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1. 发明申请

US20110256161A1 METHODS FOR ENHANCING IMMUNE RESPONSE 审中-公开
标题翻译：增强免疫应答的方法
公开(公告)号：US20110256161A1
公开(公告)日：2011-10-20
申请号：US13090011
申请日：2011-04-19
申请人： MARK R. BURNS , SUSAN K. GILMOUR , THOMAS G. O'BRIEN
发明人： MARK R. BURNS , SUSAN K. GILMOUR , THOMAS G. O'BRIEN
IPC分类号： A61K39/00 , A61P35/00 , A61P37/00 , A61P15/18 , A61P31/18 , A61P31/16 , A61P1/04 , A61K31/197 , A61P31/04
CPC分类号： A61K31/198 , A61K31/197 , A61K31/785 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction. This therapeutic approach is equally applicable to disease states whereby immune system suppression by polyamines has been demonstrated including; bacterial infections, parasitic infections including malaria and typanosomiasis, viral infections, peptic ulcers and gastric cancer due to H. Pylori infection together with prevention of pregnancy. With a small molecule drug, used in combination with DFMO, the pharmacological manipulation of polyamine levels for therapeutic benefit in various disease states is possible.
摘要翻译：该公开内容展示了使用多胺基治疗（PBT）来缓解肿瘤诱导的患者免疫系统抑制的新型治疗免疫学方法。从天然存在的多胺介导的免疫抑制的药理学释放的证明提供了对癌症的免疫治疗以及由致病载体逃避免疫反应的能力引起的各种疾病的深刻影响。这种治疗方法同样适用于已经证明多胺的免疫系统抑制的疾病状态，包括：细菌感染，包括疟疾和typanosomiasis的寄生虫感染，病毒感染，消化性溃疡和胃癌，由于H.幽门螺杆菌感染以及预防妊娠。使用与DFMO组合使用的小分子药物，多胺水平的药理学操作可用于各种疾病状态的治疗益处。

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