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1. 发明申请

WO0219961A2 PHARMACEUTICAL COMPOSITIONS FOR HEADACHE, MIGRAINE, NAUSEA AND EMESIS 审中-公开
标题翻译：药物组合物，头颅，脑膜，脑膜和脑膜炎
公开(公告)号：WO0219961A2
公开(公告)日：2002-03-14
申请号：PCT/IL0100817
申请日：2001-08-30
申请人： MEDITOR PHARMACEUTICALS LTD , BARKAN RAPHAEL , MIRIMSKY ALEXANDER
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K31/66 , A61K33/42 , A61P1/08 , A61P25/06 , A61K
CPC分类号： A61K31/66 , A61K31/17 , A61K2300/00
摘要： The use of S-alkylisothiouronium derivatives, such as, but not limited to the preferred compound S-ethylisothiouronium diethylsphosphate, for the treatment of headache, in particular migraine, as well as for the prevention or treatment of nausea and vomiting, is disclosed. The compositions of the invention are effective in preventing or alleviating emesis associated with migraine or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraine including phonophobia and photophobia.
摘要翻译：公开了使用S-烷基异硫脲衍生物，例如但不限于优选的S-乙基异硫脲二乙基磷酸酯，用于治疗头痛，特别是偏头痛，以及预防或治疗恶心和呕吐。本发明的组合物可有效预防或缓解与偏头痛或其它医学病症如化学疗法或放射疗法相关的呕吐以及偏头痛的其他症状，包括心悸和畏光。

2. 发明专利

IL154456A S-alkylisothiouronium derivatives for treating headache, migraine, nausea and emesis 未知
公开(公告)号：IL154456A
公开(公告)日：2013-05-30
申请号：IL15445603
申请日：2003-02-13
申请人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER , MEDITOR PHARMACEUTICALS LTD
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61K20060101 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K31/66 , A61K33/42 , A61P20060101 , A61P1/08 , A61P25/06 , C07C20060101
摘要： S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

3. 发明公开

EP1315505A4 PHARMACEUTICAL COMPOSITIONS FOR HEADACHE, MIGRAINE, NAUSEA AND EMESIS 有权
标题翻译：药物制剂反对头痛，偏头痛，恶心和呕吐
公开(公告)号：EP1315505A4
公开(公告)日：2006-02-22
申请号：EP01965546
申请日：2001-08-30
申请人： MEDITOR PHARMACEUTICALS LTD
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K31/66 , A61K33/42 , A61P1/08 , A61P25/06
CPC分类号： A61K31/66 , A61K31/17 , A61K2300/00

4. 发明专利

ES2296792T3 COMPOSICIONES FARMACEUTICAS PARA CEFALEA, ,MIGRAÑA, NAUSEAS Y EMESIS. 未知
公开(公告)号：ES2296792T3
公开(公告)日：2008-05-01
申请号：ES01965546
申请日：2001-08-30
申请人： MEDITOR PHARMACEUTICALS LTD
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61K31/66 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K33/42 , A61P1/08 , A61P25/06
摘要： Una farmacéutica para el tratamiento de cefalea, migraña, náuseas o emesis que comprende, como un ingrediente activo, un compuesto que tiene la siguiente fórmula general: (Ver fórmula) donde, R1 es un alquileno lineal o ramificado, saturado o no saturado, que comprende ocho átomos de carbono, opcionalmente sustituido por uno o más sustituyentes seleccionados del grupo consistente en halógeno, amina primaria, secundaria o terciaria, alcohol primario, secundario o terciario, o interrumpido por uno o más heteroátomos seleccionados del grupo consistente en O, N, y S; R 2, R 3, R 4 y R 5 son cada uno independientemente un hidrógeno, hidroxi, alquilo bajo lineal o ramificado, alquenil bajo lineal o ramificado, alquinilo bajo lineal o ramificado, alcoxi bajo, alcoxialquilo, cicloalquilo, cicloalqauilalquilo, tioalcoxi bajo, nitro, amino, ciano, sulfonil, haloalquilo, carboariloxi, carboalquilariloxi, sulfóxido de alquilo, sulfóxido de aril, sulfono alquilo, sulfono aril, sulfato alquilo, sulfato aril, sulfonamida, tioalquilo, opcionalmente sustituido por halógeno; A- es un anión fisiológicamente aceptable; dicho anión fisiológicamente aceptable está seleccionado del grupo consistente en un anión derivado de un fósforo que contiene amida ácida, acetato, adipato, alginato, citrato, aspartato, benzoato, bencenesulfonato, bitartarato, bisulfato, butirato, canforato, canforsulfonato, digluconato, glicerofosfato, hemisulfato, heptanoato, hexanoato, fumarato, hidrocloruro, 2-hidroxietanosulfonato, isotionato, lactato, maleato, metanosulfonato, nicotinato, 2-naftalenosulfonato, oxalato, palmoato, pectinato, 3-fenilpropionato, pivalato, propionato, succinato, tartrato, tiocianato, fosfato, glutamato, bicarbonato, p-toluenesulfonato, cloruro, bromuro, yoduro y undecanoato; junto con un portador o diluyente farmacéuticamente aceptable.

5. 发明专利

PT1315505E COMPOSIÇÕES FARMACÊUTICAS PARA A DOR DE CABEÇA, ENXAQUECA, NÁUSEA E EMESE 未知
公开(公告)号：PT1315505E
公开(公告)日：2008-01-28
申请号：PT01965546
申请日：2001-08-30
申请人： MEDITOR PHARMACEUTICALS LTD
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61K31/66 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K33/42 , A61P1/08 , A61P25/06

6. 发明专利

DE60131004D1 未知
公开(公告)号：DE60131004D1
公开(公告)日：2007-11-29
申请号：DE60131004
申请日：2001-08-30
申请人： MEDITOR PHARMACEUTICALS LTD
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61K31/66 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K33/42 , A61P1/08 , A61P25/06
摘要： S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

7. 发明专利

AU2001286178B2 Pharmaceutical compositions for headache, migraine, nausea and emesis 未知
公开(公告)号：AU2001286178B2
公开(公告)日：2006-09-14
申请号：AU2001286178
申请日：2001-08-30
申请人： MEDITOR PHARMACEUTICALS LTD
发明人： MIRIMSKY ALEXANDER , BARKAN RAPHAEL
IPC分类号： A61J1/06 , A61K31/66 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K33/42 , A61P1/08 , A61P25/06
摘要： S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

8. 发明专利

NO20031902L 未知
公开(公告)号：NO20031902L
公开(公告)日：2003-06-09
申请号：NO20031902
申请日：2003-04-28
申请人： MEDITOR PHARMACEUTICALS LTD
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61K31/17 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/66 , A61K33/42 , A61P1/08 , A61P25/06
摘要： S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

9. 发明专利

AU8617801A Pharmaceutical compositions for headache, migraine, nausea and emesis 未知
公开(公告)号：AU8617801A
公开(公告)日：2002-03-22
申请号：AU8617801
申请日：2001-08-30
申请人： MEDITOR PHARMACEUTICALS LTD
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K31/66 , A61K33/42 , A61P1/08 , A61P25/06
摘要： S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

10. 发明专利

CA2420410A1 PHARMACEUTICAL COMPOSITIONS FOR HEADACHE, MIGRAINE, NAUSEA AND EMESIS 未知
公开(公告)号：CA2420410A1
公开(公告)日：2002-03-14
申请号：CA2420410
申请日：2001-08-30
申请人： MEDITOR PHARMACEUTICALS LTD
发明人： BARKAN RAPHAEL , MIRIMSKY ALEXANDER
IPC分类号： A61J1/06 , A61J1/03 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/17 , A61K31/66 , A61K33/42 , A61P1/08 , A61P25/06
摘要： The use of S-alkylisothiouronium derivatives, such as, but not limited to th e preferred compound S-ethylisothiouronium diethylsphosphate, for the treatmen t of headache, in particular migraine, as well as for the prevention or treatment of nausea and vomiting, is disclosed. The compositions of the invention are effective in preventing or alleviating emesis associated with migraine or other medical conditions such as chemotherapy or radiotherapy, a s well as other symptoms of migraine including phonophobia and photophobia.

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