137119A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/031852
申请日：2009-01-23
申请人： MEDTRONIC, INC. , KING, Gary, W. , GOETZ, Steven, M. , HOUCHINS, Andrew, H. , KEACHER, Jeffrey, T. , GREENBERG, Jordan, J. , HERUTH, Kenneth, T. , LENT, Mark, S. , WACNIK, Paul, W.
发明人： KING, Gary, W. , GOETZ, Steven, M. , HOUCHINS, Andrew, H. , KEACHER, Jeffrey, T. , GREENBERG, Jordan, J. , HERUTH, Kenneth, T. , LENT, Mark, S. , WACNIK, Paul, W.
IPC分类号： A61N1/34
CPC分类号： A61N1/36139 , A61N1/36057 , A61N1/36071
摘要： Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.
摘要翻译：可以基于PNFS的检测到的生理效应来控制外周神经区域刺激（PNFS），这可能是对PNFS的传出响应。在一些示例中，闭环治疗系统可以包括感测患者的生理参数的感测模块，其可以指示患者对PNFS的反应。基于由感测模块产生的信号，可以激活，去激活或修改PNFS。患者的生理参数示例包括患者身体的心率，呼吸频率，皮肤活动，肌肉活动，血流速度，汗腺活动，引导运动反射或热活动。在一些示例中，可以基于由感测模块生成的信号来检测患者疼痛状态，并且可以基于疼痛状态的检测来控制治疗。

10. 发明申请

WO2005036502A2 THREE-DIMENSIONAL IN-VITRO SPINAL MODELS AND METHODS OF ANALYZING SUBSTANCE DISTRIBUTION THEREIN 审中-公开
标题翻译：三维体内脊髓模型和分析其中物质分布的方法
公开(公告)号：WO2005036502A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/032642
申请日：2004-10-01
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , LENT, Mark, S. , HEGLAND, Michael
发明人： HERUTH, Kenneth, T. , LENT, Mark, S. , HEGLAND, Michael
IPC分类号： G09B23/28
CPC分类号： G09B23/34 , B33Y50/00 , B33Y80/00 , G09B23/30
摘要： An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure of an adult human spinal canal. Also included is a cord structure that may be located and anchored within the passageway. The cord structure substantially mimics the size, shape, and structure of an adult human spinal cord. For example, the cord structure may include connecting elements that resemble nerve roots, dentate ligaments, and the septum posticurn of a human spine. The passageway of the model apparatus may be filled with a first fluid that simulates cerebro-spinal fluid (CSF), and a second fluid containing a drug (or simulated drug) may be introduced into the passageway, after which the drug's distribution within the passageway may be analyzed.
摘要翻译：人体脊柱的体外模型装置和用于检测和分析其中的物质分布模式的方法在一个实施例中，模型设备包括限定通道的柱体，该通道基本上模仿成人椎管的尺寸，形状和结构。还包括可以定位并锚定在通道内的绳索结构。绳结构基本上模仿成人脊髓的尺寸，形状和结构。例如，绳结构可以包括类似于神经根，齿状韧带和人体脊柱的间隔的连接元件。模型设备的通道可以填充模拟脑脊髓液（CSF）的第一流体，并且可以将含有药物（或模拟药物）的第二流体引入通道中，之后药物在通道内分布可能会被分析。

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