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1. 发明申请

WO0066708A9 ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS 审中-公开
标题翻译：哮喘相关因素作为治疗特应性包括哮喘和相关疾病的目标
公开(公告)号：WO0066708A9
公开(公告)日：2001-06-28
申请号：PCT/US0011712
申请日：2000-05-01
申请人： MAGAININ PHARMA , LOUAHED JAMILA , DONG CHARLES QU , LEVITT ROY C , MALOY W LEE , ZHOU YUHONG , NICOLAIDES NICHOLAS C
发明人： LOUAHED JAMILA , DONG CHARLES QU , LEVITT ROY C , MALOY W LEE , ZHOU YUHONG , NICOLAIDES NICHOLAS C
IPC分类号： G01N33/53 , A61K31/56 , A61K31/7088 , A61K38/00 , A61K38/16 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P11/06 , A61P37/02 , A61P37/08 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/70 , C12N15/74 , C12N15/79 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , C12N15/12
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/47
摘要： A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related disorders. The invention also includes methods for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders, methods for diagnosing susceptibility to, and assessing treatment of atopic allergy or asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein. The use of this protein as a therapeutic agent for the treatment of autoimmune diseases is also indicated.
摘要翻译：已经鉴定和分离了由IL-9诱导的新型TH2相关基因，从而为IL-9介导的疾病如特应性变态反应和哮喘相关疾病提供了治疗靶点。本发明还包括用于鉴定和使用该基因的小分子抑制剂及其产品来治疗这些病症的方法，通过测量在特应性变态反应或哮喘相关病症中的基因表达水平来诊断易感性和评估特应性变态反应或哮喘相关病症的方法使用对该蛋白特异的抗体进行生物学样品。还指出了使用这种蛋白质作为治疗自身免疫性疾病的治疗剂。

2. 发明申请

WO9944620A9 ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS 审中-公开
标题翻译： ASTHMA相关因素作为治疗原发性白血病（包括哮喘和相关疾病）的目标
公开(公告)号：WO9944620A9
公开(公告)日：2001-05-17
申请号：PCT/US9904703
申请日：1999-03-03
申请人： MAGAININ PHARMA , HOLROYD KENNETH J , LEVITT ROY C , MALOY W LEE , LOUAHED JAMILA , MCLANE MIKE , NICOLAIDES NICHOLAS C , ZHOU YUHONG , DONG QU
发明人： HOLROYD KENNETH J , LEVITT ROY C , MALOY W LEE , LOUAHED JAMILA , MCLANE MIKE , NICOLAIDES NICHOLAS C , ZHOU YUHONG , DONG QU
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/20 , A61K39/395 , A61K45/00 , A61P1/00 , A61P11/00 , A61P11/06 , A61P37/08 , A61P43/00 , C07H21/04 , C07K14/705 , C12N15/09 , C12N15/12 , C12P21/08 , G01N33/68 , A61K31/70
CPC分类号： C07K14/705 , A61K38/00 , G01N33/6872 , G01N2500/00 , Y10S977/914 , Y10S977/927
摘要： A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.
摘要翻译：已经发现钙激活的氯化物通道家族中的新基因被IL-9诱导，从而在IL-9介导的特应性过敏，哮喘相关病症和囊性纤维化的发展中提供治疗靶标。还发现了用于鉴定和使用该基因的小分子抑制剂及其产物来治疗这些疾病的方法。本发明还包括通过使用对该蛋白质特异的抗体来测量生物样品中基因表达的水平来诊断对特应性变态反应的哮喘相关疾病的易感性和评估治疗哮喘相关疾病的方法。

3. 发明申请

WO0066708A2 ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS 审中-公开
标题翻译： ASTHMA相关因素作为治疗特发性过敏症的目标，包括哮喘和相关疾病
公开(公告)号：WO0066708A2
公开(公告)日：2000-11-09
申请号：PCT/US0011712
申请日：2000-05-01
申请人： MAGAININ PHARMA , LOUAHED JAMILA , DONG QU , LEVITT ROY C , MALOY W LEE , ZHOU YUHONG , NICOLAIDES NICHOLAS C
发明人： LOUAHED JAMILA , DONG QU , LEVITT ROY C , MALOY W LEE , ZHOU YUHONG , NICOLAIDES NICHOLAS C
IPC分类号： G01N33/53 , A61K31/56 , A61K31/7088 , A61K38/00 , A61K38/16 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P11/06 , A61P37/02 , A61P37/08 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/70 , C12N15/74 , C12N15/79 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , C12N
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/47
摘要： A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related disorders. The invention also includes methods for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders, methods for diagnosing susceptibility to, and assessing treatment of atopic allergy or asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein. The use of this protein as a therapeutic agent for the treatment of autoimmune diseases is also indicated.
摘要翻译：已经鉴定和分离了由IL-9诱导的新型TH2相关基因，从而为IL-9介导的疾病如特应性变态反应和哮喘相关疾病提供治疗靶标。本发明还包括用于鉴定和使用该基因的小分子抑制剂及其治疗这些疾病的产物的方法，通过测量基因表达水平来诊断特应性变态反应或哮喘相关病症的易感性和评估治疗方法使用此蛋白特异性抗体的生物样品。也表明使用该蛋白质作为治疗自身免疫疾病的治疗剂。

4. 发明公开

EP0579763A4 NOVEL PEPTIDE COMPOSITIONS AND USES THEREFOR. 失效
标题翻译：新型肽组合物及其用途。
公开(公告)号：EP0579763A4
公开(公告)日：1994-12-21
申请号：EP92911044
申请日：1992-03-27
申请人： MAGAININ PHARMA
发明人： MALOY W LEE
IPC分类号： A61K38/00 , A61P31/12 , C07K7/08 , C07K14/00 , C07K14/46 , A61K37/02 , C07K7/10
CPC分类号： C07K14/001 , A61K38/00 , C07K14/46
摘要： Novel biologically active amphiphilic peptides and/or analogues or derivatives are used as a pharmaceutical. Such peptides have antibiotic and/or anti-viral and/or anti-tumor and/or anti-parasitic and/or spermicidal activity.

5. 发明公开

EP0671938A4 NOVEL BIOLOGICALLY ACTIVE PEPTIDES AND USES THEREFOR. 失效
标题翻译：新颖，生物活性肽及其用途。
公开(公告)号：EP0671938A4
公开(公告)日：1997-01-15
申请号：EP94900417
申请日：1993-10-22
申请人： MAGAININ PHARMA
发明人： MALOY W LEE , KARI U PRASAD
IPC分类号： A61K38/00 , A61P31/12 , C07K14/435 , C07K14/46 , C07K7/08 , C07K14/00
CPC分类号： C07K14/463 , A61K38/00 , C07K14/435
摘要： Novel biologically active amphiphilic peptides having from 21 to 26 amino acid residues, and which may be employed as pharmaceuticals.

6. 发明公开

EP0590044A4 COMPOSITION AND TREATMENT WITH BIOLOGICALLY ACTIVE PEPTIDES HAVING C-TERMINAL SUBSTITUTIONS 失效
标题翻译：具有生物活性肽的组合物和治疗具有C-末端取代
公开(公告)号：EP0590044A4
公开(公告)日：1996-06-12
申请号：EP92913961
申请日：1992-06-01
申请人： MAGAININ PHARMA
发明人： MALOY W LEE , KARI U PRASAD
IPC分类号： A61K38/00 , A61P31/12 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/46 , A61K37/02 , C07K7/10
CPC分类号： C07K7/08 , A61K38/00 , C07K14/435 , C07K14/463
摘要： A C-terminal substituted peptide or protein of formula (I), wherein X is a biologically active amphiphilic ion channel-forming peptide or protein. T is selected from the group consisting of: (a) O-R, wherein R is a substituted or unsubstituted aliphatic, aromatic or aralkyl group having from 1 to 10 carbon atoms; (b) NH-NH2; (c) NH-OH; and (d) alpha , wherein R' and R" are hydrogen or selected from the class consisting of group (i) and group (ii), wherein group (i) is a hydroxy-substituted aliphatic, aromatic or aralkyl group having no more than 10 carbon atoms, and group (ii) is an amino-substituted aliphatic, aromatic, aralkyl, or alkylaromatic group, preferably having no more than 10 carbon atoms, and at least one of R' and R" is group (i) or group (ii).

7. 发明公开

EP0667871A4 BIOLOGICALLY ACTIVE AMPHIPHILIC PEPTIDE COMPOSITIONS AND USES THEREFOR. 失效
标题翻译： BIOLOGISCH AKTIVE AMPHIPHILE PEPTIDZUSAMMENSETZUNGEN UND IHRE VERWENDUNGEN。
公开(公告)号：EP0667871A4
公开(公告)日：1995-04-06
申请号：EP92920492
申请日：1992-09-04
申请人： MAGAININ PHARMA
发明人： MALOY W LEE , KARI U PRASAD , WILLIAMS JON I
IPC分类号： A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/46
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/46
摘要： Biologically active amphiphilic peptides including one of the following basic structures: I) R1-R2-R2-R1-R2-R2-R1-R1-R2-R1-R1; II) R2-R1-R2-R2-R1-R1-R2-R2-R1-R2-R2; III) R1-R2-R2-R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R3; IV) R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R4; V) R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R2-R3; or VI) R1-R1-R3-R2-R1-R1-R1-R1-R1-R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R1. R1 is a hydrophobic amino acid and R2 is a basic hydrophilic or neutral hydrophilic amino acid, R3 is a neutral hydrophilic amino acid, and R4 is a neutral hydrophilic amino acid or proline. There is also provided a biologically active amphiphilic peptide having a structural formula selected from the group consisting of: (a) R1-R2-R2-R1-R2-R2-R1; (b) R1-R1-R2-R2-R1-R2-R2-R1; (c) R2-R1-R1-R2-R2-R1-R2-R2-R1; (d) R2-R2-R1-R1-R2-R2-R1-R2-R2-R1; and (e) R1-R2-R2-R1-R1-R2-R2-R1-R2-R2-R1, wherein R1 and R2 are hereinabove described. Such peptides may be employed as pharmaceuticals.
摘要翻译：包括以下基本结构之一的生物活性两亲性肽：I）R1-R2-R2-R1-R2-R2-R1-R1-R2-R1-R1; II）R2-R1-R2-R2-R1-R1-R2-R2-R1-R2-R2; III）R1-R2-R2-R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R3; IV）R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R4; V）R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R2-R3; 或VI）R 1 -R 1 -R 3 -R 2 -R 1 -R 1 -R 1 -R 1 -R 1 -R 1 -R 2 -R 1 -R 1 -R 2 -R 2 -R 1 -R 1 -R 2 -R 2 -R 1。 R1是疏水氨基酸，R2是碱性亲水或中性亲水氨基酸，R3是中性亲水氨基酸，R4是中性亲水氨基酸或脯氨酸。还提供了具有选自以下的结构式的生物活性两亲性肽：（a）R1-R2-R2-R1-R2-R2-R1; （b）R1-R1-R2-R2-R1-R2-R2-R1; （c）R2-R1-R1-R2-R2-R1-R2-R2-R1; （d）R2-R2-R1-R1-R2-R2-R1-R2-R2-R1; 和（e）R1-R2-R2-R1-R1-R2-R2-R1-R2-R2-R1，其中R1和R2如上所述。这样的肽可以用作药物。

8. 发明专利

AU6334200A Asthma associated factors as targets for treating atopic allergies including asthma and related disorders 未知
公开(公告)号：AU6334200A
公开(公告)日：2000-11-17
申请号：AU6334200
申请日：2000-05-01
申请人： MAGAININ PHARMA
发明人： LOUAHED JAMILA , DONG QU , LEVITT ROY C , MALOY W LEE , ZHOU YUHONG , NICOLAIDES NICHOLAS C
IPC分类号： G01N33/53 , A61K31/56 , A61K31/7088 , A61K38/00 , A61K38/16 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P11/06 , A61P37/02 , A61P37/08 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/70 , C12N15/74 , C12N15/79 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91
摘要： A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related disorders. The invention also includes methods for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders, methods for diagnosing susceptibility to, and assessing treatment of atopic allergy or asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein. The use of this protein as a therapeutic agent for the treatment of autoimmune diseases is also indicated.

10. 发明专利

CA2107674A1 NOVEL PEPTIDE COMPOSITIONS AND USES THEREFOR 未知
公开(公告)号：CA2107674A1
公开(公告)日：1992-10-09
申请号：CA2107674
申请日：1992-03-27
申请人： MAGAININ PHARMA
发明人： MALOY W LEE
IPC分类号： A61K38/00 , A61P31/12 , C07K7/08 , C07K14/00 , C07K14/46 , A61K38/16
摘要： 2107674 9217195 PCTABS00016 Novel biologically active amphiphilic peptides and/or analogues or derivatives are used as a pharmaceutical. Such peptides have antibiotic and/or anti-viral and/or anti-tumor and/or anti-parasitic and/or spermicidal activity.

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