专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004110355A3 COMPOSITIONS AND METHODS INCLUDING A RECOMBINANT HUMAN MAB THAT PROMOTES CNS REMYELINATION 审中-公开
标题翻译：包括促进中枢神经系统重建的重组人类组合物的组合物和方法
公开(公告)号：WO2004110355A3
公开(公告)日：2006-05-18
申请号：PCT/US2004015436
申请日：2004-05-17
申请人： MAYO FOUNDATION , ACORDA THERAPEUTICS , GRUSKIN ELLIOT A , CHOJNICKI ERIC , WARRINGTON ARTHUR E , BIEBER ALLAN J , RODRIGUEZ MOSES
发明人： GRUSKIN ELLIOT A , CHOJNICKI ERIC , WARRINGTON ARTHUR E , BIEBER ALLAN J , RODRIGUEZ MOSES
IPC分类号： A61K39/395 , A61K20060101 , A61K31/573 , C07K16/18
CPC分类号： C07K16/28 , A61K31/573 , A61K39/39533 , A61K39/39541 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K2317/21 , C07K2317/56 , C07K2317/75 , A61K2300/00
摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animais, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in above referenced therapeutic applications, and to pharmaceutical compositions containing them, that may be administered in desirably low doses to treat conditions involving demyelination and to promote remyelination.
摘要翻译：公开了抗体，特别是人抗体，其表现出治疗脱髓鞘疾病以及中枢神经系统的病毒，细菌或特发性起源的其它疾病，包括由脊髓损伤引起的神经功能障碍的活性。阐述神经调节剂，其包括并且包含选自能够结合中枢神经系统结构或细胞的抗体，肽类似物，半抗原，其活性片段，其激动剂，其模拟物，其单体及其组合。描述了使用多克隆IgM抗体和人单克隆抗体sHIgm22（LYM22），sHIgm46（LYM46）ebvHIgM MSI19D10，CB2bG8，AKJR4，CB2iE12，CB2iE7等治疗脱髓鞘疾病和人类和家养动物的中枢神经系统疾病的方法， MSI19E5和MSI10E10，其活性片段等。本发明还延伸到人抗体，片段，肽衍生物和类似材料及其在上述治疗应用中的用途以及含有它们的药物组合物的使用，其可以以期望的低剂量施用以治疗涉及脱髓鞘的病症，并且促进髓鞘再生。

2. 发明专利

CA2525917A1 COMPOSITIONS AND METHODS INCLUDING A RECOMBINANT HUMAN MAB THAT PROMOTES CNS REMYELINATION 未知
公开(公告)号：CA2525917A1
公开(公告)日：2004-12-23
申请号：CA2525917
申请日：2004-05-17
申请人： ACORDA THERAPEUTICS , MAYO FOUNDATION
发明人： RODRIGUEZ MOSES , WARRINGTON ARTHUR E , GRUSKIN ELLIOT A , BIEBER ALLAN J , CHOJNICKI ERIC
IPC分类号： A61K39/395 , A61K20060101 , A61K31/573 , A61P25/28 , C07K16/18
摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrat e activity in the treatment of demyelinating diseases as well as other disease s of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapte n, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animais, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in above referenced therapeuti c applications, and to pharmaceutical compositions containing them, that may b e administered in desirably low doses to treat conditions involving demyelination and to promote remyelination.

3. 发明专利

ES2451993T3 Dosis bajas de anticuerpos IgM para tratamiento de trastornos desmielinizantes 未知
公开(公告)号：ES2451993T3
公开(公告)日：2014-03-28
申请号：ES04752450
申请日：2004-05-17
申请人： MAYO FOUNDATION , ACORDA THERAPEUTICS
发明人： GRUSKIN ELLIOT A , CHOJNICKI ERIC , WARRINGTON ARTHUR E , BIEBER ALLAN J , RODRIGUEZ MOSES
IPC分类号： A61K39/395 , A61K20060101 , A61K31/573 , C07K16/18
摘要： Una composición farmacéutica que comprende un anticuerpo IgM monoclonal humano, donde dicho anticuerpocomprende una secuencia de aminoácido de región variable de cadena pesada como se expone en la FIGURA 5 ySEQ ID NO: 7 y una secuencia de aminoácido de región variable de cadena ligera como se expone en la FIGURA 6y SEQ ID NO: 9, y un transportador, vehículo o diluyente farmacéuticamente aceptable, donde dicha composición espara su uso en el tratamiento o prevención de una enfermedad de desmielinización en un humano caracterizado enque el tratamiento o prevención comprende la administración del anticuerpo en una dosis diaria en el rango de 1,25μg/kg a 2,5 μg/kg de peso corporal.

4. 发明专利

CA2967294C COMPOSITIONS AND METHODS INCLUDING A RECOMBINANT HUMAN MAB THAT PROMOTES CNS REMYELINATION 未知
公开(公告)号：CA2967294C
公开(公告)日：2020-04-28
申请号：CA2967294
申请日：2004-05-17
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION & RES , ACORDA THERAPEUTICS INC
发明人： GRUSKIN ELLIOT A , CHOJNICKI ERIC , WARRINGTON ARTHUR E , BIEBER ALLAN J , RODRIGUEZ MOSES
IPC分类号： A61K51/10 , A61K20060101 , A61K31/573 , A61K49/16 , C07K16/18
摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animais, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in above referenced therapeutic applications, and to pharmaceutical compositions containing them, that may be administered in desirably low doses to treat conditions involving demyelination and to promote remyelination.

5. 发明专利

AU2010202111B2 Compositions and methods including a recombinant human MAB that promotes CNS remyelination 未知
公开(公告)号：AU2010202111B2
公开(公告)日：2012-11-15
申请号：AU2010202111
申请日：2010-05-25
申请人： ACORDA THERAPEUTICS , MAYO FOUNDATION FOR MEDICAL EDUCATION & RES
发明人： RODRIGUEZ MOSES , GRUSKIN ELLIOT A , CHOJNICKI ERIC , WARRINGTON ARTHUR E , BIEBER ALLAN J
IPC分类号： C07K16/18 , A61K20060101 , A61K31/573 , A61K39/395
摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, 5 bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. Methods are described for treating demyelinating diseases, and diseases of the 0 central nervous system of humans and domestic animais, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHlgM MSI I 9D 10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSII9E5 and MSII0El 0, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in above referenced therapeutic applications, and to pharmaceutical 5 compositions containing them, that may be administered in desirably low doses to treat conditions involving demyelination and to promote remyelination. -CJ 4') c 0 _____ _____ 0* E q w o to L.. URUP OHIII C 0

6. 发明专利

AU2010202111A1 Compositions and methods including a recombinant human MAB that promotes CNS remyelination 未知
公开(公告)号：AU2010202111A1
公开(公告)日：2010-06-17
申请号：AU2010202111
申请日：2010-05-25
申请人： ACORDA THERAPEUTICS , MAYO FOUNDATION
发明人： RODRIGUEZ MOSES , GRUSKIN ELLIOT A , CHOJNICKI ERIC , WARRINGTON ARTHUR E , BIEBER ALLAN J
IPC分类号： A61K39/395 , A61K20060101 , A61K31/573 , C07K16/18

7. 发明专利

AU2004247021A1 Compositions and methods including a recombinant human MAB that promotes CNS remyelination 未知
公开(公告)号：AU2004247021A1
公开(公告)日：2004-12-23
申请号：AU2004247021
申请日：2004-05-17
申请人： ACORDA THERAPEUTICS , MAYO FOUNDATION FOR MEDICAL EDUCATION & RES
发明人： RODRIGUEZ MOSES , CHOJNICKI ERIC , BIEBER ALLAN J , GRUSKIN ELLIOT A , WARRINGTON ARTHUR E
IPC分类号： A61K38/00 , A61K20060101 , A61K31/573 , C07K16/18

8. 发明公开

EP1648427A4 COMPOSITIONS AND METHODS INCLUDING A RECOMBINANT HUMAN MAB THAT PROMOTES CNS REMYELINATION 有权转让
标题翻译：组合物和方法用重组人mAb促进CNS髓鞘再生
公开(公告)号：EP1648427A4
公开(公告)日：2007-04-11
申请号：EP04752450
申请日：2004-05-17
申请人： MAYO FOUNDATION , ACORDA THERAPEUTICS
发明人： GRUSKIN ELLIOT A , CHOJNICKI ERIC , WARRINGTON ARTHUR E , BIEBER ALLAN J , RODRIGUEZ MOSES
IPC分类号： C07K16/18 , A61K20060101 , A61K31/573
CPC分类号： C07K16/28 , A61K31/573 , A61K39/39533 , A61K39/39541 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K2317/21 , C07K2317/56 , C07K2317/75 , A61K2300/00
摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in above referenced therapeutic applications, and to pharmaceutical compositions containing them, that may be administered in desirably low doses to treat conditions involving demyelination and to promote remyelination.

9. 发明申请

WO2007047420A8 DRUG-IMPREGNATED ENCASEMENT 审中-公开
标题翻译：药物滥用
公开(公告)号：WO2007047420A8
公开(公告)日：2008-03-13
申请号：PCT/US2006040038
申请日：2006-10-12
申请人： SYNTHES USA , SYNTHES GMBH , FULMER MARK THOMAS , ARMBRUSTER DAVID A , FRIGG ROBERT , GRUSKIN ELLIOT A , KERR SEAN HAMILTON
发明人： FULMER MARK THOMAS , ARMBRUSTER DAVID A , FRIGG ROBERT , GRUSKIN ELLIOT A , KERR SEAN HAMILTON
IPC分类号： A61N1/30
CPC分类号： A61M31/002 , A61B17/68 , A61B17/70 , A61B17/72 , A61B17/8028 , A61B2017/00004 , A61B2017/00893 , A61C8/0013 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/072 , A61F2210/0004 , A61F2250/0067 , A61J3/00 , A61J2200/00 , A61L27/54 , A61L31/148 , A61L31/16 , A61M37/00 , A61M2205/04 , Y10T156/1051
摘要： A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material, hi one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve.
摘要翻译：提供了用于封装医疗植入物的药物浸渍套管。在一个实施例中，套筒可以包括由生物相容的材料制成的主体，该主体限定了构造成接收医疗植入物的内部空腔。在一个实施方案中，生物相容性材料是生物可再吸收的。主体可以包括从空腔穿过主体延伸的多个孔，例如穿孔或孔。套筒还可以包括第一端，第二端和浸渍在可再吸收片中的药物。在一个可能的实施例中，套筒的第一端可以是敞开的，用于接收通过其中的医疗植入物，并且第二端可以是封闭的。植入物可以被封装在套筒中并且植入患者体内，药物在体内随着时间被分配到围绕植入部位的组织。在一个实施方案中，主体由至少一片生物相容性材料制成。在一个实施方案中，套筒可以至少部分地由己内酯制成以向套筒增加拉伸性。

10. 发明专利

CA2967294A1 COMPOSITIONS AND METHODS INCLUDING A RECOMBINANT HUMAN MAB THAT PROMOTES CNS REMYELINATION 未知
公开(公告)号：CA2967294A1
公开(公告)日：2004-12-23
申请号：CA2967294
申请日：2004-05-17
申请人： MAYO FOUND FOR MEDICAL EDUCATION & RES , ACORDA THERAPEUTICS INC
发明人： GRUSKIN ELLIOT A , CHOJNICKI ERIC , WARRINGTON ARTHUR E , BIEBER ALLAN J , RODRIGUEZ MOSES
IPC分类号： A61K51/10 , A61K20060101 , A61K31/573 , A61K49/16 , C07K16/18

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式