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1. 发明专利

JP2004065954A Device to control stent profile 有权
公开(公告)号：JP2004065954A
公开(公告)日：2004-03-04
申请号：JP2003186793
申请日：2003-06-30
申请人： Medinol Ltd , メディノル・リミテッドMedinol Ltd.
发明人： JACOB RICHTER , PINCHASIK GREGORY
IPC分类号： A61F2/00 , A61F2/88 , A61F2/95 , B21F3/00 , B21F3/02 , B21F3/04 , A61M29/02
CPC分类号： A61F2/88 , A61F2/885 , A61F2/95 , A61F2002/9505 , A61F2002/9511 , A61F2210/0033 , A61F2250/0039 , B21F3/00 , B21F3/02 , B21F3/04 , B21F45/008
摘要： PROBLEM TO BE SOLVED: To provide a device for the best control of stent profiles.
SOLUTION: This device is characterized in that it is provided with an electric circuit (a power source 102, resistors 104 and 108, and a transistor gate 106) for supplying a stent 100 with electric current to heat it in order to change its profile through its phase transfer from a martensite to an austenite, and that this electric circuit is adjusted to monitor the stent phase change and control the current flowing through the stent 100 according to the monitoring results.
COPYRIGHT: (C)2004,JPO

2. 发明授权

US6436134B2 Bifurcated stent with improved side branch aperture and method of making same 有权
公开(公告)号：US6436134B2
公开(公告)日：2002-08-20
申请号：US84041401
申请日：2001-04-23
申请人： MEDINOL LTD
发明人： RICHTER JACOB , PINCHASIK GREGORY
IPC分类号： A61F2/00 , A61F2/06 , A61F2/82
CPC分类号： A61F2/856 , A61F2/07 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/91541 , A61F2002/91558 , A61F2220/0041 , A61F2220/0058 , A61F2230/0008 , A61F2230/001 , A61F2240/001
摘要： A bifurcated stent for insertion into a bifurcated vessel such as a blood vessel. In one embodiment, a first sheet is formed into a first leg, a second sheet is formed into a second leg, a third sheet is formed into a stem, and the two legs are attached to the stem. In a second embodiment, a first sheet is formed into a member having a first leg and half of a stem, a second sheet is formed into a second member having a second leg and half of a stem, and the two stem halves are combined to form the bifurcated stent. In a third embodiment, the stent comprises two sections that are serially inserted and assembled within the vessel at the site of the bifurcation to be treated.

3. 发明申请

WO03022172A3 LONGITUDINALLY FLEXIBLE STENT 审中-公开
标题翻译：长期灵活的STENT
公开(公告)号：WO03022172A3
公开(公告)日：2003-09-18
申请号：PCT/IB0203607
申请日：2002-09-06
申请人： MEDINOL LTD
发明人： PINCHASIK GREGORY , RICHTER JACOB
IPC分类号： A61F2/00 , A61F2/91 , A61F2/915 , A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054 , A61F2250/0014 , A61F2250/0067
摘要： An intravascular stent (fig. 10) especially suited for implanting in curved arterial portions. The stent (fig. 10) is formed of intertwined meander patterns forming triangular cells (804). The triangular cells (804) are adapted to provide radial support, and longitudinal flexibility after expansion. The triangular cells (804) provide increased coverage of a vessel wall. The stent (fig. 10) can have different portions adapted to optimize radial support or to optimize longitudinal flexibility. The stent (fig. 10) is curved and cells on the outside of the curve open in length, but narrow in width whereas cells on the inside of the curve shorten in length but thicken in width to maintain a density of stent element area which much more constant than otherwise between the inside and the outside of the curve. As a result, when the stent is coated with a medicine the more constant density of stent elements results in an even dose being applied to the inside wall of the lumen, avoiding the possibility that a toxic dose be supplied at one area while a less than effective dose is applied to another area.
摘要翻译：血管内支架（图10）特别适用于植入弯曲的动脉部分。支架（图10）由形成三角形细胞的相互缠绕的曲折图形形成（804）。三角形电池（804）适于在扩张后提供径向支撑和纵向柔性。三角形细胞（804）提供了血管壁的增加的覆盖。支架（图10）可以具有适于优化径向支撑或优化纵向柔性的不同部分。支架（图10）是弯曲的，曲线外侧的细胞长度开放但宽度窄，而曲线内侧的细胞长度缩短而宽度增加，以维持支架元件面积的密度在曲线的内部和外部之间比其他情况更恒定。结果，当支架涂覆有药物时，更稳定的支架元件的密度导致将均匀的剂量施加到内腔的内壁，避免了在一个区域供应毒性剂量的可能性，同时小于有效剂量应用于另一个区域。

4. 发明申请

WO2005120394A3 STENT HAVING STRUTS WITH REVERSE DIRECTION CURVATURE 审中-公开
标题翻译：具有反向方向曲线的条纹
公开(公告)号：WO2005120394A3
公开(公告)日：2006-05-18
申请号：PCT/IB2005001569
申请日：2005-06-03
申请人： MEDINOL LTD , PINCHASIK GREGORY
发明人： PINCHASIK GREGORY
IPC分类号： A61F2/00 , A61F2/90 , A61F2/06
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054 , A61F2250/0036
摘要： Disclosed is a stent having struts with reverse direction curvature for providing a reduced compressed profile and an increased expanded profile. The strut configuration comprises a plurality of arcuate sections facing in opposite convex and a concave orientation. The strut width may be gradually decreased from its ends towards the strut's mid-section to redistribute maximal strains away from portions of the stent more susceptible to permanent deformation, such as the loop portions. Varying strut lengths to offset the maximum circumferential widths of adjacent portions of the stent may further reduce the compressed stent profile. The varied stent lengths may also contribute to an increased expanded stent profile. Stents with the reverse direction curvature strut design can obtain an expanded to compressed stent diameter ratio of about 7:1 compared to conventional stents that have a ratio of up to about 5:1. The curved strut can be utilized with any stent design.
摘要翻译：公开了一种具有反向曲率的支柱的支架，用于提供减小的压缩轮廓和增加的扩张轮廓。支柱构造包括面对相反的凸起和凹形取向的多个弓形部分。支柱宽度可以从其端部朝向支柱的中间部分逐渐减小，以将最大应变远离更易于永久变形的支架的部分（例如环部分）重新分布。不同的支柱长度以抵消支架相邻部分的最大周向宽度可进一步减小压缩的支架轮廓。不同的支架长度也可能有助于增加扩张的支架构型。具有反向曲率支柱设计的支架可以获得与具有高达约5:1的比例的常规支架相比，扩张至压缩的支架直径比为约7:1。弯曲支柱可用于任何支架设计。

5. 发明申请

WO9956661A2 BIFURCATED STENT WITH IMPROVED SIDE BRANCH APERTURE AND METHOD OF MAKING SAME 审中-公开
标题翻译：具有改进的侧支撑孔的分叉杆及其制造方法
公开(公告)号：WO9956661A2
公开(公告)日：1999-11-11
申请号：PCT/IL9900230
申请日：1999-05-03
申请人： MEDINOL LTD , PINCHASIK GREGORY , RICHTER JACOB
发明人： PINCHASIK GREGORY , RICHTER JACOB
IPC分类号： A61F2/00 , A61F2/06 , A61F2/82 , A61F
CPC分类号： A61F2/856 , A61F2/07 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/91541 , A61F2002/91558 , A61F2220/0041 , A61F2220/0058 , A61F2230/0008 , A61F2230/001 , A61F2240/001
摘要： A bifurcated stent for insertion into a bifurcated vessel such as a blood vessel. In one embodiment, a first sheet is formed into a first leg, a second sheet is formed into a second leg, a third sheet is formed into a stem, and the two legs are attached to the stem. In a second embodiment, a first sheet is formed into a member having a first leg and half of a stem, a second sheet is formed into a second member having a second leg and half of a stem, and the two stem halves are combined to form the bifurcated stent. In a third embodiment, the stent comprises two sections that are serially inserted and assembled within the vessel at the site of the bifurcation to be treated.
摘要翻译：用于插入分叉血管如血管的分叉支架。在一个实施例中，第一片形成为第一腿，第二片形成为第二腿，第三片形成为杆，并且两个腿附接到杆。在第二实施例中，第一片形成为具有第一腿和杆的一半的构件，第二片形成为具有第二腿和杆的一半的第二构件，并且两个杆半组合成形成分叉支架。在第三实施例中，支架包括两个部分，其在待处理的分叉部位处串联并组装在容器内。

6. 发明申请

WO02094128A2 LONGITUDINALLY FLEXIBLE STENT 审中-公开
标题翻译：长期灵活的STENT
公开(公告)号：WO02094128A2
公开(公告)日：2002-11-28
申请号：PCT/IB0201746
申请日：2002-05-21
申请人： MEDINOL LTD , PINCHASIK GREGORY , RICHTER JACOB
发明人： PINCHASIK GREGORY , RICHTER JACOB
IPC分类号： A61F2/84 , A61F2/06 , A61F2/90 , A61F
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054
摘要： An intravascular stent especially suited for implanting in curved arterial portions. The stent retains longitudinal flexibility after expansion. The stent includes a plurality of first circumferential bands containing a pattern of loops at a first frequency and a plurality of second circumferential bands containing a pattern of loops at a second frequency higher than said first frequency, alternating with said first circumferential bands and periodically coupled thereto to form cells. The high frequency elements provide a flexibility after expansions which can be repeatedly stress by the beating heart, with out exceeding the elastic limit of the stent material.
摘要翻译：一种特别适合植入弯曲动脉部分的血管内支架。支架在扩张后保持纵向弹性。所述支架包括多个第一周期带，所述第一周向带包含第一频率的线圈图案，以及多个第二周向带，其包含高于所述第一频率的第二频率的环路图案，与所述第一周向带交替并周期性耦合形成细胞。高频元件在膨胀之后提供柔性，其可以通过跳动的心脏重复应力，超出支架材料的弹性极限。

7. 发明申请

WO0193777A3 SERPENTINE COILED LADDER STENT 审中-公开
标题翻译： SERPENTINE卷绕梯子
公开(公告)号：WO0193777A3
公开(公告)日：2002-05-16
申请号：PCT/IL0100518
申请日：2001-06-05
申请人： MEDINOL LTD , RICHTER JACOB , PINCHASIK GREGORY
发明人： RICHTER JACOB , PINCHASIK GREGORY
IPC分类号： A61F2/84 , A61F2/02 , A61F2/82 , A61F2/88 , A61F2/90 , A61M29/00 , A61F2/06
CPC分类号： A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155
摘要： A serpentine coiled ladder stent (30) is provided, in which the coil is formed from a wound strip of cells (37), wherein the sides (34, 35) of the cells (37) are serpentine windings, wherein the strip is formed of at least two side bands (34, 35) connected to each other, for example by a series of cross struts (36). The cross struts (36) may be positioned slightly askew. Each side band (34, 35) is formed in a serpentine pattern comprising a series of bends (38), wherein upon expansion of the stent (30), the bends (38) of the side bands (34, 35) open to increase the length of each of the individual cells (37) in the helical direction, thereby lengthening the strip in the helical direction to allow the stent (30) to expand without any significant unwinding of the strip.
摘要翻译：提供了蛇形盘绕的梯形支架（30），其中线圈由一个单元（37）的缠绕条形成，其中该单元（37）的侧面（34,35）是蛇形绕组，其中形成该条带至少两个彼此连接的边带（34,35），例如通过一系列交叉支柱（36）。交叉支柱（36）可以稍微偏斜地定位。每个侧带（34,35）形成为包括一系列弯曲部（38）的蛇形图案，其中在支架（30）膨胀时，侧带（34,35）的弯曲部（38）打开以增加每个单个细胞（37）的长度在螺旋方向上，从而使条带沿螺旋方向延长以允许支架（30）膨胀而没有带的任何明显的退绕。

8. 发明申请

WO0189409A2 BIFURCATED STENT WITH IMPROVED SIDE BRANCH APERTURE AND METHOD OF MAKING SAME 审中-公开
标题翻译：具有改进的侧支撑孔的分叉杆及其制造方法
公开(公告)号：WO0189409A2
公开(公告)日：2001-11-29
申请号：PCT/IL0100456
申请日：2001-05-21
申请人： MEDINOL LTD , RICHTER JACOB , PINCHASIK GREGORY
发明人： RICHTER JACOB , PINCHASIK GREGORY
IPC分类号： A61F2/00 , A61F2/06 , A61F2/82 , A61M29/00 , A61F
CPC分类号： A61F2/856 , A61F2/07 , A61F2/82 , A61F2/852 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/075 , A61F2002/91533 , A61F2002/91558 , A61F2220/0041 , A61F2220/0058 , A61F2230/001 , A61F2240/001 , A61F2250/006 , Y10S623/901 , Y10T29/496 , Y10T29/49826
摘要： A stent (5) for insertion into a blood vessel is made from a sheet having a longitudinal axis and a first portion (10) and a second portion (30). The first portion (10) has a proximal end and a distal end and a first lateral side and a second lateral side with the lateral sides of the first portion substantially parallel to the longitudinal axis and disposed apart from each other a first distance. The second portion (30) has a proximal end (16) and a distal end (17) and a first lateral side and a second lateral side with the lateral sides of the second portion substantially parallel to the longitudinal axis and disposed apart from each other a second distance that is less than the first distance. The proximal end (16) of the second portion (30) communicates with the distal end of the first portion. The first lateral side of the first portion is connected to the second lateral side of the first portion and the first lateral side of the second portion is connected to the second lateral side of the second portion to form the stent. A portion of the distal end of the first portion and a portion of the proximal end of the second portion define a branch aperture.
摘要翻译：用于插入血管的支架（5）由具有纵向轴线的片材和第一部分（10）和第二部分（30）制成。第一部分（10）具有近端和远端以及第一侧面和第二横向侧面，其中第一部分的侧面基本上平行于纵向轴线并且彼此分开设置第一距离。第二部分（30）具有近端（16）和远端（17）以及第一横向侧和第二侧面，其中第二部分的侧边基本上平行于纵向轴线并彼此分开设置第二距离小于第一距离。第二部分（30）的近端（16）与第一部分的远端连通。第一部分的第一侧面连接到第一部分的第二侧面，并且第二部分的第一侧面与第二部分的第二横向侧连接以形成支架。第一部分的远端的一部分和第二部分的近端的一部分限定分支孔。

9. 发明专利

JP2004000791A Forked stent and manufacturing method therefor 有权
公开(公告)号：JP2004000791A
公开(公告)日：2004-01-08
申请号：JP2003333781
申请日：2003-09-25
申请人： Medinol Ltd , メディノールリミティド
发明人： RICHTER JACOB , PINCHASIK GREGORY
IPC分类号： A61F2/00 , A61F2/06 , A61F2/82 , A61M29/00 , A61M29/02
CPC分类号： A61F2/856 , A61F2/07 , A61F2/82 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/075 , A61F2220/0041 , A61F2220/0058 , A61F2230/001 , A61F2240/001 , Y10S623/901 , Y10T29/494
摘要： PROBLEM TO BE SOLVED: To easily manufacture a forked stent equipped with a stem and two legs. SOLUTION: A first tubular member 110 and a second tubular member 140 are assembled into the forked stent 160. The first tubular member 110 is provided with a base end 115, a terminal 120 and a lengthwise bore 131 penetrating the base end and the terminal, and between the base end 115 and the terminal 120, a branch hole 135 is provided to communicate with the lengthwise bore 131. A dimension of the branch hole 135 is set to accept and fix the second tubular member 140. The second tubular member 140 is provided with a base end 145, a terminal 150 and a lengthwise bore 132 penetrating the base end and the terminal, and the base end 145 is located within the branch hole 135 so as to be located within the lengthwise bore 131 of the first tubular member 110. COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2002224225A STENT 审中-公开
公开(公告)号：JP2002224225A
公开(公告)日：2002-08-13
申请号：JP2002002345
申请日：2002-01-09
申请人： MEDINOL LTD
发明人： PINCHASIK GREGORY
IPC分类号： A61F2/00 , A61F2/88 , A61F2/95 , B21F3/00 , B21F3/02 , B21F3/04 , A61M29/02
摘要： PROBLEM TO BE SOLVED: To provide a stent whose hardness is properly adjusted. SOLUTION: This stent is formed of a shape memory alloy and is provided with a wire wound in a coil shape provided with a plurality of coils having a memorized winding direction, at least one part wound in the memorized winding direction and at least one part wound in the opposite winding direction. The wire wound in the coil shape is provided with a recess extended so as to partially damage the circular shape of the stent in the cross section of the circular shape and the hardness of the outer side part of at least a part of a plurality of the coils is less than the hardness of the inner side part.

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