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1. 发明申请

WO2021154817A1 ATRIOVENTRICULAR NODAL STIMULATION 审中-公开
公开(公告)号：WO2021154817A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/015226
申请日：2021-01-27
申请人： MEDTRONIC, INC.
发明人： STEGEMANN, Berthold , KORNET, Lilian , CORNELUSSEN, Richard
IPC分类号： A61N1/36 , A61B5/361 , A61B5/363 , A61N1/362 , A61N1/375
摘要： Devices and methods are described herein for treating cardiac conditions using electrical stimulation delivered to and sensing nerve activity from one or both of the AV node and nerve tissue innervating the AV node using one or more neural electrodes positioned in a location within the triangle of Koch of the right atrium.

2. 发明申请

WO2019173209A1 IMPINGEMENT DETECTION FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
公开(公告)号：WO2019173209A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020534
申请日：2019-03-04
申请人： MEDTRONIC, INC.
发明人： STEGEMANN, Berthold , CORNELUSSEN, Richard , STADLER, Robert W.
IPC分类号： A61N1/365 , A61N1/372
摘要： In some examples, a system may be used for delivering cardiac therapy or cardiac sensing. The system may include an in implantable medical device including a housing configured to be implanted on or within a heart of a patient, a fixation element configured to attach the housing to the heart; and a sensor configured to produce a signal that indicates motion of the implantable medical device. Processing circuitry may be configured to identify one or more impingements between the housing and another structure, such as a tissue of the heart, based on the signal from the sensor and provide an indication of the one or more impingements to a user.

3. 发明申请

WO2019104174A1 EFFICIENT DELIVERY OF MULTI-SITE PACING 审中-公开
公开(公告)号：WO2019104174A1
公开(公告)日：2019-05-31
申请号：PCT/US2018/062256
申请日：2018-11-21
申请人： MEDTRONIC, INC.
发明人： STEGEMANN, Berthold , CORNELUSSEN, Richard , HEYNENS, Joeri , GHOSH, Subham
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37 , A61N1/05
CPC分类号： A61N1/36843 , A61B5/0464 , A61B5/0468 , A61N1/056 , A61N1/3627 , A61N1/36514 , A61N1/3682 , A61N1/3688 , A61N1/371 , A61N1/39622
摘要： An implantable device and associated method for delivering multi-site pacing therapy is disclosed. The device comprises a set of electrodes including a first and second left ventricular electrodes spatially separated from one another and a right ventricular electrode, all coupled to an implantable pulse generator. The processing circuit coupled to the implantable pulse generator, the processing circuit configured to determine whether a prospective heart failure condition has occurred and if so to trigger the pulse generator to switch from a first pacing mode to a second pacing mode, the first pacing mode comprising delivering only a first pacing pulse to a left ventricle (LV) and thereafter delivering an RV pacing pulse to the right ventricular electrode within a single cardiac cycle and the second pacing mode comprising delivering first and a second pacing pulses to the LV and thereafter delivering an RV pacing pulse to the right ventricular electrode within a single cardiac cycle.

4. 发明申请

WO2022026312A1 DORSAL ROOT GANGLION STIMULATION IN INFLUENCING ORGAN FUNCTION 审中-公开
公开(公告)号：WO2022026312A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/042925
申请日：2021-07-23
申请人： MEDTRONIC, INC.
发明人： KORNET, Lilian , CORNELUSSEN, Richard , DE MELIS, Mirko , STEGEMANN, Berthold , HAMERS, Jules
IPC分类号： A61N1/36 , A61N1/05 , A61N1/04
摘要： Systems and methods are directed to influencing organ function by stimulating the dorsal root ganglion. Systems include at least one electrode to deliver electrical stimulation to the dorsal root ganglion to activate afferent nerves innervating at least one organ, and computing apparatus comprising one or more processors operably coupled to the at least one electrode to control the electrical stimulation.

5. 发明申请

WO2020102331A1 LEADED ELECTRICAL STIMULATION SYSTEM 审中-公开
公开(公告)号：WO2020102331A1
公开(公告)日：2020-05-22
申请号：PCT/US2019/061153
申请日：2019-11-13
申请人： MEDTRONIC, INC.
发明人： MARSHALL, Mark, T. , WHITMAN, Teresa, A. , PFEIFFER, Carla , ANDERSON, Thomas, A. , RUTTEN, Jean , ADAMS, Paul , CAMPS, Antoine , CORNELUSSEN, Richard , LEINDERS, Ralph
IPC分类号： A61N1/05 , A61N1/365 , A61N1/04 , A61N1/375
摘要： In some examples, an IMD may include a lead having at least one of the electrodes, an elongate body, a fixation helix, and a connector segment. A width of the helix transverse to a longitudinal axis of the lead is greatest at a distal end of the helix. A proximal end of the elongate body may be connected to a distal end of the pulse generator, and the helix may be attached to a distal end of the elongate body. The pulse generator may include a first connector tab. A distal end of the connector segment may be configured to receive the proximal end of the elongate body and a proximal end of the connector segment may include at least one second connector member configured to engage the first connector tab.

6. 发明申请

WO2018011725A1 PROSTHETIC VALVE FOR REGULATING FLUID FLOW 审中-公开
标题翻译：用于调节流体流量的假体阀
公开(公告)号：WO2018011725A1
公开(公告)日：2018-01-18
申请号：PCT/IB2017/054201
申请日：2017-07-12
申请人： MEDTRONIC, INC.
发明人： CORNELUSSEN, Richard , REITERS, Pascalle , WOLFHARD, Ulrich , GLYNOU, Asimina , VESTBERG, Robert
IPC分类号： A61F2/24
摘要： The invention relates to a prosthetic valve (1) for regulating fluid flow between an upstream side (4) and a downstream side (5) and being operable between an open status and a closed status. The prosthetic valve comprises: - an orifice (2) arranged in a surrounding member (3) and extending between the upstream side (4) and the downstream side (5) wherein in the open status of the prosthetic valve (1) the fluid flow through the orifice is maximally enabled and wherein in the closed status of the prosthetic valve the fluid flow through the orifice in a restriction direction (21) from the downstream side (5) to the upstream side (4) is restricted; and - a leaflet (6) arranged in the orifice and being operable between an open status corresponding to the open status of the prosthetic valve and a closed status corresponding to the closed status of the prosthetic valve. The prosthetic valve further comprises regurgitation means (8, 15, 115, 22) arranged in the prosthetic valve for achieving regurgitation in the restriction direction and arranged for becoming ineffective after a period of deployment.
摘要翻译：本发明涉及一种用于调节上游侧（4）和下游侧（5）之间的流体流动并且可在打开状态和关闭状态之间操作的人工瓣膜（1）。人工瓣膜包括：布置在周围构件（3）中并且在上游侧（4）和下游侧（5）之间延伸的孔口（2），其中在人造瓣膜（1）的打开状态下，流体流动通过所述孔最大程度地启用，并且其中在所述人工瓣膜的所述关闭状态下，流体沿限制方向（21）从所述下游侧（5）流向所述上游侧（4）的流动受到限制; 以及 - 小叶（6），其布置在所述孔口中并且可在对应于人工瓣膜的打开状态的打开状态和对应于人工瓣膜的关闭状态的关闭状态之间操作。假体瓣膜还包括布置在假体瓣膜中的回流装置（8,15,115,22），用于实现限制方向上的返流并且布置成在展开一段时间后变得无效。

7. 发明申请

WO2019139881A1 ADAPTIVE CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
公开(公告)号：WO2019139881A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/012642
申请日：2019-01-08
申请人： MEDTRONIC, INC.
发明人： STADLER, Robert W. , CORNELUSSEN, Richard , STEGEMANN, Berthold
IPC分类号： A61N1/365 , A61N1/362 , A61B5/00 , A61B5/11 , A61N1/375 , A61B5/0452
CPC分类号： A61N1/36578 , A61B5/04525 , A61B5/1102 , A61B5/4836 , A61B5/686 , A61N1/3621 , A61N1/3624 , A61N1/3627 , A61N1/36507 , A61N1/3756 , A61N1/39622 , A61N1/3987
摘要： In some examples, a system can be used for delivering cardiac resynchronization therapy (CRT). The system may include a pacing device configured to be implanted within a patient. The pacing device can include a plurality of electrodes, signal generation circuitry configured to deliver ventricular pacing via the plurality of electrodes, and a sensor configured to produce a signal that indicates mechanical activity of the heart. Processing circuitry can be configured to identify one or more features of a cardiac contraction within the signal, and determine whether the contraction was a fusion beat based on the one or more features. The system is also configured to control a timing interval for delivery of the ventricular pacing based on the determination whether the contraction was a fusion beat.

8. 发明申请

WO2017221195A1 DEVICE FOR DETECTING ATRIAL FIBRILLATION OF A SUBJECT 审中-公开
标题翻译：用于检测受试者的心房颤动的装置
公开(公告)号：WO2017221195A1
公开(公告)日：2017-12-28
申请号：PCT/IB2017/053735
申请日：2017-06-22
申请人： MEDTRONIC, INC
发明人： VIRAG, Nathalie , AASMUL, Søren , CHASSARD, Catherine , CORNELUSSEN, Richard , HILL, Gerard , LEINDERS, Robert , DE MELIS, Mirko , SCHNEIDER, Raphael , SPYROPOULOU, Vasiliki
IPC分类号： A61B5/024 , A61B5/046 , A61B5/04 , A61B5/00 , A45D31/00
CPC分类号： A61B5/046 , A61B5/02405 , A61B5/02427 , A61B5/04012 , A61B5/1455 , A61B5/6826 , A61B5/6831 , A61B5/6833 , A61B5/7264 , A61B5/7282 , A61B2505/07 , A61B2562/0233 , A61B2562/164
摘要： The invention relates to a device for detecting atrial fibrillation of a subject, comprising a member comprising - mechanical connection means to wearably connect the member to a subject; - the member further comprising an optical sensor arranged to measure a signal representing a blood perfusion parameter of the subject; the member comprising the optical sensor and mechanical connection means at such relative positions that when the mechanical connection means connect the member to the subject, the optica! sensor operatively faces the subject. The device is arranged to detect atrial fibrillation of the subject based on the signal measured by the optical sensor.
摘要翻译：本发明涉及一种用于检测对象的心房纤颤的装置，该装置包括一个构件，该构件包括：机械连接装置，用于将该构件可穿戴地连接到对象; - 所述构件还包括光学传感器，所述光学传感器布置成测量表示所述对象的血液灌注参数的信号; 所述构件包括光学传感器和机械连接装置，所述相对位置使得当所述机械连接装置将所述构件连接到所述对象时，传感器可操作地面向对象。该装置被安排成根据由光学传感器测量的信号来检测对象的心房颤动。

9. 发明申请

WO2012125222A1 ATRIAL NERVE STIMULATION WITH VENTRICULAR PACING 审中-公开
标题翻译：心脏神经刺激与静脉瓣
公开(公告)号：WO2012125222A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/022019
申请日：2012-01-20
申请人： MEDTRONIC, INC. , RAJAN, Vinayakrishnan , CORNELUSSEN, Richard , STEGEMANN, Berthold , KORNET, Lilian
发明人： RAJAN, Vinayakrishnan , CORNELUSSEN, Richard , STEGEMANN, Berthold , KORNET, Lilian
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： An implantable medical device senses atrial depolarizations having associated refractory periods thereafter and delivers electrical stimulation pulses during the associated refractory periods to stimulate the atrioventricular (AV) node to cause a prolonged conduction time of an atrial depolarization to a ventricular chamber. The device delivers a pacing pulse to a first ventricular chamber during the prolonged conduction time to cause a contraction and associated refractory period of the first ventricular chamber, the first ventricular chamber contraction occurring earlier than a contraction of a second ventricular chamber.
摘要翻译：植入式医疗装置感测其后具有相关不应期的心房去极化，并且在相关联的不应期期间传递电刺激脉冲以刺激房室（AV）节点，从而导致心室去极化延长到心室的延长的传导时间。该设备在延长的传导时间期间将起搏脉冲传送到第一心室，以引起第一心室的收缩和相关联的不应期，第一心室的收缩早于第二心室的收缩。

10. 发明申请

WO2022169721A1 SELF-CALIBRATING GLUCOSE MONITOR 审中-公开
公开(公告)号：WO2022169721A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/014646
申请日：2022-02-01
申请人： MEDTRONIC, INC.
发明人： O'BRIEN, Richard J. , KORNET, Lilian , CORNELUSSEN, Richard , ARANDA HERNANDEZ, Alfonso , SCHNEIDER, Raphael
IPC分类号： A61B5/0205 , A61B5/145
摘要： A medical system including processing circuitry configured to receive a cardiac signal indicative of a cardiac characteristic of a patient from sensing circuitry and configured to receive a glucose signal indicative of a glucose level of the patient. The processing circuitry is configured to formulate a training data set including one or more training input vectors using the cardiac signal and one or more training output vectors using the glucose signal. The processing circuitry is configured to train a machine learning algorithm using the formulated training data set. The processing circuitry is configured to receive a current cardiac signal from the patient and determine a representative glucose level using the current cardiac signal and the trained machine learning algorithm.

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