专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012015912A1 METHOD FOR PURIFYING ACTIVE POLYPEPTIDES OR IMMUNOCOJUGATES 审中-公开
标题翻译：纯化活性多肽或免疫球蛋白的方法
公开(公告)号：WO2012015912A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045524
申请日：2011-07-27
申请人： MEDIMMUNE, LLC , LINKE, Thomas , WANG, William, K. , SHAH, Ambarish , SATHISH, Hasige , HUNTER, Alan , THOMPSON, Christopher
发明人： LINKE, Thomas , WANG, William, K. , SHAH, Ambarish , SATHISH, Hasige , HUNTER, Alan , THOMPSON, Christopher
IPC分类号： B01D15/04 , B01J41/20
CPC分类号： C07K16/2851 , A61K39/3955 , A61K47/02 , A61K47/6829 , A61K47/6849 , A61K2039/505 , B01D15/166 , B01D15/363 , B01J41/14 , B01J41/20 , C07K1/18 , C07K16/2803 , C07K17/02 , C07K2317/56 , C07K2317/94 , C07K2319/35 , C07K2319/55
摘要： The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.
摘要翻译：本发明提供了通过使用阴离子交换色谱法纯化含有活性多肽或免疫缀合物及其酸性变体（例如脱酰胺化变体）的溶液来分离活性多肽或免疫缀合物的方法。

2. 发明申请

WO2013036445A1 METHODS FOR PROCESSING COAGULATION FACTORS 审中-公开
标题翻译：加工凝血因子的方法
公开(公告)号：WO2013036445A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/053319
申请日：2012-08-31
申请人： MEDIMMUNE LLC , HUNTER, Alan , WANG, Xiangyang , PABST, Timothy , WENDELER, Michaela , WANG, Jihong , CAREY, Kendall , STROUSE, Robert , VARGHESE, Johnson
发明人： HUNTER, Alan , WANG, Xiangyang , PABST, Timothy , WENDELER, Michaela , WANG, Jihong , CAREY, Kendall , STROUSE, Robert , VARGHESE, Johnson
IPC分类号： C12P21/02
CPC分类号： C12N9/6429 , C07K14/745 , C12N9/647
摘要： The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.
摘要翻译：本申请涉及用于纯化重组凝血因子蛋白的方法，包括例如凝血酶原（凝血因子）（因子II）。在实施方案中，所述方法提供显示增加的生物活性和降低凝血酶水平的纯化凝血酶原，从而增加凝血酶原的安全性。还提供了纯化的重组凝血因子蛋白。

3. 发明申请

WO2003009106A2 PORTABLE ENTERPRISE LOCAL AREA NETWORK UNIT 审中-公开
标题翻译：便利企业当地区域网络单位
公开(公告)号：WO2003009106A2
公开(公告)日：2003-01-30
申请号：PCT/US2002/023335
申请日：2002-07-22
申请人： HUNTER, Alan
发明人： HUNTER, Alan
IPC分类号： G06F
CPC分类号： H05K7/1488 , G06F1/16
摘要： A portable enterprise local area network system that simultaneously runs multiple platforms of operating systems and preferably comprises an Ethernet switch, 24-port hub, Smart-UPS, router, flip-up monitor/keyboard/mouse, power conditioner, Win2K server, SUN SOLARIS server, LINUX server and drive array, wherein all components are prewired and housed within a portable cabinet. The operating systems preferably consist of a WINDOWS platform for file/print applications; a UNIX platform for security, mail and data applications; and a SUN SOLARIS platform for web hosting and E-commerce applications.
摘要翻译：同时运行多个操作系统平台的便携式企业局域网系统，最好包括以太网交换机，24端口集线器，Smart-UPS，路由器，翻转监视器/键盘/鼠标，功率调节器，Win2K服务器，SUN SOLARIS 服务器，LINUX服务器和驱动器阵列，其中所有组件都被预接线并且容纳在便携式机柜内。操作系统优选地由用于文件/打印应用的WINDOWS平台组成; 用于安全，邮件和数据应用程序的UNIX平台; 以及用于网络托管和电子商务应用的SUN SOLARIS平台。

4. 发明申请

WO2009126807A2 BEARINGS 审中-公开
标题翻译：轴承
公开(公告)号：WO2009126807A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/040071
申请日：2009-04-09
申请人： SAINT-GOBAIN PERFORMANCE PLASTICS CORPORATION , HUNTER, Alan , HAGAN, Timothy, J. , DIMARTINO, Vincent , KUENTZLER, Boris, L.
发明人： HUNTER, Alan , HAGAN, Timothy, J. , DIMARTINO, Vincent , KUENTZLER, Boris, L.
IPC分类号： F16C35/02 , F16C33/12 , F16C17/00 , F16C33/04 , F16C33/02
CPC分类号： F16C33/10 , C10M119/02 , C10M169/02 , C10M2203/10 , C10M2203/102 , C10M2203/106 , C10M2205/028 , C10M2205/0285 , C10M2205/166 , C10M2207/026 , C10M2207/281 , C10M2207/285 , C10M2219/00 , C10N2220/022 , C10N2230/10 , C10N2230/40 , C10N2240/02 , C10N2240/20 , C10N2250/10 , F16C33/102
摘要： A bearing includes a first member having a passageway configured to engage a shaft, the first member having a metallic material; and a second member disposed around at least a portion of the first member, the second member having a metallic material and at least one radially and inwardly bent portion capable of restricting axial movement of the first member. The first and second members are movable relative to each other.
摘要翻译：轴承包括具有构造成接合轴的通道的第一构件，所述第一构件具有金属材料; 以及设置在所述第一构件的至少一部分周围的第二构件，所述第二构件具有金属材料和至少一个能够限制所述第一构件的轴向运动的径向和向内弯曲部分。第一和第二构件可相对于彼此移动。

5. 发明申请

WO2016145307A1 METHOD OF PURIFYING ALBUMIN-FUSION PROTEINS 审中-公开
标题翻译：纯化蛋白融合蛋白的方法
公开(公告)号：WO2016145307A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/022003
申请日：2016-03-11
申请人： MEDIMMUNE, LLC
发明人： PABST, Timothy , FONSECA, Mariko , THOMPSON, Christopher , HUNTER, Alan , WANG, Xiangyang , TIE, Liu , LI, Yiming
IPC分类号： C07K14/765 , C07K1/14 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36
CPC分类号： C07K14/765 , A61K38/00 , A61K47/643 , C07K1/18 , C07K1/22 , C07K14/78 , C07K2319/00
摘要： The present invention relates to a method of purifying albumin-fusion proteins to reduce the level of oxidation of susceptible amino acid residues. The method comprises an affinity matrix chromatography step and an anion exchange chromatography step. The purified albumin-fusion proteins have low levels of oxidation and retain their enhanced half-life in vivo and its bioactivity. In some embodiments, the albumin-fusion protein comprises a scaffold, such as human Tenascin C scaffold. Compositions comprising the albumin-fusion protein are further disclosed.
摘要翻译：本发明涉及净化白蛋白融合蛋白以降低易感氨基酸残基的氧化水平的方法。该方法包括亲和基质层析步骤和阴离子交换层析步骤。纯化的白蛋白融合蛋白具有低氧化水平并保持其在体内的增强的半衰期及其生物活性。在一些实施方案中，白蛋白融合蛋白包含支架，例如人腱生蛋白C支架。进一步公开了包含白蛋白融合蛋白的组合物。

6. 发明申请

WO2022003565A1 DETERGENT AND METHOD FOR PURIFYING A BIOTHERAPEUTIC 审中-公开
公开(公告)号：WO2022003565A1
公开(公告)日：2022-01-06
申请号：PCT/IB2021/055819
申请日：2021-06-29
申请人： MEDIMMUNE, LLC
发明人： HUNTER, Alan , ASPELUND, Matthew , GADRE, Dhanesh , LINKE, Thomas , REZVANI, Kamiyar , XI, Guoling
IPC分类号： C07K1/18 , C07K1/22 , C07K1/36 , A61K38/00
摘要： Provided herein is an environmentally compatible detergent for use in purification of a recombinantly produced biotherapeutic. The environmentally compatible detergent includes Laureth-9 and can be used for viral clearance, cell lysis, and removal of impurities such as host cell proteins an endotoxins. Advantageously, Laureth-9 does not adversely impact product quality.

7. 发明申请

WO2014209508A1 SEPARATION OF RECOMBINANT POLYCLONAL ANTIBODY MULTIMERS WITH MINIMAL SEPARATION OF MONOMERS 审中-公开
标题翻译：具有最小单体分离的重组多环抗体多聚体的分离
公开(公告)号：WO2014209508A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/037684
申请日：2014-05-12
申请人： MEDIMMUNE, LLC
发明人： HUNTER, Alan , PABST, Timothy , WANG, Jihong , WANG, Xiangyang , LIU, Hongji
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , B01D15/327 , B01D15/3847 , C07K1/16 , C07K16/065 , B01D15/361
摘要： The invention provides a method tor removing multimers from a preparation of recombinant polyclonal antibodies (rpAbs) while maintaining the ratio of monomers within a narrow range. The invention provides a method of separating recombinant polyclonal antibody multimers with minimal separation of monomers comprising subjecting a mixture comprising a plurality of monoclonal antibodies to at least one separation process selected from the group consisting of multi-modal chromatography, apatite chromatography, and hydrophobic interaction chromatography thereby producing an antibody monomer preparation that is substantially free of multimers.
摘要翻译：本发明提供了从重组多克隆抗体（rpAb）的制备中去除多聚体的方法，同时保持单体在窄范围内的比例。本发明提供了一种分离重组多克隆抗体多聚体的方法，其中单体分离最小，包括使包含多种单克隆抗体的混合物至少选自多模式色谱法，磷灰石色谱法和疏水相互作用色谱法从而产生基本上不含多聚体的抗体单体制剂。

8. 发明申请

WO2014100443A3 METHODS OF PRODUCING IMMUNOCONJUGATES 审中-公开
公开(公告)号：WO2014100443A3
公开(公告)日：2014-06-26
申请号：PCT/US2013/076625
申请日：2013-12-19
申请人： MEDIMMUNE, LLC
发明人： HUNTER, Alan , LINKE, Thomas , PABST, Tim , WENDELER, Michaela , WANG, Xiangyang , TOHMPSON, Chris , XI, Guoling , FULTON, Andrew
IPC分类号： A61K39/02 , C12P21/06 , C12P21/08
摘要： The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.

9. 发明公开

EP3434346A1 PURIFIED ACTIVE POLYPEPTIDES OR IMMUNOCONJUGATES 有权转让
公开(公告)号：EP3434346A1
公开(公告)日：2019-01-30
申请号：EP18174165.3
申请日：2011-07-27
申请人： Medimmune, LLC
发明人： LINKE, Thomas , WANG, William, K , SHAH, Ambarish , SATHISH, Hasige , HUNTER, Alan , THOMPSON, Christopher
IPC分类号： B01D15/04 , B01J41/20 , C07K16/28 , C07K1/18 , B01J41/14 , A61K47/68
摘要： The present invention provides isolated active polypeptides or immunoconjugates, which can be obtained by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.

10. 发明公开

EP3268389A1 METHOD OF PURIFYING ALBUMIN-FUSION PROTEINS 有权
标题翻译：纯化白蛋白融合蛋白的方法
公开(公告)号：EP3268389A1
公开(公告)日：2018-01-17
申请号：EP16762595.3
申请日：2016-03-11
申请人： Medimmune, LLC
发明人： PABST, Timothy , FONSECA, Mariko , THOMPSON, Christopher , HUNTER, Alan , WANG, Xiangyang , TIE, Liu , LI, Yiming
IPC分类号： C07K14/765 , C07K1/14 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36
摘要： The present invention relates to a method of purifying albumin-fusion proteins to reduce the level of oxidation of susceptible amino acid residues. The method comprises an affinity matrix chromatography step and an anion exchange chromatography step. The purified albumin-fusion proteins have low levels of oxidation and retain their enhanced half-life in vivo and its bioactivity. In some embodiments, the albumin-fusion protein comprises a scaffold, such as human Tenascin C scaffold. Compositions comprising the albumin-fusion protein are further disclosed.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式