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1. 发明公开

EP1590648A4 NOVEL METHOD FOR SEQUENCE DETERMINATION USING NMR 审中-公开
标题翻译： BY NMR序列测定的新方法
公开(公告)号：EP1590648A4
公开(公告)日：2007-04-18
申请号：EP03810037
申请日：2003-05-20
申请人： MASSACHUSETTS INST TECHNOLOGY , ISTITUTO G RONZONI
发明人： SASISEKHARAN RAM , VENKATARAMAN GANESH , RAMAN RAHUL , CASU BENITO , TORRI GIANGIACOMO , GUERRINI MARCO
IPC分类号： G01N24/08
CPC分类号： G01N24/08 , Y10T436/143333
摘要： The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived (figure 1). Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis (figures 2 & 3).

2. 发明申请

WO0223190A3 METHODS AND PRODUCTS RELATED TO LOW MOLECULAR WEIGHT HEPARIN 审中-公开
标题翻译：与低分子重量蛋白相关的方法和产品
公开(公告)号：WO0223190A3
公开(公告)日：2003-03-13
申请号：PCT/US0128457
申请日：2001-09-12
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： SUNDARAM MALLIKARJUM , VENKATARAMAN GANESH , SHRIVER ZACHARY , LIU DONGFANG , QI YI WEI , SASISEKHARAN RAM
IPC分类号： G01N33/50 , A61K31/715 , A61K31/727 , A61P7/02 , A61P9/10 , A61P35/00 , C12Q1/34 , C12Q1/48 , G01N33/00 , G01N33/15 , G01N33/66 , G01N33/86 , C12Q1/25
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译：本发明涉及用于表征和使用多糖的方法和产品。描述了低分子量肝素产品和使用方法。还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。

3. 发明申请

WO0166772A9 HEPARINASE III AND USES THEREOF 审中-公开
标题翻译： HEPARINASE III及其用途
公开(公告)号：WO0166772A9
公开(公告)日：2005-03-10
申请号：PCT/US0107464
申请日：2001-03-08
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： DONGFANG LIU , POJASEK KEVIN , SHRIVER ZACHARY , HOLLEY KRISTINE , EL-SHABRAWI YOSUF , VENKATARAMAN GANESH , SASISEKHARAN RAM
IPC分类号： C12N15/09 , A61K31/726 , A61K38/00 , A61K38/51 , A61K45/00 , A61K47/48 , A61K48/00 , A61P9/00 , A61P17/06 , A61P27/02 , A61P35/00 , A61P35/04 , C08B37/00 , C08B37/10 , C12N9/24 , C12N9/88 , C12N15/60 , C12P19/26 , C12P19/28 , C12Q1/34 , C12Q1/527 , A61K31/715
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译：本发明涉及肝素酶III及其突变体。根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等。本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。

4. 发明公开

EP1575534A4 D4,5 GLYCURONIDASE AND USES THEREOF 有权
标题翻译： D4.5甘露糖苷酶及其用途
公开(公告)号：EP1575534A4
公开(公告)日：2008-05-21
申请号：EP03815291
申请日：2003-05-05
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： MYETTE JAMES R , SHRIVER ZACHARY , VENKATARAMAN GANESH , SASISEKHARAN RAM , MCLEAN MAITLAND W
IPC分类号： A61K38/00 , C07H21/04 , C12N9/24 , C12Q1/34 , A61K38/47
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166
摘要： The invention relates to &Dgr;4,5 glycuronidase, related compositions, and methods of use thereof.

5. 发明申请

WO0065521A3 SYSTEM AND METHOD FOR POLYMER NOTATION 审中-公开
标题翻译：用于聚合物符号的系统和方法
公开(公告)号：WO0065521A3
公开(公告)日：2001-10-25
申请号：PCT/US0010990
申请日：2000-04-24
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： VENKATARAMAN GANESH , SHRIVER ZACHARY , RAMAN RAHUL , SASISEKHARAN RAM , KEISER NISHLA
IPC分类号： C08G85/00 , C07K1/00 , G06F17/30 , G06F19/00 , G06F19/28
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. In one embodiment, the fields are capable of storing binary values. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. A computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence. The polymer is represented by a second data structure, tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the polymer. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction. The invention also involves a notational system referred to as Property Encoded Nomenclature.
摘要翻译：公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。在一个实施例中，这些字段能够存储二进制值。聚合物可以是例如多糖，化学单元可以是糖。用于确定化学单元的查询序列的属性是否匹配化学单元的聚合物的性质的计算机实现的方法。查询序列由有形地体现在计算机可读介质中的第一数据结构表示，包括包括用于存储对应于查询序列的属性的值的多个位字段的标识符。聚合物由有形地体现在计算机可读介质中的第二数据结构表示，包括标识符，其包括用于存储对应于聚合物的性质的值的多个位域。本发明还涉及聚合物如核酸，多肽和多糖的测序方法以及鉴定多糖 - 蛋白质相互作用的方法。本发明还涉及称为属性编码术语的符号系统。

6. 发明申请

WO0012726A3 RATIONALLY DESIGNED HEPARINASES DERIVED FROM HEPARINASE I AND II 审中-公开
标题翻译：从HEPARINASE I和II衍生的方法设计的HEPARINASES
公开(公告)号：WO0012726A3
公开(公告)日：2000-06-29
申请号：PCT/US9919841
申请日：1999-08-27
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： SHRIVER ZACHARY , VENKATARAMAN GANESH , SASISEKHARAN RAM , LIU DONGFANG
IPC分类号： C12N15/09 , A61K38/00 , A61K38/51 , A61P17/06 , A61P27/02 , A61P35/00 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/88 , C12N9/99 , C12N15/60 , C12Q1/527 , C12Q1/68 , C12N11/00
CPC分类号： A61K38/47 , C08B37/0078 , C12N9/88 , C12N9/99
摘要： Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
摘要翻译：提供具有改变的结合特异性和活性的修饰的肝素酶。提供编码相同的分离的核酸以及载体和宿主细胞。还提供了使用改性肝素酶的方法。

7. 发明申请

WO0232406A3 METHODS AND PRODUCTS RELATED TO PULMONARY DELIVERY OF POLYSACCHARIDES 审中-公开
标题翻译：与多糖输送多糖有关的方法和产品
公开(公告)号：WO0232406A3
公开(公告)日：2002-10-10
申请号：PCT/US0132444
申请日：2001-10-18
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： LIU DONGFANG , VENKATARAMAN GANESH , SUNDARAM MALLIKARJUN , QI YIWEI , SASISEKHARAN RAM
IPC分类号： A61K9/12 , A61K9/00 , A61K9/72 , A61K31/702 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/732 , A61K31/737 , A61K47/24 , A61K47/34 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P37/08
CPC分类号： A61K9/0075 , A61K31/727 , A61K31/737
摘要： The invention relates to methods for delivering polysaccharides by a pulmonary route to achieve local and systemic therapeutic effects. The polysaccharides may be formulated or unformulated and in some instances have an extremely fast absorption rate.
摘要翻译：本发明涉及通过肺部递送多糖的方法以实现局部和全身治疗效果。多糖可以配制或未配制，并且在一些情况下具有极快的吸收速率。

8. 发明申请

WO0166772A2 HEPARINASE III AND USES THEREOF 审中-公开
标题翻译： HEPARINASE III及其用途
公开(公告)号：WO0166772A2
公开(公告)日：2001-09-13
申请号：PCT/US0107464
申请日：2001-03-08
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： DONGFANG LIU , POJASEK KEVIN , SHRIVER ZACHARY , HOLLEY KRISTINE , EL-SHABRAWI YOSUF , VENKATARAMAN GANESH , SASISEKHARAN RAM
IPC分类号： C12N15/09 , A61K31/726 , A61K38/00 , A61K38/51 , A61K45/00 , A61K47/48 , A61K48/00 , A61P9/00 , A61P17/06 , A61P27/02 , A61P35/00 , A61P35/04 , C08B37/00 , C08B37/10 , C12N9/24 , C12N9/88 , C12N15/60 , C12P19/26 , C12P19/28 , C12Q1/34 , C12Q1/527 , A61K31/715
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译：本发明涉及肝素酶III及其突变体。根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等。本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。

9. 发明公开

EP1397484A4 METHODS AND PRODUCTS RELATED TO FGF DIMERIZATION 审中-公开
标题翻译：工艺和产品均与FGF-二聚CONNECTION
公开(公告)号：EP1397484A4
公开(公告)日：2005-05-25
申请号：EP02753866
申请日：2002-03-27
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： KWAN CHIPONG , VENKATARAMAN GANESH , SHRIVER ZACHARY , RAMAN RAHUL , SASISEKHARAN RAM
IPC分类号： G01N33/50 , A61K38/00 , A61K38/22 , A61P17/02 , A61P25/00 , A61P29/00 , A61P43/00 , C07K14/50 , C07K19/00 , C12N15/09 , G01N33/15 , C12N1/00
CPC分类号： C07K14/50 , A61K38/00

10. 发明申请

WO2004055491A8 NOVEL METHOD FOR SEQUENCE DETERMINATION USING NMR 审中-公开
标题翻译：用NMR进行序列确定的新方法
公开(公告)号：WO2004055491A8
公开(公告)日：2007-05-18
申请号：PCT/US0315850
申请日：2003-05-20
申请人： MASSACHUSETTS INST TECHNOLOGY , ISTITUTO G RONZONI
发明人： SASISEKHARAN RAM , VENKATARAMAN GANESH , RAMAN RAHUL , CASU BENITO , TORRI GIANGIACOMO , GUERRINI MARCO
IPC分类号： G01V3/00 , G01N24/08
CPC分类号： G01N24/08 , Y10T436/143333
摘要： The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived (figure 1). Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis (figures 2 & 3).
摘要翻译：本发明涉及多糖分析方法。特别地，衍生出关于多糖的组成和序列信息（图1）。一些方法使用NMR结合另一种实验方法，例如用于分析的毛细管电泳技术（图2和图3）。

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