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1. 发明授权

US3542790A Substituted 5,11-dihydro-10,10-dioxodibenzo(c,f)(1,2)thiazepines 失效
标题翻译：取代的5,11-二氢-10,10-二氧代苯氧基（C，F）（1,2）噻唑烷
公开(公告)号：US3542790A
公开(公告)日：1970-11-24
申请号：US3542790D
申请日：1966-12-07
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES JEAN
IPC分类号： C07D281/02 , C07D93/42
CPC分类号： C07D281/02

2. 发明授权

US3651087A Dibenzothiazepine ether intermediates 失效
标题翻译：二苯并噻吩中间体
公开(公告)号：US3651087A
公开(公告)日：1972-03-21
申请号：US1877470
申请日：1970-03-18
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES JEAN
IPC分类号： C07D281/02 , C07D451/06 , A61K27/00 , C07D93/42
CPC分类号： C07D451/06 , C07D281/02 , Y10S514/869
摘要： NOVEL COMPOUNDS OF FORMULA I HAVING ANTIHISTAMINIC AND OTHER PHARMACOLOGICAL ACTIVITY

11-(Z-O-),5,5-DI(O=),6-R:1,R1,R8,R9-6,11-DIHYDRODIBENZ

(C,F)(1,2)THIAZEPINE

THIS INVENTION IS CONCERNED WITH A NOVEL GROUP OF CHEMICAL SUBSTANCES HAVING ANTIHISTAMINIC AND OTHER PHARMACOLOGIC ACTIVITIES, AND INTERMEDIATES FOR THEIR PREPARATION.

3. 发明授权

US3557291A Octalone carbodylic acids and their derivatives 失效
标题翻译： OCTALONE CARBODYLIC ACIDS及其衍生物
公开(公告)号：US3557291A
公开(公告)日：1971-01-19
申请号：US3557291D
申请日：1968-06-28
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES JEAN
IPC分类号： C07C45/74 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/753 , C07C65/20
CPC分类号： C07C49/747 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , Y10S514/937 , Y10S514/96
摘要： 1. A PHARMACEUTICAL COMPOSITION IN DOSAGE UNIT FORM COMPRISING A PHARMACEUTICAL CARRIER AND FROM 50 TO 500 MG. OF A COMPOUND HAVING THE FORMULA

3,3-DI(CH3-),6-R,7-Y,8-X-1,2,3,4,5,6,7,8-OCTAHYDRO-

NAPHTHALEN-1-ONE

WHEREIN R IS PHENYL OR PHENYL BEARING FROM ONE TO TWO SUBSTITUENTS SELECTED FROM ALKOXY HAVING UP TO FOUR CARBON ATOMS, HALOGEN AND HUDROXYL AND WHEREIN ONE OF X AND Y IS CARBOXYL AND THE OTHER IS THE GROUP

-CO-N(-R1)-R2

IN WHICH R1 AND R2 ARE HYDROGEN OR LOWER ALKYL HAVING UP TO FOUR CARBON ATOMS.

4. 发明授权

US3647877A Aminopropionanilides 失效
标题翻译：氨基磷酸
公开(公告)号：US3647877A
公开(公告)日：1972-03-07
申请号：US3647877D
申请日：1970-04-13
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES JEAN , BOUZARD DANIEL
IPC分类号： A61K31/165 , C07C233/16 , C07C103/44
CPC分类号： A61K31/165 , C07C233/16
摘要： THIS INVENTION RELATES TO AMINOPROPIONANILIDES, WHICH ARE PREPARED BY ACYLATION OF 4''-AMINO-5''-CHLORO-2''-METHOXY-(2-DIETHYLAMINO)PROPIONANILIDE WITH (LOWER) ALKANOYL HALIDES OR (LOWER) ALKANOIC ACID ANHYDRIDES. THE DIETHYLAMINO PROPIONANILIDE PRODUCTS ARE PHARMACOLOGICALLY ACTIVE IN MAMMALS AND WHEN ADMINISTERED THERETO IN EFFECTIVE DOSES PRODUCED DEPRESSION OF THE CENTRAL NERVOUS SYSTEM WITH RESULTING HYPNOSIS. DIETHYLAMINOPROPIONANILIDES WHICH ARE PARTICULARLY USEFUL AS HYPNOTIC AGENTS ARE 2''METHOXY-4''-ACETAMIDO-5''-CHLORO-(2-DIETHYLAMINO)PROPIONANILIDE AND 2''-METHOXY-4''-PROPIONAMIDO-5''-CHLORO(2-DIETHYLAMINO)PROPIONANILIDE.

5. 发明授权

US3519633A Certain substituted 5,11-dihydro-10,10-dioxo - dibenz(c,f)(1,2)thiazepin - 5 - yloxyamines 失效
标题翻译：某些取代的5,11-二氢-10,10-二氧基 - 二苯并（C，F）（1,2）噻唑烷-5-磺酰胺
公开(公告)号：US3519633A
公开(公告)日：1970-07-07
申请号：US65778567
申请日：1967-08-02
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES JEAN
IPC分类号： C07D281/02 , C07D451/06 , C07D67/00
CPC分类号： C07D451/06 , C07D281/02 , Y10S514/869

6. 发明授权

US3704250A Octalone carboxylic acid anhydrides 失效
标题翻译：十氯烷羧酸酐
公开(公告)号：US3704250A
公开(公告)日：1972-11-28
申请号：US3704250D
申请日：1970-06-05
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES J
IPC分类号： C07C45/74 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/753 , C07D211/56 , C07D295/185 , C07D307/92 , C07D5/32
CPC分类号： C07D295/185 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/753 , C07D211/56 , C07D307/92
摘要： OCTALONE CARBOXYLIC ACIDS AND THEIR DERIVATIVES, WHICH IN PART ARE USEFUL AS CHOLERETIC AGENTS.

7. 发明授权

US3700663A Dibenzothiazepine ethers 失效
标题翻译：二苯并噻唑类
公开(公告)号：US3700663A
公开(公告)日：1972-10-24
申请号：US2497170
申请日：1970-03-18
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES JEAN
IPC分类号： C07D281/02 , C07D451/06 , C07D93/42
CPC分类号： C07D451/06 , C07D281/02 , Y10S514/869
摘要： DIBENZO(C,F)(1,2)THIAZEPINE

5,5-DI(O=),6-R11,11-(Z-O-),R1,R8,R9-6,11-DIHYDRO

NOVEL COMPOUNDS OF FORMULA I HAVING ANTIHISTAMINIC AND OTHER PHARMACOLOGICAL ACTIVITY.

8. 发明授权

US3644417A Coronary vasodilator compounds 失效
标题翻译：冠状血管扩张剂化合物
公开(公告)号：US3644417A
公开(公告)日：1972-02-22
申请号：US3644417D
申请日：1969-07-02
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES , BOUZARD DANIEL
IPC分类号： C07D285/36 , C07D93/42 , A61K27/00
CPC分类号： C07D285/36 , Y10S514/929
摘要： 5,5-DIOXO-6-METHYL-11-(13 - (N-METHYL-N-(1-PHENYL-2PROPLY)AMINO)PROPYL)DIBENZO(1,2,5)THIADIAZEPINE POSSESSES CORONARY VASODILATOR ACTION AND FREEDOM FROM SIDE EFFECTS SUCH AS TACHYCARDIA AND SEDATIVE ACTION.

9. 发明授权

US3532742A Octalone carboxylic acids and their derivatives 失效
标题翻译：十氯烷羧酸及其衍生物
公开(公告)号：US3532742A
公开(公告)日：1970-10-06
申请号：US3532742D
申请日：1964-08-13
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES J
IPC分类号： C07C45/74 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/753 , C07C63/00
CPC分类号： C07C49/747 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , Y10S514/937 , Y10S514/96

10. 发明专利

DE1470110A1 未知
公开(公告)号：DE1470110A1
公开(公告)日：1969-11-20
申请号：DE1470110
申请日：1964-12-05
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , E KREIGHBAUM WILLIAM
IPC分类号： C07D285/36
摘要： The invention comprises dibenzo[1,2,5]thiadiazepine-5,5-dioxides of the general formula wherein R3 represents H or one or two substituents selected from halogen, Me, CF3 or C1- 4 alkoxy, alkylthio or alkylsulphonyl, R6 represents H, halogen, Me, CF3, -NMe2 or -SO2NME2, or alkoxycarbonyl, alkoxy, alkylthio, alkylsulphonyl or alkanoyl of up to 4C, Alk represents ethylene or trimethylene optionally having one Me or Et substituent, -NR1R2 represents amino, pyrrolidino, piperidino, morpholino, thiamorpholino, piperazino or 4-R4-piperazino (where R4 is C1- 4 alkyl or hydroxyalkyl, C2- 5 alkoxycarbonyl, or alkanoyloxyalkyl of up to 7C), R1 represents H or a group as defined for R4, and R2 represents C1- 4 alkyl or hydroxyalkyl, or an oxaalkylene, azaalkylene or thiaalkylene group the second valence of which is attached to Alk to form a heterocyclic ring, and their acid addition salts. Those compounds in which R1 is other than H are prepared by reacting the corresponding 11-unsubstituted compound with a compound of the general formula X-Alk-NR1R2 (where X is Cl, Br, I, p - C1H4SO3-, CH3SO3-, HSO4-, -OCO2- or C2H5OCO2-) in the presence of a strong base. Those compounds in which R1 is H are prepared by the foregoing process using a compound X-Alk-NR1R2 wherein R1 is a C2- 5 alkoxycarbonyl group which is subsequently removed by acid or alkaline hydrolysis, or (when R2 is C1- 4 alkyl) by reacting a compound in which R1 is Me with an alkyl chloroformate to form a compound in which R1 is a C2- 5 alkoxycarbonyl group, this being then removed as before. N - (3 - Chloropropyl) - N - methylcarbamic acid ethyl ester is prepared by reacting 3-dimethylaminopropyl - (1) chloride with ethyl chloroformate. Pharmaceutical compositions in dosage unit forms comprise the compounds of the invention and a pharmaceutical carrier. They act as psychotrophic agents and muscle relaxants.

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