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1. 发明申请

WO0015176A3 TREATMENT OF CARCINOMAS USING SQUALAMINE IN COMBINATION WITH OTHER ANTI-CANCER AGENTS OR MODALITIES 审中-公开
标题翻译：用其他抗癌药或联合方案治疗癌症
公开(公告)号：WO0015176A3
公开(公告)日：2000-07-20
申请号：PCT/US9920645
申请日：1999-09-10
申请人： MAGAININ PHARMA , ZASLOFF MICHAEL , WILLIAMS JON , SOKOLOFF MITCHELL H
发明人： ZASLOFF MICHAEL , WILLIAMS JON , SOKOLOFF MITCHELL H
IPC分类号： A61K45/00 , A61K31/00 , A61K31/136 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/198 , A61K31/351 , A61K31/407 , A61K31/41 , A61K31/437 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/565 , A61K31/575 , A61K31/7004 , A61K33/24 , A61K33/42 , A61P5/02 , A61P5/28 , A61P35/00 , A61K31/595
CPC分类号： A61K31/00 , A61K31/575 , A61K2300/00
摘要： A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. Synergistically effective amounts are preferred. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds. As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, doxorubicin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents. Alternatively, the first treatment may be a treatment with one or more conventional anti-hormonal agents. As examples, the anti-hormonal agents may be a LHRH (luteinizing hormone releasing hormone) agonist or an anti-androgen such as flutamide, biclutamide, nilutamide, and luprolide. These conventional cancer treatments compounds and the squalamine may be administered by any suitable route. The first treatment procedure may take place prior to the second treatment procedure, after the second treatment procedure, or the two treatment procedures may take place simultaneously. As an alternative, the first treatment procedure may be a conventional radiation treatment regimen. As a further alternative the first treatment procedure may be a combination of treatment with one or more conventional cytotoxic chemical compounds and a conventional radiation treatment regimen.
摘要翻译：治疗肿瘤的方法包括使用常规癌症治疗技术的第一治疗程序和包括施用有效量的角鲨胺的第二治疗程序。协同有效量是优选的。第一治疗程序可以是用一种或多种常规细胞毒化学化合物治疗。作为实例，细胞毒化学化合物可以是亚硝基脲（例如BCNU），环磷酰胺，阿霉素，5-氟尿嘧啶，紫杉醇及其衍生物，顺铂或其他含有铂的癌症治疗剂。或者，第一次治疗可以是用一种或多种常规抗激素药物治疗。作为实例，抗激素药可以是LHRH（促黄体激素释放激素）激动剂或抗雄激素药，例如氟他胺，双氯苯酰胺，尼鲁米特和亮丙瑞林。这些常规的癌症治疗化合物和角鲨胺可以通过任何合适的途径施用。第一治疗程序可以在第二治疗程序之前，第二治疗程序之后或两个治疗程序可以同时进行。作为替代，第一治疗程序可以是常规的放射治疗方案。作为另一种选择，第一治疗程序可以是用一种或多种常规细胞毒化学化合物治疗和常规放射治疗方案的组合。

2. 发明申请

WO9640728A3 AMINOSTEROL COMPOUNDS USEFUL AS INHIBITORS OF THE SODIUM/PROTON EXCHANGER (NHE), PHARMACEUTICAL METHODS AND COMPOSITIONS EMPLOYING SUCH INHIBITORS, AND PROCESSES FOR EVALUATING THE NHE-INHIBITORY EFFICACY OF COMPOUNDS 审中-公开
标题翻译：作为钠/原子交换剂（NHE）的抑制剂的AMINOSTEROL化合物，使用这种抑制剂的药物方法和组合物，以及评价化合物的NHE抑制作用的方法
公开(公告)号：WO9640728A3
公开(公告)日：1997-03-27
申请号：PCT/US9610508
申请日：1996-06-07
申请人： MAGAININ PHARMA
发明人： ZASLOFF MICHAEL , SHINNAR ANN , KINNEY WILLIAM , WILLIAMS JON , RAO MEENA , ANDERSON MARK , MCLANE MICHAEL , JONES STEVEN
IPC分类号： A61K31/575 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P43/00 , C07J41/00 , G01N33/48 , G01N33/50
CPC分类号： G01N33/5008 , C07J41/0005 , G01N33/5011 , G01N33/5044 , G01N33/505 , G01N33/5058 , G01N33/5061 , G01N33/5088 , G01N2500/00
摘要： Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

3. 发明公开

EP1119361A4 TREATMENT OF CARCINOMAS USING SQUALAMINE IN COMBINATION WITH OTHER ANTI-CANCER AGENTS OR MODALITIES 审中-公开
标题翻译： BE UNG V ON EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP1119361A4
公开(公告)日：2006-10-04
申请号：EP99952905
申请日：1999-09-10
申请人： MAGAININ PHARMA
发明人： ZASLOFF MICHAEL , WILLIAMS JON , SOKOLOFF MITCHELL H
IPC分类号： A61K45/00 , A61K31/00 , A61K31/136 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/198 , A61K31/351 , A61K31/407 , A61K31/41 , A61K31/437 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/565 , A61K31/575 , A61K31/7004 , A61K33/24 , A61K33/42 , A61P5/02 , A61P5/28 , A61P35/00 , A61K31/59
CPC分类号： A61K31/00 , A61K31/575 , A61K2300/00
摘要： A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. Synergistically effective amounts are preferred. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds. As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, doxorubicin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents. Alternatively, the first treatment may be a treatment with one or more conventional anti-hormonal agents. As examples, the anti-hormonal agents may be a LHRH (luteinizing hormone releasing hormone) agonist or an anti-androgen such as flutamide, biclutamide, nilutamide, and luprolide. These conventional cancer treatments compounds and the squalamine may be administered by any suitable route. The first treatment procedure may take place prior to the second treatment procedure, after the second treatment procedure, or the two treatment procedures may take place simultaneously. As an alternative, the first treatment procedure may be a conventional radiation treatment regimen. As a further alternative the first treatment procedure may be a combination of treatment with one or more conventional cytotoxic chemical compounds and a conventional radiation treatment regimen.
摘要翻译：用于治疗肿瘤的方法包括使用常规癌症治疗技术的第一种治疗方法和包括给予有效量的角鲨胺的第二种治疗方法。协同有效量是优选的。第一种治疗方法可以是用一种或多种常规细胞毒性化学化合物治疗。作为实例，细胞毒性化合物可以是亚硝基脲（如BCNU），环磷酰胺，多柔比星，5-氟尿嘧啶，紫杉醇及其衍生物，顺铂或其它含铂的癌症治疗剂。或者，第一种治疗可以是用一种或多种常规抗激素剂治疗。作为实例，抗激素剂可以是LHRH（黄体生成激素释放激素）激动剂或抗雄激素，例如氟他胺，二扑他丁胺，尼鲁替丁和氟他洛林。这些常规的癌症治疗化合物和角鲨胺可以通过任何合适的途径施用。第一处理程序可以在第二处理程序之前，第二处理程序之后进行，或者两个处理程序可以同时进行。作为替代方案，第一种治疗方法可以是常规的放射治疗方案。作为另一种替代方案，第一种治疗方法可以是治疗与一种或多种常规细胞毒性化合物和常规放射治疗方案的组合。

4. 发明专利

DE69722793D1 未知
公开(公告)号：DE69722793D1
公开(公告)日：2003-07-17
申请号：DE69722793
申请日：1997-04-25
申请人： MAGAININ PHARMA
发明人： ZASLOFF MICHAEL , WILLIAMS JON
IPC分类号： A61K45/00 , A61K31/00 , A61K31/40 , A61K31/407 , A61K31/475 , A61K31/505 , A61K31/513 , A61K31/575 , A61K31/675 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K33/24 , A61P35/00 , A61K31/56 , A61K7/16 , H04L7/033
摘要： A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds. As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, adriamycin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents. The cytotoxic chemical compound and the squalamine may be administered by any suitable route. The first treatment procedure may take place prior to the second treatment procedure, after the second treatment procedure, or the two treatment procedures may take place simultaneously. In one example, the first treatment procedure (e.g., a one time intravenous dosage of BCNU) is completed before the second treatment procedure with squalamine begins. As an alternative, the first treatment procedure may be a conventional radiation treatment regimen.

5. 发明专利

CA2255856A1 THERAPEUTIC USES FOR AN AMINOSTEROL COMPOUND 未知
公开(公告)号：CA2255856A1
公开(公告)日：1997-11-27
申请号：CA2255856
申请日：1997-05-16
申请人： MAGAININ PHARMA
发明人： ANDERSON MARK , ZASLOFF MICHAEL , KINNEY WILLIAM , WILLIAMS JON
IPC分类号： A61K31/575 , A61P3/04 , A61P7/10 , A61P19/02 , A61P29/00 , A61P31/22 , A61P35/00 , A61P35/02 , A61P43/00 , C07J41/00
摘要： A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of cancers, such as leukemia; inflammation; arthritis; and viruses, such as HSV. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, inflammation, arthritis, herpes simplex virus, melanoma, and leukemia may be treated by administering an effective amount of the pharmaceutical compositions. Viral replication, weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

6. 发明专利

AT242635T 未知
公开(公告)号：AT242635T
公开(公告)日：2003-06-15
申请号：AT97921396
申请日：1997-04-25
申请人： MAGAININ PHARMA
发明人： ZASLOFF MICHAEL , WILLIAMS JON
IPC分类号： A61K45/00 , A61K31/00 , A61K31/40 , A61K31/407 , A61K31/475 , A61K31/505 , A61K31/513 , A61K31/575 , A61K31/675 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K33/24 , A61P35/00 , A61K31/56
摘要： A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds. As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, adriamycin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents. The cytotoxic chemical compound and the squalamine may be administered by any suitable route. The first treatment procedure may take place prior to the second treatment procedure, after the second treatment procedure, or the two treatment procedures may take place simultaneously. In one example, the first treatment procedure (e.g., a one time intravenous dosage of BCNU) is completed before the second treatment procedure with squalamine begins. As an alternative, the first treatment procedure may be a conventional radiation treatment regimen.

7. 发明专利

AU726909B2 Therapeutic uses for an aminosterol compound 未知
公开(公告)号：AU726909B2
公开(公告)日：2000-11-23
申请号：AU3130697
申请日：1997-05-16
申请人： MAGAININ PHARMA
发明人： ZASLOFF MICHAEL , WILLIAMS JON , KINNEY WILLIAM , ANDERSON MARK
IPC分类号： A61K31/575 , A61P3/04 , A61P7/10 , A61P19/02 , A61P29/00 , A61P31/22 , A61P35/00 , A61P35/02 , A61P43/00 , C07J41/00
摘要： A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

8. 发明专利

CA2252584C TREATMENT OF CARCINOMAS USING SQUALAMINE IN COMBINATION WITHOTHER ANTI-CANCER AGENTS 未知
公开(公告)号：CA2252584C
公开(公告)日：2008-06-10
申请号：CA2252584
申请日：1997-04-25
申请人： MAGAININ PHARMA
发明人： ZASLOFF MICHAEL , WILLIAMS JON
IPC分类号： A61K31/575 , A61K45/00 , A61K31/00 , A61K31/40 , A61K31/407 , A61K31/475 , A61K31/505 , A61K31/513 , A61K31/675 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K33/24 , A61K45/06 , A61P35/00
摘要： A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds. As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, adriamycin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents. The cytotoxic chemical compound and the squalamine may be administer ed by any suitable route. The first treatment procedure may take place prior to the second treatment procedure, after the second treatment procedure, or the two treatment procedures may take place simultaneously. In one example, the first treatment procedure (e.g., a one time intravenous dosage of BCNU) is completed before the second treatment procedure with squalamine begins. As an alternative, th e first treatment procedure may be a conventional radiation treatment regimen.

9. 发明专利

AU735884B2 Treatment of carcinomas using squalamine in combination with other anti-cancer agents 未知
公开(公告)号：AU735884B2
公开(公告)日：2001-07-19
申请号：AU2744197
申请日：1997-04-25
申请人： MAGAININ PHARMA
发明人： ZASLOFF MICHAEL , WILLIAMS JON
IPC分类号： A61K45/00 , A61K31/00 , A61K31/40 , A61K31/407 , A61K31/475 , A61K31/505 , A61K31/513 , A61K31/575 , A61K31/675 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K33/24 , A61P35/00 , A61K31/56
摘要： A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds. As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, adriamycin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents. The cytotoxic chemical compound and the squalamine may be administered by any suitable route. The first treatment procedure may take place prior to the second treatment procedure, after the second treatment procedure, or the two treatment procedures may take place simultaneously. In one example, the first treatment procedure (e.g., a one time intravenous dosage of BCNU) is completed before the second treatment procedure with squalamine begins. As an alternative, the first treatment procedure may be a conventional radiation treatment regimen.

10. 发明专利

AU5194998A Certain aminosterol compounds and uses therefor 未知
公开(公告)号：AU5194998A
公开(公告)日：1998-05-29
申请号：AU5194998
申请日：1997-10-31
申请人： MAGAININ PHARMA
发明人： ZASLOFF MICHAEL , WILLIAMS JON , KINNEY WILLIAM , ALPER SETH
IPC分类号： A61K31/575 , C07J41/00

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