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1. 发明申请

WO2009103050A1 METHOD OF QUANTITATION BY MASS SPECTROMETRY 审中-公开
标题翻译：通过质谱法定量的方法
公开(公告)号：WO2009103050A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/034213
申请日：2009-02-16
申请人： MDS ANALYTICAL TECHNOLOGIES , LIFE TECHNOLOGIES CORPORATION , THOMSON, Bruce A. , LE BLANC, Yves
发明人： THOMSON, Bruce A. , LE BLANC, Yves
IPC分类号： G01N31/00
CPC分类号： H01J49/0009
摘要： Quantitation is performed using data from a mass spectrometer. A calibration ion mass spectrum is acquired for each of a plurality of known quantities of a material. From the calibration spectra a plurality of ions that identify the material is determined, and for each ion of the plurality of ions a linear range and linear function are determined. A sample ion mass spectrum is acquired for an unknown quantity of the material. A sample intensity is measured for each ion of the plurality of ions from the sample spectrum. After acquiring the sample spectrum, one or more ions are selected from the plurality of ions such that the sample intensity of each of the one or more ions is within a linear range of the ion. The unknown quantity is calculated from the sample intensities and linear functions of the one or more ions.
摘要翻译：使用质谱仪的数据进行定量。对于多种已知量的材料中的每一种获取校准离子质谱。从校准光谱中确定识别材料的多个离子，并且对于多个离子的每个离子确定线性范围和线性函数。对于未知量的材料获取样品离子质谱。从样品光谱测量多个离子的每个离子的样品强度。在获取样品光谱之后，从多个离子中选出一个或多个离子，使得一个或多个离子中的每一个的样品强度在离子的线性范围内。从一个或多个离子的样品强度和线性函数计算未知量。

2. 发明申请

WO2009105491A3 METHOD OF IMPROVING SIGNAL-TO-NOISE FOR QUANTITATION BY MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2009105491A3
公开(公告)日：2009-08-27
申请号：PCT/US2009/034430
申请日：2009-02-18
申请人： MDS ANALYTICAL TECHNOLOGIES , LIFE TECHNOLOGIES CORPORATION , THOMSON, Bruce, A. , LE BLANC, Yves
发明人： THOMSON, Bruce, A. , LE BLANC, Yves
IPC分类号： G01N31/00
摘要： Selectivity of a measurement from a mass spectrometer is improved by selecting an extracted ion current window for the measurement after data acquisition. A plurality of mass spectra are acquired over a period of time. A first extracted ion current window is selected and from the plurality of mass spectra a first intensity as a function of time is calculated for an ion using the first extracted ion current window. A second extracted ion current window is selected and from the plurality of mass spectra a second intensity as a function of time is calculated for the ion using the second extracted ion current window. A first signal-to-noise ratio of the first intensity is compared with a second signal-to-noise ratio of the second intensity. If the second signal-to-noise ratio is greater than the first signal-to-noise ratio, the second intensity as a function of time is used for the measurement.

3. 发明申请

WO2009094759A8 METHOD OF OPERATING A LINEAR ION TRAP TO PROVIDE LOW PRESSURE SHORT TIME HIGH AMPLITUDE EXCITATION 审中-公开
公开(公告)号：WO2009094759A8
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000087
申请日：2009-01-26
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS Inc, doing business throught its SCIEX Division , LIFE TECHNOLOGIES CORPORATION , GUNA, Mircea , LE BLANC, Yves
发明人： GUNA, Mircea , LE BLANC, Yves
IPC分类号： H01J49/10 , H01J49/26
摘要： In accordance with an aspect of an embodiment of the present invention, there is provided a method for fragmenting ions in an ion trap of a mass spectrometer. The method comprises a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1 x 10-4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; and, e) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap.

4. 发明申请

WO2009094760A1 METHOD OF OPERATING A LINEAR ION TRAP TO PROVIDE LOW PRESSURE SHORT TIME HIGH AMPLITUDE EXCITATION WITH PULSED PRESSURE 审中-公开
标题翻译：操作线性离子阱的方法提供低压短时间高倍数激发与脉冲压力
公开(公告)号：WO2009094760A1
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000088
申请日：2009-01-26
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS Inc., doing business through its Sciex divison , LIFE TECHNOLOGIES CORPORATION , GUNA, Mircea , COLLlNGS, Bruce , LE BLANC, Yves
发明人： GUNA, Mircea , COLLlNGS, Bruce , LE BLANC, Yves
IPC分类号： H01J49/10 , H01J49/26
CPC分类号： H01J49/426 , H01J49/0063 , H01J49/24
摘要： Methods for fragmenting ions in an ion trap are described. These methods involve a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1 x 10-4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; e) providing a non- steady-state pressure increase of at least 10% of the operating pressure within the ion trap by delivering a neutral gas into the ion trap for at least a portion of the retention time interval to raise the pressure in the ion trap to a varying first elevated-pressure in the range between about 6 x 10-5 Torr to about 5 x 10-4 Torr for a first elevated-pressure duration; and f) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. The excitation time interval and the first elevated-pressure duration substantially overlap in time.
摘要翻译：描述了在离子阱中分离离子的方法。这些方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10 -4 Torr的操作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; e）通过将中性气体输送到离子阱中至少保留时间间隔的一部分来提供离子阱内至少10％的工作压力的非稳态压力增加，以提高离子中的压力在第一升高的压力持续时间内在约6×10 -5 Torr至约5×10 -4 Torr之间的范围内捕获到变化的第一升高压力; 和f）在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低到小于兴奋水平的保持水平以保留片段的离子阱内的母离子。激发时间间隔和第一升高压力时间基本上在时间上重叠。

5. 发明申请

WO2009070871A1 SYSTEMS AND METHODS FOR ANALYZING SUBSTANCES USING A MASS SPECTROMETER 审中-公开
标题翻译：使用质谱仪分析物质的系统和方法
公开(公告)号：WO2009070871A1
公开(公告)日：2009-06-11
申请号：PCT/CA2008/002083
申请日：2008-11-27
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC. DOING BUSINESS THROUGH ITS SCIEX DIVISION , APPLIED BIOSYSTEMS INC. , BONNER, Ron, F. , BURTON, Lyle, L. , LE BLANC, Yves
发明人： BONNER, Ron, F. , BURTON, Lyle, L. , LE BLANC, Yves
IPC分类号： H01J49/26 , G01N27/00
CPC分类号： H01J49/004 , G01N30/7233 , G01N30/86 , H01J49/0027 , Y10T436/24
摘要： Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selecting the emitted ions for a designated ion; fragmenting the designated ions; scanning for a plurality of designated ion fragments; determining a designated fragment chromatographic trace for each designated ion fragment; and generating a combined chromatographic trace corresponding to a non-linear combination of a plurality of designated fragment chromatographic traces.
摘要翻译：用于分析样品中化合物的系统和方法。在一个实施例中，本技术涉及分析样品的方法，包括：从样品中发射离子; 选择发射的离子指定的离子; 破碎指定的离子; 扫描多个指定的离子碎片; 确定每个指定离子片段的指定片段色谱痕迹; 以及产生对应于多个指定片段色谱痕迹的非线性组合的组合色谱图。

6. 发明申请

WO2011031259A1 TARGETED ION PARKING FOR QUANTITATION 审中-公开
标题翻译：定点离岸停泊
公开(公告)号：WO2011031259A1
公开(公告)日：2011-03-17
申请号：PCT/US2009/056420
申请日：2009-09-09
申请人： MDS ANALYTICAL TECHNOLOGIES , APPLIED BIOSYSTEMS (CANADA) LIMITED , LE BLANC, Yves
发明人： LE BLANC, Yves
IPC分类号： B01D59/44
CPC分类号： H01J49/4295
摘要： A plurality of targeted ion characteristics and a charge reduction amount are received. A subset of ionized molecules of a sample corresponding to each characteristic of the plurality of targeted ion characteristics is transmitted from a first location to a second location, producing a plurality of selected ionized molecules. Reagent ions are transmitted to the second location to reduce the charge state of the selected ionized molecules. The charge state reduction of the selected ionized molecules is stopped at the charge state reduction amount, producing a plurality of parked targeted ions in the second location. The targeted ion characteristics can include mobilities or mass-to-charge ratios. Analyte quantitation information can be obtained by performing targeted ion parking on a plurality of standards, developing a calibration function, performing targeted ion parking on a sample and using the calibration function to determine the concentration of the analyte in the sample.
摘要翻译：接收多个目标离子特性和电荷减少量。对应于多个目标离子特性的每个特征的样品的电离分子的子集从第一位置传输到第二位置，产生多个选择的电离分子。试剂离子被传输到第二位置以减少所选离子化分子的电荷状态。所选择的电离分子的电荷状态减少在电荷状态降低量处停止，在第二位置产生多个停放的靶向离子。目标离子特征可以包括迁移率或质荷比。分析物定量信息可以通过对多个标准进行靶向离子停放，开发校准功能，对样品进行靶向离子停留并使用校准函数来确定样品中分析物的浓度来获得。

7. 发明申请

WO2011073794A2 METHOD OF PROCESSING IONS 审中-公开
标题翻译：处理离子的方法
公开(公告)号：WO2011073794A2
公开(公告)日：2011-06-23
申请号：PCT/IB2010/003304
申请日：2010-12-17
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , HAGER, James, W. , LE BLANC, Yves
发明人： HAGER, James, W. , LE BLANC, Yves
IPC分类号： H01J49/00
CPC分类号： H01J49/005 , H01J49/0031
摘要： A method for obtaining fragment ions having product ion spectrum with a mixture of high, medium and lower energy product ions. The method includes (a) providing a selected RF field to an ion optical element upstream of an ion containment field; (b) transmitting ions through the ion optical element and into the ion containment field such that the selected RF field determines, at least in part, a selected kinetic energy profile of the ions within the ion containment field, wherein the selected kinetic energy profile is selected to fragment the ions to concurrently provide a plurality of groups of product ions; and (c) detecting each group of product ions in the plurality of groups of product ions.
摘要翻译：用高，中，低能产物离子的混合物获得具有产物离子光谱的碎片离子的方法。该方法包括：（a）向离子容纳场上游的离子光学元件提供选定的RF场; （b）将离子传输通过离子光学元件并进入离子容纳场，使得所选择的RF场至少部分地确定离子包含场内的离子的选定的动能分布，其中所选择的动能分布是被选择以分离离子以同时提供多组产物离子; 和（c）检测多组产物离子中的每组产物离子。

8. 发明申请

WO2007048218A1 METHOD, SYSTEM AND COMPUTER SOFTWARE PRODUCT FOR SPECIFIC IDENTIFICATION OF REACTION PAIRS ASSOCIATED BY SPECIFIC NEUTRAL DIFFERENCES 审中-公开
标题翻译：方法，系统和计算机软件产品特异性识别与特定中性差异相关的反应对
公开(公告)号：WO2007048218A1
公开(公告)日：2007-05-03
申请号：PCT/CA2006/001340
申请日：2006-08-16
申请人： MDS INC. , APPLERA CORPORATION , LE BLANC, Yves , BLOOMFIELD, Nic
发明人： LE BLANC, Yves , BLOOMFIELD, Nic
IPC分类号： G01N27/00 , G01N30/72 , G01N37/00 , H01J49/02 , H01J49/26
CPC分类号： H01J49/0036 , G06F19/703 , H01J49/0045
摘要： A first mass spectrum and a second mass spectrum of the same ion sample can be analyzed to determine reaction pairs. These reaction pairs are determined based on a selected neutral difference by shifting the second mass spectrum by the neutral difference relative to the first mass spectrum to provide a shifted mass spectrum. Then, the shifted mass spectrum is compared with the first mass spectrum of the ion sample to determine the reaction pairs based on the neutral difference.
摘要翻译：可以分析相同离子样品的第一质谱和第二质谱以确定反应对。这些反应对是通过将第二质谱相对于第一质谱转移中性差而基于选定的中性差来确定的，以提供转移的质谱。然后，将移位的质谱与离子样品的第一质谱进行比较，以基于中性差来确定反应对。

9. 发明申请

WO2006130983A1 DYNAMIC BACKGROUND SIGNAL EXCLUSION IN CHROMATOGRAPHY/MASS SPECTROMETRY DATA-DEPENDENT DATA ACQUISITION 审中-公开
标题翻译：动态背景信号排除在色谱/质谱中数据依赖性数据采集
公开(公告)号：WO2006130983A1
公开(公告)日：2006-12-14
申请号：PCT/CA2006/000943
申请日：2006-06-08
申请人： MDS INC. DOING BUSINESS THROUGH ITS MDS SCIEX DIVISION , LE BLANC, Yves , BLOOMFIELD, Nicholas
发明人： LE BLANC, Yves , BLOOMFIELD, Nicholas
IPC分类号： G01N30/88 , G01N30/72 , G01N37/00 , H01J49/26
CPC分类号： G01N30/8675 , G01N30/72 , G01N30/861 , G01N30/8641 , H01J49/0031
摘要： Methods and systems for obtaining mass spectrographic data of a substance. Methods include subjecting a substance to a chromatographic process or other separating process, ionizing the output thereof, and subjecting the ionized output to recursive mass spectrometry analyses; and provide improved processing and analysis of data acquired during the repeated analyses. Systems according to one aspect of the invention comprise ion sources, mass spectrometers capable of analyzing ions of selected mass, and controllers adapted to receive from the mass spectrometers and retain signals representing data representing pluralities of mass spectrograms. The controllers can be adapted to generate information useful for describing extracted ion chromatograms, using data associated with the pluralities of mass spectrograms and non-linear curve approximation algorithms; and to use the generated information to generate further information useful in further analysis of the ionized substance.
摘要翻译：获取物质质谱数据的方法和系统。方法包括使物质进行色谱法或其他分离过程，电离其输出，并对离子化输出进行递归质谱分析; 并对重复分析中获取的数据进行改进的处理和分析。根据本发明的一个方面的系统包括离子源，能够分析所选质量的离子的质谱仪，以及适于从质谱仪接收并保留表示代表多个质谱图的数据的信号的控制器。控制器可以适应于使用与多个质谱图和非线性曲线近似算法相关联的数据来产生用于描述提取的离子色谱图的信息; 并使用所产生的信息来产生进一步分析电离物质的有用信息。

10. 发明申请

WO2004090933A2 DYNAMIC BACKGROUND SIGNAL EXCLUSION IN CHROMATOGRAPHY/MASS SPECTROMETRY DATA-DEPENDENT, DATA ACQUISITION 审中-公开
标题翻译：动态背景信号排除在色谱/质谱中数据依赖性，数据采集
公开(公告)号：WO2004090933A2
公开(公告)日：2004-10-21
申请号：PCT/CA2004/000540
申请日：2004-04-08
申请人： MDS INC., DOING BUSINESS AS MDS SCIEX , LE BLANC, Yves
发明人： LE BLANC, Yves
IPC分类号： H01J49/00
CPC分类号： H01J49/0027 , G01N30/72 , G01N30/8641 , G01N30/8689 , H01J49/0045
摘要： A method and system for obtaining mass spectrographic data of a substance. The method includes (a) subjecting the substance to a chromatographic process and ionizing the output thereof; (b) obtaining a current mass spectrogram of the output; (c) identifying at least one ion having a fast rising mass signal by comparing the current mass spectrum obtained in step (b) against one or more previously acquired mass spectrums of the output; and (d) fragmenting the identified ion and recording a mass spectrum resulting therefrom. A mass spectrometer system, includes a chromatography column; a mass spectrometer, including an ion source for ionizing the output of the chromatographic column, in which the mass spectrometer is capable of isolating, fragmenting and mass analyzing an ion of selected mass; and a data-dependent, data acquisition controller programmed to operate the mass spectrometer so as to obtain a current mass spectrogram of the output, identify one or more ions having fast rising mass signals by comparing the current mass spectrum against one or more previously acquired mass spectra of the output, and fragmenting of said identified ions and recording a mass spectrum resulting therefrom.
摘要翻译：用于获得物质的质谱数据的方法和系统。该方法包括（a）使物质进行色谱处理并使其输出电离; （b）获得输出的当前质谱图; （c）通过将步骤（b）中获得的当前质谱与输出的一个或多个先前获取的质谱进行比较来鉴定具有快速上升质量信号的至少一个离子; 和（d）将所鉴定的离子碎裂并记录由此产生的质谱。质谱仪系统，包括色谱柱; 质谱仪，其包括离子源，用于离子化色谱柱的输出，其中质谱仪能够分离，碎裂和质量分析所选质量的离子; 以及数据相关的数据采集控制器，其被编程为操作质谱仪以获得输出的当前质谱图，通过将当前质谱与一个或多个先前获取的质量进行比较来识别具有快速上升质量信号的一个或多个离子输出的光谱和所述鉴定的离子的碎裂并记录由其产生的质谱。

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