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1. 发明申请

WO2006058280A3 DEVICES, SYSTEMS AND METHODS FOR FLUID DELIVERY 审中-公开
公开(公告)号：WO2006058280A3
公开(公告)日：2006-06-01
申请号：PCT/US2005/042891
申请日：2005-11-23
申请人： MEDRAD, INC. , KALAFUT, John, F. , MISHLER, David, A.
发明人： KALAFUT, John, F. , MISHLER, David, A.
IPC分类号： A61M37/00
摘要： A fluid injection apparatus includes at least one pressurizing mechanism and at least a first fluid container (for example, a syringe or a bulk container) operably associated with the at least one pressurizing mechanism. The first fluid container is adapted to contain a first fluid to be injected. The fluid injection apparatus also includes a controller operably associated with the at least one pressurizing mechanism. The controller includes a programming system to allow programming of an injection protocol including, for example, a plurality of phases. At least one parameter generator is provided to determine parameters of at least one of the plurality of phases of the protocol based at least in part upon a type of the injection procedure.

2. 发明申请

WO2009158212A1 IDENTIFICATION OF REGIONS OF INTEREST AND EXTRACTION OF TIME VALUE CURVES IN IMAGING PROCEDURES 审中-公开
标题翻译：识别兴趣区域和提取成像过程中时间曲线的曲线
公开(公告)号：WO2009158212A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/047168
申请日：2009-06-12
申请人： MEDRAD, INC. , KEMPER, Corey , KALAFUT, John, F.
发明人： KEMPER, Corey , KALAFUT, John, F.
IPC分类号： G09G3/04
CPC分类号： G06K9/6223 , G06K2209/051 , G06T7/0012 , G06T7/0016 , G06T7/11 , G06T7/143 , G06T2207/10081 , G06T2207/30061
摘要： A method of extracting at least one time-value curve to determine a protocol in an imaging procedure using an imaging system, includes determining a first N-dimensional data set of pixel values of a portion of a body of the patient at a first time using the imaging system, determining at least a second N-dimensional data set of pixel values of the portion at a second time, computing a number of correlated segments of the imaged portion corresponding to a predetermined number of regions of interest of the patient by computing a similarity metric of a time series of pixel values, computing the at least one time-value curve for at least one of the regions of interest, and determining a protocol for a diagnostic scan using the image system based at least in part upon data from the time value curve.
摘要翻译：一种提取至少一个时间值曲线以在使用成像系统的成像过程中确定协议的方法包括：在第一时间使用第一时间确定患者身体的一部分的像素值的第一N维数据集所述成像系统在第二时间确定所述部分的像素值的至少第二N维数据集合，通过计算所述成像系统计算与所述患者感兴趣的预定区域相对应的所述成像部分的相关片段的数量计算像素值的时间序列的相似性度量，计算所述感兴趣区域中的至少一个区域的至少一个时间值曲线，以及至少部分地基于来自所述图像系统的数据，使用所述图像系统确定用于诊断扫描的协议时间曲线。

3. 发明申请

WO2009149367A1 APPARATUS AND METHODS FOR DELIVERY OF FLUID INJECTION BOLUSES TO PATIENTS AND HANDLING HARMFUL FLUIDS 审中-公开
标题翻译：用于输送流体注射器对患者和处理有害流体的装置和方法
公开(公告)号：WO2009149367A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046437
申请日：2009-06-05
申请人： MEDRAD, INC. , UBER, Arthur, E., III , TROCKI, Mark , MABIE, Marc, A. , MCCUTCHAN, Larry , SIDDOWAY, L., George , COWAN, Kevin, P. , COATES, Lisa, M. , KALAFUT, John, F. , HUGHES, Aaron , GRIFFITHS, David, M. , TWICHELL, Peter , GULICK, Julie , TROMBLEY, Frederick, W., III
发明人： UBER, Arthur, E., III , TROCKI, Mark , MABIE, Marc, A. , MCCUTCHAN, Larry , SIDDOWAY, L., George , COWAN, Kevin, P. , COATES, Lisa, M. , KALAFUT, John, F. , HUGHES, Aaron , GRIFFITHS, David, M. , TWICHELL, Peter , GULICK, Julie , TROMBLEY, Frederick, W., III
IPC分类号： E03B11/00
CPC分类号： A61N5/1007 , A61M5/007 , A61M5/16827 , A61M5/1785 , A61M2005/1402 , A61M2202/0225 , A61M2202/049 , A61M2206/11 , A61M2206/18 , Y10T137/0318
摘要： A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.
摘要翻译：公开了一种危险流体输送容器和危险流体输送系统。危险流体输送容器包括封闭至少部分屏蔽的外壳的壳体。第一和第二流体通道元件设置在壳体内，第一流体路径元件和第二流体路径元件流体耦合在一起。可以提供泵单元，用于将流体从第一和第二流体路径元件任选地分配到第三流体路径元件中。此外，公开了用于引燃危险流体输送容器和减轻层流注射团块扩散的方法。此外，公开了一种用于注射器或其他容器的放射性流体输送容器。放射性流体输送容器允许注射器或容器在注射过程中使用而不从容器中取出。

4. 发明申请

WO2009012023A1 DEVICES, SYSTEMS AND METHODS FOR DETERMINATION OF PARAMETERS FOR A PROCEDURE, FOR ESTIMATION OF CARDIOPULMONARY FUNCTION AND FOR FLUID DELIVERY 审中-公开
标题翻译：用于确定程序参数的装置，系统和方法，用于估计心脏功能和流体输送
公开(公告)号：WO2009012023A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/067982
申请日：2008-06-24
申请人： MEDRAD, INC. , KALAFUT, John, F. , KEMPER, Corey
发明人： KALAFUT, John, F. , KEMPER, Corey
IPC分类号： A61B5/08
CPC分类号： A61B6/481 , A61B5/055 , A61B6/504 , A61B6/507
摘要： A method of determining at least one parameter for an imaging procedure including the injection of a contrast enhancement fluid which includes a contrast enhancing agent, includes: substituting into a model discrete point data determined from at least one contrast time enhancement curve measured using an imaging system for a first region of interest resulting from injection of a bolus of the contrast enhancement fluid. In several embodiments, a sufficient number of data points can be substituted into the model to determine values for physiological variables in the model. The variables can, for example, be related to cardiopulmonary function. At least one data point from at least a second contrast time enhancement curve for a second region of interest measured using the imaging system can also substituted into the model.
摘要翻译：一种确定用于成像过程的至少一个参数的方法，该成像过程包括注射包含对比度增强剂的对比度增强流体，包括：将由使用成像系统测量的至少一个对比度时间增强曲线确定的模型离散点数据替换用于由注射大量对比度增强液体引起的第一感兴趣区域。在几个实施例中，足够数量的数据点可以被替换到模型中以确定模型中的生理变量的值。变量可以例如与心肺功能相关。使用成像系统测量的第二感兴趣感兴趣区域的至少一个对比度时间增强曲线的至少一个数据点也可以代入该模型。

5. 发明申请

WO2009058647A1 SYSTEM AND METHOD FOR PROPORTIONAL MIXING AND CONTINUOUS DELIVERY OF FLUIDS 审中-公开
标题翻译：用于比例混合和连续输送流体的系统和方法
公开(公告)号：WO2009058647A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/080885
申请日：2008-10-23
申请人： MEDRAD, INC. , REILLY, David, M. , KALAFUT, John, F. , SCHRIVER, Ralph, H.
发明人： REILLY, David, M. , KALAFUT, John, F. , SCHRIVER, Ralph, H.
IPC分类号： A61B6/00
CPC分类号： A61M5/16827 , A61M5/007 , A61M5/1422
摘要： A system and method for mixing and delivering fluids such as contrast media and saline is disclosed including at least two fluid sources, a pump, a joining fluid path connecting the at least two fluid sources to an inlet to the pump, and a valve device in the fluid path upstream of the pump. The valve device includes an actuator adapted to restrict flow in at least one of respective fluid lines connecting the at least two fluid sources to the pump inlet. A patient interface device may be associated with an outlet of the pump. The valve device actuator is generally adapted to restrict the flow in at least one of the respective fluid lines such that an incremental positional change in valve device actuator position provides a substantially linear change in fluid mixture ratio of the fluids from the at least two fluid sources to the pump inlet.
摘要翻译：公开了用于混合和输送诸如造影剂和盐水的流体的系统和方法，其包括至少两个流体源，泵，将至少两个流体源连接到泵的入口的连接流体路径，以及将泵装置泵的上游的流体路径。阀装置包括致动器，其适于限制在将至少两个流体源连接到泵入口的各个流体管线中的至少一个中的流动。患者接口装置可以与泵的出口相关联。阀装置致动器通常适于限制相应流体管线中的至少一个中的流动，使得阀装置致动器位置的增量位置变化提供来自至少两个流体源的流体的流体混合比的基本线性变化到泵入口。

6. 发明申请

WO2008083313A2 METHODS AND SYSTEMS FOR INTEGRATED RADIOPHARMACEUTICAL GENERATION, PREPARATION, TRANSPORTATION, AND ADMINISTRATION 审中-公开
标题翻译：综合放射免疫法生成，制备，运输和管理的方法与系统
公开(公告)号：WO2008083313A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/089101
申请日：2007-12-28
申请人： MEDRAD, INC. , HIRSCHMAN, Alan, D. , UBER, Arthur, E., III , COWAN, Kevin, P. , REILLY, David, M. , RHINEHART, Edward, J. , KALAFUT, John, F. , UBER, Bronwyn , TROMBLEY, Frederick, W., Iii , REMIS, Steven, J. , LEVIN, Paul , GRIFFITH, Scott , DESCALZI, Douglas , DEWIT, Richard
发明人： HIRSCHMAN, Alan, D. , UBER, Arthur, E., III , COWAN, Kevin, P. , REILLY, David, M. , RHINEHART, Edward, J. , KALAFUT, John, F. , UBER, Bronwyn , TROMBLEY, Frederick, W., Iii , REMIS, Steven, J. , LEVIN, Paul , GRIFFITH, Scott , DESCALZI, Douglas , DEWIT, Richard
IPC分类号： A61K51/00 , A61B6/03
CPC分类号： A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/00 , G06F19/3468 , G16H20/17 , G21F5/015 , G21G4/08
摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
摘要翻译：公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

7. 发明申请

WO2013172811A1 SYSTEMS AND METHODS FOR DETERMINATION OF PHARMACEUTICAL FLUID INJECTION PROTOCOLS BASED ON X-RAY TUBE VOLTAGE 审中-公开
标题翻译：用于确定基于X射线管电压的药液注射方案的系统和方法
公开(公告)号：WO2013172811A1
公开(公告)日：2013-11-21
申请号：PCT/US2012/037744
申请日：2012-05-14
申请人： MEDRAD, INC. , KALAFUT, John, F. , KEMPER, Corey
发明人： KALAFUT, John, F. , KEMPER, Corey
IPC分类号： G01N23/06 , A61M31/00 , A61M35/00
CPC分类号： A61B6/481 , A61B6/00 , A61B6/032 , A61B6/469 , A61B6/482 , A61B6/504 , A61B6/54 , A61B6/545
摘要： A system for patient imaging is provided. The system includes an imaging system and a parameter generator to determine parameters of at least a first phase of an injection procedure. The imaging system includes a scanner that has at least one x-ray tube. The parameter generator is programmed to determine at least one of the parameters on the basis of a voltage to be applied to the at least one x-ray tube during an imaging procedure. A method of controlling an injector system is also provided, and the method includes determining injection parameters, at least one of which is determined on the basis of a voltage to be applied to an x-ray tube during the imaging procedure, as well as controlling the injector system at least in part on the basis of the determined injection parameters.
摘要翻译：提供了一种用于患者成像的系统。该系统包括成像系统和参数发生器，以确定注射过程的至少第一阶段的参数。成像系统包括具有至少一个X射线管的扫描仪。参数发生器被编程为基于在成像过程期间施加到至少一个X射线管的电压来确定参数中的至少一个。还提供了一种控制注射器系统的方法，并且该方法包括确定注射参数，其中至少一个基于在成像过程期间施加到X射线管的电压来确定，以及控制喷射器系统至少部分地基于确定的喷射参数。

8. 发明申请

WO2011163578A2 MODELING OF PHARMACEUTICAL PROPAGATION AND PARAMETER GENERATION FOR INJECTION PROTOCOLS 审中-公开
标题翻译：药物传播建模与注射方案参数生成
公开(公告)号：WO2011163578A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041802
申请日：2011-06-24
申请人： MEDRAD, INC. , KALAFUT, John, F.
发明人： KALAFUT, John, F.
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , A61B6/507 , G06F19/00
摘要： A system includes a parameter generation system to determine at least one parameter for an injection procedure (for example, a parameter of an injection protocol or an imaging system parameter), the parameter generator system includes a physiologically based pharmacokinetic model to model propagation of a contrast medium injected into a patient including at least one of a non-linear saturation term in a peripheral venous compartment, at least one configurable transport delay term through at least one compartment, or an adaptation to model volumetric flow rate of blood and an effect thereof on the propagation of contrast medium after injection of contrast medium ceases. The physiologically based pharmacokinetic model can, for example, be discretizable.
摘要翻译：系统包括参数产生系统以确定用于注射过程的至少一个参数（例如，注射方案或成像系统参数的参数），参数发生器系统包括用于模拟对比度的传播的基于生理学的药代动力学模型包括在外周静脉隔室中的非线性饱和项中的至少一个的介质，至少一个可配置的运输延迟项通过至少一个隔室，或适应于血液的模型容积流量及其效果注射造影剂后造影剂的传播停止。基于生理学的药代动力学模型可以例如是可离散的。

9. 发明申请

WO2006055813A2 MODELING OF PHARMACEUTICAL PROPAGATION 审中-公开
标题翻译：药物传播建模
公开(公告)号：WO2006055813A2
公开(公告)日：2006-05-26
申请号：PCT/US2005/041913
申请日：2005-11-16
申请人： MEDRAD, INC. , KALAFUT, John, F. , UBER, Arthur, E.
发明人： KALAFUT, John, F. , UBER, Arthur, E.
IPC分类号： A61M31/00
CPC分类号： A61M5/007 , A61B5/0044 , A61B5/02028 , A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/0295 , A61B5/055 , A61B5/7257 , A61B6/032 , A61B6/481 , A61B6/504 , A61B6/507 , A61B6/583 , A61B8/13 , A61B8/481 , A61K49/0002 , G01R33/5601 , G06F19/00 , G06F19/321 , G06F19/3468 , G16H50/50
摘要： A method of delivering a contrast enhancing fluid to a patient using an injector system, including: determining at least one patient transfer function for the patient based upon data specific to the patient, the at least one patient transfer function providing a time enhancement output for a given input; determining a desired time enhancement output; using the at least one patient transfer function to determine an injection procedure input; and controlling the injector system at least in part on the basis of the determined injection procedure input. The injection procedure input can determined considering at least one operational limitation or constraint of the injector system. A method of modeling propagation of a pharmaceutical fluid in a patient, includes: collecting data corresponding to a time response curve resulting from injection of the fluid; and determining at least one mathematical model describing the data. The mathematical model can, for example, be a model which is not determined by a continuous or a discrete-time Fourier deconvolution of the data. A method of controlling injection of a pharmaceutical fluid into a patient using an injector in a medical procedure, includes: collecting data corresponding to a patient response curve resulting from injection of the fluid; determining at least one mathematical model describing the data; and controlling the injector during the medical procedure to control injection of the fluid into the patient to create patient response at least in part on the basis of the mathematical model. A method of controlling injection of a contrast medium into a patient using an injector in a medical imaging procedure using an imaging scanner, includes: determining at least one mathematical model to predict a time enhancement response resulting from injection of the contrast medium; determining an injection protocol to approximate a predetermined time enhancement response in the patient by determining a constrained input solution to the mathematical model; and using the injection protocol to control the injector during the medical imaging procedure to control injection of the contrast medium into the patient to create an image of a region of interest.
摘要翻译：一种使用注射器系统将对比度增强流体递送到患者的方法，包括：基于患者特有的数据确定患者的至少一个患者转移功能，所述至少一个患者传递函数为给定输入; 确定期望的时间增强输出; 使用所述至少一个患者传递函数来确定注射过程输入; 以及至少部分地基于所确定的喷射过程输入来控制喷射器系统。注射过程输入可以考虑至少一个注射器系统的操作限制或约束来确定。一种建模患者体内药液传播的方法，包括：收集对应于由注射液体引起的时间响应曲线的数据; 以及确定描述数据的至少一个数学模型。数学模型可以例如是不是由数据的连续或离散时间傅里叶解卷积决定的模型。一种在医疗过程中使用注射器控制药物流体注入到患者体内的方法包括：收集对应于由注射流体引起的患者反应曲线的数据; 确定描述数据的至少一个数学模型; 以及在所述医疗过程期间控制所述注射器以控制将流体注射到患者体内，以至少部分地基于所述数学模型产生患者反应。一种使用成像扫描仪在医疗成像程序中使用注射器将造影剂注射到患者体内的方法包括：确定至少一个数学模型以预测由注射造影剂引起的时间增强响应; 通过确定所述数学模型的约束输入解决方案来确定注射协议以近似所述患者中的预定时间增强响应; 并且在医疗成像过程期间使用注射方案来控制注射器以控制将造影剂注射到患者体内以创建感兴趣区域的图像。

10. 发明申请

WO2008067362A2 MULTIPLE LUMEN DIFFUSION CATHETER 审中-公开
标题翻译：多重流明扩散导管
公开(公告)号：WO2008067362A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/085736
申请日：2007-11-28
申请人： MEDRAD, INC. , SCHWARTZ, Robert, S. , VAN TASSEL, Robert, A. , GELBLUM, Eugene, A. , HIRSCHMAN, Alan, D. , KALAFUT, John, F. , REILLY, David, M. , RHINEHART, Edward, J. , TROMBLEY, Frederick, W. , UBER, Arthur, E.
发明人： SCHWARTZ, Robert, S. , VAN TASSEL, Robert, A. , GELBLUM, Eugene, A. , HIRSCHMAN, Alan, D. , KALAFUT, John, F. , REILLY, David, M. , RHINEHART, Edward, J. , TROMBLEY, Frederick, W. , UBER, Arthur, E.
IPC分类号： A61M25/00
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多个孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体（例如造影剂）的浓度和推注。

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