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1. 发明申请

WO2020076790A1 ANTIBODIES DIRECTED AGAINST STAPHYLOCOCCUS AUREUS LEUKOTOXINS 审中-公开
公开(公告)号：WO2020076790A1
公开(公告)日：2020-04-16
申请号：PCT/US2019/055144
申请日：2019-10-08
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： TKACZYK, Christine , SELLMAN, Bret , DU, Qun , DAMSCHRODER, Melissa , CORTI, Davide , MINOLA, Andrea
IPC分类号： C07K16/12 , A61K39/085 , A61P31/00 , A61K39/00
摘要： The present disclosure is directed to leukotoxin-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect leukotoxin and/or in methods of treating and preventing Staphylococcus aureus infections.

2. 发明申请

WO2020023644A3 ANTIBODY DIRECTED AGAINST S. AUREUS CLUMPING FACTOR A (CLFA) 审中-公开
公开(公告)号：WO2020023644A3
公开(公告)日：2020-01-30
申请号：PCT/US2019/043254
申请日：2019-07-24
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： TKACZYK, Christine , SELLMAN, Bret , BORROK III, Martin , CORTI, Davide , MINOLA, Andrea
IPC分类号： A61P31/04 , C07K16/12
摘要： The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

3. 发明申请

WO2020023644A2 ANTIBODY DIRECTED AGAINST S. AUREUS CLUMPING FACTOR A (CLFA) 审中-公开
公开(公告)号：WO2020023644A2
公开(公告)日：2020-01-30
申请号：PCT/US2019/043254
申请日：2019-07-24
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： TKACZYK, Christine , SELLMAN, Bret , BORROK III, Martin , CORTI, Davide , MINOLA, Andrea
IPC分类号： A61P31/04 , C07K16/12
摘要： The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

4. 发明公开

EP3840838A2 ANTIBODY DIRECTED AGAINST S.AUREUS CLUMPING FACTOR A (CLFA) 审中-实审
公开(公告)号：EP3840838A2
公开(公告)日：2021-06-30
申请号：EP19749544.3
申请日：2019-07-24
申请人： MedImmune, LLC , Humabs Biomed SA
发明人： TKACZYK, Christine , SELLMAN, Bret , BORROK III, Martin , CORTI, Davide , MINOLA, Andrea
IPC分类号： A61P31/04 , C07K16/12

5. 发明公开

EP3864040A1 ANTIBODIES DIRECTED AGAINST STAPHYLOCOCCUS AUREUS LEUKOTOXINS 审中-实审
公开(公告)号：EP3864040A1
公开(公告)日：2021-08-18
申请号：EP19795711.1
申请日：2019-10-08
申请人： Medimmune, LLC , Humabs BioMed SA
发明人： TKACZYK, Christine , SELLMAN, Bret , DU, Qun , DAMSCHRODER, Melissa , CORTI, Davide , MINOLA, Andrea
IPC分类号： C07K16/12 , A61K39/085 , A61P31/00 , A61K39/00

6. 发明申请

WO2014074470A1 METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES 审中-公开
标题翻译：治疗金黄色葡萄球菌相关疾病的方法
公开(公告)号：WO2014074470A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068385
申请日：2013-11-05
申请人： MEDIMMUNE, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , HAMILTON, Melissa , HUA, Lei
IPC分类号： A61K39/085
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , C07K2317/52 , C07K2317/565 , C07K2317/76
摘要： The present invention provides for methods of preventing and/or treating S. aureusassociated bacteremia and sepsis, and methods for preventing and/or treating S. aureus associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (antiAT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus -associated pneumonia in an immunocompromised mammalian subject.
摘要翻译：本发明提供了预防和/或治疗金黄色葡萄球菌相关菌血症和败血症的方法，以及在使用抗-S的免疫受损患者中预防和/或治疗金黄色葡萄球菌相关性肺炎的方法。金黄色葡萄球菌α毒素（antiAT）抗体。还提供了降低哺乳动物受试者的血液或心脏中的金黄色葡萄球菌细菌负荷的方法，包括向受试者施用有效量的分离的抗S。金黄色葡萄球菌α毒素（抗AT）抗体或其抗原结合片段。在哺乳动物受试者中降低金黄色葡萄球菌细菌凝集和/或血栓栓塞损伤形成的方法，包括向受试者施用有效量的分离的抗S。还提供了金黄色葡萄球菌α毒素（抗AT）抗体或其抗原结合片段。还提供了在免疫受损的哺乳动物受试者中预防或降低金黄色葡萄球菌相关性肺炎的严重性的方法。

7. 发明申请

WO2012109285A3 ANTIBODIES THAT SPECIFICALLY BIND STAPHYLOCOCCUS AUREUS ALPHA TOXIN AND METHODS OF USE 审中-公开
公开(公告)号：WO2012109285A3
公开(公告)日：2012-08-16
申请号：PCT/US2012/024201
申请日：2012-02-07
申请人： MEDIMMUNE, LLC , SELLMAN, Bret , TKACZYK, Christine , HUA, Lei , CHOWDHURY, Partha , VARKEY, Reena , DAMSCHRODER, Melissa , PENG, Li , OGANESYAN, Vaheh , HILLIARD, Jamese, Johnson
发明人： SELLMAN, Bret , TKACZYK, Christine , HUA, Lei , CHOWDHURY, Partha , VARKEY, Reena , DAMSCHRODER, Melissa , PENG, Li , OGANESYAN, Vaheh , HILLIARD, Jamese, Johnson
IPC分类号： C12P21/08 , C07K16/00 , A61K39/40 , A61K39/085
摘要： The disclosure provides compositions, methods of manufacture and methods of use of antibodies and fragments that bind Staphylococcus aureus alpha toxin. More specifically, the disclosure provides VH CDR and VL CDR region sequences of antibodies or antigen-binding fragments. Method of preventing, treating or managing a condition associated with Staphylococcus aureus infection using the antibodies are also disclosed.

8. 发明申请

WO2020076789A3 COMBINATIONS OF ANTI-STAPHYLOCOCCUS AUREUS ANTIBODIES 审中-公开
公开(公告)号：WO2020076789A3
公开(公告)日：2020-04-16
申请号：PCT/US2019/055143
申请日：2019-10-08
申请人： MEDIMMUNE, LLC
发明人： TKACZYK, Christine , SELLMAN, Bret , DU, Qun , DAMSCHRODER, Melissa , COHEN, Taylor
IPC分类号： C07K16/12 , C07K16/22 , A61P31/04 , A61K39/395
摘要： The present disclosure is directed to anti- Staphylococcus aureus antibody combinations including combinations of antibodies that bind to S. aureus alpha toxin (AT) protein, clumping factor A protein (ClfA), and/or at least one leukotoxin protein. Methods of treating and preventing infections comprising administering the antibody combinations are also provided herein.

9. 发明申请

WO2020076789A2 COMBINATIONS OF ANTI-STAPHYLOCOCCUS AUREUS ANTIBODIES 审中-公开
公开(公告)号：WO2020076789A2
公开(公告)日：2020-04-16
申请号：PCT/US2019/055143
申请日：2019-10-08
申请人： MEDIMMUNE, LLC
发明人： TKACZYK, Christine , SELLMAN, Bret , DU, Qun , DAMSCHRODER, Melissa , COHEN, Taylor
摘要： The present disclosure is directed to anti- Staphylococcus aureus antibody combinations including combinations of antibodies that bind to S. aureus alpha toxin (AT) protein, clumping factor A protein (ClfA), and/or at least one leukotoxin protein. Methods of treating and preventing infections comprising administering the antibody combinations are also provided herein.

10. 发明申请

WO2014074540A2 ANTIBODIES TO S. AUREUS SURFACE DETERMINANTS 审中-公开
标题翻译： S.Ausus表面活性剂的抗体
公开(公告)号：WO2014074540A2
公开(公告)日：2014-05-15
申请号：PCT/US2013/068624
申请日：2013-11-06
申请人： MEDIMMUNE, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , CHOWDHURY, Partha, S. , HUA, Lei , PAVLIK, Peter , BUONPANE, Rebecca , CHANG, Chew-Shun
IPC分类号： A61K39/40
CPC分类号： C07K16/1271 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/56938
摘要： Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.
摘要翻译：公开了针对金黄色葡萄球菌（金黄色葡萄球菌）表面决定簇抗原和分泌毒素的抗体及其抗原结合片段。还提供了使用抗体及其抗原结合片段检测，诊断和处理金黄色葡萄球菌的方法。

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