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1. 发明申请

WO2008030488A2 STENTS WITH CONNECTORS AND STABILIZING BIODEGRADABLE ELEMENTS 审中-公开
标题翻译：具有连接器和稳定可生物降解元件的STENTS
公开(公告)号：WO2008030488A2
公开(公告)日：2008-03-13
申请号：PCT/US2007019389
申请日：2007-09-06
申请人： MED INST INC , COOK INC , LEEWOOD ALAN R , GREWE DAVID D , HIATT MARK , RAGHEB ANTHONY O , VOORHEES III WILLIAM D , ROEDER BLAYNE A , PURDY JAMES D
发明人： LEEWOOD ALAN R , GREWE DAVID D , HIATT MARK , RAGHEB ANTHONY O , VOORHEES III WILLIAM D , ROEDER BLAYNE A , PURDY JAMES D
IPC分类号： A61F2/82 , A61F2/86
CPC分类号： A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/825 , A61F2002/826 , A61F2002/91566 , A61F2002/91575 , A61F2002/9511 , A61F2210/0004 , A61F2220/0075 , A61F2250/0031 , A61F2250/0071
摘要： Various stent structures are provided with improved axial and torsional flexibility. One type of stent structure includes multiple segmented stent structures connected to each other by biodegradable interconnectors. A delivery system adapted to delivery the multiple segmented stents is also described. Another type of stent structure includes biodegradable connectors that are incorporated into a framework of non-biodegradable interconnecting members that form the support structure of the stent. The biodegradable connectors in both stent structures degrade or are absorbed after the stent is deployed. Stabilizing elements may be provided to the stent structures to supplement the stiffness of the stent with stability during loading and deployment.
摘要翻译：各种支架结构具有改进的轴向和扭转弹性。一种类型的支架结构包括通过可生物降解的互连器彼此连接的多个分段的支架结构。还描述了适于递送多个分段支架的递送系统。另一种类型的支架结构包括可生物降解的连接器，其被结合到形成支架的支撑结构的不可生物降解的互连构件的框架中。支架结构中的可生物降解的连接器在支架部署后降解或被吸收。可以将稳定元件提供给支架结构，以在加载和展开期间具有稳定性补充支架的刚度。

2. 发明申请

WO9933515A3 APPARATUS FOR SUPPLYING RADIOACTIVE GAS TO A DELIVERY DEVICE 审中-公开
标题翻译：将放射性气体供应给送货装置的装置
公开(公告)号：WO9933515A3
公开(公告)日：1999-09-16
申请号：PCT/US9825129
申请日：1998-12-01
申请人： COOK INC , MED INST INC , APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
IPC分类号： A61M36/04 , A61F2/958 , A61M36/12 , A61N5/10 , A61M36/06
CPC分类号： A61M25/10182 , A61M25/10185 , A61N5/1002 , A61N2005/1021
摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).
摘要翻译：公开了一种填充有诸如惰性放射性气体的辐射载体材料用于治疗血管成形术后的再狭窄的导管装置和恶性肿瘤。膨胀的导管包括单个单元或者可替换地，用于运输放射性载体材料的多个离散室，并且血液可以在用规定的辐射治疗期间继续流动。当放射性载体是诸如氙133的气体时，可以使用注射装置（1400），其允许使用可装载到放射源小瓶外壳或室（1403）中的标准放射性气体源小瓶（1401）。用于封闭小瓶（1404）的装置还可以用作推动机构（1442），以将源小瓶（1401）推向一个或多个允许将放射性气体输送到导管的刺穿套管（1406,1454）。在一系列实施例中，放射性气体通过诸如多位置阀的选择器装置（1409）被抽出到诸如注射器的气密可变容积腔室（1411）中，然后将其放置以将气体输送到导管。在处理之后，将气体取出到注射器中并返回到源小瓶（1401）。在另一系列实施例中，使用填充有液体的注射器将气体直接置换到输送导管（1422）中，或者进入将气体注射到输送导管（1422）的第二注射器中。

3. 发明专利

AU737096B2 Apparatus for supplying radioactive gas to a delivery device 未知
公开(公告)号：AU737096B2
公开(公告)日：2001-08-09
申请号：AU1604099
申请日：1998-12-01
申请人： COOK INC , MED INST INC
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
IPC分类号： A61M36/04 , A61F2/958 , A61M36/12 , A61N5/10 , A61M36/06
摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).

4. 发明专利

CA2425665C COATED IMPLANTABLE MEDICAL DEVICE 未知
公开(公告)号：CA2425665C
公开(公告)日：2013-07-16
申请号：CA2425665
申请日：2001-10-31
申请人： COOK INC , MED INST INC
发明人： RAGHEB ANTHONY O , BATES BRIAN L , STEWART JOSEPH M IV , BOURDEAU WILLIAM J , CHOULES BRIAN D , PURDY JAMES D , FEARNOT NEAL E
IPC分类号： A61L29/00 , A61L31/16 , A61F2/00 , A61F2/86 , A61K31/337 , A61K31/4545 , A61L27/54 , A61P9/10 , A61P35/00
摘要： A medical device includes a structure adapted for introduction into a patient, the structure being formed of a non-porous bio compatible metal material having a textured surface. The medical device also includes a layer of a bioactive material posited directly upon the textured surface of the base material of the structure. The surface of the base material is textured with a mean surface roughness of about 10 µin. and a surface roughness range between about 1 µin. and about 100 µin. The surface roughness of the surface of the base material is sufficient for adhesion of the bioactive material to the surface.

5. 发明专利

HK1053270A1 Coated implantable medical device 未知
公开(公告)号：HK1053270A1
公开(公告)日：2003-10-17
申请号：HK03105622
申请日：2003-08-05
申请人： COOK INC , MED INST INC
发明人： RAGHEB ANTHONY O , BATES BRIAN L , STEWART JOSEPH M IV , BOURDEAU WILLIAM J , CHOULES BRIAN D , PURDY JAMES D , FEARNOT NEAL E
IPC分类号： A61L20060101 , A61L29/00 , A61F2/00 , A61F2/86 , A61K31/337 , A61K31/4545 , A61L27/54 , A61L31/16 , A61P9/10 , A61P35/00
摘要： A medical device ( 10 ) includes a structure ( 12 ) adapted for introduction into a patient, the structure ( 12 ) being formed of a preferably non-porous base material ( 14 ) having a roughened or textured surface ( 16 ). The structure ( 12 ) is conveniently configured as a vascular stent with a base material ( 14 ) of stainless steel, nitinol or another suitable material. The medical device ( 10 ) also includes a layer ( 18 ) of a bioactive material posited directly upon the roughened or textured surface ( 16 ) of the base material ( 14 ) of the structure ( 12 ). The surface ( 16 ) of the base material ( 14 ) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface ( 16 ) is thought to have a mean surface roughness of about 10 muin. (about 250 nm) and a surface roughness range between about 1 muin. and about 100 muin. (about 25 nm and about 2.5 mum). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface ( 16 ) of the base material ( 14 ) of the structure ( 12 ) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

6. 发明专利

DE60129578T2 未知
公开(公告)号：DE60129578T2
公开(公告)日：2008-04-03
申请号：DE60129578
申请日：2001-10-31
申请人： MED INST INC , COOK INC
发明人： RAGHEB ANTHONY O , BATES BRIAN L , STEWART JOSEPH M , BOURDEAU WILLIAM J , CHOULES BRIAN D , PURDY JAMES D , FEARNOT NEAL E
IPC分类号： A61L29/00 , A61L31/16 , A61F2/00 , A61F2/86 , A61K31/337 , A61K31/4545 , A61L27/54 , A61P9/10 , A61P35/00
摘要： A medical device ( 10 ) includes a structure ( 12 ) adapted for introduction into a patient, the structure ( 12 ) being formed of a preferably non-porous base material ( 14 ) having a roughened or textured surface ( 16 ). The structure ( 12 ) is conveniently configured as a vascular stent with a base material ( 14 ) of stainless steel, nitinol or another suitable material. The medical device ( 10 ) also includes a layer ( 18 ) of a bioactive material posited directly upon the roughened or textured surface ( 16 ) of the base material ( 14 ) of the structure ( 12 ). The surface ( 16 ) of the base material ( 14 ) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface ( 16 ) is thought to have a mean surface roughness of about 10 muin. (about 250 nm) and a surface roughness range between about 1 muin. and about 100 muin. (about 25 nm and about 2.5 mum). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface ( 16 ) of the base material ( 14 ) of the structure ( 12 ) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

7. 发明专利

DE60129578D1 未知
公开(公告)号：DE60129578D1
公开(公告)日：2007-09-06
申请号：DE60129578
申请日：2001-10-31
申请人： MED INST INC , COOK INC
发明人： RAGHEB ANTHONY O , BATES BRIAN L , STEWART JOSEPH M , BOURDEAU WILLIAM J , CHOULES BRIAN D , PURDY JAMES D , FEARNOT NEAL E
IPC分类号： A61L29/00 , A61L31/16 , A61F2/00 , A61F2/86 , A61K31/337 , A61K31/4545 , A61L27/54 , A61P9/10 , A61P35/00
摘要： A medical device ( 10 ) includes a structure ( 12 ) adapted for introduction into a patient, the structure ( 12 ) being formed of a preferably non-porous base material ( 14 ) having a roughened or textured surface ( 16 ). The structure ( 12 ) is conveniently configured as a vascular stent with a base material ( 14 ) of stainless steel, nitinol or another suitable material. The medical device ( 10 ) also includes a layer ( 18 ) of a bioactive material posited directly upon the roughened or textured surface ( 16 ) of the base material ( 14 ) of the structure ( 12 ). The surface ( 16 ) of the base material ( 14 ) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface ( 16 ) is thought to have a mean surface roughness of about 10 muin. (about 250 nm) and a surface roughness range between about 1 muin. and about 100 muin. (about 25 nm and about 2.5 mum). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface ( 16 ) of the base material ( 14 ) of the structure ( 12 ) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

8. 发明专利

CA2425665A1 COATED IMPLANTABLE MEDICAL DEVICE 未知
公开(公告)号：CA2425665A1
公开(公告)日：2003-04-03
申请号：CA2425665
申请日：2001-10-31
申请人： COOK INC , MED INST INC
发明人： RAGHEB ANTHONY O , FEARNOT NEAL E , BATES BRIAN L , STEWART JOSEPH M IV , PURDY JAMES D , BOURDEAU WILLIAM J , CHOULES BRIAN D
IPC分类号： A61L29/00 , A61F2/00 , A61F2/86 , A61K31/337 , A61K31/4545 , A61L27/54 , A61L31/16 , A61P9/10 , A61P35/00
摘要： A medical device (10) includes a structure (12) adapted for introduction int o a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12 ) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (1 0) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structur e (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surfa ce roughness of about 10 .mu.in. (about 250 nm) and a surface roughness range between about 1/.mu.in. and about 100 .mu.in. (about 25 nm and about 2.5 .mu.m). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14 ) of the structure (12) is additionally advantageous in the low toxicity of th e sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

9. 发明专利

CA2316963A1 APPARATUS FOR SUPPLYING RADIOACTIVE GAS TO A DELIVERY DEVICE 未知
公开(公告)号：CA2316963A1
公开(公告)日：1999-07-08
申请号：CA2316963
申请日：1998-12-01
申请人： MED INST INC , COOK INC
发明人： BATES BRIAN L , APPLE MARC G , FEARNOT NEAL E , DEFORD JOHN A , PURDY JAMES D
IPC分类号： A61M36/04 , A61F2/958 , A61M36/12 , A61N5/10 , A61M36/06
摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).

10. 发明申请

WO2007098234A3 GRAFT MATERIAL FOR PROSTHESES 审中-公开
标题翻译：遗传物质
公开(公告)号：WO2007098234A3
公开(公告)日：2008-08-21
申请号：PCT/US2007004565
申请日：2007-02-20
申请人： MED INST INC , PURDY JAMES D , GREWE DAVID D , NINAN LAL , SUN JICHAO , DIERKING WILLIAM K
发明人： PURDY JAMES D , GREWE DAVID D , NINAN LAL , SUN JICHAO , DIERKING WILLIAM K
IPC分类号： A61L27/36 , A61L27/34 , A61L27/48 , A61L27/56 , A61L31/00 , A61L31/10 , A61L31/12 , A61L31/14
CPC分类号： A61L27/34 , A61L27/3629 , A61L27/3633 , A61L27/48 , A61L27/56 , A61L31/005 , A61L31/10 , A61L31/128 , A61L31/146 , B32B1/08 , B32B5/02 , B32B5/18 , B32B27/065 , B32B27/12 , B32B27/18 , B32B27/205 , B32B27/28 , B32B27/283 , B32B27/40 , B32B2262/0276 , B32B2266/06 , B32B2535/00 , C08F255/00 , C08F283/006 , C08F283/12 , C08F289/00 , C08F291/00 , C08G18/3228 , C08G18/4854 , C08G18/61 , C08G2101/00 , Y10T428/31844
摘要： A graft material (200) for an endoluminal prosthesis comprises a porous polymeric sheet (210), extracellular matrix material (ECM) such as small intestine submucosa (211) disposed on at least a portion of the porous polymeric sheet and at least one polymer layer (212) disposed on at least a portion of the ECM. The ECM (211) may be in gel form. The polymer stent (210) and the polymer layer (212) may be of foam material and may comprise a polyurethane urea and a surface modifying agent such as a siloxane.
摘要翻译：用于腔内假体的移植材料（200）包括多孔聚合物片（210），细胞外基质材料（ECM），例如设置在多孔聚合物片材的至少一部分上的小肠粘膜下层（211）和至少一个聚合物层（212）设置在ECM的至少一部分上。 ECM（211）可以是凝胶形式。聚合物支架（210）和聚合物层（212）可以是泡沫材料，并且可以包含聚氨酯脲和表面改性剂如硅氧烷。

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