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1. 发明申请

WO2009134479A1 THERAPY PROGRAM MODIFICATION BASED ON AN ENERGY THRESHOLD 审中-公开
标题翻译：基于能量阈值的治疗方案修改
公开(公告)号：WO2009134479A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/031965
申请日：2009-01-26
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： A61N1/372 , G06F19/00 , A61M5/142 , A61N1/34 , A61N1/36
CPC分类号： A61N1/36185 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61N1/36514 , A61N1/37264 , G06F19/00 , G06F19/3481
摘要： A therapy program is modified to decompose a therapy field generated by therapy delivery by a medical device according to a therapy program into a plurality of subfields based on a comparison between an energy associated with the therapy program and a threshold value. The therapy field defined by the therapy program may be decomposed into a plurality of subfields when an electrical stimulation energy of the stimulation signal defined by the therapy program exceeds the maximum energy output of the medical device or of a channel of the medical device. Therapy subprograms may be generated for each of the therapy subfields. An energy associated with each of the therapy subfields may be less than the energy threshold value of the medical device.
摘要翻译：基于与治疗程序相关联的能量与阈值之间的比较，修改治疗程序以将通过治疗程序的医疗装置的治疗传递产生的治疗场分解成多个子场。当治疗程序定义的刺激信号的电刺激能量超过医疗装置或医疗装置的通道的最大能量输出时，治疗程序定义的治疗领域可以被分解成多个子场。可以为每个治疗子区域产生治疗子程序。与每个治疗子场相关联的能量可以小于医疗装置的能量阈值。

2. 发明申请

WO2009134477A1 THERAPY PROGRAM MODIFICATION 审中-公开
标题翻译：治疗方案修改
公开(公告)号：WO2009134477A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/031801
申请日：2009-01-23
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： A61N1/08 , A61N1/36 , A61N1/34
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/36007
摘要： A therapy program may be generated based on an algorithmic model of a baseline therapy field, which may represent a therapy field resulting from therapy delivery via the first therapy system based on a first therapy program. A second therapy program that controls therapy delivery by a second therapy system may be generated based on the baseline therapy field model. For example, therapy parameter values of the second therapy program may be selected to maintain at least one field characteristic of the baseline therapy field model. In some examples, the second therapy system may result from a hardware modification to the first therapy system. In other examples, the first and second therapy systems may be associated with different patients. For example, the baseline therapy field model may be an efficacious therapy field for a patient class, and a second therapy program may be generated for a patient in the class.
摘要翻译：可以基于基线治疗领域的算法模型来产生治疗程序，其可以代表由基于第一治疗程序的经由第一治疗系统的治疗递送产生的治疗领域。可以基于基线治疗场模型来产生控制第二疗法系统治疗传递的第二疗法程序。例如，可以选择第二治疗程序的治疗参数值以保持基线治疗场模型的至少一个场特征。在一些示例中，第二治疗系统可能由对第一治疗系统的硬件修改而产生。在其他实施例中，第一和第二治疗系统可以与不同的患者相关联。例如，基线治疗场模型可以是患者类别的有效治疗领域，并且可以为该类别中的患者生成第二治疗程序。

3. 发明申请

WO2008150589A1 AUTOMATIC VOIDING DIARY 审中-公开
标题翻译：自动灭火器
公开(公告)号：WO2008150589A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/061500
申请日：2008-04-25
申请人： MEDTRONIC, INC. , GERBER, Martin, T. , RONDONI, John, C.
发明人： GERBER, Martin, T. , RONDONI, John, C.
IPC分类号： A61B7/00 , A61B5/20
CPC分类号： H04R5/023 , A61B5/0031 , A61B5/14507 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/6846 , A61B7/008 , A61F13/42 , A61N1/36007 , A61N1/37211
摘要： A device that may be used as an automatic voiding diary detects urinary and/or fecal voiding events and records voiding information indicative of the voiding events without the need for significant patient interaction. The device includes a microphone that captures internal and/or external sounds that are associated with voiding events and generates an electrical signal based the sounds. The device processes the electrical signal to determine whether the signal is indicative of the occurrence of a voiding event (i.e., the device detects voiding events) by, for example, comparing the electrical signal to a signal template or comparing an amplitude of the signal to a threshold. The device may be a device implanted within the patient or an external device that can be carried or attached to the body or clothing of the patient.
摘要翻译：可用作自动排尿日记的装置检测尿和/或粪便排泄事件并且记录指示排尿事件的排泄信息，而不需要显着的患者相互作用。该装置包括麦克风，其捕获与排尿事件相关联的内部和/或外部声音，并基于声音产生电信号。该装置处理电信号以确定该信号是否指示通过例如将电信号与信号模板进行比较或将信号的幅度与一个门槛。该装置可以是植入患者体内的装置或可携带或附接到患者身体或衣服的外部装置。

4. 发明申请

WO2007127460A2 TREE-BASED ELECTRICAL STIMULATOR PROGRAMMING 审中-公开
标题翻译：基于树的电刺激编程
公开(公告)号：WO2007127460A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010398
申请日：2007-04-30
申请人： MEDTRONIC, INC. , GERBER, Martin, T. , RONDONI, John, C.
发明人： GERBER, Martin, T. , RONDONI, John, C.
CPC分类号： A61N1/36071 , A61N1/37247 , G06F19/00
摘要： The disclosure describes an implantable stimulation system that guides programming with a therapeutic tree. All possible stimulation parameters are arranged on the therapeutic tree, with each level of the therapeutic tree containing a different stimulation parameter type. Each level includes nodes that are connected to nodes of adjacent levels. A program path is created by moving through nodes of lower levels. The stimulation parameter types are arranged so that coarse adjustments occur at higher levels of the tree and fine adjustments occur at lower levels of the tree. The nodes of the program path define the stimulation parameters of the delivered stimulation therapy. Performance feedback may be used by the system to evaluate nodes of the therapeutic tree and define the program path. The performance feedback may include beneficial effects, adverse effects, and system performance related to the stimulation therapy. Additionally, one or more sensors may provide the performance feedback.
摘要翻译：本公开描述了一种用治疗树指导编程的可植入刺激系统。所有可能的刺激参数被布置在治疗树上，治疗树的每个水平含有不同的刺激参数类型。每个级别包括连接到相邻级别的节点的节点。通过移动较低级别的节点创建程序路径。刺激参数类型被布置为使得在较高级别的树上进行粗调，并且在较低级别处发生精细调整。节目路径的节点定义了递送的刺激疗法的刺激参数。系统可以使用性能反馈来评估治疗树的节点并定义程序路径。性能反馈可以包括与刺激疗法相关的有益效果，不利影响和系统性能。另外，一个或多个传感器可以提供性能反馈。

5. 发明申请

WO2009134475A1 THERAPY PROGRAM MODIFICATION BASED ON A THERAPY FIELD MODEL 审中-公开
标题翻译：基于治疗场模型的治疗方案修改
公开(公告)号：WO2009134475A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/031650
申请日：2009-01-22
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： A61N1/372 , G06F19/00
CPC分类号： A61M5/1723 , A61M5/14276 , A61M2205/054 , A61M2210/0693 , A61N1/36003 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/37235 , A61N1/37247 , A61N1/37264 , G06F19/00 , G16H40/63 , G16H50/50
摘要： Techniques for modeling therapy fields for therapy delivered by medical devices are described. Each therapy field model is based on a set of therapy parameters and represents where therapy will propagate from the therapy system delivering therapy according to the set of therapy parameters. Therapy field models may be useful in guiding the modification of therapy parameters. As one example, a processor compares an algorithmic model of a therapy field to a reference therapy field and adjusts at least one therapy parameter based on the comparison. As another example, a processor adjusts at least one therapy parameter to increase an operating efficiency of the therapy system while substantially maintaining the modeled therapy field.
摘要翻译：描述了医疗器械治疗治疗领域的建模技术。每个治疗领域模型基于一组治疗参数，并且表示治疗将根据治疗参数集合递送疗法的治疗系统传播的地方。治疗领域模型可能有助于指导治疗参数的修改。作为一个示例，处理器将治疗领域的算法模型与参考治疗领域进行比较，并且基于该比较来调整至少一个治疗参数。作为另一示例，处理器调整至少一个治疗参数以增加治疗系统的操作效率，同时基本上维持建模的治疗领域。

6. 发明申请

WO2007130239A1 EXTERNAL VOIDING SENSOR SYSTEM 审中-公开
标题翻译：外部无声传感器系统
公开(公告)号：WO2007130239A1
公开(公告)日：2007-11-15
申请号：PCT/US2007/007834
申请日：2007-03-29
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： A61B5/20 , A61F13/42
CPC分类号： A61B5/6808 , A61B5/01 , A61B5/202 , A61F13/42
摘要： The disclosure describes an absorbent pad worn by a patient that measures one or more urinary voiding parameters. One or more sensors that measure voiding parameters are integrally formed with the pad, e.g., interwoven with the absorbent pad material or positioned to form one or more sensor layers between layers of absorbent material. The sensors store measured parameters as information in a memory, e.g., as a log, locally or in a separate device. In some embodiments, the pad includes an electrical stimulator that provides stimulation therapy for urinary incontinence based on measured parameters.
摘要翻译：本公开描述了由患者佩戴的测量一个或多个排尿参数的吸收垫。测量空隙参数的一个或多个传感器与垫整体形成，例如与吸收垫材料交织或定位成在吸收材料层之间形成一个或多个传感器层。传感器将测量参数作为信息存储在存储器中，例如作为日志在本地或在单独的设备中存储。在一些实施例中，垫包括电刺激器，其基于测量的参数提供针对尿失禁的刺激治疗。

7. 发明申请

WO2007130173A1 PATIENT-INDIVIDUALIZED EFFICACY RATING 审中-公开
标题翻译：患者个性化效能评分
公开(公告)号：WO2007130173A1
公开(公告)日：2007-11-15
申请号：PCT/US2007/001940
申请日：2007-01-25
申请人： MEDTRONIC, INC. , GERBER, Martin, T. , RONDONI, John, C.
发明人： GERBER, Martin, T. , RONDONI, John, C.
IPC分类号： A61N1/372 , G06F19/00
CPC分类号： A61N1/37247 , G16H50/50
摘要： The disclosure is directed to techniques for providing a patient- individualized efficacy rating. Different stimulation parameters impact efficacy. For example, efficacy may be a function of parameters such as electrode combination, stimulation amplitude, pulse width, and pulse rate. Efficacy may vary from patient-to-patient. For example, efficacy may vary according to age, gender, physiology, disease state, activity level, or activity profile. Comparable stimulation programs may provide' different efficacy levels for different patients, according to patient characteristics or desires. Patients may rank efficacy parameters differently. The efficacy parameters may include desirable therapeutic effects and undesirable side effects. For one patient, optimization of a particular efficacy parameter may be the paramount concern. Other patients may be willing to compromise the outcome of the same parameter in favor of better outcomes with other efficacy parameters. A patient-individualized efficacy rating permits a patient and clinician to customize efficacy evaluation according to the patient's condition or needs.
摘要翻译：本公开涉及用于提供患者个体化功效评级的技术。不同刺激参数影响疗效。例如，功效可以是诸如电极组合，刺激幅度，脉冲宽度和脉率之类的参数的函数。疗效可能因患者而异。例如，功效可以根据年龄，性别，生理，疾病状态，活动水平或活动情况而变化。可比较的刺激方案可以根据患者的特征或欲望为不同的患者提供不同的功效水平。患者可以不同地对功效参数进行排序。功效参数可以包括期望的治疗效果和不期望的副作用。对于一个患者，特定功效参数的优化可能是至关重要的。其他患者可能愿意危及相同参数的结果，有利于其他功效参数的更好结局。患者个性化的功效评级允许患者和临床医生根据患者的状况或需要定制功效评估。

8. 发明申请

WO2007127455A2 TREE-BASED ELECTRICAL STIMULATOR PROGRAMMING FOR PAIN THERAPY 审中-公开
标题翻译：用于疼痛治疗的基于TREE的电刺激器编程
公开(公告)号：WO2007127455A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010381
申请日：2007-04-30
申请人： MEDTRONIC, INC. , GERBER, Martin, T. , RONDONI, John, C.
发明人： GERBER, Martin, T. , RONDONI, John, C.
CPC分类号： A61N1/36071 , A61N1/37247 , G06F19/00
摘要： The disclosure describes an implantable stimulation system that guides programming with a therapeutic tree. All possible stimulation parameters are arranged on the therapeutic tree, with each level of the therapeutic tree containing a different stimulation parameter type. Each level includes nodes that are connected to nodes of adjacent levels. A program path is created by moving through nodes of lower levels. The stimulation parameter types are arranged so that coarse adjustments occur at higher levels of the tree and fine adjustments occur at lower levels of the tree. The nodes of the program path define the stimulation parameters of the delivered stimulation therapy. The user may provide information such as efficacy input and/or medication dosage information to the system for identifying the most efficacious program path in treating pain of the patient. Additionally or alternatively, efficacy feedback may be received from physiological parameter sensors.
摘要翻译：本公开描述了一种用治疗树引导编程的可植入刺激系统。所有可能的刺激参数被布置在治疗树上，治疗树的每个水平含有不同的刺激参数类型。每个级别包括连接到相邻级别的节点的节点。通过移动较低级别的节点创建程序路径。刺激参数类型被布置为使得在较高级别的树上进行粗调，并且在较低级别处发生精细调整。程序路径的节点定义了递送的刺激疗法的刺激参数。用户可以向系统提供诸如功效输入和/或药物剂量信息的信息，以识别治疗患者疼痛的最有效的程序路径。附加地或替代地，可以从生理参数传感器接收功效反馈。

9. 发明申请

WO2009134480A1 THERAPY PROGRAM MODIFICATION BASED ON AN ENERGY THRESHOLD 审中-公开
标题翻译：基于能量阈值的治疗方案修改
公开(公告)号：WO2009134480A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/031967
申请日：2009-01-26
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： G06F19/00 , A61N1/372 , A61M5/142 , A61N1/34 , A61N1/36
CPC分类号： A61N1/37264 , A61M5/14276 , A61N1/36017 , A61N1/36021 , A61N1/36071 , A61N1/36146 , A61N1/37247
摘要： A therapy program is modified to decompose an electrical stimulation signal defined by the therapy program into a plurality of subsignals based on a comparison between an energy associated with the stimulation signal and a threshold value. An electrical stimulation signal defined by a therapy program may be decomposed into a plurality of subsignals when an electrical stimulation energy of the stimulation signal exceeds the maximum energy output of the medical device or of a channel of the medical device. The energy associated with each one of the subsignals may be less than the energy threshold value of the medical device.
摘要翻译：基于与刺激信号相关联的能量与阈值之间的比较，修改治疗程序以将由治疗程序定义的电刺激信号分解成多个子信号。当刺激信号的电刺激能量超过医疗设备或医疗设备的通道的最大能量输出时，由治疗程序定义的电刺激信号可以被分解成多个子信号。与每个子信号相关联的能量可以小于医疗装置的能量阈值。

10. 发明申请

WO2009134478A1 THERAPY PROGRAM MODIFICATION 审中-公开
标题翻译：治疗方案修改
公开(公告)号：WO2009134478A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/031806
申请日：2009-01-23
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： A61N1/37 , A61N1/372 , A61N1/34 , A61N1/36
CPC分类号： A61N1/37 , A61N1/36071 , A61N1/37247 , G06F19/00
摘要： A therapy program may be modified based on information indicative of a change in a therapy field, which may represent a region of a patient's tissue to which therapy is delivered. Upon receiving information indicative of a therapy field change, an algorithmic model of a present therapy field may be generated and compared to an algorithmic model of a baseline therapy field, which indicates a therapy field that provides efficacious therapy to the patient. If a characteristic of the present therapy field differs from the baseline therapy field model, the current therapy program may be modified. In another example, upon receiving information indicative of a therapy field change, the current therapy program may be modified, and an algorithmic model of a therapy field based on the modified therapy program may be compared to a baseline therapy field model to determine whether the modified therapy program is a suitable alternative.
摘要翻译：可以基于指示治疗领域的变化的信息来修改治疗程序，其可以代表递送治疗的患者组织的区域。在接收到指示治疗场变化的信息时，可以产生当前治疗领域的算法模型，并将其与基线治疗领域的算法模型进行比较，其指示向患者提供有效治疗的治疗领域。如果本治疗领域的特征与基线治疗场模型不同，则可以修改当前的治疗程序。在另一示例中，当接收到指示治疗场变化的信息时，可以修改当前治疗程序，并且可以将基于修改的治疗程序的治疗领域的算法模型与基线治疗场模型进行比较，以确定是否修改治疗方案是一种合适的替代方案。

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