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1. 发明专利

AU2012272848A1 Compositions and methods for the treatment of cancer 未知
公开(公告)号：AU2012272848A1
公开(公告)日：2014-02-13
申请号：AU2012272848
申请日：2012-06-21
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LIPPARD STEPHEN J , PARK GA YOUNG , JOHNSTONE TIMOTHY , FAROKHZAD OMID C , GADDE SURESH
IPC分类号： A61K9/51 , A61K33/24 , A61P35/00 , C07F15/00
摘要： The present invention relates to compositions, kits, and methods for treatment of cancers. In some cases, the composition comprises a platinum compound comprising a phenanthridine ligand.

2. 发明申请

WO2005067580A3 NAPHTHOFLUORESCEIN-BASED METAL SENSORS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：基于石墨烯的金属传感器及其制造和使用方法
公开(公告)号：WO2005067580A3
公开(公告)日：2009-03-26
申请号：PCT/US2005001834
申请日：2005-01-19
申请人： MASSACHUSETTS INST TECHNOLOGY , LIPPARD STEPHEN J , CHANG CHRISTOPHER J , NOLAN ELIZABETH
发明人： LIPPARD STEPHEN J , CHANG CHRISTOPHER J , NOLAN ELIZABETH
IPC分类号： C07D221/18 , C07D307/34 , C07D409/00 , C07D421/00 , C07F3/06 , C12Q1/00 , C12Q1/68
CPC分类号： C07D405/14 , C07D311/78 , C07D405/12 , C07D493/10
摘要： The present invention is directed, in part, to naphthofluorescein-based ligands for detection of metal ions, and methods of making and using the same.
摘要翻译：本发明部分地涉及用于检测金属离子的萘并荧光素基配体及其制备和使用方法。

3. 发明公开

EP2512522A4 PARTICLES FOR MULTIPLE AGENT DELIVERY 审中-公开
标题翻译：粒子进行多次ACTIVE
公开(公告)号：EP2512522A4
公开(公告)日：2013-09-25
申请号：EP10842613
申请日：2010-12-16
申请人： BRIGHAM & WOMENS HOSPITAL , MASSACHUSETTS INST TECHNOLOGY
发明人： FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S , VALENCIA PEDRO M
IPC分类号： A61K47/48 , A61K9/20 , A61K9/22 , A61K47/30 , A61P25/28 , A61P35/00
CPC分类号： A61K45/06 , A61K47/593 , A61K47/60 , A61K47/6937

4. 发明专利

AT182628T 未知
公开(公告)号：AT182628T
公开(公告)日：1999-08-15
申请号：AT93901926
申请日：1992-12-18
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： DONAHUE BRIAN A , TONEY JEFFREY H , ESSIGMANN JOHN M , LIPPARD STEPHEN J , PIL PIETER M , BRUHN SUZANNE L , BROWN STEVEN J , KELLETT PATTI J
IPC分类号： C12N15/09 , A61K38/00 , C07K14/39 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C12P21/02 , C12P21/08 , C12Q1/68
摘要： DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.

5. 发明专利

CA1273935A PLATINUM-INTERCALATIVE COMPLEXES FOR THE TREATMENT OF CANCER 未知
公开(公告)号：CA1273935A
公开(公告)日：1990-09-11
申请号：CA482918
申请日：1985-05-31
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： LIPPARD STEPHEN J , BOWLER BRUCE E
IPC分类号： C07D219/14 , A61K31/28 , A61K31/555 , A61P35/00 , C07F15/00
摘要： Anticancer drug compositions are provided by chemically linking a platinum anticancer drug to an intercalative drug with a linking group that does not inactivate either drug.

6. 发明申请

WO2010047765A2 NANOSTRUCTURES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的纳米结构
公开(公告)号：WO2010047765A2
公开(公告)日：2010-04-29
申请号：PCT/US2009005687
申请日：2009-10-20
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , LIPPARD STEPHEN J , DHAR SHANTA , FAROKHZAD OMID C , KOLISHETTI NAGESH , GU FRANK X
发明人： LIPPARD STEPHEN J , DHAR SHANTA , FAROKHZAD OMID C , KOLISHETTI NAGESH , GU FRANK X
IPC分类号： A61K9/16 , A61K33/24 , A61P13/08
CPC分类号： A61K9/48 , A61K9/143 , A61K31/555 , A61K33/24 , A61K47/48092 , A61K47/48869 , A61K47/48915 , A61K47/549 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.
摘要翻译：本发明提供了可用于治疗患有癌症或有癌症发生危险的受试者的组合物，制剂，制剂，试剂盒和方法。本发明的一些实施方案可以包含包含多个包含铂（IV）治疗活性前体的颗粒的组合物。

7. 发明申请

WO2009079549A2 INHIBITORS OF BACTERIAL NITRIC OXIDE SYNTHASE, AND RELATED SCREENING METHODS 审中-公开
标题翻译：细菌一氧化氮合酶抑制剂及相关筛选方法
公开(公告)号：WO2009079549A2
公开(公告)日：2009-06-25
申请号：PCT/US2008087137
申请日：2008-12-17
申请人： MASSACHUSETTS INST TECHNOLOGY , LIPPARD STEPHEN J , MCQUADE LINDSEY E , NUDLER EVGENY A
发明人： LIPPARD STEPHEN J , MCQUADE LINDSEY E , NUDLER EVGENY A
IPC分类号： G01N33/52 , C12N1/21 , C12N15/09 , C12R1/07 , C12R1/19 , G01N21/64
CPC分类号： C12Q1/26 , C07D401/14 , C07D405/12 , C07D405/14 , C12Q1/025 , G01N2333/90254 , G01N2500/10
摘要： The invention relates in part to compounds that act as highly nitric oxide (NO)- specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore, they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS.
摘要翻译：本发明部分涉及作为高度一氧化氮（NO）特异性开启荧光探针的化合物。本发明还涉及这些基于荧光素的传感器选择性筛选细菌一氧化氮合酶（bNOS）抑制剂的用途。本发明的化合物容易检测体内产生的一氧化氮。因此，它们可用于测量bNOS产生NO的测定。使用本发明的传感器，可以筛选小分子库用于bNOS的抑制剂。

8. 发明申请

WO2014160216A3 DUAL TARGETING ANTICANCER AGENTS 审中-公开
标题翻译：双目标抗体药剂
公开(公告)号：WO2014160216A3
公开(公告)日：2015-01-22
申请号：PCT/US2014026064
申请日：2014-03-13
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： LIPPARD STEPHEN J , SUNTHARALINGAM KOGULARAMANAN , SONG YING
IPC分类号： C07F15/00 , A61K31/282
CPC分类号： C07F15/0093 , A61K31/555
摘要： Methods, compounds, and compositions for treating a proliferative disorder or other physiological conditions via a dual targeting anticancer therapy are provided. In some embodiments, a dual targeting anticancer therapy may utilize a composition comprising a platinum agent. The platinum agent may comprise a precursor to a therapeutically active platinum compound and at least one precursor to a vitamin E agent. The vitamin E agent may target cancer cells via a different mechanism of action than the therapeutically active · platinum compound resulting in a dual targeting anticancer agent. The method of treatment may involve administering to a patient the dual targeting anticancer agent. Following administration, a therapeutically active platinum compound and a vitamin E agent may form at the physiologically relevant site.
摘要翻译：提供了通过双重靶向抗癌治疗来治疗增殖性病症或其他生理条件的方法，化合物和组合物。在一些实施方案中，双重靶向抗癌疗法可以使用包含铂剂的组合物。铂剂可以包含治疗活性的铂化合物的前体和维生素E剂的至少一种前体。维生素E剂可以通过与治疗活性的铂化合物不同的作用机制来靶向癌细胞，导致双重靶向抗癌剂。治疗方法可以包括向患者施用双重靶向抗癌剂。给药后，可在生理相关部位形成治疗活性的铂化合物和维生素E剂。

9. 发明申请

WO2012177935A8 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2012177935A8
公开(公告)日：2013-02-28
申请号：PCT/US2012043626
申请日：2012-06-21
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , LIPPARD STEPHEN J , PARK GA YOUNG , JOHNSTONE TIMOTHY , FAROKHZAD OMID C , GADDE SURESH
发明人： LIPPARD STEPHEN J , PARK GA YOUNG , JOHNSTONE TIMOTHY , FAROKHZAD OMID C , GADDE SURESH
IPC分类号： A61K9/51 , A61K33/24 , A61P35/00 , C07F15/00
CPC分类号： C07F15/0093
摘要： The present invention relates to compositions, kits, and methods for treatment of cancers. In some cases, the composition comprises a platinum compound comprising a phenanthridine ligand.
摘要翻译：本发明涉及用于治疗癌症的组合物，试剂盒和方法。在一些情况下，组合物包含含有菲啶配体的铂化合物。

10. 发明申请

WO2011019864A3 METHODS FOR MOBILE ZINC MEASUREMENT 审中-公开
标题翻译：移动式锌测量方法
公开(公告)号：WO2011019864A3
公开(公告)日：2011-06-23
申请号：PCT/US2010045245
申请日：2010-08-12
申请人： GEN HOSPITAL CORP , MASSACHUSETTS INST TECHNOLOGY , LIPPARD STEPHEN J , ZHANG XIAO-AN , MEDAROVA ZDRAVKA , MOORE ANNA
发明人： LIPPARD STEPHEN J , ZHANG XIAO-AN , MEDAROVA ZDRAVKA , MOORE ANNA
IPC分类号： G01N33/52 , C07D311/86 , C07D405/12
CPC分类号： G01N33/5308 , G01N33/57434 , G01N33/582
摘要： This invention relates to a method for using a zinc sensor compound to detect a disease associated with the disruption of zinc homeostasis, such as prostate cancer. The zinc sensor compound comprises an optical reporter having two or more recognition units where each of the recognition units is capable of associating with at least one zinc ion.
摘要翻译：本发明涉及使用锌传感器化合物来检测与锌稳态的破坏相关的疾病如前列腺癌的方法。锌传感器化合物包含具有两个或更多个识别单元的光学报道分子，其中每个识别单元能够与至少一个锌离子缔合。

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