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1. 发明申请

WO2008067982A2 ANTIVIRAL COMPOSITION AND METHOD OF USE 审中-公开
标题翻译：抗病毒组合物和使用方法
公开(公告)号：WO2008067982A2
公开(公告)日：2008-06-12
申请号：PCT/EP2007/010512
申请日：2007-12-04
申请人： MARINOMED BIOTECHNOLOGIE GMBH , GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva , MEIER, Christiane , PRETSCH, Alexander
发明人： GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva , MEIER, Christiane , PRETSCH, Alexander
IPC分类号： A61K31/731 , A61P31/16 , A61K31/737
CPC分类号： A61K31/731
摘要： The present invention provides for the use of iota-, kappa- or lambdacarrageenan or mixtures thereof for the manufacture of an antiviral pharmaceutical composition for the prophylaxis or treatment of a rhinovirus infection.
摘要翻译：本发明提供了用于制备用于预防或治疗鼻病毒感染的抗病毒药物组合物的碘酸，κ或羔羊卡他定或其混合物的用途。

2. 发明申请

WO2010057856A1 USE OF ESCIN FOR TREATMENT OF TYPE IV HYPERSENSITIVITY REACTION 审中-公开
标题翻译：用于治疗IV型超敏反应的用途
公开(公告)号：WO2010057856A1
公开(公告)日：2010-05-27
申请号：PCT/EP2009/065237
申请日：2009-11-16
申请人： MARINOMED BIOTECHNOLOGIE GMBH , PRIESCHL-GRASSAUER, Eva , FRIEDRICH, Thomas
发明人： PRIESCHL-GRASSAUER, Eva , FRIEDRICH, Thomas
IPC分类号： A61K36/49 , A61K36/77 , A61K31/704 , A61P43/00
CPC分类号： A61K36/77
摘要： The present invention provides the use of escin for the manufacture of a pharmaceutical preparation for the treatment of a Type IV hypersensitivity reaction or symptoms of a Type IV hypersensitivity reaction, like for instance contact dermatitis.
摘要翻译：本发明提供了用于制备用于治疗IV型超敏反应或IV型超敏反应症状（例如接触性皮炎）的药物制剂的用途。

3. 发明申请

WO2017009480A1 METHOD FOR IMPROVING AQUEOUS SOLUBILITY OF WATER-INSOLUBLE OR SLIGHTLY WATER-SOLUBLE DRUGS 审中-公开
标题翻译：改善水不溶性或轻度水溶性药物水溶性的方法
公开(公告)号：WO2017009480A1
公开(公告)日：2017-01-19
申请号：PCT/EP2016/066999
申请日：2016-07-15
申请人： MARINOMED BIOTECHNOLOGIE GMBH
发明人： GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva , BODENTEICH, Angelika , MOROKUTTI-KURZ, Martina , NAKOWITSCH, Sabine , KAINTZ, Cornelia
IPC分类号： A61K9/08 , A61K31/58 , A61K47/26
CPC分类号： A61K9/08 , A61K8/0291 , A61K8/602 , A61K9/0043 , A61K9/0048 , A61K31/56 , A61K31/58 , A61K47/26 , A61K2800/10 , A61Q19/00
摘要： A method of increasing the solubility of a water-insoluble or slightly water- soluble hydrophobic organic compound in an aqueous solvent comprises adding a saponin component selected from the group consisting of escin, glycyrrhizin, and Quillaya saponaria extract to the aqueous solvent in an amount sufficient to trigger the formation of micelles, wherein in a first step the hydrophobic organic compound is pre-dissolved in an organic solvent, whereupon in a second step the organic solvent comprising the pre-dissolved compound is admixed to the aqueous solvent; whereupon at least a part of the insoluble or slightly soluble hydrophobic organic compound gets solubilized and dissolved in the aqueous solvent, yielding an aqueous composition having an increased concentration of said organic compound dissolved therein. The invention also relates to pharmaceutical or cosmetic compositions comprising a water-insoluble or slightly water-soluble organic compound dissolved in an aqueous solvent at substantially increased concentrations.
摘要翻译：增加水不溶性或轻微水溶性的疏水性有机化合物在水性溶剂中的溶解度的方法包括将一种选自由七叶素，甘草酸和奎拉亚皂甙提取物组成的组中的皂苷组分加入到水溶剂中，其量足够触发胶束的形成，其中在第一步骤中将疏水性有机化合物预溶解在有机溶剂中，于是在第二步中将包含预溶解的化合物的有机溶剂与水溶剂混合; 因此至少一部分不溶性或微溶性疏水性有机化合物溶解并溶解在水性溶剂中，得到溶解有所述有机化合物浓度增加的水性组合物。本发明还涉及药物或化妆品组合物，其包含以基本上增加的浓度溶解在水性溶剂中的水不溶性或微溶于水的有机化合物。

4. 发明申请

WO2011076367A2 SYNERGISTIC ANTIVIRAL COMPOSITION AND USE THEREOF 审中-公开
标题翻译：协同抗病毒组合物及其用途
公开(公告)号：WO2011076367A2
公开(公告)日：2011-06-30
申请号：PCT/EP2010/007726
申请日：2010-12-17
申请人： MARINOMED BIOTECHNOLOGIE GMBH , GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva , MEIER, Christiane , KÖNIG-SCHUSTER, Marielle
发明人： GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva , MEIER, Christiane , KÖNIG-SCHUSTER, Marielle
IPC分类号： A61K31/13
CPC分类号： A61K47/36 , A61K31/13 , A61K31/19 , A61K31/731 , A61K45/06 , A61K2300/00
摘要： The present invention relates to iota- and/or kappa-carrageenan in combination with a neuraminidase inhibitor for use as a medicament in the prophylactic or therapeutic treatment of a symptom, condition or disease caused by or associated with an infection by an influenza virus.
摘要翻译：本发明涉及与用于预防或治疗由流感病毒感染引起或与流感病毒感染有关的症状，疾病或疾病的药物的神经氨酸酶抑制剂组合的伊托和/或κ卡拉胶。

5. 发明申请

WO2010000437A1 ANTIALLERGIC MARINE BIOPOLYMERS 审中-公开
标题翻译：抗海洋生物多样性
公开(公告)号：WO2010000437A1
公开(公告)日：2010-01-07
申请号：PCT/EP2009/004696
申请日：2009-06-30
申请人： MARINOMED BIOTECHNOLOGIE GMBH , GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva
发明人： GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva
IPC分类号： A61K31/731 , A61P11/06 , A61P27/14 , A61P37/08
CPC分类号： A61K31/731 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions based on carrageenan as an active ingredient, for use as a medicament in the prophylactic or therapeutic treatment of allergic conditions or diseases, with the proviso that the carrageenan comprises iota- and/or kappa-carrageenan and is substantially free of lambda carrageenan. Typically, the invention relates to liquid formulations, gels and dry powder compositions comprising iota- and/or kappa-carrageenan and, optionally, one or more non-carrageenan therapeutic agents for administration to the respiratory tract, the gastrointestinal tract or the eyes. The compositions of the invention have been found to be efficacious in the prevention and treatment of type I allergies and additionally, may exert an adjuvant function upon combined mucosal administration with non-carrageenan therapeutic agents.
摘要翻译：本发明涉及基于角叉菜胶作为活性成分的药物组合物，其用作用于预防或治疗过敏性疾病或疾病的药物，条件是所述角叉菜聚糖包含碘和/或κ-角叉菜胶，并且基本上没有lambda卡拉胶。通常，本发明涉及包含伊塔卡朋和/或卡帕角叉菜胶的液体制剂，凝胶和干粉组合物，以及任选的一种或多种用于向呼吸道，胃肠道或眼睛施用的非角叉菜胶治疗剂。已经发现本发明的组合物在预防和治疗I型过敏中是有效的，并且另外可以在与非角叉菜胶治疗剂组合的粘膜给药时发挥佐剂功能。

6. 发明申请

WO2017009351A1 STUFFY NOSE DEBLOCKING COMPOSITION HAVING ANTIVIRAL ACTIVITY 审中-公开
标题翻译：具有抗病毒活性的抗坏血酸组合物
公开(公告)号：WO2017009351A1
公开(公告)日：2017-01-19
申请号：PCT/EP2016/066565
申请日：2016-07-12
申请人： MARINOMED BIOTECHNOLOGIE GMBH
发明人： GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva , BODENTEICH, Angelika , KOLLER, Christiane , MOROKUTTI-KURZ, Martina
IPC分类号： A61K9/00 , A61K45/06 , A61K31/047 , A61K31/731 , A61K33/14 , A61P11/02 , A61P31/16
CPC分类号： A61K45/06 , A61K9/0043 , A61K9/08 , A61K9/12 , A61K31/047 , A61K31/731 , A61K33/14 , A61K47/26 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition having a stuffy nose deblocking activity, characterized in that the composition comprises a hyperosmolar aqueous solution of a non-ionic osmolality adjusting agent, optionally in combination with an ionic osmolality adjusting agent, wherein the composition further comprises iota-carrageenan and/or kappa-carrageenan as an active antiviral ingredient in an antivirally effective amount, with the proviso that the composition in its ready-for-use formulation contains no more than 1.5% w/v of the ionic osmolality adjusting agent. The composition is useful for deblocking a stuffy nose and for prophylactic or therapeutic intervention of a number of viral infections of the upper respiratory tract.
摘要翻译：本发明涉及一种具有鼻塞解封活性的药物组合物，其特征在于组合物包含非离子重量克分子渗透浓度调节剂的高渗透水溶液，任选与离子渗透浓度调节剂组合其中所述组合物进一步包含抗角叉菜胶和/或κ-角叉菜胶作为抗病毒有效量的活性抗病毒成分，条件是其即用型制剂中的组合物含有不超过1.5％w / v的离子渗透压调节剂。该组合物可用于解封塞鼻塞，并用于预防性或治疗性干预上呼吸道的多种病毒感染。

7. 发明申请

WO2012126777A1 INHIBITION OF NEURAMINIDASE ACTIVITY 审中-公开
标题翻译：神经酰胺酶活性的抑制
公开(公告)号：WO2012126777A1
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054407
申请日：2012-03-13
申请人： MARINOMED BIOTECHNOLOGIE GmbH , PRIESCHL-GRASSAUER, Eva , GRASSAUER, Andreas , LEIBBRANDT, Andreas
发明人： PRIESCHL-GRASSAUER, Eva , GRASSAUER, Andreas , LEIBBRANDT, Andreas
IPC分类号： A61K31/155 , A61K31/215 , A61K31/415 , A61K31/731 , A61K31/737 , A61P31/16
CPC分类号： A61K31/731 , A61K9/0043 , A61K31/195 , A61K31/245 , A61K31/351 , A61K31/737 , A61K2300/00
摘要： The present invention relates to novel inhibitors of neuraminidase for use as a medicament in the prophylactic or therapeutic treatment of a symptom, condition or disease caused by or associated with an infection or co-infection by a virus having neuraminidase (NA) activity, particularly of the orthomyxo- or paramyxovirus families.
摘要翻译：本发明涉及神经氨酸酶的新型抑制剂，用作预防或治疗由具有神经氨酸酶（NA）活性的病毒感染或共感染引起或与之相关的症状，病症或疾病的药物，特别是正粘型或副粘病毒家族。

8. 发明申请

WO2009027057A1 ANTIVIRAL COMPOSITION COMPRISING A SULFATED POLYSACCHARIDE 审中-公开
标题翻译：包含磺化多糖的抗病毒组合物
公开(公告)号：WO2009027057A1
公开(公告)日：2009-03-05
申请号：PCT/EP2008/006910
申请日：2008-08-22
申请人： MARINOMED BIOTECHNOLOGIE GMBH , GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva
发明人： GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva
IPC分类号： A61K31/431 , A61K31/737 , A61P31/14 , A61P31/16 , A61P31/20
CPC分类号： A61K31/731 , A61K31/737
摘要： The present invention provides for the use of iota- and/or kappa-carrageenan for the manufacture of an antiviral pharmaceutical composition for the prophylaxis or treatment of a pathological condition or disease caused by or associated with an infection by a respiratory virus selected from the group consisting of orthomyxovirus, paramyxovirus, adenovirus and coronavirus. The present invention further provides for the use of fucoidan, in particular of high molecular weight fucoidan, for the manufacture of an antiviral pharmaceutical composition for the prophylaxis or treatment of a pathological condition or disease caused by or associated with an infection by a respiratory virus selected from the group consisting of orthomyxovirus and paramyxovirus.
摘要翻译：本发明提供了用于制造用于预防或治疗由选自下组的呼吸道病毒感染引起或与之相关的病理状况或疾病的抗病毒药物组合物的用途和/或κ-角叉菜胶的用途由正粘病毒，副粘病毒，腺病毒和冠状病毒组成。本发明进一步提供了岩藻依聚糖，特别是高分子量岩藻依聚糖在制备抗病毒药物组合物中的应用，所述抗病毒药物组合物用于预防或治疗由选择的呼吸病毒感染引起或与之相关的病理状况或疾病由正粘病毒和副粘病毒组成。

9. 发明公开

EP2515889A2 SYNERGISTIC ANTIVIRAL COMPOSITION AND USE THEREOF 有权
标题翻译：协同抗病毒组合物及其使用
公开(公告)号：EP2515889A2
公开(公告)日：2012-10-31
申请号：EP10810910.9
申请日：2010-12-17
申请人： Marinomed Biotechnologie GmbH
发明人： GRASSAUER, Andreas , PRIESCHL-GRASSAUER, Eva , MEIER, Christiane , KÖNIG-SCHUSTER, Marielle
IPC分类号： A61K31/13 , A61K31/731 , A61K31/19
CPC分类号： A61K47/36 , A61K31/13 , A61K31/19 , A61K31/731 , A61K45/06 , A61K2300/00
摘要： The present invention relates to iota- and/or kappa-carrageenan in combination with a neuraminidase inhibitor for use as a medicament in the prophylactic or therapeutic treatment of a symptom, condition or disease caused by or associated with an infection by an influenza virus.

10. 发明公开

EP2355835A1 USE OF ESCIN FOR TREATMENT OF TYPE IV HYPERSENSITIVITY REACTION 审中-公开
标题翻译：七叶素IV型超敏反应中的用途
公开(公告)号：EP2355835A1
公开(公告)日：2011-08-17
申请号：EP09749154.2
申请日：2009-11-16
申请人： Marinomed Biotechnologie GmbH
发明人： PRIESCHL-GRASSAUER, Eva , FRIEDRICH, Thomas
IPC分类号： A61K36/49 , A61K36/77 , A61K31/704 , A61P43/00
CPC分类号： A61K36/77
摘要： The present invention provides the use of escin for the manufacture of a pharmaceutical preparation for the treatment of a Type IV hypersensitivity reaction or symptoms of a Type IV hypersensitivity reaction, like for instance contact dermatitis.

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