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1. 发明申请

WO2010017238A1 NONINVASIVE MEASUREMENT OF GLUCOSE AND OTHER ANALYTES 审中-公开
标题翻译：葡萄糖和其他分析物的无意识测量
公开(公告)号：WO2010017238A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/052756
申请日：2009-08-04
申请人： MASIMO LABORATORIES, INC. , KIANI, Massi Joe, E. , LAMEGO, Marcelo , MERRITT, Sean , DALVI, Cristiano , VO, Hung , BRUINSMA, Johannes , POEZE, Jeroen , LESMANA, Ferydan , OLSEN, Gregory, A.
发明人： KIANI, Massi Joe, E. , LAMEGO, Marcelo , MERRITT, Sean , DALVI, Cristiano , VO, Hung , BRUINSMA, Johannes , POEZE, Jeroen , LESMANA, Ferydan , OLSEN, Gregory, A.
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6843 , A61B2562/0233 , A61B2562/04 , A61B2562/046 , A61B2562/146
摘要： The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source, such as an emitter 104, comprises LEDs 1102 and super-luminescent LEDs 1104. The emitter 104 may emit light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, a detector 106 comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid or matrix geometry.
摘要翻译：本公开涉及用于测量各种血液成分或分析物（例如葡萄糖）的非侵入性方法，装置和系统。在一个实施例中，诸如发射器104的光源包括LED 1102和超发光LED 1104.发射器104可以发射约1610nm，约1640nm和约1665nm的至少波长的光。在一个实施例中，检测器106包括以特殊几何形状布置的多个光电检测器，其包括基本上线性的基本相等间隔的几何形状，基本上线性的基本上不等间隔的几何形状，以及基本上格栅或矩阵几何形状。

2. 发明申请

WO2012075322A3 HANDHELD PROCESSING DEVICE INCLUDING MEDICAL APPLICATIONS FOR MINIMALLY AND NON INVASIVE GLUCOSE MEASUREMENTS 审中-公开
公开(公告)号：WO2012075322A3
公开(公告)日：2012-06-07
申请号：PCT/US2011/062941
申请日：2011-12-01
申请人： MASIMO LABORATORIES, INC. , LAMEGO, Marcelo, M. , KIANI, Massi Joe, E. , POEZE, Jeroen , DALVI, Cristiano , MERRITT, Sean , VO, Hung , OLSEN, Gregory, A. , LESMANA, Ferdyan
发明人： LAMEGO, Marcelo, M. , KIANI, Massi Joe, E. , POEZE, Jeroen , DALVI, Cristiano , MERRITT, Sean , VO, Hung , OLSEN, Gregory, A. , LESMANA, Ferdyan
IPC分类号： G06Q10/10 , A61B5/1455 , A61B5/145
摘要： The present disclosure includes a handheld processing device including medical applications for minimally and noninvasive glucose measurements. In an embodiment, the device creates a patient specific calibration using a measurement protocol of minimally invasive measurements and noninvasive measurements, eventually creating a patient specific noninvasive glucometer. Additionally, embodiments of the present disclosure provide for the processing device to execute medical applications and non-medical applications.

3. 发明申请

WO2011011730A1 INTERFERENCE DETECTOR FOR PATIENT MONITOR 审中-公开
标题翻译：患者监护仪的干扰检测器
公开(公告)号：WO2011011730A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/043120
申请日：2010-07-23
申请人： MASIMO LABORATORIES, INC. , POEZE, Jeroen , OLSEN, Gregory, A. , LAMEGO, Marcelo
发明人： POEZE, Jeroen , OLSEN, Gregory, A. , LAMEGO, Marcelo
IPC分类号： A61B5/00
CPC分类号： G01R13/0281 , A61B5/0015 , A61B5/0261 , A61B5/14532 , A61B5/14551 , A61B5/7203 , A61B5/7228 , A61B2560/0242 , A61B2560/0276 , G01R29/0814
摘要： A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and non- invasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.
摘要翻译：公开了一种用于检测和计算环境和/或环境噪声水平的系统，例如由电力线，环境光，光调光器，电视或计算机显示器，电源或变压器和医疗设备产生的电磁干扰。在一些实施例中，系统对由光检测器检测到的干扰信号进行频率分析，并确定集中在分析频带中的干扰信号的功率。最坏情况的干扰电平可以通过从计算的功率值中选择最大值来确定。在一些实施例中，所确定的干扰信号功率可以与被配置为可靠且非侵入地检测用户的生理参数的患者监测系统的噪声容限进行比较。比较的结果可以直观地呈现给用户。在一些实施例中，系统可用于执行电磁干扰的抽查检查。

4. 发明申请

WO2010003134A2 PROTRUSION, HEAT SINK, AND SHIELDING FOR IMPROVING SPECTROSCOPIC MEASUREMENT OF BLOOD CONSTITUENTS 审中-公开
标题翻译：用于改善血液成分的光谱测量的突起，散热片和屏蔽
公开(公告)号：WO2010003134A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049638
申请日：2009-07-02
申请人： MASIMO LABORATORIES, INC. , KIANI, Massi, Joe E. , LAMEGO, Marcelo , MERRITT, Sean , DALVI, Cristiano , VO, Hung , BRUINSMA, Johannes , POEZE, Jeroen , LESMANA, Ferydan , OLSEN, Greg
发明人： KIANI, Massi, Joe E. , LAMEGO, Marcelo , MERRITT, Sean , DALVI, Cristiano , VO, Hung , BRUINSMA, Johannes , POEZE, Jeroen , LESMANA, Ferydan , OLSEN, Greg
IPC分类号： A61B5/00
CPC分类号： A61B5/02427 , A61B5/02416 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/4875 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6843 , A61B5/70 , A61B5/7275 , A61B2562/146
摘要： A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.
摘要翻译：用于测量医学患者的一个或多个生理参数的非侵入式生理传感器可以包括介于光源和光电检测器之间的凸块。可以将隆起放置成与患者的身体组织接触并由此减小身体组织的厚度。结果，可以减小光源与光电检测器之间的光路长度。另外，传感器可以包括可以将热量从光源引出的散热器。而且，传感器可以包括在光源和光电检测器之间的光路中的屏蔽。屏蔽可以减少光电探测器接收到的噪音。

5. 发明申请

WO2011035070A1 IMPROVING ANALYTE MONITORING USING ONE OR MORE ACCELEROMETERS 审中-公开
标题翻译：改进使用一个或多个加速度计的分析仪监控
公开(公告)号：WO2011035070A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/049190
申请日：2010-09-16
申请人： MASIMO LABORATORIES, INC. , POEZE, Jeroen , BRUINSMA, Johannes , LAMEGO, Marcelo
发明人： POEZE, Jeroen , BRUINSMA, Johannes , LAMEGO, Marcelo
IPC分类号： A61N5/00 , G01P15/00
CPC分类号： A61B5/14532 , A61B5/14551 , A61B5/6838 , A61B2562/0219 , A61B2562/0233
摘要： The present disclosure relates to methods, devices, and systems for measuring a blood analyte, such as glucose. The disclosure relates more specifically to the use of one or more accelerometers in such methods, devices, and systems to aid in the collection of data, operation of the device, filtering, and other uses. In some embodiments, the accelerometers are three-dimensional accelerometers. An accelerometer can be used in conjunction with analyte monitoring that may be performed with infrared, near infrared, or other wavelength spectroscopy. The accelerometer may allow a monitoring instrument to expect noisy measurement data, indicate positioning of a measurement site for improved expected results, indicate position of the instrument, or help the user to properly place or control the instrument. It may also improve analyte monitoring by providing motion information that can be used to help determine and reduce or remove movement-related signal artifacts or noise that may be present within the monitoring signal.
摘要翻译：本公开涉及用于测量诸如葡萄糖的血液分析物的方法，装置和系统。本公开更具体地涉及在这种方法，设备和系统中使用一个或多个加速度计来帮助数据的收集，设备的操作，过滤和其它用途。在一些实施例中，加速度计是三维加速度计。加速度计可以与可以用红外线，近红外或其他波长光谱法进行的分析物监测结合使用。加速度计可以允许监测仪器期望噪声测量数据，指示测量位置的定位以改善预期结果，指示仪器的位置，或帮助用户正确地放置或控制仪器。它还可以通过提供运动信息来改善分析物监测，运动信息可用于帮助确定和减少或消除可能存在于监测信号内的运动相关信号伪影或噪声。

6. 发明公开

EP2326239A2 PROTRUSION, HEAT SINK, AND SHIELDING FOR IMPROVING SPECTROSCOPIC MEASUREMENT OF BLOOD CONSTITUENTS 有权
标题翻译：优势改善血液成分的光谱测量
公开(公告)号：EP2326239A2
公开(公告)日：2011-06-01
申请号：EP09774583.0
申请日：2009-07-02
申请人： Masimo Laboratories, Inc.
发明人： KIANI, Massi, Joe E. , LAMEGO, Marcelo , MERRITT, Sean , DALVI, Cristiano , VO, Hung , BRUINSMA, Johannes , POEZE, Jeroen , LESMANA, Ferdyan , OLSEN, Greg
IPC分类号： A61B5/00
CPC分类号： A61B5/02427 , A61B5/02416 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/4875 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6843 , A61B5/70 , A61B5/7275 , A61B2562/146
摘要： A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.

7. 发明公开

EP2456352A1 INTERFERENCE DETECTOR FOR PATIENT MONITOR 有权
标题翻译：干扰检测器用于病人监护仪
公开(公告)号：EP2456352A1
公开(公告)日：2012-05-30
申请号：EP10740072.3
申请日：2010-07-23
申请人： Masimo Laboratories, Inc.
发明人： POEZE, Jeroen , OLSEN, Gregory, A. , LAMEGO, Marcelo
IPC分类号： A61B5/00
CPC分类号： G01R13/0281 , A61B5/0015 , A61B5/0261 , A61B5/14532 , A61B5/14551 , A61B5/7203 , A61B5/7228 , A61B2560/0242 , A61B2560/0276 , G01R29/0814
摘要： A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and non-invasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.

8. 发明公开

EP2326240A1 NONINVASIVE MEASUREMENT OF GLUCOSE AND OTHER ANALYTES 审中-公开
标题翻译：葡萄糖和其它分析物的无创测量
公开(公告)号：EP2326240A1
公开(公告)日：2011-06-01
申请号：EP09791157.2
申请日：2009-08-04
申请人： Masimo Laboratories, Inc.
发明人： KIANI, Massi Joe, E. , LAMEGO, Marcelo , MERRITT, Sean , DALVI, Cristiano , VO, Hung , BRUINSMA, Johannes , POEZE, Jeroen , LESMANA, Ferydan , OLSEN, Gregory, A.
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6843 , A61B2562/0233 , A61B2562/04 , A61B2562/046 , A61B2562/146
摘要： The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source, such as an emitter 104, comprises LEDs 1102 and super-luminescent LEDs 1104. The emitter 104 may emit light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, a detector 106 comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid or matrix geometry.

9. 发明授权

EP2478487B1 SPOT CHECK MONITOR CREDIT SYSTEM 有权转让
公开(公告)号：EP2478487B1
公开(公告)日：2019-12-18
申请号：EP10763906.4
申请日：2010-09-14
申请人： Masimo Laboratories, Inc.
发明人： KIANI, Massi Joe, E. , LAMEGO, Marcelo , OLSEN, Gregory, A. , DALVI, Cristiano , BRUINSMA, Johannes , POEZE, Jeroen
IPC分类号： G16H40/63

10. 发明授权

EP2326239B1 PROTRUSION FOR IMPROVING SPECTROSCOPIC MEASUREMENT OF BLOOD CONSTITUENTS 有权
标题翻译：改进血液成分的光谱测量的推动力
公开(公告)号：EP2326239B1
公开(公告)日：2017-06-21
申请号：EP09774583.0
申请日：2009-07-02
申请人： Masimo Laboratories, Inc.
发明人： KIANI, Massi Joe E. , LAMEGO, Marcelo , MERRITT, Sean , DALVI, Cristiano , VO, Hung , BRUINSMA, Johannes , POEZE, Jeroen , LESMANA, Ferdyan , OLSEN, Greg
IPC分类号： A61B5/00
CPC分类号： A61B5/02427 , A61B5/02416 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/4875 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6843 , A61B5/70 , A61B5/7275 , A61B2562/146
摘要： A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.
摘要翻译：用于测量医学患者的一个或多个生理参数的非侵入式生理传感器可以包括介于光源和光电检测器之间的凸块。可以将隆起放置成与患者的身体组织接触并由此减小身体组织的厚度。结果，可以减小光源与光电检测器之间的光路长度。另外，传感器可以包括可以将热量从光源引出的散热器。而且，传感器可以包括在光源和光电检测器之间的光路中的屏蔽。屏蔽可以减少光电探测器接收到的噪音。

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