专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010008693A3 HIGH-REPETITION-RATE GUIDED-MODE FEMTOSECOND LASER 审中-公开
标题翻译：高反射率引导模式FEMTOSECOND激光
公开(公告)号：WO2010008693A3
公开(公告)日：2010-06-24
申请号：PCT/US2009045816
申请日：2009-06-01
申请人： MASSACHUSETTS INST TECHNOLOGY , KAERTNER FRANZ , BYUN HYUNIL , CHEN JIAN , PUDO DOMINIK , IPPEN ERICH
发明人： KAERTNER FRANZ , BYUN HYUNIL , CHEN JIAN , PUDO DOMINIK , IPPEN ERICH
IPC分类号： H01S3/067 , H01S3/11 , H01S3/23
CPC分类号： H01S3/1115 , H01S3/0632 , H01S3/067 , H01S3/06725 , H01S3/06741 , H01S3/06791 , H01S3/2308 , H01S2301/085
摘要： Femtosecond pulse trains in waveguide lasers with high fundamental repetition rates are achieved by exploiting the nonlinearity in the waveguide. Components of the apparatus include an optical resonator, a saturable absorber for starting and stabilizing mode-locking, and a gain element. Part of the laser cavity or the entire laser cavity is made of waveguide or fiber (collectively called "waveguide" herein). The net dispersion of the laser cavity can be anomalous. This anomalous dispersion in combination with the positive self-phase modulation nonlinearity in the waveguide creates soliton formation to shorten the pulse duration in the invented lasers. Conversely, a normal dispersive waveguide with negative self-phase modulation nonlinearity can also be used.
摘要翻译：通过利用波导中的非线性来实现具有高基波重复率的波导激光器中的飞秒脉冲串。该装置的组件包括光谐振器，用于启动和稳定锁模的可饱和吸收器和增益元件。激光腔或整个激光腔的一部分由波导或光纤（这里统称为“波导”）制成。激光腔的净色散可能是异常的。这种与波导中的正自相位调制非线性结合的异常色散产生孤子形成，以缩短本发明的激光器中的脉冲持续时间。相反，也可以使用具有负自相位调制非线性的正常色散波导。

2. 发明公开

EP2958985A4 METHODS AND DEVICES FOR ELECTROPORATION 有权
标题翻译：法及穿孔设备
公开(公告)号：EP2958985A4
公开(公告)日：2016-08-17
申请号：EP13875553
申请日：2013-02-20
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： C12M1/42 , C12N13/00
CPC分类号： A01K67/0278 , A01K2217/072 , C12M35/02 , C12N13/00
摘要： An apparatus for electroporation of biological cells is provided. The apparatus includes a sample container having an insulator chamber for holding the cells. The sample container has a first electrode and a second electrode to provide electrical connection for electroporation. The insulator chamber is configured to contain at least one cell monolayer. The apparatus also includes a pulse generator that can generate a predetermined pulse for electroporation of the cells.

3. 发明公开

EP3228695A4 AN ELECTRIC SHOCK PIPE AND CELL ELECTROPORATOR HAVING ELECTRIC SHOCK PIPE 审中-公开
公开(公告)号：EP3228695A4
公开(公告)日：2018-07-25
申请号：EP15864958
申请日：2015-12-02
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： C12M1/42 , C12M1/24
CPC分类号： C12M35/02 , C12M1/24 , C12M1/42 , C12M23/08
摘要： The present invention provides a shock tube and a cell electroporation device with the shock tube and belongs to the technical field of biomedical instruments and equipment. The shock tube and the cell electroporation device solve the present technical problems such as poor cell electroporation stability. The shock tube comprises a tube, a first electrode, a second electrode and a stopple, wherein the tube is internally provided with a cavity for accommodating a target liquid sample. The first electrode is arranged at one end of the tube. The second electrode is arranged in the stopple, and the outer end of the second electrode can be electrically connected with the exterior via an opening of the stopple. The stopple is internally provided with an elastic piece connected with the second electrode. The outer side of the elastic piece is connected with the stopple, and the inner side of the elastic piece is connected with the second electrode. The invention further provides a cell electroporation device where the shock tube can be placed. The shock tube can effectively improve sealability between the second electrode and the opening, thereby preventing outside air from entering the cavity when the liquid sample is added, and the cell electroporation device is convenient to operate and facilitates observation.

4. 发明专利

CA2901759C METHODS AND DEVICES FOR ELECTROPORATION 未知
公开(公告)号：CA2901759C
公开(公告)日：2021-01-12
申请号：CA2901759
申请日：2013-02-20
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： C12M1/42 , C12N13/00
摘要： An apparatus for electroporation of biological cells is provided. The apparatus includes a sample container having an insulator chamber for holding the cells. The sample container has a first electrode and a second electrode to provide electrical connection for electroporation. The insulator chamber is configured to contain at least one cell monolayer. The apparatus also includes a pulse generator that can generate a predetermined pulse for electroporation of the cells.

5. 发明专利

CA2880623A1 EMG DIAGNOSTIC METHOD FOR TRAUMATIC BRAIN INJURY 未知
公开(公告)号：CA2880623A1
公开(公告)日：2016-08-02
申请号：CA2880623
申请日：2015-02-02
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： A61B5/0488
摘要： A method for assessing and diagnosing traumatic brain injury (e.g. concussion)from electromyographic (EMG) signal. The method includes placing an electrode set coupled to an amplifier unit on the subject's skin that overlying muscle(s), acquiring EMG signals from the subject through the electrode set, processing the acquired EMG signals using a signal processing algorithm that including Fourier transformation. The power frequency spectrum (also power spectrum) is obtained and used to determine anomaly in EMG from subjects who had traumatic brain injury.

6. 发明专利

CA2090355A1 Method of Gene Transfer Using Galactosylated Histones 未知
公开(公告)号：CA2090355A1
公开(公告)日：1994-08-26
申请号：CA2090355
申请日：1993-02-25
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： C12N15/87

7. 发明专利

CA2974743A1 DIAGNOSTIC METHOD AND APPARATUS FOR BRAIN INJURY BASED ON EMG FREQUENCY POWER SPECTRA ANALYSIS 未知
公开(公告)号：CA2974743A1
公开(公告)日：2016-08-11
申请号：CA2974743
申请日：2015-12-29
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： A61B5/0488 , A61B5/16
摘要： A method and a device for diagnosing brain injury (e.g. concussion) based on analysis of electromyogram (EMG) signals and presence of neurological modulation impairment of motor activity are described. The method consists of recording specific EMG signals under defined conditions, processing the acquired EMG signals, extracting the relevant information, and making diagnosis of brain injury and disorders that are associated with brain pathology. Specifically, the steps and device involved in the method include placing an EMG electrode set on the subject's body area, acquiring EMG signals from a subject's muscle(s) undergoing contraction, processing the acquired EMG signals using a signal processing algorithm that includes Fourier transformation. The resulting EMG data with a frequency domain (frequency power spectra) are then analyzed in comparison with databases stored in the device and used to determine anomaly of diagnostic value in the EMG power spectra from subjects. A diagnosis can be made based the altered EMG frequency power spectra that reflect the neurological modulation impairment of motor neurons. The diagnostic value, determination, management suggestions are displayed on the device.

8. 发明专利

CA2090355C METHOD OF GENE TRANSFER USING GALACTOSYLATED HISTONES 未知
公开(公告)号：CA2090355C
公开(公告)日：1997-04-08
申请号：CA2090355
申请日：1993-02-25
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： C12N15/87
摘要： The present invention relates to the field of introducing genetic material to cultured cells and into cells of animals in vivo. In particular, the invention relates to the use of receptor-targeted neoglycoprotein to carry genetic material into cells. The invention also uses nuclear-localization signals(Gerace et al. Annu. Rev. Cell Biol. 1988, 4:335-374), to facilitate the entry of genetic materials into cell nucleus for gene expression. The present invention has a wide variety of applications, for example, in treatment of genetic diseases, in study of cell biology, and in genetic interventions of physiological and pathological processes. The present invention is a effective method for introducing and expressing genes in hepatoma cells and hepatocytes in vivo. Its design has several novel features. First, this invention uses a simple coupling reagent (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) to chemically add galactose to a protein, histone, in a one step reaction. The galactosylated protein (for example, albumin, histone and any other protein) has high affinity for the ASGP receptor; Second, the invention uses a protein which is a natural DNA-binding protein; Three, this invention uses a protein which crosses the membranes of cell nucleus by a facilitated process in addition to simple diffusion. This feature contributes greatly to the high level expression of the introduced foreign genes; Last, the galactosylated histone 1 is the physical embodiment of all the features in this invention. This means this gene delivery system has only one component and is simple, reliable, and efficient from engineering-design point of view.

9. 发明专利

CA2901759A1 METHODS AND DEVICES FOR ELECTROPORATION 未知
公开(公告)号：CA2901759A1
公开(公告)日：2014-08-28
申请号：CA2901759
申请日：2013-02-20
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： C12M1/42 , C12N13/00
摘要： An apparatus for electroporation of biological cells is provided. The apparatus includes a sample container having an insulator chamber for holding the cells. The sample container has a first electrode and a second electrode to provide electrical connection for electroporation. The insulator chamber is configured to contain at least one cell monolayer. The apparatus also includes a pulse generator that can generate a predetermined pulse for electroporation of the cells.

10. 发明专利

GB2452304A Wall socket adaptor providing higher sockets 未知
公开(公告)号：GB2452304A
公开(公告)日：2009-03-04
申请号：GB0716911
申请日：2007-08-30
申请人： CHEN JIAN
发明人： CHEN JIAN
IPC分类号： H01R31/02 , H01R13/73 , H01R25/00 , H01R27/02 , H01R31/06
摘要： A socket adaptor has a body 11 with an extension 13 portion. The body has a plurality of sockets 12 on the front, and the extension portion has pins 14 on the back, to plug into a wall socket outlet plate 2, such as a mains socket. The pins are lower than the sockets, so that the leads 31 of plugs 3 plugged into the adaptor are not as sharply bent as if the sockets were level with the pins. The adaptor may have switches (15, Fig 5) for each socket and may have supports (16, Fig 6) to mount the adaptor on the wall.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式