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1. 发明专利

AU2017202550B2 METHODS AND COMPOSITIONS FOR PRESERVING PHOTORECEPTOR AND RETINAL PIGMENT EPITHELIAL CELLS 未知
公开(公告)号：AU2017202550B2
公开(公告)日：2018-07-05
申请号：AU2017202550
申请日：2017-04-19
申请人： MASSACHUSETTS EYE & EAR INFIRMARY
发明人： VAVVAS DEMETRIOS , TRICHONAS GEORGIOS , MILLER JOAN , MURAKAMI YUSUKE
IPC分类号： A61K31/12 , A61K31/195 , A61K31/40 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/519 , A61K38/06 , A61K45/06 , A61P27/02
摘要： [00332] Provided are methods and compositions for maintaining the viability of photoreceptor cells and/or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or ncovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and/or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

2. 发明专利

CA3001661A1 HIGH-DOSE STATINS FOR AGE-RELATED MACULAR DEGENERATION 未知
公开(公告)号：CA3001661A1
公开(公告)日：2017-04-20
申请号：CA3001661
申请日：2016-10-14
申请人： MASSACHUSETTS EYE & EAR INFIRMARY
发明人： VAVVAS DEMETRIOS , MILLER JOAN W
IPC分类号： A61K31/40 , A61K31/395 , G01N33/00 , G01N33/50
摘要： Methods of using a high-dose statin for treatment of AMD in a patient can be used to regress drusen and/or drusenoid pigment epithelial detachments (PEDs), to prevent atrophy of the RPE and/or one or more photoreceptors, to prevent vision loss and/or improve visual acuity, and/or to prevent progression from dry AMD to wet AMD.

3. 发明专利

AU2014248768A1 Modified mullerian inhibiting substance (MIS) proteins and uses thereof for the treatment of diseases 未知
公开(公告)号：AU2014248768A1
公开(公告)日：2015-09-24
申请号：AU2014248768
申请日：2014-03-12
申请人： MASSACHUSETTS EYE & EAR INFIRMARY , MASSACHUSETTS GEN HOSPITAL
发明人： DONAHOE PATRICIA K , VAVVAS DEMETRIOS , PEPIN DAVID , HOANG MIEN VAN
IPC分类号： A61K38/22
摘要： The present invention relates to modified recombinant human MIS protein which has improved cleavage and increased bioactivity and increased potency as compared to wild-type human MIS protein. Other aspects of the invention relate to methods to prevent and treat cancers, such as cancers that express the MIS receptor type II (MISRII) by administering to a subject a composition comprising a recombinant human MIS protein. Another aspect of the present invention relates to methods to lower plasma androgen levels in a subject, and/or for the treatment of a subject with a disease characterized by excess androgen. Another aspect provides pharmaceutical compositions and kits and methods for use comprising a recombinant human MIS protein. Another aspect of the present invention relates to methods to decrease the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with the recombinant MIS protein that lowers the effective dose of the chemotherapeutic agent.

4. 发明专利

ZA201803097B HIGH-DOSE STATINS FOR AGE-RELATED MACULAR DEGENERATION 未知
公开(公告)号：ZA201803097B
公开(公告)日：2022-12-21
申请号：ZA201803097
申请日：2018-05-11
申请人： MASSACHUSETTS EYE & EAR INFIRMARY
发明人： VAVVAS DEMETRIOS , MILLER JOAN W
摘要： Methods of using a high-dose statin for treatment of AMD in a patient can be used to regress drusen and/or drusenoid pigment epithelial detachments (PEDs), to prevent atrophy of the RPE and/or one or more photoreceptors, to prevent vision loss and/or improve visual acuity, and/or to prevent progression from dry AMD to wet AMD.

5. 发明专利

AU2016338540B2 High-dose statins for age-related macular degeneration 未知
公开(公告)号：AU2016338540B2
公开(公告)日：2022-04-28
申请号：AU2016338540
申请日：2016-10-14
申请人： MASSACHUSETTS EYE & EAR INFIRMARY
发明人： VAVVAS DEMETRIOS , MILLER JOAN W
IPC分类号： A61K31/40 , A61K31/395 , G01N33/00 , G01N33/50
摘要： Methods of using a high-dose statin for treatment of AMD in a patient can be used to regress drusen and/or drusenoid pigment epithelial detachments (PEDs), to prevent atrophy of the RPE and/or one or more photoreceptors, to prevent vision loss and/or improve visual acuity, and/or to prevent progression from dry AMD to wet AMD.

6. 发明专利

PH12018500745A1 HIGH-DOSE STATINS FOR AGE-RELATED MACULAR DEGENERATION 未知
公开(公告)号：PH12018500745A1
公开(公告)日：2018-10-15
申请号：PH12018500745
申请日：2018-04-04
申请人： MASSACHUSETTS EYE & EAR INFIRMARY
发明人： VAVVAS DEMETRIOS , MILLER JOAN W
IPC分类号： A61K31/395 , A61K31/40 , G01N33/00 , G01N33/50
摘要： Methods of using a high-dose statin for treatment of AMD in a patient can be used to regress drusen and/or drusenoid pigment epithelial detachments (PEDs), to prevent atrophy of the RPE and/or one or more photoreceptors, to prevent vision loss and/or improve visual acuity, and/or to prevent progression from dry AMD to wet AMD.

7. 发明专利

AU2011242465B2 Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells 未知
公开(公告)号：AU2011242465B2
公开(公告)日：2017-01-19
申请号：AU2011242465
申请日：2011-04-23
申请人： MASSACHUSETTS EYE & EAR INFIRMARY
发明人： VAVVAS DEMETRIOS , TRICHONAS GEORGIOS , MILLER JOAN , MURAKAMI YUSUKE
IPC分类号： A61K31/12 , A61K31/195 , A61K31/40 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/519 , A61K38/06 , A61K45/06 , A61P27/02
摘要： Provided are methods and compositions for maintaining the viability of photoreceptor cells and/or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or neovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and/or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

8. 发明专利

ES2853935T3 Proteínas modificadas de sustancia inhibidora muleriana (MIS) y usos de las mismas para el tratamiento de enfermedades 未知
公开(公告)号：ES2853935T3
公开(公告)日：2021-09-20
申请号：ES14779351
申请日：2014-03-12
申请人： MASSACHUSETTS GEN HOSPITAL , MASSACHUSETTS EYE & EAR INFIRMARY
发明人： DONAHOE PATRICIA K , VAVVAS DEMETRIOS , PEPIN DAVID , HOANG MIEN VAN
IPC分类号： A61K38/22
摘要： Proteína recombinante de sustancia inhibidora muleriana (MIS) que comprende una combinación de una secuencia líder distinta de MIS en lugar de la secuencia líder de MIS de los aminoácidos 1-25 de SEQ ID NO: 1, y una modificación de residuo del aminoácido 450 de SEQ ID NO 1: para aumentar la escisión en comparación con la ausencia de dicha modificación, en la que el residuo de aminoácido 450 de SEQ ID NO: 1 se cambia de Q a R, en la que la proteína recombinante de MIS ha aumentado la escisión y ha aumentado el rendimiento de la producción in vitro en comparación con la proteína de MIS de tipo natural correspondiente a los residuos de aminoácido de SEQ ID NO: 1, en la que la secuencia líder distinta de MIS se selecciona del grupo que consiste en: una secuencia líder de albúmina, un péptido señal de inmunoglobulina fusionado a un propéptido activador de plasminógeno de tipo tisular (IgSP-tPA), un péptido señal de inmunoglobulina murina (IgSP), una secuencia señal de MPIF-1 (MKVSVAALSCLMLVTALGSQA; SEQ ID NO: 15); una secuencia señal de estaniocalcina (MLQNSAVLLLLVISASA; SEQ ID NO:16); una secuencia señal de invertasa (MLLQAFLFLLAGFAAKISA; SEQ ID NO:17); una secuencia señal del factor alfa de apareamiento de la levadura (secuencia líder de toxina mortal de K. lactis); una secuencia señal híbrida (MKWVSFISLLFLFSSAYSRSLEKR; SEQ ID NO:18); una secuencia señal híbrida de HSA/MFa-1 (MKWVSFISLLFLFSSAYSRSLDKR; SEQ ID NO:19); una secuencia líder de fusión mortal de K. lactis/MFa- 1 (MNIFYIFLFLLSFVQGSLDKR; SEQ ID NO:20); una secuencia señal de inmunoglobulina Ig (MGWSCIILFLVATATGVHS; SEQ ID NO:21); una secuencia señal de precursor de fibulina B (MERAAPSRRVPLPLLLLGGLALLAAGVDA; SEQ ID NO:22); una secuencia señal del precursor de la clusterina (MMKTLLLFVGLLLTWESGQVLG; SEQ ID NO: 23); y la secuencia señal de la proteína 4 de unión al factor de crecimiento de tipo insulina (MLPLCLVAALLLAAGPGPSLG; SEQ ID NO:24) o fragmentos funcionales de los mismos.

9. 发明专利

DK2968470T3 MODIFICERET MÜLLERSK INHIBERENDE SUBSTANS (MIS)-PROTEINER OG ANVENDELSER DERAF TIL BEHANDLINGEN AF SYGDOMME 未知
公开(公告)号：DK2968470T3
公开(公告)日：2021-02-01
申请号：DK14779351
申请日：2014-03-12
申请人： MASSACHUSETTS GEN HOSPITAL , MASSACHUSETTS EYE & EAR INFIRMARY
发明人： PEPIN DAVID , HOANG MIEN VAN , DONAHOE PATRICIA K , VAVVAS DEMETRIOS
IPC分类号： A61K38/22

10. 发明专利

AU2016338540A1 High-dose statins for age-related macular degeneration 未知
公开(公告)号：AU2016338540A1
公开(公告)日：2018-05-24
申请号：AU2016338540
申请日：2016-10-14
申请人： MASSACHUSETTS EYE & EAR INFIRMARY
发明人： VAVVAS DEMETRIOS , MILLER JOAN W
IPC分类号： A61K31/40 , A61K31/395 , G01N33/00 , G01N33/50
摘要： Methods of using a high-dose statin for treatment of AMD in a patient can be used to regress drusen and/or drusenoid pigment epithelial detachments (PEDs), to prevent atrophy of the RPE and/or one or more photoreceptors, to prevent vision loss and/or improve visual acuity, and/or to prevent progression from dry AMD to wet AMD.

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