专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005024440A3 POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION 审中-公开
公开(公告)号：WO2005024440A3
公开(公告)日：2005-03-17
申请号：PCT/US2004/026968
申请日：2004-08-19
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GRIFFIN, Robert, G. , HU, Kan-Nian
发明人： GRIFFIN, Robert, G. , HU, Kan-Nian
IPC分类号： A61B5/055 , A61K49/00
摘要： We describe polarizing agents for use in enhancing NMR and MRI signals via dynamic nuclear polarization (DNP). The polarizing agents include two or more paramagnetic centers, preferably two paramagnetic centers. In a preferred embodiment, the polarizing agent comprises two nitroxide radicals tethered by a polyethylene glycol chain of variable length. Signal enhancements of up to 175 have been achieved in comparison with factors of ~45 at similar concentrations of monomeric radical such as TEMPO.

2. 发明申请

WO2007134160A2 TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION 审中-公开
标题翻译：温度 - 跳动动态核极化
公开(公告)号：WO2007134160A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068654
申请日：2007-05-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GRIFFIN, Robert, G. , HU, Kan-Nian , JOO, Chan, Gyu
发明人： GRIFFIN, Robert, G. , HU, Kan-Nian , JOO, Chan, Gyu
IPC分类号： G06Q30/00
CPC分类号： G01R33/62 , G01N24/08 , G01N24/087 , G01N24/10 , G01R33/282 , G01R33/30 , G01R33/46
摘要： In one aspect, the present invention provides a method for enhancing the sensitivity of liquid- state NMR or MRI experiments. In general, the method involves (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent with at least one unpaired electron and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the at least one unpaired electron of the polarizing agent; (c) melting the frozen sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the molten sample. In certain embodiments, the methods further comprise a step of freezing a sample in a magnetic field to provide the frozen sample in a magnetic field. The freezing, polarizing, melting and detecting steps may be repeated as many times as desired. In another aspect, the present invention provides systems for performing these methods.
摘要翻译：一方面，本发明提供了一种提高液态NMR或MRI实验灵敏度的方法。通常，该方法包括（a）在磁场中提供冷冻样品，其中冷冻样品包括具有至少一个不成对电子的偏振剂和具有至少一个旋转半核的分析物; （b）通过用具有激发所述至少一种不成对的电子中的电子自旋跃迁的频率的辐射照射所述冷冻样品来使所述分析物的所述至少一个旋转半核偏振; （c）熔化冷冻样品以产生熔融样品; 和（d）检测熔融样品中分析物的至少一个旋转半核中的核自旋跃迁。在某些实施方案中，所述方法还包括在磁场中冷冻样品以在磁场中提供冷冻样品的步骤。冷冻，极化，熔化和检测步骤可以根据需要重复多次。在另一方面，本发明提供了用于执行这些方法的系统。

3. 发明申请

WO2008048714A3 BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION 审中-公开
公开(公告)号：WO2008048714A3
公开(公告)日：2008-04-24
申请号：PCT/US2007/068659
申请日：2007-05-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GRIFFIN, Robert, G. , HU, Kan-Nian , SWAGER, Timothy, M , SONG, Changsik , DANE, Eric
发明人： GRIFFIN, Robert, G. , HU, Kan-Nian , SWAGER, Timothy, M , SONG, Changsik , DANE, Eric
IPC分类号： G01N24/12 , A01N43/40 , C07D207/46 , C07D419/12
摘要： The present invention provides biradicals with a structure of formula (I) and methods for performing dynamic nuclear polarization using the biradicals. The methods involve (a) providing a fro∑en sample in a magnetic field, the frozen sample including a biradical of formula (1) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation haviig a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the. The present inventon also provides methods for making biradicals with a structure of formula (IA).

4. 发明公开

EP2018545A2 BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION 审中-公开
标题翻译：双自由基极化资金用于动态核极化
公开(公告)号：EP2018545A2
公开(公告)日：2009-01-28
申请号：EP07870172.9
申请日：2007-05-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： GRIFFIN, Robert G. , HU, Kan-Nian , SWAGER, Timothy M , SONG, Changsik , DANE, Eric
IPC分类号： G01N24/12 , A01N43/40 , C07D207/46 , C07D419/12
CPC分类号： G01R33/281 , C07D401/12 , G01N24/087 , G01R33/465 , G01R33/5601 , Y10T436/24
摘要： The present invention provides biradicals with a structure of formula (I) and methods for performing dynamic nuclear polarization using the biradicals. The methods involve (a) providing a fro∑en sample in a magnetic field, the frozen sample including a biradical of formula (1) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation haviig a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the. The present inventon also provides methods for making biradicals with a structure of formula (IA).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式