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1. 发明申请

WO1998026839A1 METHOD AND APPARATUS FOR DIAGNOSIS AND TREATMENT OF ARRHYTHMIAS 审中-公开
标题翻译： ARRHYTHMIAS诊断和治疗方法与装置
公开(公告)号：WO1998026839A1
公开(公告)日：1998-06-25
申请号：PCT/US1997023323
申请日：1997-12-16
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , PETERSON, David, K. , JIRAK, Thomas, L. , ZHOU, Ren , HILL, Michael, R., S.
IPC分类号： A61N01/368
CPC分类号： A61N1/3622 , A61N1/3688
摘要： A pacemaker provided with a mode switching feature adapted to stabilize ventricular heart rate during atrial fibrillation. In a preferred embodiment of the invention, the device nominally operates in an atrial synchronized pacing mode such as DDD, DDDR, VDD or VDDR. In response to detection of atrial rhythm characteristics consistent with atrial fibrillation, the device switches into a non-atrial synchronized, ventricular rate stabilization pacing mode with the base ventricular pacing rate modulated on a beat by beat basis based upon preceding intrinsic or paced ventricular heartbeat intervals to adjust the pacing interval towards a desired preset rate stabilization target pacing interval which is typically less than the programmed base pacing interval of the device. While the ventricular rate stabilization mode is in effect, the current pacing interval is set equal to the preceding intrinsic or paced interval, with an increment if the preceding interval is less than the desired or target pacing interval, as typically will be the case, or with a decrement if the preceding interval is greater than the desired pacing interval. In a preferred embodiment of the invention, the device paces both the atria and ventricles in a DDI rate stabilization pacing mode with the ventricular pacing interval being modulated.
摘要翻译：心脏起搏器配有模式切换功能，适用于在心房颤动期间稳定心室心率。在本发明的优选实施例中，该装置名义上以心房同步起搏模式（例如DDD，DDDR，VDD或VDDR）操作。为了响应与心房颤动一致的心房节律特征的检测，该装置转换成非心房同步的心室速率稳定起搏模式，其基本心室起搏速度基于先前的固有或起搏心室心跳间隔以搏动为基础进行调整以将起搏间隔调整到期望的预设速率稳定化目标起搏间隔，其通常小于设备的编程的基本起搏间隔。当心室速率稳定模式有效时，将当前起搏间隔设置为等于前一个固有或起搏间隔，如果前一个间隔小于期望的或目标起搏间隔，则增量，如通常情况，或如果前一个间隔大于所需的起搏间隔，则递减。在本发明的优选实施例中，该装置以调节心室起搏间隔的DDI速率稳定起搏模式对心房和心室起搏。

2. 发明申请

WO1994016768A1 METHOD AND APPARATUS FOR DETECTION AND TREATMENT OF TACHYCARDIA AND FIBRILLATION 审中-公开
标题翻译：用于检测和处理TACHYCARDIA和FIBRILLATION的方法和装置
公开(公告)号：WO1994016768A1
公开(公告)日：1994-08-04
申请号：PCT/US1993012230
申请日：1993-12-15
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , OLSON, Walter, H. , PETERSON, David, K.
IPC分类号： A61N01/365
CPC分类号： A61N1/3621 , A61N1/3962
摘要： An apparatus for detecting, identifying and treating tachyarrhythmias. Tachyarrhythmias are detected and identified by the use of overlapping ranges of intervals. Provisional identification of tachyarrhythmia is accomplished by measuring and tracking intervals within two overlapping or adjacent interval ranges. Further classification and identification of tachyarrhythmias is accomplished by determining the relative numbers of intervals within a preceding series falling within a third interval range, overlapping one or both of the interval ranges. In response to identification of the tachyarrhythmia, an appropriate therapy is selected and delivered.
摘要翻译：一种用于检测，识别和治疗快速性心律失常的装置。通过使用重叠的间隔范围来检测和鉴定快速性心律失常。通过测量和跟踪两个重叠或相邻间隔范围内的间隔来实现快速性心律失常的临床鉴定。快速性心律失常的进一步分类和识别是通过确定前一系列中间隔在第三区间范围内的间隔的相对数量来实现的，该间隔与间隔范围中的一个或两个重叠。响应于快速性心律失常的鉴定，选择并递送适当的治疗。

3. 发明申请

WO1998025670A1 METHOD AND APPARATUS FOR DIAGNOSIS AND TREATMENT OF ARRHYTHMIAS 审中-公开
标题翻译： ARRHYTHMIAS诊断和治疗方法与装置
公开(公告)号：WO1998025670A1
公开(公告)日：1998-06-18
申请号：PCT/US1997023061
申请日：1997-12-10
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , PETERSON, David, K. , HILL, Michael, R., S. , ZHOU, Ren , PRIEVE, Kathleen, A.
IPC分类号： A61N01/368
CPC分类号： A61N1/3962 , A61N1/3622
摘要： An implantable pacemaker employing an arrhythmia prevention pacing modality particularly optimized for inclusion in dual chamber pacemakers and anti-arrhythmia devices which include dual chamber pacemakers. When the pacing mode is in effect, the device alters timing of scheduled atrial and/or ventricular pacing pulses in response to depolarizations sensed during the refractory periods and to ventricular depolarizations sensed outside of the pacemaker's A-V escape intervals. The arrhythmia prevention pacing mode is activated and deactivated in conjunction with the operation of arrhythmia detection features which may also be employed by the device to trigger delivery of anti-arrhythmia therapies.
摘要翻译：采用心律不齐预防起搏模式的植入式起搏器，其特别优化包括在双室起搏器和包括双室起搏器的抗心律失常装置中。当起搏模式有效时，设备响应于在不应期期间感测到的去极化以及在起搏器的A-V逃逸间隔之外感测到的心室去极化来改变调度的心房和/或心室起搏脉冲的时间。心律失常预防起搏模式与心律失常检测特征的操作一起被激活和失活，该功能也可以由该装置用于触发抗心律失常治疗的递送。

4. 发明公开

EP0618823A1 METHOD AND APPARATUS FOR TERMINATION OF VENTRICULAR ARRHYTHMIAS 失效
标题翻译：方法和设备的麻烦室性心律失常。
公开(公告)号：EP0618823A1
公开(公告)日：1994-10-12
申请号：EP92924195.0
申请日：1992-10-30
申请人： MEDTRONIC, INC.
发明人： BERG, Gary, L. , ROSSING, Martin, A. , PETERSON, David, K. , NEUMAN, Robert, A.
IPC分类号： A61N1
CPC分类号： A61N1/3931 , A61N1/3918 , A61N2001/083
摘要： L'invention concerne un défibrillateur implantable doté d'une pluralité d'électrodes de défibrillation (500, 502, 504, 506, 508, 510) qui peuvent être reformées par une matrice de commutation (512) afin de définir une pluralité de passages de défibrillation. Le dispositif peut mesurer l'impédance le long d'un passage sélectionné de défibrillation, lors de l'émission d'une impulsion d'impédance, et il peut surveiller si l'impulsion permet ou non de réaliser la défibrillation ou la cardioversion. Lorsqu'une défaillance à réaliser la cardioversion a été détectée conjointement à un changement mesuré d'impédance supérieur à une quantité prédéterminée, un nouveau passage de défibrillation est sélectionné et peut utiliser certaines ou toutes les électrodes employés pour définir le passage d'impédance original. Le dispositif peut comporter également des appareils (524, 554, 550) pour varier l'amplitude relative des impulsions de défibrillation appliquées à des électrodes individuelles utilisées en régimes séquentiels ou simultanés à impulsions d'électrodes multiples afin d'égaliser la répartition du courant par rapport aux impédances de passages mesurées.

5. 发明申请

WO1993009844A1 METHOD AND APPARATUS FOR TERMINATION OF VENTRICULAR ARRHYTHMIAS 审中-公开
标题翻译：用于终止静脉曲张的方法和装置
公开(公告)号：WO1993009844A1
公开(公告)日：1993-05-27
申请号：PCT/US1992009368
申请日：1992-10-30
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , BERG, Gary, L. , ROSSING, Martin, A. , PETERSON, David, K. , NEUMAN, Robert, A.
IPC分类号： A61N01/39
CPC分类号： A61N1/3931 , A61N1/3918 , A61N2001/083
摘要： An implantable defibrillator provided with a plurality of defibrillation electrodes (500, 502, 504, 506, 508, 510), which may be reconfigured by a switch matrix (512) to define a plurality of defibrillation pathways. The device is capable of measuring the impedance along a selected defibrillation pathway, during delivery of an impedance pulse, and monitoring the success or failure of the pulse to accomplish defibrillation or cardioversion. In response to a detected failure to accomplish cardioversion in conjunction with a measured change of impedance of greater than a predetermined amount, a new defibrillation pathway is selected, which may employ some or all of the electrodes employed to define the original impedance pathway. The device also includes apparatus (524, 554, 550) for varying the relative amplitude of defibrillation pulses applied to individual electrodes used in sequential or simultaneous, multiple electrode pulse regimens, in order to equalize current distribution, in response to measured pathway impedances.

6. 发明申请

WO1993003791A1 DISCRIMINATION OF VENTRICULAR TACHYCARDIA FROM VENTRICULAR FIBRILLATION 审中-公开
标题翻译：从心室颤动中辨认心室TACHYCARDIA
公开(公告)号：WO1993003791A1
公开(公告)日：1993-03-04
申请号：PCT/US1992006541
申请日：1992-08-06
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , BARDY, Gust, H. , OLSEN, Walter, H. , PETERSON, David, K. , TAEPKE, Robert, T.
IPC分类号： A61N01/39
CPC分类号： A61N1/3621 , A61N1/365 , A61N1/3962
摘要： An implantable cardioverter/defibrillator provided with two pairs of electrodes (500-502, 504-510), the second pair being selected by a switch matrix (512), each pair of electrodes coupled to processing circuitry (514-518, 530-534) for identifying a predetermined fiducial point in the electrical signal associated with a ventricular depolarization. The cumulative beat to beat variability of the intervals separating the two identified fiducial points, over a series of detected polarizations is analyzed (524-528). The result of this analysis is used to distinguish between ventricular tachycardia and ventricular fibrillation and to activate appropriate treatment equipment (522, 548-558).

7. 发明公开

EP1015073A1 METHOD AND APPARATUS FOR DIAGNOSIS AND TREATMENT OF ARRHYTHMIAS 失效
标题翻译：方法和设备的诊断和治疗VONARRHYTMIEN
公开(公告)号：EP1015073A1
公开(公告)日：2000-07-05
申请号：EP97952442.8
申请日：1997-12-10
申请人： MEDTRONIC, INC.
发明人： PETERSON, David, K. , HILL, Michael, R., S. , ZHOU, Ren , PRIEVE, Kathleen, A.
IPC分类号： A61N1/368
CPC分类号： A61N1/3962 , A61N1/3622
摘要： An implantable pacemaker employing an arrhythmia prevention pacing modality particularly optimized for inclusion in dual chamber pacemakers and anti-arrhythmia devices which include dual chamber pacemakers. When the pacing mode is in effect, the device alters timing of scheduled atrial and/or ventricular pacing pulses in response to depolarizations sensed during the refractory periods and to ventricular depolarizations sensed outside of the pacemaker's A-V escape intervals. The arrhythmia prevention pacing mode is activated and deactivated in conjunction with the operation of arrhythmia detection features which may also be employed by the device to trigger delivery of anti-arrhythmia therapies.

8. 发明公开

EP0957984A1 METHOD AND APPARATUS FOR DIAGNOSIS AND TREATMENT OF ARRHYTHMIAS 失效
标题翻译：方法和设备的诊断和治疗心律失常
公开(公告)号：EP0957984A1
公开(公告)日：1999-11-24
申请号：EP97951739.0
申请日：1997-12-16
申请人： MEDTRONIC, INC.
发明人： PETERSON, David, K. , JIRAK, Thomas, L. , ZHOU, Ren , HILL, Michael, R., S.
IPC分类号： A61N1
CPC分类号： A61N1/3622 , A61N1/3688
摘要： A pacemaker provided with a mode switching feature adapted to stabilize ventricular heart rate during atrial fibrillation. In a preferred embodiment of the invention, the device nominally operates in an atrial synchronized pacing mode such as DDD, DDDR, VDD or VDDR. In response to detection of atrial rhythm characteristics consistent with atrial fibrillation, the device switches into a non-atrial synchronized, ventricular rate stabilization pacing mode with the base ventricular pacing rate modulated on a beat by beat basis based upon preceding intrinsic or paced ventricular heartbeat intervals to adjust the pacing interval towards a desired preset rate stabilization target pacing interval which is typically less than the programmed base pacing interval of the device. While the ventricular rate stabilization mode is in effect, the current pacing interval is set equal to the preceding intrinsic or paced interval, with an increment if the preceding interval is less than the desired or target pacing interval, as typically will be the case, or with a decrement if the preceding interval is greater than the desired pacing interval. In a preferred embodiment of the invention, the device paces both the atria and ventricles in a DDI rate stabilization pacing mode with the ventricular pacing interval being modulated.

9. 发明授权

EP1015073B1 APPARATUS FOR DIAGNOSIS AND TREATMENT OF ARRHYTHMIAS 失效
标题翻译：用于诊断和治疗心律失常的装置
公开(公告)号：EP1015073B1
公开(公告)日：2003-11-12
申请号：EP97952442.8
申请日：1997-12-10
申请人： MEDTRONIC, INC.
发明人： PETERSON, David, K. , HILL, Michael, R., S. , ZHOU, Ren , PRIEVE, Kathleen, A.
IPC分类号： A61N1/368
CPC分类号： A61N1/3962 , A61N1/3622
摘要： An implantable pacemaker employing an arrhythmia prevention pacing modality particularly optimized for inclusion in dual chamber pacemakers and anti-arrhythmia devices which include dual chamber pacemakers. When the pacing mode is in effect, the device alters timing of scheduled atrial and/or ventricular pacing pulses in response to depolarizations sensed during the refractory periods and to ventricular depolarizations sensed outside of the pacemaker's A-V escape intervals. The arrhythmia prevention pacing mode is activated and deactivated in conjunction with the operation of arrhythmia detection features which may also be employed by the device to trigger delivery of anti-arrhythmia therapies.
摘要翻译：一种使用预防心律失常起搏方式的植入式起搏器，特别适用于双室起搏器和包括双腔起搏器的抗心律失常装置。当起搏模式起作用时，该装置响应于在不应期期间感测的去极化和在起搏器的A-V脱离间隔外感测到的心室去极化，改变预定的心房和/或心室起搏脉冲的时序。心律失常预防起搏模式与心律失常检测特征的操作一起被激活和停用，该特征也可以被设备用来触发抗心律失常治疗的递送。

10. 发明授权

EP0957984B1 APPARATUS FOR DIAGNOSIS AND TREATMENT OF ARRHYTHMIAS 失效
标题翻译：设备的诊断和治疗心律失常
公开(公告)号：EP0957984B1
公开(公告)日：2003-03-19
申请号：EP97951739.8
申请日：1997-12-16
申请人： MEDTRONIC, INC.
发明人： PETERSON, David, K. , JIRAK, Thomas, L. , ZHOU, Ren , HILL, Michael, R., S.
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3688
摘要： A pacemaker provided with a mode switching feature adapted to stabilize ventricular heart rate during atrial fibrillation. In a preferred embodiment of the invention, the device nominally operates in an atrial synchronized pacing mode such as DDD, DDDR, VDD or VDDR. In response to detection of atrial rhythm characteristics consistent with atrial fibrillation, the device switches into a non-atrial synchronized, ventricular rate stabilization pacing mode with the base ventricular pacing rate modulated on a beat by beat basis based upon preceding intrinsic or paced ventricular heartbeat intervals to adjust the pacing interval towards a desired preset rate stabilization target pacing interval which is typically less than the programmed base pacing interval of the device. While the ventricular rate stabilization mode is in effect, the current pacing interval is set equal to the preceding intrinsic or paced interval, with an increment if the preceding interval is less than the desired or target pacing interval, as typically will be the case, or with a decrement if the preceding interval is greater than the desired pacing interval. In a preferred embodiment of the invention, the device paces both the atria and ventricles in a DDI rate stabilization pacing mode with the ventricular pacing interval being modulated.

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