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1. 发明申请

WO2004024075A2 CHEMOKINE RECEPTOR ANTAGONISTS AS THERAPEUTIC AGENTS 审中-公开
标题翻译：化疗受体拮抗剂作为治疗药物
公开(公告)号：WO2004024075A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028349
申请日：2003-09-11
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , MUNN, David, H. , MELLOR, Andrew, L. , PEIPER, Stephen, C.
发明人： MUNN, David, H. , MELLOR, Andrew, L. , PEIPER, Stephen, C.
IPC分类号： A61K
CPC分类号： G01N33/6863 , C07K16/2866 , C07K16/40 , C07K2317/76 , G01N33/5047 , G01N2333/52
摘要： The present invention provides methods and compositions to reduce immune tolerance at specific sites. In one aspect, the present invention comprises methods and compositions to reduce tumorigenicity. In an embodiment, the present invention reduces recruitment of tolerance-inducing antigen presenting cells (APCs) or their precursors to a tumor and/or tumor draining lymph node by decreasing binding of at least one tumor-associated of at least one tumor-associated ligand to a chemokine receptor present on the tolerance-inducing APCs or APC precursors. In an embodiment, the chemokine receptor is CCR6 and the tumor-associated ligand is mip-3α. In another aspect, the present invention comprises methods and compositions to reduce immune tolerance to a virus. In an embodiment, the virus is HIV. The present invention further provides for the development of CCR6 antibodies and antagonists as therapeutic agents to prevent or reduce immune tolerance.
摘要翻译：本发明提供减少特定部位免疫耐受性的方法和组合物。一方面，本发明包括减少致瘤性的方法和组合物。在一个实施方案中，本发明通过减少至少一种与肿瘤相关联的至少一种肿瘤相关的配体的结合来减少对肿瘤和/或肿瘤引流淋巴结的耐受诱导抗原呈递细胞（APC）或其前体的募集涉及存在于耐受性APC或APC前体上的趋化因子受体。在一个实施方案中，趋化因子受体是CCR6，肿瘤相关配体是mip-3alpha。另一方面，本发明包括降低对病毒的免疫耐受性的方法和组合物。在一个实施方案中，病毒是HIV。本发明进一步提供CCR6抗体和拮抗剂作为治疗剂的发展，以预防或降低免疫耐受性。

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