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1. 发明申请

US20140320849A1 MICROFLUIDIC SYSTEMS AND DEVICES FOR MOLECULAR CAPTURE, MANIPULATION, AND ANALYSIS 有权
标题翻译：用于分子捕获，操作和分析的微流体系统和装置
公开(公告)号：US20140320849A1
公开(公告)日：2014-10-30
申请号：US13872013
申请日：2013-04-26
申请人： MAX-PLANCK-INSTITUT FÜR EISENFORSCHUNG GMBH , ACADEMIA SINICA
发明人： Chia-Fu Chou , Lesser-Rojas Leonardo , Ming-Li Chu , Andreas Erbe
IPC分类号： G01N27/26 , G01N21/65
CPC分类号： G01N21/65 , B03C5/026 , B03C2201/26 , G01N33/48721
摘要： Methods, systems, and devices are disclosed for molecular capture, manipulation, and analysis. In one aspect, a device to aggregate and characterize particles in a fluid includes an electrically insulative substrate including a channel to carry an electrically conducting fluid containing particles, electrodes located in the channel forming a nanoscale opening and including an insulating layer over their surface at the opening, a first circuit to apply a non-uniform ac electric field and a dc bias signal across the electrodes, in which the applied non-uniform ac electric field produces a positive dielectrophoretic force to aggregate the particles in a trapping region including the opening and adjacent region, a second circuit to detect changes in a dc current caused by at least some of the particles in the trapping region, and an optical device that directs a coherent light beam on the opening to determine Raman spectra of the particles in the trapping region.
摘要翻译：公开了用于分子捕获，操纵和分析的方法，系统和装置。在一个方面，用于聚集和表征流体中的颗粒的装置包括电绝缘基板，其包括用于承载含有颗粒的导电流体的通道，位于通道中的电极形成纳米级开口，并且在其表面上包括绝缘层打开，跨越电极施加不均匀交流电场和直流偏置信号的第一电路，其中所施加的不均匀交流电场产生积极的介电电泳力，以将颗粒聚集在包括开口的捕获区域中，相邻区域，用于检测由捕获区域中的至少一些颗粒引起的直流电流的变化的第二电路，以及将相干光束引导到开口上以确定捕获区域中的颗粒的拉曼光谱的光学装置。

2. 发明授权

US09915614B2 Microfluidic systems and devices for molecular capture, manipulation, and analysis 有权
公开(公告)号：US09915614B2
公开(公告)日：2018-03-13
申请号：US13872013
申请日：2013-04-26
申请人： Academia Sinica , Max-Planck-Institut Für Eisenforschung GmbH
发明人： Chia-Fu Chou , Lesser-Rojas Leonardo , Ming-Lee Chu , Andreas Erbe
IPC分类号： G01N21/00 , G01N21/65 , B03C5/02 , G01N33/487
CPC分类号： G01N21/65 , B03C5/026 , B03C2201/26 , G01N33/48721
摘要： Methods, systems, and devices are disclosed for molecular capture, manipulation, and analysis. In one aspect, a device to aggregate and characterize particles in a fluid includes an electrically insulative substrate including a channel to carry an electrically conducting fluid containing particles, electrodes located in the channel forming a nanoscale opening and including an insulating layer over their surface at the opening, a first circuit to apply a non-uniform ac electric field and a dc bias signal across the electrodes, in which the applied non-uniform ac electric field produces a positive dielectrophoretic force to aggregate the particles in a trapping region including the opening and adjacent region, a second circuit to detect changes in a dc current caused by at least some of the particles in the trapping region, and an optical device that directs a coherent light beam on the opening to determine Raman spectra of the particles in the trapping region.

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