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1. 发明申请

WO2005001445A3 SYSTEMS AND METHODS FOR PHASE MEASUREMENTS 审中-公开
标题翻译：用于相位测量的系统和方法
公开(公告)号：WO2005001445A3
公开(公告)日：2005-12-15
申请号：PCT/US2004019456
申请日：2004-06-18
申请人： MASSACHUSETTS INST TECHNOLOGY , FANG-YEN CHRISTOPHER M , POPESCU GABRIEL , YANG CHANGHUEI , WAX ADAM P , DASARI RAMACHANDRA R , FELD MICHAEL S
发明人： FANG-YEN CHRISTOPHER M , POPESCU GABRIEL , YANG CHANGHUEI , WAX ADAM P , DASARI RAMACHANDRA R , FELD MICHAEL S
IPC分类号： G01B9/02 , G01J9/04 , G01N21/45
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention
摘要翻译：本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。实施例涉及用于用光成像小生物物体的光学装置。这些实施方案可以应用于例如细胞生理学和神经科学领域。这些优选实施例基于相位测量和成像技术的原理。使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生在本发明的系统中

2. 发明申请

WO2009009081A3 TOMOGRAPHIC PHASE MICROSCOPY 审中-公开
标题翻译： TOMOGRAPHIC相显微镜
公开(公告)号：WO2009009081A3
公开(公告)日：2009-11-19
申请号：PCT/US2008008447
申请日：2008-07-10
申请人： MASSACHUSETTS INST TECHNOLOGY , CHOI WONSHIK , DASARI RAMACHANDRA RAO , FANG-YEN CHRISTOPHER M , FELD MICHAEL S
发明人： CHOI WONSHIK , DASARI RAMACHANDRA RAO , FANG-YEN CHRISTOPHER M , FELD MICHAEL S
IPC分类号： G01N21/47 , A61B3/12 , A61B5/00
CPC分类号： G01N21/45 , G01N21/51 , G01N21/6458 , G01N21/6486 , G01N2021/458 , G01N2201/061 , G01N2201/105 , G01N2201/12
摘要： The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase- shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time -dependent changes in cell structure and the quantitative characterization of specimen- induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.
摘要翻译：本发明涉及使用具有可变照明角度的相移激光干涉显微镜在活体或非活细胞，组织或生物体中定量三维映射折射率的系统和方法。优选的实施方案提供细胞和多细胞生物体的层析成像以及细胞结构的时间依赖性变化以及在组织光散射中具有多种应用的高分辨率显微镜中的样品诱导的像差的定量表征。

3. 发明专利

CA2529942A1 SYSTEMS AND METHODS FOR PHASE MEASUREMENTS 未知
公开(公告)号：CA2529942A1
公开(公告)日：2005-01-06
申请号：CA2529942
申请日：2004-06-18
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： POPESCU GABRIEL , FANG-YEN CHRISTOPHER M , DASARI RAMACHANDRA R , FELD MICHAEL S , YANG CHANGHUEI , WAX ADAM P
IPC分类号： G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combination s of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the field s of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the s ub- micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellul ar machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optic al interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or i n the alternative the principles of LCI and LSS can be combined to result in systems of the present invention

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