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1. 发明申请

WO03006687A3 NOVEL TARGET GENES FOR DISEASES OF THE HEART 审中-公开
标题翻译：心脏疾病的新目标基因
公开(公告)号：WO03006687A3
公开(公告)日：2003-08-28
申请号：PCT/EP0207704
申请日：2002-07-10
申请人： MEDIGENE AG , REUNER BIRGIT , BUNK DANIELA , HENKEL THOMAS
发明人： REUNER BIRGIT , BUNK DANIELA , HENKEL THOMAS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to a variety of genes abnormally expressed in heart tissue as well as to fragments of such genes. Assessment of the expression level of these genes may be used for testing the predisposition of mammals and preferably humans of a heart disease or for an acute state of such a disease. Preferred diseases in accordance with the invention are congestive heart failure, dilative cardiomyopathy, hypertrophic cardiomyopathy and ischemic cardiomyopathy. The present invention further relates to methods of identifying compounds capable of normalizing the expression level of the aforementioned genes and of further genes affected by the abnormal expression. The identified compounds may be used for formulating compositions, preferably pharmaceutical compositions for preventing or treating diseases. They may be used as lead compounds for the development of medicament having an inproved efficiency, a longer half-life, a decreased toxicity etc. and to be employed in the treatment of heart diseases. Included in the invention are also somatic gene therapy methods comparing the introduction of at least one functional copy of any of the above-mentioned genes into a suitable cell. Finally, the invention relates to non-human transgenic animals comprising at least one of the aformentioned genes in their germ line. The transgenic animals of the invention may be used for the development of medicaments for the treatment of heart diseases.
摘要翻译：本发明涉及在心脏组织中异常表达的各种基因以及这些基因的片段。这些基因的表达水平的评估可以用于测试哺乳动物，优选人心脏病或这种疾病的急性状态的倾向。根据本发明的优选疾病是充血性心力衰竭，扩张性心肌病，肥厚性心肌病和缺血性心肌病。本发明还涉及鉴定能够使上述基因的表达水平正常化的化合物和受异常表达影响的其它基因的方法。鉴定的化合物可用于配制组合物，优选用于预防或治疗疾病的药物组合物。它们可以用作开发具有提高的效率，更长的半衰期，降低的毒性等等并用于治疗心脏病的药物的铅化合物。本发明中还包括体细胞基因治疗方法，比较将任何上述基因的至少一个功能拷贝引入合适的细胞中。最后，本发明涉及在其种系中包含至少一个上述基因的非人转基因动物。本发明的转基因动物可用于开发用于治疗心脏病的药物。

2. 发明申请

WO0192567A3 NOVEL TARGET GENES FOR DISEASES OF THE HEART 审中-公开
标题翻译：心脏疾病的新目标基因
公开(公告)号：WO0192567A3
公开(公告)日：2003-02-13
申请号：PCT/EP0106165
申请日：2001-05-30
申请人： MEDIGENE AG , BUNK DANIELA , REUNER BIRGIT , BECK JOACHIM , HENKEL THOMAS
发明人： BUNK DANIELA , REUNER BIRGIT , BECK JOACHIM , HENKEL THOMAS
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , C07K14/47 , C12N15/09 , C12N15/85 , C12Q1/50 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K49/00 , C07K16/18
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2217/075 , A01K2267/03 , A01K2267/0375 , C07K14/47 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a variety of genes abnormally expressed in heart tissue as well as to fragments of such genes. Assessment of the expression level of these genes may be used for testing the predisposition of mammals and preferably humans for a heart disease or for an acute state of such a disease. Preferred diseases in accordance with the invention are congestive heart failure, dilative cardiomyopathy, hypertrophic cardiomyopathy and ischemic cardiomyopathy. The present invention further relates to methods of identifying compounds capable of normalizing the expression level of the aforementioned genes and of further genes affected by the abnormal expression. The identified compounds may be used for formulating compositions, preferably pharmaceutical compositions for preventing or treating diseases. They may also be used as lead compounds for the development of medicaments having an improved efficiency, a longer half-life, a decreased toxicity etc. and to be employed in the treatment of heart diseases. Included in the invention are also somatic gene therapy methods comprising the introduction of at least one functional copy of any of the above-mentioned genes into a suitable cell. Finally, the invention relates to non-human transgenic animals comprising at least one of the aforementioned genes in their germ line. The transgenic animals of the invention may be used for the development of medicaments for the treatment of heart diseases.
摘要翻译：本发明涉及在心脏组织中异常表达的各种基因以及这些基因的片段。这些基因的表达水平的评估可以用于测试哺乳动物和优选人心脏病或这种疾病的急性状态的倾向。根据本发明的优选疾病是充血性心力衰竭，扩张性心肌病，肥厚性心肌病和缺血性心肌病。本发明还涉及鉴定能够使上述基因的表达水平正常化的化合物和受异常表达影响的其它基因的方法。鉴定的化合物可用于配制组合物，优选用于预防或治疗疾病的药物组合物。它们也可以用作开发具有改善的效率，更长的半衰期，降低的毒性等等并且用于治疗心脏病的药物的铅化合物。本发明还包括体细胞基因治疗方法，其包括将任何上述基因的至少一个功能拷贝引入合适的细胞中。最后，本发明涉及在其种系中包含至少一个上述基因的非人转基因动物。本发明的转基因动物可用于开发用于治疗心脏病的药物。

3. 发明申请

WO0146388A2 PATHOLOGICALLY MODIFIED MYOCARDIAL CELL, PRODUCTION AND USE THEREOF 审中-公开
标题翻译：病理改变的心脏肌肉细胞，生产和使用
公开(公告)号：WO0146388A2
公开(公告)日：2001-06-28
申请号：PCT/EP0013101
申请日：2000-12-21
申请人： MEDIGENE AG , ROENICKE VOLKER , NAVE BARBARA , HENKEL THOMAS
发明人： ROENICKE VOLKER , NAVE BARBARA , HENKEL THOMAS
IPC分类号： C12N15/09 , C12N5/077 , C12Q1/02 , G01N33/50 , C12N5/06 , A61K35/34 , C12N5/08 , C12N5/10
CPC分类号： C12N5/0657 , C12N2501/235 , C12N2501/365 , C12N2501/999 , C12N2503/02 , G01N33/5014 , G01N2500/10
摘要： The invention relates to a pathologically modified myocardial cell which can be produced from healthy cardiac tissue by providing or isolating at least one healthy myocardial cell, by stimulating said isolated myocardial cell using the appropriate hormones, hormone analogues and/or zytokines and by detecting the pathologically modified myocardial cell(s) by localising at least one signal molecule. The invention also relates to a method for producing said pathologically modified myocardial cell and to the use thereof, including a method for detecting or identifying cardioactive substances.
摘要翻译：患病的心脏肌肉细胞，从健康的心脏组织制备通过提供或分离至少一种健康的心脏肌肉细胞，刺激通过适当的激素，激素类似物和/或细胞因子的分离的心脏肌细胞; 通过确定至少一个信号分子的位置，以及它们的制备方法和它们的用途，包括用于检测或鉴定的活性物质心脏的方法的至少一个患病的心肌细胞检测。

4. 发明申请

WO03037323A2 INHIBITORS OF THE FATTY ACID OXIDATION FOR PROPHYLAXIS AND TREATMENT OF DISEASES RELATED TO MITOCHONDRIAL DYSFUNCTION 审中-公开
标题翻译：抑制脂肪酸氧化预防和治疗与线粒体功能障碍有关的疾病
公开(公告)号：WO03037323A2
公开(公告)日：2003-05-08
申请号：PCT/EP0211913
申请日：2002-10-24
申请人： MEDIGENE AG GES FUER MOLEKULAR , HENKEL THOMAS , REHFUESS CHRISTOPH
发明人： HENKEL THOMAS , REHFUESS CHRISTOPH
IPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495 , A61K31/197
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substitued oxirane carboxylic acid.
摘要翻译：描述了通过抑制生物体的一种或多种细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。特别地，脂肪酸氧化通过借助于芳烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制肉毒碱 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性而被抑制的芳基烷基取代的环氧乙烷羧酸。

5. 发明申请

WO02097128A3 METHOD FOR IDENTIFYING SUBSTANCES DIRECTED AGAINST MYOCARDIAL CELL HYPERTROPHY 审中-公开
标题翻译：一种用于识别物质的侵害心肌肥大
公开(公告)号：WO02097128A3
公开(公告)日：2003-09-12
申请号：PCT/EP0205924
申请日：2002-05-29
申请人： MEDIGENE AG , HENKEL THOMAS , ROENICKE VOLKER , NAVE BARBARA
发明人： HENKEL THOMAS , ROENICKE VOLKER , NAVE BARBARA
IPC分类号： C12N5/077 , C12Q1/68 , C12N5/10
CPC分类号： C12N5/0657 , C12N2510/00 , C12Q1/6897
摘要： The invention relates to a method for the in vitro examination of myocardial cell hypertrophy characterized in that at least one parameter for myocardial cell hypertrophy can be measured by using the expression rate of a heterologous marker protein in at least one myocardial cell containing a nucleic acid that codes for the heterologous marker protein.
摘要翻译：本发明的一个目的是一种用于心肌细胞肥大的体外研究中，其特征在于，用于在异源标志物蛋白的表达的至少一种心肌细胞的速率心肌细胞肥大的至少一个参数的方法中，核酸是异源标记蛋白可测量含有编码。

6. 发明专利

DE10210285A1 未知
公开(公告)号：DE10210285A1
公开(公告)日：2003-11-13
申请号：DE10210285
申请日：2002-03-08
申请人： MEDIGENE AG
发明人： HENKEL THOMAS , ROHRBACH MARTIN
IPC分类号： C12N9/22 , C12N15/10 , C12N15/55 , C12N9/16

7. 发明专利

DE10126371A1 未知
公开(公告)号：DE10126371A1
公开(公告)日：2003-02-27
申请号：DE10126371
申请日：2001-05-30
申请人： MEDIGENE AG
发明人： HENKEL THOMAS , ROENICKE VOLKER , NAVE BARBARA
IPC分类号： C12N5/077 , C12Q1/68 , C12Q1/6897 , C12N5/16

8. 发明专利

CA2410949A1 NOVEL TARGET GENES FOR DISEASES OF THE HEART 未知
公开(公告)号：CA2410949A1
公开(公告)日：2001-12-06
申请号：CA2410949
申请日：2001-05-30
申请人： MEDIGENE AG
发明人： HENKEL THOMAS , BUNK DANIELA , BECK JOACHIM , REUNER BIRGIT , STOSS OLIVER
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , C07K14/47 , C12N15/09 , C12N15/85 , C12Q1/50 , C12Q1/68 , C12Q1/6883 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566

9. 发明专利

AU8438598A Heart and skeleton muscle specific nucleic acid, the production and use thereof 未知
公开(公告)号：AU8438598A
公开(公告)日：1998-12-30
申请号：AU8438598
申请日：1998-06-15
申请人： MEDIGENE AG
发明人： HOFMANN MARION ELKE , DOMDEY HORST , HENKEL THOMAS
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K48/00 , A61P9/04 , A61P9/10 , C07K14/47 , C07K16/18 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/6886 , C12N15/85 , G01N33/50

10. 发明专利

AU2003218702A1 REVERSIBLE TOXIN AND THE USE THEREOF 未知
公开(公告)号：AU2003218702A1
公开(公告)日：2003-09-22
申请号：AU2003218702
申请日：2003-03-07
申请人： MEDIGENE AG
发明人： HENKEL THOMAS , ROHRBACH MARTIN
IPC分类号： C12N9/22 , C12N15/10 , C12N15/55 , C07K14/195 , C12N15/62 , C12N15/81

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