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    • 1. 发明申请
    • WALL MOUNTED TOY TRACK SET
    • 墙上安装的玩具跟踪设置
    • WO2012027753A3
    • 2012-05-31
    • PCT/US2011049587
    • 2011-08-29
    • MATTEL INCO'CONNOR STACY LNUTTALL MICHAELSCHMIDT PAULOSTENDORFF ERICSO KAR FAI ERICLEUNG YAT SANYU GLENN
    • O'CONNOR STACY LNUTTALL MICHAELSCHMIDT PAULOSTENDORFF ERICSO KAR FAI ERICLEUNG YAT SANYU GLENN
    • A63H18/00A63H18/02
    • A63H18/02F16M13/022Y10T29/49826
    • A track set and a plurality of wall mounts is disclosed herein, each of the plurality of wall mounts having: a planar member; a mount member configured to be snap fittingly engaged into the planar member; wherein the mount member is configured to releasably engage a front surface of the planar member and wherein the front surface of planar member further comprises a ledge portion that is configured to engage a bottom portion of the mount member and a feature that is configured to engage an upper portion of the mount member. The track set having a first track segment configured to engage at least one of the plurality of wall mounts and direct an object in a first direction generally down the first track segment; and a U-turn device configured to receive the object from the first track segment and redirect the object it in a direction substantially opposite to the first direction down a second track segment. The second track segment being configured to engage at least another one of the plurality of wall mounts.
    • 本文公开了一种轨道组和多个壁挂架,多个壁挂架中的每一个具有:平面构件; 安装构件,其构造成卡扣配合地接合到所述平面构件中; 其中所述安装构件被构造成可释放地接合所述平面构件的前表面,并且其中所述平面构件的所述前表面还包括被构造成接合所述安装构件的底部部分的凸缘部分和被构造成接合 安装构件的上部。 所述轨道组具有第一轨道段,其被配置为接合所述多个壁挂架中的至少一个,并且在第一方向上大体向下沿着所述第一轨道段引导物体; 以及U形转向装置,其被配置为从第一轨道段接收物体,并且使物体沿与第一方向基本相反的方向向下沿着第二轨道段重定向。 第二轨道段被配置成接合多个壁挂架中的至少另一个。
    • 4. 发明申请
    • METHODS AND COMPOSITIONS FOR ENHANCED DELIVERY OF BIOACTIVE MOLECULES
    • 用于增强生物活性分子的方法和组合物
    • WO0236169A3
    • 2003-07-31
    • PCT/US0145154
    • 2001-10-31
    • PR PHARMACEUTICALS INCLEWIS DANNYSCHMIDT PAULHINDS KENNETH
    • LEWIS DANNYSCHMIDT PAULHINDS KENNETH
    • A61K9/50A61K9/51A61K38/00A61K47/34A61K47/48A61P25/04
    • A61K47/6927A61K47/593A61K47/60A61K47/61
    • Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.
    • 已经开发了用于受控的,延长释放生物活性分子例如治疗性蛋白质,肽和寡核苷酸的制剂。 这些制剂基于由可生物降解的合成聚合物如聚(乳酸)(PLA),聚(乙醇酸)(PGA)及其共聚物的组合形成的固体微粒或纳米颗粒。 将生物活性分子偶联到亲水性聚合物如聚乙二醇或聚丙二醇上,并配制成提供受控释放。 相对于缺乏偶联亲水聚合物的相同生物活性分子,生物活性分子更稳定,免疫原性更小,具有更低的爆发水平和更高的药物负载量的改善的释放速率分布。 控制释放制剂可以通过注射,吸入,鼻腔或口服给药。