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    • 1. 发明申请
    • ANTI-IL-9 ANTIBODY FORMULATIONS AND USES THEREOF
    • 抗IL-9抗体制剂及其用途
    • WO2005117967A3
    • 2007-02-01
    • PCT/US2005012464
    • 2005-04-12
    • MEDIMMUNE INCALLAN CHRISTIAN B
    • ALLAN CHRISTIAN B
    • A61K39/395A61K47/02A61K47/18C07K16/06C07K16/24
    • A61K39/39591A61K47/02A61K47/183A61K2039/505C07K16/065C07K16/244
    • The present invention provides liquid formulations of antibodies or antibody fragments that immunospecifically bind to an IL-9 polypeptide, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. In particular, the present invention provides liquid formulations of antibodies or fragments thereof that immunospecifically bind to an IL-9 polypeptide, which formulations are substantially free of surfactants, sugars, sugar alcohols, amino acids other than histidine (preferably with pKa values of less than 5 and above 7), and/or other common excipients. Furthermore, the invention provides methods of preventing, treating or ameliorating a disease or disorder associated with or characterized by aberrant expression and/or activity of an IL-9 polypeptide, a disease or disorder associated with or characterized by aberrant expression and/or activity of the IL-9R or one or more subunits thereof, an autoimmune disease, an inflammatory disease, a proliferative disease, or an infection (preferably, a respiratory infection), or one or more symptoms thereof, utilizing the liquid formulations of the present invention.
    • 本发明提供免疫特异性结合IL-9多肽的抗体或抗体片段的液体制剂,该制剂表现出稳定性,低至不可检测的聚集水平,并且抗体或抗体片段的生物活性几乎不损失或不损失, 即使在长时间的存储。 特别地,本发明提供免疫特异性结合IL-9多肽的抗体或其片段的液体制剂,该制剂基本上不含表面活性剂,糖,糖醇,组氨酸以外的氨基酸(优选pKa值小于 5和7以上),和/或其它常用赋形剂。 此外,本发明提供了预防,治疗或改善与IL-9多肽的异常表达和/或活性相关或特征性的疾病或病症的方法,所述异常表达和/或活性与 利用本发明的液体制剂,其IL-9R或其一个或多个亚单位,自身免疫性疾病,炎性疾病,增殖性疾病或感染(优选呼吸道感染)或其一种或多种症状。
    • 4. 发明申请
    • ANTI-INTEGRIN alphanubeta3 ANTIBODY FORMULATIONS AND USES THEREOF
    • 抗生素alphanubeta3抗体制剂及其用途
    • WO2004066957A3
    • 2005-04-07
    • PCT/US2004002701
    • 2004-01-30
    • MEDIMMUNE INCALLAN CHRISTIAN B
    • ALLAN CHRISTIAN B
    • A61K20060101A61K39/395C07K16/28
    • A61K39/39591C07K16/2848
    • The present invention provides liquid formulations of antibodies or antibody fragments that immunospecifically bind to integrin alphanubeta3 , which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. In particular, the present invention provides liquid formulations of antibodies or fragments thereof that immunospecifically bind to integrin alphanubeta3 , which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides methods of preventing, treating or ameliorating an inflammatory disorder, an autoimmune disorder, a disorder associated with aberrant expression and/or activity of integrin alphanubeta3, a disorder associated with abnormal bone metabolism, a disorder associated with aberrant angiogenesis or cancer utilizing the liquid formulations of the present invention.
    • 本发明提供了抗体或抗体片段的液体制剂,其免疫特异性结合整联蛋白alphanubeta3,该制剂表现出稳定性,低至不可检测的聚集水平,以及甚至在长时间内抗体或抗体片段的生物活性也很少甚至没有丧失 储存期 特别地,本发明提供免疫特异性结合整联蛋白氨基酸3的抗体或其片段的液体制剂,该制剂基本上不含表面活性剂,无机盐和/或其它常用赋形剂。 此外,本发明提供了预防,治疗或改善炎性病症,自身免疫性疾病,与整合素alphanubeta3的异常表达和/或活性相关的病症,与异常骨代谢相关的疾病,与异常血管生成或癌症相关的病症的方法 利用本发明的液体制剂。