专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO9903488A3 BIOLOGICALLY ACTIVE PEPTIDES WITH REDUCED TOXICITY IN ANIMALS AND A METHOD FOR PREPARING SAME 审中-公开
标题翻译：动物中具有降低毒性的生物活性肽及其制备方法
公开(公告)号：WO9903488A3
公开(公告)日：1999-04-08
申请号：PCT/US9814610
申请日：1998-07-15
申请人： MAGAININ PHARMA
发明人： KARI U PRASAD , WILLIAMS TAFFY J , MCLANE MICHAEL
IPC分类号： A61K38/00 , A61P31/00 , A61P35/00 , C07K1/02 , C07K14/435 , C07K14/46 , C07K14/47 , A61K38/17 , A61K38/04 , C07K14/00
CPC分类号： C07K14/46 , A61K38/00 , C07K14/43563
摘要： The present invention relates to biologically active peptides with reduced toxicity and methods of preparing them. The peptides of the invention, which can be unsubstituted or N-terminal substituted have formula (I), wherein X is a biologically active amphiphilic ion channel-forming peptide or protein, T is a lipophilic moiety or hydrogen, and W is T or hydrogen. Preferably T is formula (II), wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. The peptides and proteins of the invention have improved antimicrobial and anti-tumor biological activity while exhibiting reduced toxicity. A preferred method of reducing toxicity involves the formation of related methane sulfonate derivatives or analogues. Additionally, the compounds of the invention may be used to treat sepsis, septic shock, and lung infections, such as those occuring in cystic fibrosis.
摘要翻译：本发明涉及毒性降低的生物活性肽及其制备方法。可以是未取代或N-末端取代的本发明的肽具有式（I），其中X是生物活性两亲离子通道形成肽或蛋白质，T是亲脂性部分或氢，W是T或氢。 T优选为式（II），其中R为具有至少2个且不超过10个碳原子的烃（烷基或芳族或烷基芳族）。 T优选为辛酰基。本发明的肽和蛋白质具有改善的抗微生物和抗肿瘤生物活性，同时显示降低的毒性。降低毒性的优选方法涉及形成相关的甲磺酸衍生物或类似物。此外，本发明的化合物可用于治疗败血症，败血性休克和肺部感染，例如发生在囊性纤维化中的那些。

2. 发明专利

AU1728895A Ion-channel forming amphiphilic peptides having n-terminal modifications 未知
公开(公告)号：AU1728895A
公开(公告)日：1995-08-01
申请号：AU1728895
申请日：1995-01-18
申请人： MAGAININ PHARMA
发明人： KARI U PRASAD , WILLIAMS TAFFY J , MCLANE MICHAEL
IPC分类号： A61K38/00 , A61P31/04 , A61P31/12 , C07K1/107 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/46 , A61K38/17

3. 发明专利

CA2151046A1 TREATMENT OF SEPTIC SHOCK WITH CONJUGATED BIOLOGICALLY ACTIVE PEPTIDES 未知
公开(公告)号：CA2151046A1
公开(公告)日：1994-06-23
申请号：CA2151046
申请日：1993-12-06
申请人： MAGAININ PHARMA
发明人： HENDI MUKTA , RAO MEENA , WILLIAMS TAFFY J
IPC分类号： A61K38/00 , A61K47/48 , A61P9/00 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/46 , C07K17/02 , C07K17/08 , C07K17/10 , C07K7/04 , C07K9/00
摘要： A compound which is a conjugate of a biologically active amphiphilic peptide and a conjugate moiety. The conjugate moiety may be a carbohydrate (such as dextran or hetastarch); a protein; polyvinyl pyrrolidone, a polyalkylene glycol; or polyvinyl alcohol. Such compounds neutralize bacterial endotoxins, and thus are particularly useful in the treatment or prevention of septic shock.

4. 发明专利

AU8300598A Biologically active peptides with reduced toxicity in animals and a method for preparing same 未知
公开(公告)号：AU8300598A
公开(公告)日：1999-02-10
申请号：AU8300598
申请日：1998-07-15
申请人： MAGAININ PHARMA
发明人： KARI U PRASAD , WILLIAMS TAFFY J , MCLANE MICHAEL
IPC分类号： A61K38/00 , A61P31/00 , A61P35/00 , C07K1/02 , C07K14/435 , C07K14/46 , C07K14/47

5. 发明专利

CA2180748A1 ION-CHANNEL FORMING AMPHIPHILIC PEPTIDES HAVING N-TERMINAL MODIFICATIONS 未知
公开(公告)号：CA2180748A1
公开(公告)日：1995-07-20
申请号：CA2180748
申请日：1995-01-18
申请人： MAGAININ PHARMA
发明人： KARI U PRASAD , WILLIAMS TAFFY J , MCLANE MICHAEL
IPC分类号： A61K38/00 , A61P31/04 , A61P31/12 , C07K1/107 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/46 , A61K38/16 , A61K38/09 , A61K38/10
摘要： An N-terminal substituted peptide or protein having formula (1). X is a biologically active amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and preferably, T is formula (2), wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. W is T or hydrogen. The N-terminal substituted peptides and proteins have improved biological activity against target cells, viruses, and virally-infected cells.

6. 发明专利

CA2294518A1 BIOLOGICALLY ACTIVE PEPTIDES WITH REDUCED TOXICITY IN ANIMALS AND A METHOD FOR PREPARING SAME 未知
公开(公告)号：CA2294518A1
公开(公告)日：1999-01-28
申请号：CA2294518
申请日：1998-07-15
申请人： MAGAININ PHARMA
发明人： MCLANE MICHAEL , WILLIAMS TAFFY J , KARI U PRASAD
IPC分类号： A61K38/00 , A61P31/00 , A61P35/00 , C07K1/02 , C07K14/435 , C07K14/46 , C07K14/47
摘要： The present invention relates to biologically active peptides with reduced toxicity and methods of preparing them. The peptides of the invention, which can be unsubstituted or N-terminal substituted have formula (I), wherein X is a biologically active amphiphilic ion channel-forming peptide or protein, T is a lipophilic moiety or hydrogen, and W is T or hydrogen. Preferably T is formula (II), wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. The peptides and proteins of the invention have improved antimicrobial and anti-tumor biological activity while exhibiting reduced toxicity. A preferred method of reducing toxicity involves the formation of related methane sulfonate derivatives or analogues. Additionally, the compounds of the invention may be used to treat sepsis, septic shock, and lung infections, such as those occuring in cystic fibrosis.

7. 发明专利

AU693518B2 Ion-channel forming amphiphilic peptides having n-terminal modifications 未知
公开(公告)号：AU693518B2
公开(公告)日：1998-07-02
申请号：AU1728895
申请日：1995-01-18
申请人： MAGAININ PHARMA
发明人： KARI U PRASAD , WILLIAMS TAFFY J , MCLANE MICHAEL
IPC分类号： A61K38/00 , A61P31/04 , A61P31/12 , C07K1/107 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/46 , A61K38/17

8. 发明专利

AU5741794A Treatment of septic shock with conjugated biologically active peptides 未知
公开(公告)号：AU5741794A
公开(公告)日：1994-07-04
申请号：AU5741794
申请日：1993-12-06
申请人： MAGAININ PHARMA
发明人： HENDI MUKTA , RAO MEENA , WILLIAMS TAFFY J
IPC分类号： A61K38/00 , A61K47/48 , A61P9/00 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/46 , C07K17/02 , C07K17/08 , C07K17/10 , C07K7/04 , A61K37/02 , C07K9/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式